The whole work deals with problems of crisis intervention concentrated on a specific area of working place in the telephone line of confidence. This work includes the theory concerning our theme, from the general characteristics of crises to crisis intervention. Further it engages in the telephonic crisis intervention. It explains main rules of crisis intervention and deals with suicidal themes and questions of ethics. The whole work contains the description, classification, comparison and summary of information and facts. In the conclusion, it focuses on the possibilities and limitations during communication between both parts of telephone calls.

Monoamine oxidase (E.C.I.4.3.4) (MAO) oxidatively deaminates the biogenic amines normally present in the organism. The activities of the neurons utilizing these amines i.e. noradrenaline, dopamine and serotonin, are supposed to be involved in the pathogenesis of various psychiatric diseases. It is speculated that the MAO activity is changed as well as the monoaminergic activity in some psychiatric disorders. In the present thesis the MAO activity has been studied in brain tissue and in platelets in some psychiatric disorders. The result was as follows: MAO activities in different parts of the human brain seem to be highly intercorrelated in each individual. The brain MAO activity is also weakly correlated both to the concentration of 5-HT and of 5-HIAA, which may indicate that the MAO activity reflects the serotoninergic turnover in the brain. The MAO activity in brains from 15 suicides was compared to a control material of 20 individuals without known mental disorders, and it was found to be lower in the suicides in all 13 analysed brain parts. As eight of the patients had been chronic alcoholics, they were excluded and the remaining seven non-alcoholic suicides were tested as regards MAO activity by analysis of variance and still found to have significantly lower MAO activity than the controls. The eight chronic alcoholics in the suicide series had the most significantly (p<0.005) reduction of the MAO activity as compared to the control group. Rats were given chronic treatments with ethanol, either by 10 °/o ethanol as the only water supply or by exposition to ethanol vapor twice a day. In neither of these cases was the brain MAO activity changed as compared to control rats. The result supports the hypothesis that the low MAO activity found in alcoholic suicides most likely is related to a constitutional factor and not to a direct effect of the ethanol intake. Platelet MAO activity was found to be significantly reduced in human alcoholics as compared to matched controls. If samples were drawn from the alcoholic patients during their abstinence phase, there could be seen a transitory rise in the platelet MAO activity. This increased activity had its maximum after two weeks, and after four weeks the MAO activity had returned to the initial, low level. No difference as regards MAO activity, neither in brain tissue nor in platelets, could be registered when chronic schizophrenics were compared to matched controls. Reduced brain MAO activity was found in a group of patients diagnosed as cycloid psychoses when comparing the activity to controls or to the schizophrenic patients. The platelet MAO activity was also found to be lower in cycloid psychoses than in a group of unipolar affective psychoses, who repeatedly have been found not to differ from normals. These findings suggest that low MAO activities in brain and platelets reflect a phychic constitution in the individual making him more vulnerable for suicidal behaviour, ethanol abuse or cycloid psychosis. / digitalisering@umu.se

The aim of this dissertation is to present the issue of legal possession of firearms in the Czech Republic and identify problematic areas within this topic. Dissertation examines whether the current policy of legal possession of firearms is adequate, considering all consequences that this possession brings. Considerable attention is paid to this policy tools and unintended consequences. Dissertation uses the method of desk- research. Within its boundaries content analysis and comparison of available data and documents is made. In the empirical part semi-standardized questionnaire with experts selected from specific areas was conducted as well as a questionnaire survey with license applicants and holders. The main bodies of theory are cultural theory of risk and other heuristics describing distorted risk perception, as well as ethnic security dilemma, which is relevant considering the current threats. Particular empirical support was found, which suggests misperception of risks, when insignificant risks -as driving force for firearms acquisition - are overrated. Firearms holders and applicant are therefore influenced by unfounded fear. Dissertation shows new perspective on the impact of weapons in dealing with emergencies and coexistence with migrants. Examined group of firearms license holders and...

