Several methods of surgical stabilization of the atlantoaxial joint are described in the veterinary literature. Threaded acrylic pins placed ventrally together with polymethylmethacrylate (PMMA) is a well-established technique that has been widely used in clinical cases. However, Kishigami tension bands are a less technically demanding procedure with potentially fewer complications. The purpose of this study was to biomechanically compare these two techniques in ventral-to-dorsal bending in both mature and immature dogs. Seventeen normal canine cadavers <15kg were collected and radiographed to determine skeletal maturity. The cervical spines were dissected leaving bony and ligamentous structures intact. Eight mature spines and 9 immature spines were randomly divided into two groups. In one group a Kishigami tension band was applied over the dorsal arch of the atlas and attached to the spinous process of the axis using orthopedic wire. In the second group, six acrylic pins were placed ventrally in the atlas, axis, and transarticularly. The pins were then cut and covered with PMMA. The specimens were potted in custom steel pots and biomechanically analyzed in ventral-to-dorsal four-point bending. Load-displacement curves representing the degree of stiffness were compared between the groups. Stabilization using ventral pins and PMMA had a significantly greater stiffness than a Kishigami tension band when bending in ventral to dorsal bending. Within the stabilized vertebral segment, there was no significant difference between the stiffness of immature vs. mature bone. Further analysis in torsion and analysis in abnormal dogs will be helpful in establishing the clinical significance of these findings. / Master of Science

The glenohumeral joint is the most dislocated joint in the body due to the lack of bony constraints and dependence on soft tissue, primarily muscles and ligaments, to stabilize the joint. The goal of this study was to develop a computational model of the glenohumeral joint whereby joint behavior was dictated by articular contact, ligamentous constraints, muscle loading, and external perturbations. Validation of this computational model was achieved by comparing predicted results from the model to the results of a cadaveric experiment in which the relative contribution of muscles and ligaments to anterior joint stability was examined. The results showed the subscapularis to be critical to stabilization in both neutral and external rotations, the biceps stabilized the joint in neutral but not external rotation, and the inferior glenohumeral ligament resisted anterior displacement only in external rotation. Knowledge gained from this model could assist in pre-operative planning or the design of orthopedic implants. Use of this model as a companion to cadaveric testing could save valuable time and resources.

A displasia coxofemoral é a afecção ortopédica mais frequente na espécie canina e, pela estatística apresentada pela Orthopaedic Foundation for Animals o buldogue inglês é a raça com maior acometimento proporcionalmente. Entretanto carece em literatura dados sobre o desenvolvimento e morbidade desta doença na raça. O objetivo desse estudo foi avaliar a morfologia e morfometria da articulação coxofemoral de cães da raça buldogue inglês por meio de exame radiográfico e por tomografia computadorizada comparando-os com achados da avaliação ortopédica e cinética. A hipótese proposta é de que buldogues podem apresentar alterações radiográficas compatíveis com a displasia coxofemoral sem apresentar manifestações clínicas da doença. De cada articulação avaliada foram adquiridos dados por meio de exame ortopédico, avaliação cinética, radiográfica e por tomografia computadorizada. Foram feitas avaliação subjetiva das alterações morfológicas radiográficas e aferição do ângulo de Norberg, ângulo de inclinação do colo femoral e o escore de subluxação dorsolateral. Os dados obtidos foram correlacionados por meio dos coeficiêntes de Spearman. Trinta cães foram avaliados, 20 machos e 10 fêmeas. As médias de idade e peso dos participantes do estudo foram de 3,5 anos e 26,1 kg respectivamente. 76,6% dos animais apresentaram escore de condição corporal acima do considerado ideal e 63,3% viviam em ambiente de piso liso. Entretanto esses fatores de risco avaliados não apresentaram correlação com nenhuma alteração pesquisada. 63,3% dos cães apresentaram alterações nas articulações dos joelhos e 40% nas articulações coxofemorais pela avaliação ortopédica. Pela palpação da articulação coxofemoral foram observadas alterações em 50% dos animais, sendo a crepitação leve representando 86,6% das alterações, e crepitação de grau moderado e discreta manifestação de dor em 13,3%. A frequência de alterações morfológicas radiográficas observada foi de 98,3% para subluxação coxofemoral, 81,6% para o achatamento da cabeça do fêmur, 70% para presença de osteófitos ou entesófitos periarticulares e 61,1% para o arrasamento acetabular. A conformação radiográfica da articulação coxofemoral mais frequente foi de cabeça femoral com formato discretamente elíptico e discretamente subluxada, bordas acetabulares craniolateral arredondada e dorsal encurtada com discreta presença de osteófitos. A média das mensurações morfológicas obtidas no estudo foram abaixo dos valores considerado de normalidade, sendo de 94,94° para o ângulo de Norberg, 27,13% para o escore de subluxação dorsolateral e 128,53° para o ângulo de inclinação do colo femoral. A presença de osteófitos periarticulares obteve correlação estatística com presença de crepitação à palpação da coxofemoral, assim como o arrasamento acetabular com a presença de dor ao exame ortopédico. Entretanto as manifestações clínicas não coincidiram proporcionalmente às alterações observadas pelos métodos de diagnóstico por imagem. É questionado se a conformação muscular da raça pode contribuir para contrabalancear