Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T17:23:45Z No. of bitstreams: 1 DIS_CYNTHIA_ROCHA_DULLIUS_PARCIAL.pdf: 1616329 bytes, checksum: b78ba61ceee893e19c9a37cda76e7f26 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T17:23:52Z (GMT) No. of bitstreams: 1 DIS_CYNTHIA_ROCHA_DULLIUS_PARCIAL.pdf: 1616329 bytes, checksum: b78ba61ceee893e19c9a37cda76e7f26 (MD5) / Made available in DSpace on 2017-06-30T17:23:59Z (GMT). No. of bitstreams: 1 DIS_CYNTHIA_ROCHA_DULLIUS_PARCIAL.pdf: 1616329 bytes, checksum: b78ba61ceee893e19c9a37cda76e7f26 (MD5) Previous issue date: 2017-03-31 / Introduction: Respiratory infections are responsible for high morbidity and mortality in most countries. Streptococcus pneumoniae (pneumococcus) remains the main agent responsible for these infections, whether they are invasive or not. Invasive pneumococcal disease (IPD) is one in which pneumococcus is found in noble liquids, that is, previously sterile material. This study aimed to evaluate the microbiological characteristics of pneumococcus in patients admitted to a terciary hospital. Methods: A cross-sectional study with descriptive and analytical analysis, consisted of patients hospitalized at the S?o Lucas Hospital of PUCRS (HSL /PUCRS, Porto Alegre, RS) who had laboratory identification of Streptococcus pneumoniae in noble liquid from January 2005 to July 2016. Results: The majority of the population was male (58.6%) and had a mean age of 55 years (P25-75 31-71). The most frequent diagnostic was pneumonia and pneumococcus was more frequently recovered from blood culture. More than 25% of the studied population had some degree of known immunosuppression (25.3%). There was no difference in mortality when subdividing the population into having comorbidities and / or need for ICU/MV. The overall mortality of the sample was 31.1%. The most common serotypes were 19A, 3, 12F e 8. The theoretical vaccine coverage in the sample was 34.4% for the PPV23 and 50.5% for PCV13 and PPV23 associated. Conclusions: In this IPD sample, the most common serotypes were 19A, 3, 12F and 8, although it was not possible to relate them to a higher mortality ou need to ICU/MV. / Introdu??o: As infec??es respirat?rias s?o respons?veis por alta morbi-mortalidade na maioria dos pa?ses. O Streptococcus pneumoniae (pneumococo) segue sendo o principal agente destas infec??es, sendo elas invasivas ou n?o. Doen?a pneumoc?cica invasiva (DPI) ? aquela em que o pneumococo ? encontrado em l?quidos nobres, isto ?, material previamente est?ril. Este trabalho teve por objetivo avaliar as caracter?sticas microbiol?gicas do pneumococo em pacientes internados em hospital terci?rio. M?todos: Estudo transversal, com an?lise descritiva e anal?tica, realizado com pacientes internados no Hospital S?o Lucas da PUCRS (HSL/PUCRS, Porto Alegre, RS) que apresentaram identifica??o laboratorial de Streptococcus pneumoniae em l?quido nobre, de janeiro de 2005 at? julho de 2016. Resultados: Foram avaliadas 99 cepas de pneumococo. Os pacientes dos quais foram obtidas essas amostras eram em sua maioria do sexo masculino (58,6%) e com idade mediana de 55 anos (P25-75 31-71). O agravo mais frequente foi pneumonia e o pneumococo foi mais frequentemente recuperado em hemocultura. Mais de 25% da popula??o estudada tinha algum grau de imunossupress?o conhecida (25,3%). N?o houve diferen?a de mortalidade ao se subdividir a popula??o em comorbidades e/ ou necessidade de UTI/VM. A mortalidade global da amostra foi 31,1%. Os sorotipos mais comuns foram o 19A, 3, 12F e 8. A cobertura vacinal te?rica na amostra foi de 34,3% para PPV23 isoladamente e de 50,5% para a PCV13 e PPV23 associadas. Conclus?es: Nesta amostra de DPI, os sorotipos mais frequentes foram 19A, 3, 12F e 8, embora n?o tenha sido poss?vel relacionar com maior mortalidade ou necessidade de UTI/VM.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-01-23T14:32:12Z No. of bitstreams: 1 JoseliaCarvalhoDeAraujo_TESE.pdf: 3928125 bytes, checksum: 0bbfff12dcac909ca31b3fd04d95aef8 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-01-25T12:04:49Z (GMT) No. of bitstreams: 1 JoseliaCarvalhoDeAraujo_TESE.pdf: 3928125 bytes, checksum: 0bbfff12dcac909ca31b3fd04d95aef8 (MD5) / Made available in DSpace on 2018-01-25T12:04:49Z (GMT). No. of bitstreams: 1 JoseliaCarvalhoDeAraujo_TESE.pdf: 3928125 bytes, checksum: 0bbfff12dcac909ca31b3fd04d95aef8 (MD5) Previous issue date: 2017-04-10 / Este trabalho versa sobre a natureza da centralidade urbana em Natal. Apresenta como pressuposto de tese que a natureza da centralidade urbana ? diversa em seus conte?dos, processos e formas, por ser o espa?o urbano permeado por igual diversidade. Objetiva explicitar a natureza da centralidade urbana em Natal, considerando os conte?dos, processos e formas que a constituem, bem como os fatores concorrentes para a sua diversifica??o. Para atingir o objetivo estabelecido, orienta-se pela teoria da produ??o do espa?o, de Henri Lefebvre, buscando apreender os processos que v?m se desencadeando no contexto urbano de Natal, desde a d?cada de 1980 ? atualidade, sob uma perspectiva dial?tica. Como aux?lio ? leitura da realidade, baseia-se em importantes aportes te?ricos atinentes ? tem?tica da centralidade urbana, espa?o urbano e economia terci?ria; n?o descuidando da produ??o acad?mica sobre a tem?tica, e sobre a Cidade do Natal, do exame a documentos que tamb?m tratam da hist?ria da referida cidade, arquivos oficiais junto a ?rg?os p?blicos, bancos de dados, pesquisa de