QC 20101216

Objetivo: Estudar o perfil epidemiológico da mortalidade por Homicídios, Acidentes de Transporte e Suicídios no município de Belo Horizonte e Região Metropolitana, na série histórica de 1980 a 2000. Métodos: O estudo apresenta um desenho ecológico, do tipo série histórica. Os indicadores de mortalidade foram os coeficientes específicos por sexo, idade e gerais padronizados; a mortalidade proporcional; a razão de mortalidade segundo sexo e idade e os incrementos / decrementos percentuais. A população utilizada como padrão foi a de 1980. Os óbitos por Homicídios, Acidentes de Transporte e Suicídios e as estimativas populacionais, segundo o ano calendário, sexo, idade e município de residência foram extraídos da base de dados do DATASUS. No período entre 1980 e 1995, os óbitos foram codificados, segundo a IX Classificação Internacional de Doenças - CID 9ª Revisão, e, a partir de 1996, segundo a CID - 10ª Revisão. A análise de tendência temporal foi desenvolvida no software SPSS para Windows, utilizando-se a técnica de regressão linear simples, com nível de significância (? < 0,05). Resultados: Nas duas regiões geográficas, os indicadores de mortalidade apresentaram maior magnitude para o sexo masculino. A razão de coeficientes específicos de mortalidade apresentou maior magnitude nas faixas etárias entre 20 e 49 anos. Os coeficientes específicos de mortalidade por Homicídios apresentaram maior magnitude na região Metropolitana e os Suicídios e Acidentes de Transporte, em Belo Horizonte. Os maiores coeficientes de mortalidade por Homicídios e Suicídios, em ambas regiões e sexos, ocorreram entre a faixa de 15 a 49 anos, e por Acidentes de Transporte, na faixa etária de \"70 anos e mais\". Com relação à variação percentual dos coeficientes de mortalidade, verificaram-se incrementos percentuais para os Homicídios, exceto na faixa etária de 40 a 49 anos, ocorrendo decrementos destes indicadores para os Acidentes de Transporte, em todas as faixas etárias. Os Suicídios, mesmo com oscilações, apresentaram incrementos nas faixas etárias de \"15 a 19 anos\" e \"40 a 49 anos\". As tendências dos coeficientes específicos de mortalidade, ao longo da série, apresentaram ascensão para os Homicídios (p < 0,05), exceto, na faixa etária de \"40 a 49 anos\". Os Acidentes de Transporte apresentaram tendência de declínio ou estabilização, ao longo do período. Para os Suicídios ocorreu uma tendência de ascensão no sexo masculino, na faixa etária de \"20 a 29\" e de \"40 a 49 anos\". A tendência dos coeficientes gerais padronizados de mortalidade por Homicídios, em ambas regiões, apresentou um padrão de ascensão (p < 0,05). Nos Acidentes de Transporte e nos Suicídios observou-se uma tendência de estabilização, com um discreto declínio no sexo feminino.(p < 0,05). Conclusão: A evolução dos coeficientes, ao longo da série histórica, evidenciou a importância epidemiológica dos três grupos de causas externas, entre as quais destacaram-se os Homicídios, em ambas as regiões estudadas. Considerando os diferentes espaços geográficos e, as desigualdades sócio-espaciais, esses resultados sugerem a necessidade de implantação de programas efetivos de promoção e prevenção em saúde, direcionados para os jovens, adultos e idosos, principalmente do sexo masculino. Tais medidas podem contribuir para o controle e para a diminuição da expansão destes agravos, de fundamental importância para a Saúde Pública. / Objective: To study the epidemiological profile of mortality from Homicides, Traffic Accidents and Suicides in Belo Horizonte and its Metropolitan Region, Brazil, in a historical time series from 1980 to 2000. Methods: The study adopts an ecological design, by means of a time series. The mortality indices used were the age-specific and general standardized coefficients, proportional mortality, mortality rates according to gender and percentage increases / decreases. The 1980 population was as standard Homicides, Traffic Accidents and Suicides deaths and population estimates, according to calendar year, gender, age and city of residence were extracted from the DATASUS database. For the period between 1980 and 1995, deaths were coded according to the IX International Classification of Diseases - ICD 9th Review and, from 