a instabilidade articular apresentada pelos métodos avaliados / Hip dysplasia is the most common orthopedic disorder in dogs, and the statistics presented by the Orthopedic Foundation for Animals English Bulldog is the race with most animals affected proportionately. However it lacks in literature data of the development and morbidity of this disease in the race. The aim of this study was to evaluate the morphology and morphometry of the hip joint of English Bulldogs through radiographic examination and computed tomography comparing them with findings from orthopedic and kinetic evaluation. The hypothesis proposed is that Bulldogs may have radiographic changes compatible with hip dysplasia without showing clinical symptoms of the disease. From each joint evaluated were acquired data through orthopedic examination, and kinetics, radiographic and computed tomography evaluations. They were made subjective evaluation of radiographic morphological changes and measuring the Norberg angle, femoral neck inclination angle and the dorsolateral subluxation score. The data were correlated by the Spearman\'s rank. Thirty dogs were evaluated, 20 males and 10 females. The mean age and weight of the study participants was 3.5 years and 26.1 kg respectively. 76.6% of the animals had a body condition score considered above ideal and 63.3% lived in flat floor environment. However, these risk factors evaluated were not correlated with any changes searched. 63.3% of dogs showed changes in knee joints and 40% in hip joints by the orthopedic evaluation. Abnormalities were observed in 50% of animals by palpation of the hip joint, the slight crackle representing 86.6% of the changes, and moderate crackle and mild degree manifestation of pain in 13.3%. The frequency of morphological radiographic changes observed was 98.3% for hip subluxation, 81.6% for the femoral head flattening, 70% for the presence of periarticular osteophytes or entesophytes and 61.1% for the acetabular razing. The most common radiographic conformation of the hip joint was femoral head slightly elliptical shape and discreetly subdisluxated, rounded craniolateral acetabular edge and shrtened dorsal edge with discreet presence of osteophytes. The average morphological measurements obtained in the study were below the values considered normal, being 94.94° for the angle of Norberg, 27.13% for dorsolateral subluxation score and 128.53° for inclination angle of the femoral neck. The presence of periarticular osteophytes have statistical correlation with the presence of ckakle on palpation of the hip joint, as well as the acetabular razing with the presence of painful on orthopedic examination. However the clinical manifestations were not proportionaly coincidence with the changes observed by the diagnostic imaging methods. It questioned whether the muscle conformation of the race can help to counteract the instability joint presented by the evaluated methods

Complexos de Subluxação vertebral são disfunções biomecânicas articulares que cursam com hipomobilidade, disfunção neural e de tecido conectivo. Avaliou-se a presença de complexos de subluxação vertebral (CS) em 492 equinos praticantes da atividade de salto, observados na rotina clínica de um examinador com 9 anos de experiência em quiropraxia veterinária. Os animais incluídos no estudo formam divididos por sexo e 4 grupos de idade. As idades variaram entre 4 e 19 anos (média de 9,9 anos), sendo 207 machos castrados, 249 fêmeas e 36 garanhões. O número médio de complexos de subluxação encontrado na coluna dos animais foi de 11,9 num total de 30 segmentos motores vertebrais avaliados. O número médio de complexos de subluxação da coluna cervical foi de 2,7; de 5,8 na coluna torácica, e de 2,6 na coluna lombar. Os segmentos motores acometidos com maior frequência foram L3, L2 e L1, nesta ordem. Não houve diferença significativa (p>0,05) nas médias do número de complexos de subluxação entre os sexos. Também não houve diferença significativa nas médias do número de complexos de subluxação entre grupos de idade para a coluna lombar e torácica, porém houve diferença significativa (p=0,028) no número médio de complexos de subluxação entre os grupos de idades de 0-5anos e acima de 15 anos na coluna cervical. Apresentaram complexo de subluxação no sacro 24,4% dos animais. A maioria dos animais não apresentou dor à palpação muscular, porém demonstraram aumento do tônus muscular. Pode-se concluir que a incidência de complexos de subluxação na coluna cervical aumenta com a idade. / Vertebral subluxation complexes are dysfunctional spinal segments characterized by hypomobility with altered neural and connective tissue function. Data collected from 492 showjumping horses evaluated by a veterinary chiropractor with 9 years of experience was analyzed for the presence of Vertebral Subluxation Complexes. The animals were divided into age groups and sex categories. Their age varied from 4 to 19 (mean=9.9) and there were 207 geldings, 249 females and 36 stallions included in the study. The animals had in average 11.9 vertebral subluxation complexes in 30 analyzed spinal segments along their spine. Per spinal segment, the animals presented in average 2.7 cervical, 5.8 thoracic and 2.6 lumbar subluxation complexes and 24,4% of the horses had subluxation complex in the sacrum. The most affected vertebrae were L3, L2 and L4, in this order. There was no significant difference (p>0.05) in the mean of subluxation complexes between sexes and between age groups for the lumbar and thoracic spine. There were significant difference (p=0.028) in the mean of subluxation complexes at the cervical spine between the age groups of 0-6 years and 15 years and above. Most of the animals had no pain to muscle palpation, but they showed an increase in muscle tone. It was concluded that the prevalence of subluxation complexes in the cervical spine increases with age.

