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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 61 to 67 of 67 (0.074 seconds)| 61 |
Funktionelle Analyse und Charakterisierung des Gpr1-Proteins in der Hefe Yarrowia lipolyticaGentsch, Marcus 11 November 2003 (has links) (PDF)
In der Hefe Yarrowia lipolytica führen Mutationen im GPR1-Gen zu Essigsäuresensitivität. Die Deletion dieses Genes hat demgegenüber keinen Effekt auf den Phänotyp. In dieser Arbeit wurde das Gpr1-Protein näher charakterisiert. Es zeigte sich, dass GPR1-Mutantenstämme wesentlich schneller Acetat akkumulierten als der Wildtyp. Außerdem konnte bestetigt werden, dass Gpr1p ein integrales Membranprotein ist. Mittels Ortspezifischer Analyse wurden verschiedene funktionelle Bereiche untersucht. Das Protein unterliegt zudem einer Phosphorylierung/Dephosphorylierung. Auf der Grundlage der dargelegten Ergebnisse wurde ein Funktionsmodell für Gpr1p erstellt.
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Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) im Erwachsenenalter: Stressreagibilität und Stressbewältigung unter Laborbedingungen und im Alltag / Attention-deficit/hyperacitvity disorder (ADHD) in adulthood: Stressreagibility and stress-related coping under laboratory conditions and in everyday lifeLackschewitz, Halina 29 October 2008 (has links)
No description available.
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Nächtliche Glucoseanstiege durch die Stressreaktion beim Klingeln eines Weckers können durch geschultes Pflegepersonal vermieden werden. Eine Analyse mittels kontinuierlichen Glucose-Monitorings (GlucoDay® S) bei Patienten mit Typ-1-Diabetes / Glycaemic rises after waking up in response to an alarm clock in type 1-diabetic patients analysed with continuous glucose monitoring (GlucoDay® S)Berndt-Zipfel, Christine 11 October 2011 (has links)
No description available.
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Funktionelle Analyse und Charakterisierung des Gpr1-Proteins in der Hefe Yarrowia lipolyticaGentsch, Marcus 08 December 2003 (has links)
In der Hefe Yarrowia lipolytica führen Mutationen im GPR1-Gen zu Essigsäuresensitivität. Die Deletion dieses Genes hat demgegenüber keinen Effekt auf den Phänotyp. In dieser Arbeit wurde das Gpr1-Protein näher charakterisiert. Es zeigte sich, dass GPR1-Mutantenstämme wesentlich schneller Acetat akkumulierten als der Wildtyp. Außerdem konnte bestetigt werden, dass Gpr1p ein integrales Membranprotein ist. Mittels Ortspezifischer Analyse wurden verschiedene funktionelle Bereiche untersucht. Das Protein unterliegt zudem einer Phosphorylierung/Dephosphorylierung. Auf der Grundlage der dargelegten Ergebnisse wurde ein Funktionsmodell für Gpr1p erstellt.
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Phyletic Distribution and Diversification of the Phage Shock Protein Stress Response System in Bacteria and ArchaeaPopp, Philipp F, Gumerov, Vadim M., Andrianova, Ekaterina P., Bewersdorf, Lisa, Mascher, Thorsten, Zhulin, Igor B., Wolf, Diana 19 March 2024 (has links)
Maintaining cell envelope integrity is of vital importance for all microorganisms. Not surprisingly, evolution has shaped conserved protein protection networks that connect stress perception, transmembrane signal transduction, and mediation of cellular responses upon cell envelope stress. The phage shock protein (Psp) stress response is one such conserved protection network. Most knowledge about the Psp response derives from studies in the Gram-negative model bacterium Escherichia coli, where the Psp system consists of several well-defined protein components. Homologous systems were identified in representatives of the Proteobacteria, Actinobacteria, and Firmicutes. However, the Psp system distribution in the microbial world remains largely unknown. By carrying out a large-scale, unbiased comparative genomics analysis, we found components of the Psp system in many bacterial and archaeal phyla and describe that the predicted Psp systems deviate dramatically from the known prototypes. The core proteins PspA and PspC have been integrated into various (often phylum-specifically) conserved protein networks during evolution. Based on protein domain-based and gene neighborhood analyses of pspA and pspC homologs, we built a natural classification system for Psp networks in bacteria and archaea. We validate our approach by performing a comprehensive in vivo protein interaction study of Psp domains identified in the Gram-positive model organism Bacillus subtilis and found a strong interconnected protein network. Our study highlights the diversity of Psp domain organizations and potentially diverse functions across the plethora of the microbial landscape, thus laying the ground for studies beyond known Psp functions in underrepresented organisms.
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Synthesis and mechanism-of-action of a novel synthetic antibiotic based on a dendritic system with bow-tie topologyRevilla-Guarinos, Ainhoa, Popp, Philipp F., Dürr, Franziska, Lozano-Cruz, Tania, Hartig, Johanna, de la Mata, Francisco Javier, Gómez, Rafael, Mascher, Thorsten 21 May 2024 (has links)
Over the course of the last decades, the continuous exposure of bacteria to antibiotics—at least in parts due to misprescription, misuse, and misdosing—has led to the widespread development of antimicrobial resistances. This development poses a threat to the available medication in losing their effectiveness in treating bacterial infections. On the drug development side, only minor advances have been made to bring forward novel therapeutics. In addition to increasing the efforts and approaches of tapping the natural sources of new antibiotics, synthetic approaches to developing novel antimicrobials are being pursued. In this study, BDTL049 was rationally designed using knowledge based on the properties of natural antibiotics. BDTL049 is a carbosilane dendritic system with bow-tie type topology, which has antimicrobial activity at concentrations comparable to clinically established natural antibiotics. In this report, we describe its mechanism of action on the Gram-positive model organism Bacillus subtilis. Exposure to BDTL049 resulted in a complex transcriptional response, which pointed toward disturbance of the cell envelope homeostasis accompanied by disruption of other central cellular processes of bacterial metabolism as the primary targets of BDTL049 treatment. By applying a combination of whole-cell biosensors, molecular staining, and voltage sensitive dyes, we demonstrate that the mode of action of BDTL049 comprises membrane depolarization concomitant with pore formation. As a result, this new molecule kills Gram-positive bacteria within minutes. Since BDTL049 attacks bacterial cells at different targets simultaneously, this might decrease the chances for the development of bacterial resistances, thereby making it a promising candidate for a future antimicrobial agent.
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Vergleich von Anästhesieverfahren bei chirurgischen Eingriffen an der oberen Extremität / Regional anesthesia compared to general anesthesia for outpatient surgery on the upper limbGeibel, Stephan 09 August 2017 (has links)
No description available.
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