1996 onwards, according to the ICD - 10th Review. The temporal tendency analysis was carried out using SPSS software for Windows, by means of the simple linear regression technique, with an ? < 0,05 significance level. Results: In both regions, mortality rates were higher among men. The age-specific mortality coefficient ratio was higher in the age ranges from 20 to 49 years. While age-specific Homicides mortality rates were more elevated in the Metropolitan region, a larger number of Suicides and Traffic Accidents occurred in Belo Horizonte. For both regions and genders, the highest Homicides and Suicides mortality rates occurred in the age range from 15 to 49 years, while Traffic Accidents deaths were highest in the range of \"70 years and older\". Concerning the percentage variation in mortality coefficients, a percentage increase occurred for Homicides, except in the age range from 40 to 49 years, while Traffic Accidents mortality rates decreased along all age ranges. In spite of oscillations, Suicides deaths increased in the group \"15 to 19 years\" and from \"40 to 49 years\". The time series displayed a rising tendency in specific Homicides mortality rates (p < 0,05), except in the age group \"40 to 49 years\". Traffic Accidents revealed a downward or stabilizing tendency throughout the period. For Suicides, an upward tendency appeared among men between \"20 and 29\" and between \"40 and 49\" years old. In both regions, there was a rising tendency in the general standardized Homicide mortality rates (p < 0,05). A stabilizing tendency was observed for Traffic Accidents and Suicides, with a slight decrease among women.(p < 0,05). Conclusion: The evolution in mortality rates in the time series disclosed the epidemiological importance of these three groups of external causes, especially Homicides, in both regions. In view of different geographical areas and socio-spatial inequalities, these results point towards the need to implant efficient health promotion and prevention programs, mostly at men, aimed young, adult and aged persons. These measures can contribute to the control and decrease in the expansion of these harmful situations, which is essential for Public Health.

Made available in DSpace on 2016-04-29T13:31:17Z (GMT). No. of bitstreams: 1 Mariana Galletti Ferretti.pdf: 660996 bytes, checksum: e851a68c363ccc6177202d947faf2b3f (MD5) Previous issue date: 2015-04-24 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Building on the lacanian concept of the real that which is beyond the signifier and the order of the symbolic , this study intends to articulate such a concept to the renowned shakespearian tragedies of Hamlet, Macbethand King Lear. It examines in what measure the study on the suicides, present in these shakespearian works, enables the articulation between the concepts of the real and that of the passage to the act. To Lacan, suicide can be a sort of passage to the act that bears, in its self, a relation to the real. Since these suicides are perpetrated by women, it is most relevant that we focus on the matter of the femininity in psychoanalysis, a subject which, in turn, can provide us with important resources to help us think about the topic. To Lacan there is no complementarity, exactly because women can t be represented in a aggregation; it is this non-existing relation between sexes, one of the fundamental lacanian psychoanalytic principles, that makes this analytic practice a Other treatment. Since it is aiming for the real, not femininity, a woman s analytic process has the potency to enable her to exist not as A but as one woman / Tendo como base o conceito lacaniano de real aquilo que está para além da ordem do significante e, portanto, do registro simbólico , esta pesquisa pretende articular tal conceito às consagradas tragédias de Shakespeare Hamlet, Macbeth e Rei Lear. Busca-se examinar em que medida o estudo do suicídio nessas obras shakespearianas possibilita a articulação entre os conceitos de real e de passagem ao ato. Para Lacan, o suicídio pode ser uma forma de passagem ao ato e esta traz, em si mesma, uma ligação com o real. Dado que tais suicídios são atos protagonizados por mulheres, torna-se pertinente nos debruçarmos sobre a questão da feminilidade