La scoliose de l’adulte est une pathologie dont la prévalence augmente avec de le vieillissement de la population. De plus, la demande fonctionnelle est de plus en plus importante chez ces patients. De nombreuses études ont montré un bénéfice du traitement chirurgical de la déformation de l’adulte par rapport au traitement médical en termes d’amélioration des scores fonctionnels, de qualité de vie et de satisfaction. Néanmoins, cette chirurgie est associée à de nombreuses complications (jusque 50% dans certaines séries), pour la plupart mécaniques telle la pseudarthrose, la rupture d’implant, la dégradation des étages adjacents. Ainsi, si l’analyse radiographique de la scoliose a bien été explorée, certaines questions demeurent comme les phénomènes responsables d’une aggravation brutale de la déformation chez certains patients ou les causes d’échecs. L’objectif de ce travail était d’analyser la scoliose de l’adulte, en 3D à l’aide de la stéréoradiographie et d’évaluer le système musculaire de ces patients afin de mettre en évidence des relations entre déformations rachidiennes notamment par l’analyse du plan horizontal, et dégénérescence musculaire.La 1e partie de ce travail était consacrée à l’analyse 3D de la scoliose : tout d’abord avec l’analyse de reproductibilité chez l’adulte des mesures 3D effectuées par stéréoradiographie, puis par l’analyse de l’alignement global de ces patients avec une déformation rachidienne, à l’aide d’un nouveau paramètre prenant en compte la position de la jonction cervico-céphalique. Apres avoir analysé l’alignement postural, le système musculaire pelvi-rachidien a été étudié dans la 2e partie. En effet, en plus de l’alignement du squelette, c’est l’activation du système musculaire qui est responsable du maintien d’une posture érigée. Nous avons décrit les caractéristiques musculaires des patients avec une scoliose lombaire et analysé les relations avec les paramètres radiographiques de la déformation, montrant que selon le type de déformation certains groupes musculaires étaient plus touchés par l’atrophie et l’infiltration graisseuse. En les comparant à des sujets jeunes et âgés sans déformation, nous avons observé que les patients avec une scoliose avaient une dégénérescence musculaire à la fois liée à la déformation et au vieillissement. Dans une 3e partie, en faisant le lien entre les données de la posture par la stéréoradiographie et les données musculaires de l’IRM, nous avons utilisé un modèle musculosquelettique personnalisé pour mieux comprendre les contraintes exercées sur les segments vertébraux et donc pour essayer d’expliquer les faillites mécaniques.Ainsi, l’association de mesures 3D radiographiques et de l’analyse musculaire pourrait permettre en comprenant mieux les phénomènes dégénératifs, de mieux prédire l’aggravation de la déformation et donc de la prévenir par une rééducation ciblée. Par exemple, un renforcement des érecteurs du rachis mais aussi des fléchisseurs pourrait permettre de mieux maintenir la posture. Et, un renforcement des érecteurs et fléchisseurs de hanche pourrait permettre d’activer de manière plus efficace, les mécanismes de compensation telle la rétroversion pelvienne. De plus, la mise en évidence de facteur de risque musculosquelettique d’aggravation de la déformation entrainerait une prise en charge plus précoce de ces patients. Une analyse longitudinale serait donc intéressante. / Adult degenerative scoliosis is a pathology whose prevalence increases with the aging of the population. Moreover, the functional demand is more and more important in these patients. Many studies have shown a benefit of surgical treatment of adult spinal deformity compared to medical treatment in terms of improved functional scores, quality of life and satisfaction. Nevertheless, this surgery is associated with many complications (up to 50% in some series), mostly mechanical such as nonunion, implant rupture, degradation of adjacent levels. Thus, if the radiographic analysis of scoliosis has been well explored, some questions remain like the phenomena responsible for a sudden worsening of the deformation in certain patients or the causes of failures. The aim of this work was to analyze adult scoliosis in 3D using stereoradiography and to evaluate the muscular system of these patients in order to highlight the relationships between spinal deformities, particularly by the horizontal plane analysis, and muscle degeneration.The first part of this work was dedicated to the 3D analysis of scoliosis: first, with the analysis of reproducibility in the adult of 3D stereoradiographic measurements, then by the analysis of the global alignment of these patients with spinal deformity, using a new parameter taking into account the position of the cervico-cephalic junction. After analyzing the postural alignment, the spino-pelvic muscular system was studied in the second part. Indeed, in addition to the alignment of the skeleton, it is the activation of the muscular system that is responsible for maintaining an erect posture. We described the muscular features of patients with lumbar scoliosis and analyzed the relationships with the radiographic parameters of the deformity, showing that depending on the type of deformity some muscle groups were more affected by atrophy and fatty infiltration. Comparing them to young and elderly subjects without deformity, we observed that patients with scoliosis had muscle degeneration that was both related to deformity and aging. In the third part, by linking stereoradiographic posture data with muscular MRI data, we used a personalized musculoskeletal model to better understand the constraints on vertebral segments and therefore to try to explain the mechanical failures.Thus, the combination of 3D radiographic measurements and muscle analysis could better predict muscle degeneration and worsening of deformity and thus prevent it by targeted rehabilitation. For example, a strengthening of the erectors of the spine but also of the flexors could allow better maintaining the posture. And, a strengthening of the erectors and hip flexors could allow activating more effectively, compensation mechanisms such pelvic retroversion. In addition, the demonstration of a musculoskeletal risk factor worsening the deformity would lead to an earlier management of these patients. A longitudinal analysis would be interesting.

Tyrimo objektas: minkštojo įtvaro ir elektrostimuliacijos poveikis girnelės padėčiai. Tyrimo tikslas: nustatyti minkštojo įtvaro ir elektrostimuliacijos poveikį girnelės padėčiai ir skausmui, esant girnelės chondromaliacijai. Tyrimo uždaviniai: 1. Įvertinti girnelės padėtį ir skausmą prieš ir po minkštojo įtvaro taikymo. 2. Įvertinti girnelės padėtį ir skausmą prieš ir po raumenų elektrostimuliacijos taikymo. 3. Palyginti gautus duomenis prieš ir po minkštojo įtvaro ir raumenų elektrostimuliacijos taikymo. Tyrimo hipotezė: Minkštasis įtvaras turi didesnį poveikį girnelės padėčiai ir skausmo mažinimui nei raumenų elektrostimuliacija, esant girnelės chondromaliacijai. Tyrimo išvados: 1. Minkštasis įtvaras sumažino girnelės poslinkį ir skausmą; 2. Elektrostimuliacija sumažino girnelės poslinkį ir skausmą; 3. Minkštasis įtvaras yra efektyvesnis nei elektrostimuliacija mažinant girnelės panirimą ir skausmą. / Object of the research: effect of kinesio taping and electrostimulation for position of patella. The aim of the research: determine the effect of the kinesio taping and electrostimulation to reduce patellar subluxation and pain for patients with patellar chondromaliacia. The task of the research: 1. Evaluate patellar position and pain before and after application of kinesio taping; 2. Evaluate patellar position and pain before and after application of electrostimulation; 3. Compare results of patellar position and pain before and after application of both methods: kinesio taping and electrostimulation. Hypothesis: kinesio taping will have a greater effect on reduction of patellar subluxation and pain than electrical muscle stimulation for patients with patellar chondromaliacia. Conclusions: 1. Kinesio tape method significantly reduced patellar subluxation and pain; 2. Electrostimulation method significantly reduced patellar subluxation and pain; 3. Kinesio tape method is more effective than electrostimulation reducing patellar subluxation and pain.