na psicanálise, tema esse que pode nos fornecer importantes subsídios para pensarmos sobre os mesmos. Para Lacan, não existe complementaridade entre as partes justamente porque as mulheres não podem ser representadas num conjunto; trata-se da não existência da relação sexual, um dos preceitos fundamentais da psicanálise de Lacan, que faz da prática analítica um tratamento Outro. Visto que sua direção é o real, não há a intenção de tamponar a angústia, mas sim tocá-la naquilo que concerne ao objeto a, de maneira a movimentar o desejo articulado ao gozo. Com efeito, uma passagem ao ato pode ser evitada e, no que tange à feminilidade, o processo analítico de uma mulher tem a potencialidade de possibilitar que ela venha a existir não como A, mas como uma mulher

Objetivo: Estudar o perfil epidemiológico da mortalidade por Homicídios, Acidentes de Transporte e Suicídios no município de Belo Horizonte e Região Metropolitana, na série histórica de 1980 a 2000. Métodos: O estudo apresenta um desenho ecológico, do tipo série histórica. Os indicadores de mortalidade foram os coeficientes específicos por sexo, idade e gerais padronizados; a mortalidade proporcional; a razão de mortalidade segundo sexo e idade e os incrementos / decrementos percentuais. A população utilizada como padrão foi a de 1980. Os óbitos por Homicídios, Acidentes de Transporte e Suicídios e as estimativas populacionais, segundo o ano calendário, sexo, idade e município de residência foram extraídos da base de dados do DATASUS. No período entre 1980 e 1995, os óbitos foram codificados, segundo a IX Classificação Internacional de Doenças - CID 9ª Revisão, e, a partir de 1996, segundo a CID - 10ª Revisão. A análise de tendência temporal foi desenvolvida no software SPSS para Windows, utilizando-se a técnica de regressão linear simples, com nível de significância (? < 0,05). Resultados: Nas duas regiões geográficas, os indicadores de mortalidade apresentaram maior magnitude para o sexo masculino. A razão de coeficientes específicos de mortalidade apresentou maior magnitude nas faixas etárias entre 20 e 49 anos. Os coeficientes específicos de mortalidade por Homicídios apresentaram maior magnitude na região Metropolitana e os Suicídios e Acidentes de Transporte, em Belo Horizonte. Os maiores coeficientes de mortalidade por Homicídios e Suicídios, em ambas regiões e sexos, ocorreram entre a faixa de 15 a 49 anos, e por Acidentes de Transporte, na faixa etária de \"70 anos e mais\". Com relação à variação percentual dos coeficientes de mortalidade, verificaram-se incrementos percentuais para os Homicídios, exceto na faixa etária de 40 a 49 anos, ocorrendo decrementos destes indicadores para os Acidentes de Transporte, em todas as faixas etárias. Os Suicídios, mesmo com oscilações, apresentaram incrementos nas faixas etárias de \"15 a 19 anos\" e \"40 a 49 anos\". As tendências dos coeficientes específicos de mortalidade, ao longo da série, apresentaram ascensão para os Homicídios (p < 0,05), exceto, na faixa etária de \"40 a 49 anos\". Os Acidentes de Transporte apresentaram tendência de declínio ou estabilização, ao longo do período. Para os Suicídios ocorreu uma tendência de ascensão no sexo masculino, na faixa etária de \"20 a 29\" e de \"40 a 49 anos\". A tendência dos coeficientes gerais padronizados de mortalidade por Homicídios, em ambas regiões, apresentou um padrão de ascensão (p < 0,05). Nos Acidentes de Transporte e nos Suicídios observou-se uma tendência de estabilização, com um discreto declínio no sexo feminino.(p < 0,05). Conclusão: A evolução dos coeficientes, ao longo da série histórica, evidenciou a importância epidemiológica dos três grupos de causas externas, entre as quais destacaram-se os Homicídios, em ambas as regiões estudadas. Considerando os diferentes espaços geográficos e, as desigualdades sócio-espaciais, esses resultados sugerem a necessidade de implantação de programas efetivos de promoção e prevenção em saúde, direcionados para os jovens, adultos e idosos, principalmente do sexo masculino. Tais medidas podem contribuir para o controle e para a diminuição da expansão destes agravos, de fundamental importância para a Saúde Pública. / Objective: To study the epidemiological profile of mortality from Homicides, Traffic