Complexos de Subluxação vertebral são disfunções biomecânicas articulares que cursam com hipomobilidade, disfunção neural e de tecido conectivo. Avaliou-se a presença de complexos de subluxação vertebral (CS) em 492 equinos praticantes da atividade de salto, observados na rotina clínica de um examinador com 9 anos de experiência em quiropraxia veterinária. Os animais incluídos no estudo formam divididos por sexo e 4 grupos de idade. As idades variaram entre 4 e 19 anos (média de 9,9 anos), sendo 207 machos castrados, 249 fêmeas e 36 garanhões. O número médio de complexos de subluxação encontrado na coluna dos animais foi de 11,9 num total de 30 segmentos motores vertebrais avaliados. O número médio de complexos de subluxação da coluna cervical foi de 2,7; de 5,8 na coluna torácica, e de 2,6 na coluna lombar. Os segmentos motores acometidos com maior frequência foram L3, L2 e L1, nesta ordem. Não houve diferença significativa (p>0,05) nas médias do número de complexos de subluxação entre os sexos. Também não houve diferença significativa nas médias do número de complexos de subluxação entre grupos de idade para a coluna lombar e torácica, porém houve diferença significativa (p=0,028) no número médio de complexos de subluxação entre os grupos de idades de 0-5anos e acima de 15 anos na coluna cervical. Apresentaram complexo de subluxação no sacro 24,4% dos animais. A maioria dos animais não apresentou dor à palpação muscular, porém demonstraram aumento do tônus muscular. Pode-se concluir que a incidência de complexos de subluxação na coluna cervical aumenta com a idade. / Vertebral subluxation complexes are dysfunctional spinal segments characterized by hypomobility with altered neural and connective tissue function. Data collected from 492 showjumping horses evaluated by a veterinary chiropractor with 9 years of experience was analyzed for the presence of Vertebral Subluxation Complexes. The animals were divided into age groups and sex categories. Their age varied from 4 to 19 (mean=9.9) and there were 207 geldings, 249 females and 36 stallions included in the study. The animals had in average 11.9 vertebral subluxation complexes in 30 analyzed spinal segments along their spine. Per spinal segment, the animals presented in average 2.7 cervical, 5.8 thoracic and 2.6 lumbar subluxation complexes and 24,4% of the horses had subluxation complex in the sacrum. The most affected vertebrae were L3, L2 and L4, in this order. There was no significant difference (p>0.05) in the mean of subluxation complexes between sexes and between age groups for the lumbar and thoracic spine. There were significant difference (p=0.028) in the mean of subluxation complexes at the cervical spine between the age groups of 0-6 years and 15 years and above. Most of the animals had no pain to muscle palpation, but they showed an increase in muscle tone. It was concluded that the prevalence of subluxation complexes in the cervical spine increases with age.

Complexos de Subluxação vertebral são disfunções biomecânicas articulares que cursam com hipomobilidade, disfunção neural e de tecido conectivo. Avaliou-se a presença de complexos de subluxação vertebral (CS) em 492 equinos praticantes da atividade de salto, observados na rotina clínica de um examinador com 9 anos de experiência em quiropraxia veterinária. Os animais incluídos no estudo formam divididos por sexo e 4 grupos de idade. As idades variaram entre 4 e 19 anos (média de 9,9 anos), sendo 207 machos castrados, 249 fêmeas e 36 garanhões. O número médio de complexos de subluxação encontrado na coluna dos animais foi de 11,9 num total de 30 segmentos motores vertebrais avaliados. O número médio de complexos de subluxação da coluna cervical foi de 2,7; de 5,8 na coluna torácica, e de 2,6 na coluna lombar. Os segmentos motores acometidos com maior frequência foram L3, L2 e L1, nesta ordem. Não houve diferença significativa (p>0,05) nas médias do número de complexos de subluxação entre os sexos. Também não houve diferença significativa nas médias do número de complexos de subluxação entre grupos de idade para a coluna lombar e torácica, porém houve diferença significativa (p=0,028) no número médio de complexos de subluxação entre os grupos de idades de 0-5anos e acima de 15 anos na coluna cervical. Apresentaram complexo de subluxação no sacro 24,4% dos animais. A maioria dos animais não apresentou dor à palpação muscular, porém demonstraram aumento do tônus muscular. Pode-se concluir que a incidência de complexos de subluxação na coluna cervical aumenta com a idade. / Vertebral subluxation complexes are dysfunctional spinal segments characterized by hypomobility with altered neural and connective tissue function. Data collected from 492 showjumping horses evaluated by a veterinary chiropractor with 9 years of experience was analyzed for the presence of Vertebral Subluxation Complexes. The animals were divided into age groups and sex categories. Their age varied from 4 to 19 (mean=9.9) and there were 207 geldings, 249 females and 36 stallions included in the study. The animals had in average 11.9 vertebral subluxation complexes in 30 analyzed spinal segments along their spine. Per spinal segment, the animals presented in average 2.7 cervical, 5.8 thoracic and 2.6 lumbar subluxation complexes and 24,4% of the horses had subluxation complex in the sacrum. The most affected vertebrae were L3, L2 and L4, in this order. There was no significant difference (p>0.05) in the mean of subluxation complexes between sexes and between age groups for the lumbar and thoracic spine. There were significant difference (p=0.028) in the mean of subluxation complexes at the cervical spine between the age groups of 0-6 years and 15 years and above. Most of the animals had no pain to muscle palpation, but they showed an increase in muscle tone. It was concluded that the prevalence of subluxation complexes in the cervical spine increases with age.

A displasia coxofemoral é a afecção ortopédica mais frequente na espécie canina e, pela estatística apresentada pela Orthopaedic Foundation for Animals o buldogue inglês é a raça com maior acometimento proporcionalmente. Entretanto carece em literatura dados sobre o desenvolvimento e morbidade desta doença na raça. O objetivo desse estudo foi avaliar a morfologia e morfometria da articulação coxofemoral de cães da raça buldogue inglês por meio de exame radiográfico e por tomografia computadorizada comparando-os com achados da avaliação ortopédica e cinética. A hipótese proposta é de que buldogues podem apresentar alterações radiográficas compatíveis com a displasia coxofemoral sem apresentar manifestações clínicas da doença. De cada articulação avaliada foram adquiridos dados por meio de exame ortopédico, avaliação cinética, radiográfica e por tomografia computadorizada. Foram feitas avaliação subjetiva das alterações morfológicas radiográficas e aferição do ângulo de Norberg, ângulo de inclinação do colo femoral e o escore de subluxação dorsolateral. Os dados obtidos foram correlacionados por meio dos coeficiêntes de Spearman. Trinta cães foram avaliados, 20 machos e 10 fêmeas. As médias de idade e peso dos participantes do estudo foram de 3,5 anos e 26,1 kg respectivamente. 76,6% dos animais apresentaram escore de condição corporal acima do considerado ideal e 63,3% viviam em ambiente de piso liso. Entretanto esses fatores de risco avaliados não apresentaram correlação com nenhuma alteração pesquisada. 63,3% dos cães apresentaram alterações nas articulações dos joelhos e 40% nas articulações coxofemorais pela avaliação ortopédica. Pela palpação da articulação coxofemoral foram observadas alterações em 50% dos animais, sendo a crepitação leve representando 86,6% das alterações, e crepitação de grau moderado e discreta manifestação de dor em 13,3%. A frequência de alterações morfológicas radiográficas observada foi de 98,3% para subluxação coxofemoral, 81,6% para o achatamento da cabeça do fêmur, 70% para presença de osteófitos ou entesófitos periarticulares e 61,1% para o arrasamento acetabular. A conformação radiográfica da articulação coxofemoral mais frequente foi de cabeça femoral com formato discretamente elíptico e discretamente subluxada, bordas acetabulares craniolateral arredondada e dorsal encurtada com discreta presença de osteófitos. A média das mensurações morfológicas obtidas no estudo foram abaixo dos valores considerado de normalidade, sendo de 94,94° para o ângulo de Norberg, 27,13% para o escore de subluxação dorsolateral e 128,53° para o ângulo de inclinação do colo femoral. A presença de osteófitos periarticulares obteve correlação estatística com presença de crepitação à palpação da coxofemoral, assim como o arrasamento acetabular com a presença de dor ao exame ortopédico. Entretanto as manifestações clínicas não coincidiram proporcionalmente às alterações observadas pelos métodos de diagnóstico por imagem. É questionado se a conformação muscular da raça pode contribuir para contrabalancear a instabilidade articular apresentada pelos métodos avaliados / Hip dysplasia is the most common orthopedic disorder in dogs, and the statistics presented by the Orthopedic Foundation for Animals English Bulldog is the race with most animals affected proportionately. However it lacks in literature data of the development and morbidity of this disease in the race. The aim of this study was to evaluate the morphology and morphometry of the hip joint of English Bulldogs through radiographic examination and computed tomography comparing them with findings from orthopedic and kinetic evaluation. The hypothesis proposed is that Bulldogs may have radiographic changes compatible with hip dysplasia without showing clinical symptoms of the disease. From each joint evaluated were acquired data through orthopedic examination, and kinetics, radiographic and computed tomography evaluations. They were made subjective evaluation of radiographic morphological changes and measuring the Norberg angle, femoral neck inclination angle and the dorsolateral subluxation score. The data were correlated by the Spearman\'s rank. Thirty dogs were evaluated, 20 males and 10 females. The mean age and weight of the study participants was 3.5 years and 26.1 kg respectively. 76.6% of the animals had a body condition score considered above ideal and 63.3% lived in flat floor environment. However, these risk factors evaluated were not correlated with any changes searched. 