Accidents and Suicides in Belo Horizonte and its Metropolitan Region, Brazil, in a historical time series from 1980 to 2000. Methods: The study adopts an ecological design, by means of a time series. The mortality indices used were the age-specific and general standardized coefficients, proportional mortality, mortality rates according to gender and percentage increases / decreases. The 1980 population was as standard Homicides, Traffic Accidents and Suicides deaths and population estimates, according to calendar year, gender, age and city of residence were extracted from the DATASUS database. For the period between 1980 and 1995, deaths were coded according to the IX International Classification of Diseases - ICD 9th Review and, from 1996 onwards, according to the ICD - 10th Review. The temporal tendency analysis was carried out using SPSS software for Windows, by means of the simple linear regression technique, with an ? < 0,05 significance level. Results: In both regions, mortality rates were higher among men. The age-specific mortality coefficient ratio was higher in the age ranges from 20 to 49 years. While age-specific Homicides mortality rates were more elevated in the Metropolitan region, a larger number of Suicides and Traffic Accidents occurred in Belo Horizonte. For both regions and genders, the highest Homicides and Suicides mortality rates occurred in the age range from 15 to 49 years, while Traffic Accidents deaths were highest in the range of \"70 years and older\". Concerning the percentage variation in mortality coefficients, a percentage increase occurred for Homicides, except in the age range from 40 to 49 years, while Traffic Accidents mortality rates decreased along all age ranges. In spite of oscillations, Suicides deaths increased in the group \"15 to 19 years\" and from \"40 to 49 years\". The time series displayed a rising tendency in specific Homicides mortality rates (p < 0,05), except in the age group \"40 to 49 years\". Traffic Accidents revealed a downward or stabilizing tendency throughout the period. For Suicides, an upward tendency appeared among men between \"20 and 29\" and between \"40 and 49\" years old. In both regions, there was a rising tendency in the general standardized Homicide mortality rates (p < 0,05). A stabilizing tendency was observed for Traffic Accidents and Suicides, with a slight decrease among women.(p < 0,05). Conclusion: The evolution in mortality rates in the time series disclosed the epidemiological importance of these three groups of external causes, especially Homicides, in both regions. In view of different geographical areas and socio-spatial inequalities, these results point towards the need to implant efficient health promotion and prevention programs, mostly at men, aimed young, adult and aged persons. These measures can contribute to the control and decrease in the expansion of these harmful situations, which is essential for Public Health.

This diploma thesis analyzes mortality from external causes in the region of CZ between 2014 and 2018. The main focus is on external causes of death as a group, suicide rates, and mortality from traffic accidents. Another aim of this thesis is, besides the description of mortality from external causes, to identify regional correlation and differences in mortality from external causes and selected causes of death (suicides and traffic accidents). This study uses correlation, factor, and cluster analysis. Because of the low numbers of deaths in the case of women (in all dependent variables), the study analyzes mortality from both sexes together. Based on created factors clusters of regions are developed. Results show the difference between regions in CZ in mortality external causes. Regions also vary in suicide mortality rates and traffic accident mortality rates. Independent variables that correlate with mortality from external causes vary for external causes as a group, for suicides, and for mortality from traffic accidents. Keywords: external causes of death, suicides, traffic accidents, factor analysis, cluster analysis

Reproduction de : Thèse de doctorat : Sciences de l'information et de la communication : Metz : 2005. / Titre provenant de l'écran-titre. Notes bibliographiques.