63.3% of dogs showed changes in knee joints and 40% in hip joints by the orthopedic evaluation. Abnormalities were observed in 50% of animals by palpation of the hip joint, the slight crackle representing 86.6% of the changes, and moderate crackle and mild degree manifestation of pain in 13.3%. The frequency of morphological radiographic changes observed was 98.3% for hip subluxation, 81.6% for the femoral head flattening, 70% for the presence of periarticular osteophytes or entesophytes and 61.1% for the acetabular razing. The most common radiographic conformation of the hip joint was femoral head slightly elliptical shape and discreetly subdisluxated, rounded craniolateral acetabular edge and shrtened dorsal edge with discreet presence of osteophytes. The average morphological measurements obtained in the study were below the values considered normal, being 94.94° for the angle of Norberg, 27.13% for dorsolateral subluxation score and 128.53° for inclination angle of the femoral neck. The presence of periarticular osteophytes have statistical correlation with the presence of ckakle on palpation of the hip joint, as well as the acetabular razing with the presence of painful on orthopedic examination. However the clinical manifestations were not proportionaly coincidence with the changes observed by the diagnostic imaging methods. It questioned whether the muscle conformation of the race can help to counteract the instability joint presented by the evaluated methods

Introdução: As mucopolissacaridoses (MPSs) são doenças de deposito lisossômico causadas por deficiências enzimáticas envolvidas na degradação das glicosaminoglicanas. O catabolismo das glicosaminoglicanas pode ser bloqueado isoladamente ou em combinações, podendo ocorrer o acúmulo de dermatan sulfato, heparan sulfato, queratan sulfato, e o acido hialurônico. Existem sete tipos de MPSs (tipos I, II, III, IV, VI, VII e IX) causados por onze deficiências enzimáticas conhecidas; o comprometimento multissistêmico progressivo é uma característica comum à maioria dos tipos. O espectro de manifestações neurológicas é amplo e o diagnóstico precoce de tais manifestações é fundamental para um melhor prognóstico. A terapia de reposição enzimática (TRE) é atualmente disponível para o tratamento de alguns tipos de MPS, entretanto não há evidências de melhorias dos sintomas neurológicos com o uso da TRE. Objetivo: O objetivo deste estudo foi descrever as alterações neurológicas e de neuroimagem nos diversos tipos de MPSs. Métodos: Vinte pacientes com diagnóstico de mucopolissacaridoses (MPS) foram incluídos no estudo e avaliados conforme o protocolo clínico e de neuroimagem pré-estabelecido. Os pacientes foram submetidos à ressonância magnética (RM) de crânio e coluna em aparelhos de 1,5 Tesla. Resultados: Dentre os 20 pacientes da amostra, dois pacientes apresentavam MPS I (10%), três MPS II (15%), nove MPS IV (45%) e seis MPS VI (30%). As idades variaram de três a 26 anos (12,5 ± 6,1) e 13 (65%) pacientes eram do sexo masculino. Os pacientes com MPSs tipo I e II apresentaram uma ampla diversidade clínica e de neuroimagem. Desde casos oligossintomáticos com exame neurológico normal até um atraso significativo do desenvolvimento neuropsicomotor (DNPM), com alterações cognitivas, motoras e sensitivas persistentes foram encontrados. Os exames de RM dos pacientes com MPSs I e II apresentaram alterações tais como espessamento da díploe, alargamento dos espaços perivasculares, dilatação ventricular e comprometimento da substância branca. Alterações degenerativas na coluna vertebral estiveram presentes em todos os pacientes com MPSs I e II, a despeito da maioria estar em regime de TRE. Compressão medular foi observada em apenas um paciente com MPS I e em nenhum paciente MPS II. Dos nove pacientes com MPS IV, dois apresentaram atraso do DNPM, um deles com alterações cognitivas persistentes; em todos os pacientes encontramos déficits motores e seis dentre os nove apresentaram alterções de sensibilidade profunda. Na RM dos pacientes com MPS IV, observamos hipoplasia do processo odontóide em todos os pacientes, e em oito foram encontrados sinais de compressão medular. Subluxação atlanto-axial foi vista em seis pacientes. Estenose do canal e lipomatose epidural também contribuíram para compressão medular, e três pacientes apresentaram dois níveis de compressão. Na RM do crânio, dois pacientes com MPS IV apresentaram alterações da substância branca. Nos pacientes com MPS VI, a cognição esteve preservada e alterações de reflexos e sensibilidade profunda foram encontradas. Além das alterações clássicas encontradas em outros pacientes com outros tipos de MPSs, a RM dos pacientes com MPS VI mostrou alterações morfológicas dos diâmetros do crânio e da fossa média. Mesmo apresentando força muscular