Les amines biogènes sont des composés allergènes, notamment rencontrés dans les produits fermentés tel que le vin. Les bactéries lactiques du vin, dont Oenococcus oeni, le principal acteur de la fermentation malolactique, sont capables de produire ces molécules, à partir de précurseurs azotés. Afin de réduire la teneur en amines biogènes, il est nécessaire de comprendre le rôle de cette production, chez les souches impliquées dans la synthèse de ces métabolites. Le projet européen BiamFood FP7 (n°211441) a été mis en place pour répondre à cette problématique. Au cours de mon travail de thèse, des outils moléculaires ont été développés afin de muter de manière ciblée les gènes de O. oeni et d’exprimer des gènes d’intérêt. Ainsi, les clusters hdc de Lactobacillus hilgardii et odc de O. oeni, responsables respectivement de la synthèse de l’histamine et de la putrescine, ont été clonés dans le vecteur pGID052 et transférés dans la souche de laboratoire O. oeni ATCC BAA-1163, déficiente pour la production d’amines biogènes. Cette stratégie n’ayant pas donnée lieu à la production d’amine biogène, mon travail de recherche s’est orienté vers la caractérisation biochimique de l’ornithine décarboxylase de O. oeni. L’ornithine décarboxylase de O. oeni BR14/97 a été sur-produite chez E. coli via le système pET. Après purification de l’enzyme, le pH optimal et la température optimale de fonctionnement, 5,5 et 35°C respectivement, ont été caractérisés. Les constantes cinétiques Km = 1 mM et Vmax = 0,57 U. mg-1 ont également été déterminées en mesurant la putrescine produite par HPLC (Gomez-Alonso et al, 2007). De plus, l’ODC de O. oeni BR14/97 est spécifique de la L-ornithine et ne peut pas dégrader la L-lysine en cadavérine, ce qui implique la présence d’une voie métabolique propre à la production de cadavérine chez cette souche. Dans un second axe du projet, l’influence de la source azotée et notamment des peptides versus acides aminés libres, a été étudiée chez une souche de Lactobacillus plantarum, isolée du vin et productrice de tyramine. Les peptides contenant de la tyrosine, sont utilisés par cette souche pour former de la tyramine. La production augmente en phase stationnaire de croissance, et est corrélée à l’expression du transporteur tyrP. L’analyse de la tyrosine présente dans le milieu de culture montre que ces peptides seraient dégradés dans le milieu extracellulaire chez L. plantarum. / Biogenic amines are indesirable compounds found in fermented products like wine. Lactic acid bacteria from wine, including Oenococcus oeni, the main actor of malolactic fermentation, are able to produce these molecules from nitrogenous precursors. In order to limited biogenic amines accumulation, it is necessary to understand the role of this production by strains responsible for the synthesis of these metabolites in food. That is why the European BiamFood project was put in place. Along my thesis, molecular tools were developed in order to mutate O. oeni genes (encoding decarboxylases), and to express genes of interest. Genetic clusters hdc from L. higardii and odc from O. oeni, responsible for histamine and putrescine synthesis respectively, were cloned into the pGID052 vector and transferred into the laboratory strain O. oeni ATCC BAA-1163, which is not able to produce any biogenic amines. However no biogenic amines production was observed. My work thesis was then redirected in the in vitro biochemical characterization of the ODC from O. oeni. The odc from O. oeni BR14/97 was overproduced in E. coli BL21 via the pET system. Optima pH and temperature were determined with the purified enzyme obtained. Kinetic constants Km = 1 mM and Vmax = 0,57 U.mg-1 were also determined by measuring putrescine production by HPLC (Gomez-Alonso et al, 2007). Furthermore, ODC from O. oeni BR14/97 is specific for the L-ornithine and can not decarboxylated the L-lysine into cadaverine. In a second part of the BiamFood project, the impact of nitrogen sources, especially peptides compared to free amino acids, was studied in a Lactobacillus plantarum strain, isolated from wine and able to produce tyramine. Peptides containing tyrosine residues are used by this strain to produce tyramine. Tyramine production increases during the growth and reaches a maximum at stationary phase. The production is correlated with tyrP expression. The tyrosine measured in culture media shows that peptides may be hydrolyzed in the extracellular medium in L. plantarum.