normal, todos os pacientes com MPS VI apresentaram algum grau de compressão medular. Em quatro pacientes encontramos subluxação atlanto-axial e em três estenose do canal medular. Conclusões: A heterogeneidade clínica e de neuroimagem foram marcantes nos pacientes com MPSs tipos I e II. Alterações degenerativas do coluna vertebral estiveram presentes em todos os pacientes destes grupo, a despeito da TRE. Os achados clínicos e de neuroimagem nos pacientes com MPS IV reforçam o comprometimento primário do sistema nervoso central neste tipo de MPS. Além disso, os efeitos secundários da doença sobre o medula requerem avaliação neurológica e RM da coluna total periodicamente. Nos pacientes com MPS VI, apesar do exame clínico mostrar apenas alterações sutis, o comprometimento do neuroeixo foi um achado universal pela RM, demonstrando a necessidade de seguimento radiológico mesmo em pacientes oligossintomáticos em regime de TRE / Introduction: Mucopolysaccharidosis (MPS) are lisosomal storage disorders caused by deficiencies of glycosaminoglycans catabolism enzymes, leading to deposition of mucopolysaccharides; over time, there is cellular damage affecting several organs and systems. There are seven distinct phenotypes of MPS (types I, II, III, IV, VI, VII e IX) with eleven known enzymatic defects, which may result in accumulation of dermatan sulfate, heparan sulfate, queratan sulfate, and hyaluronic acid. Neurological manifestations are broad, and an early detection of these manifestations is essential to ensure a better prognosis of MPS patients. Enzymatic replacement therapy (ERT) is currently available to treat some types of MPS, albeit there is no evidence of direct neurological improvement with ERT. Objective: The objective of this study was to describe the clinical neurological abnormalities and neuroimaging findings in a sample of patients with diagnosis of MPS. Methods: Twenty patients previously diagnosed with distinct types of MPS were enrolled in the clinical and MRI protocol. Brain and spinal cord MRI were performed in 1.5 Tesla machines. Results: Amongst the 20 patients, two had diagnosis of MPS I (10%), three had MPS II (15%), nine had MPS type IV (45%), and six had MPS type VI (30%). The ages ranged between three and 26 years-old (mean 12,5 ± 6,1) and 13 pacients (65%) were male. Clinical findings in patients with MPS I and II were broad, ranging from an unremarkable neurologic examination to severe milestones delay, and cognitive, motor, and sensitive impairment. Neuroimaging features in patients with MPS I and II showed diploe thickness, enlargement of perivascular spaces, hydrocephalus and white matter abnormalities. Degenerative abnormalities in the spine were present in all patients with MPS I and MPS II. On the other hand, spinal cord compression was found in only one patient with MPS I and in none of the MPS II patients. Among the nine MPS IV patients, two had delayed milestones and one of those exhibited persistent cognitive impairment. All patients with MPS IV had motor deficits and six of them presented impairment of deep sensory modalities. Neuroimaging of patients with MPS IV showed white matter abnormalities in two and spinal cord compression in eight patients, with three of them presenting two levels of spinal cord compression. The main mechanism of compression was atlantoaxial subluxation; in addition, other abnormalities such as spinal stenosis and epidural lipomatosis also contributed to spinal cord compression in MPS IV patients. Patients with MPS VI had preserved cognition, but sensory exam and deep tendon reflex were abnormal. Other than classical brain MRI abnormalities, patients with MPS type VI also presented with changes in the middle cranial fossa and increased anteroposterior skull diameter. Even though all six patients with MPS VI presented normal muscle strength, all of them had some degree of spinal cord compression; four patients had atlantoaxial subluxation and three had spinal stenosis. Conclusions: Clinical and neuroimaging heterogeneity was remarkable in patients with MPS types I and II. Degenerative features in vertebrae were found in all patients with MPS I and II, despite ERT. Our clinical and neuroimaging findings in patients with MPS IV support the central nervous system impairment in these patients; additionally, it was possible to understand the underlying spinal cord compression mechanisms in MPS. Although clinical abnormalities were not meaningful in patients with MPS VI, they presented significant MRI abnormalities despite ERT. Routine assessments including neurologic examination and spinal cord MRI is extremely important in MPS patients