campo, entrevistas junto a gestores p?blicos e l?deres de organiza??es da sociedade civil organizada. Como resultado do processo investigativo, explicita que a natureza da centralidade urbana em Natal ? diversa e multic?ntrica. Diversa, por terem sido reveladas v?rias dimens?es de centralidade, em conformidade com a natureza dos seus conte?dos: hist?rica, cultural, simb?lica, ideol?gica e econ?mica; sendo a dimens?o econ?mica da centralidade urbana proeminente no espa?o urbano, e estando a mesma permeada junto ?s demais, dado que a cidade ? lugar de trocas, onde o fator econ?mico se faz proeminente, e preside a produ??o do espa?o urbano. Multic?ntrica, pelos v?rios centros urbanos que v?m se conformando desde a forma??o do N?cleo do Centro hist?rico de Natal ? atualidade, com as novas centralidades, decorrentes do processo de expans?o do terci?rio moderno na cidade. / This paper deals with the nature of urban centrality in Natal. It presents as a thesis assumption that the nature of urban centrality is diverse in its contents, processes and forms, since it is the urban space permeated by equal diversity. It aims to explain the nature of urban centrality in Natal, considering the contents, processes and forms that constitute it, as well as the factors competing for its diversification. In order to reach the established goal, Henri Lefebvre's theory of Space Production seeks to understand the processes that have been unfolding in the urban context of Natal, from the 1980s to the present, from a dialectical perspective. It is as an aid to the reading of reality, it is based on important theoretical contributions concerning the theme of urban centrality, urban space and tertiary economy; it?s not neglecting the academic production on the subject, and on the City of Natal, from examining documents that also deal with the history of the city, official files with public agencies, databases, field research, interviews with public managers and leaders of organized civil society organizations. As a result of the investigative process, he explains that the nature of urban centrality in Natal is diverse and multicentric. Diverse, for having been revealed several dimensions of centrality, according to the nature of its contents: historical, cultural, symbolic, ideological and economic; It?s being the economic dimension of urban centrality prominent in urban space, and being permeated with the others, given that the city is a place of exchanges, in which the economic one becomes prominent, and presides over the production of the urban space. Multicentric, by the various urban centers that have been conforming since the formation of the nucleus of the historical center of Natal to the present, with the new centralities, resulting from the process of expansion of the modern tertiary in the city.

Made available in DSpace on 2014-12-17T15:42:05Z (GMT). No. of bitstreams: 1 GuttoRSF_DISSERT.pdf: 5697314 bytes, checksum: 6d49e92c8978493580da74eee2885a8f (MD5) Previous issue date: 2013-02-22 / The present work aims to study the theoretical level of some processes employed in the refining of petroleum fractions and tertiary recovery of this fluid. In the third chapter, we investigate a method of hydrogenation of oil fractions by QTAIM (Quantum Theory of Atoms in Molecules) and thermodynamic parameters. The study of hydrogenation reactions, and the stability of the products formed, is directly related to product improvement in the petrochemical refining. In the fourth chapter, we study the theoretical level of intermolecular interactions that occur in the process of tertiary oil recovery, or competitive interactions involving molecules of non-ionic surfactants, oil and quartz rock where oil is accumulated. Calculations were developed using the semiempirical PM3 method (Parametric Model 3). We studied a set of ten non-ionic surfactants, natural and synthetic origin. The study of rock-surfactant interactions was performed on the surface of the quartz (001) completely hydroxylated. Results were obtained energetic and geometric orientations of various surfactants on quartz. QTAIM was obtained through the analysis of the electron density of interactions, and thus, providing details about the formation of hydrogen bonds and hydrogen-hydrogen systems studied. The results show that the adsorption of ethoxylated surfactants in the rock surface occurs through the hydrogen bonding of the type CH---O, and surfactants derivatives of polyols occurs by OH---O bonds. For structures adsorption studied, the large distance of the surfactant to the surface together with the low values of charge density, indicate that there is a very low interaction, characterizing physical adsorption in all surfactants studied. We demonstrated that surfactants with polar group comprising oxyethylene units, showed the lowest adsorption onto the surface of quartz, unlike the derivatives of polyols / O presente trabalho tem como objetivo o estudo a n?vel te?rico de alguns processos empregados no refino das fra??es do petr?leo e na recupera??o terci?ria deste fluido. No terceiro capitulo, investigamos um m?todo de hidrogena??o das fra??es de petr?leo atrav?s da QTAIM (Quantum Theory of Atoms in Molecules) e par?metros termodin?micos. O estudo das rea??es de hidrogena??o, bem como a estabilidade dos produtos formados, est? diretamente relacionada ? melhoria dos produtos de refino na ind?stria petroqu?mica. No quarto cap?tulo, realizamos o estudo a n?vel te?rico das intera??es intermoleculares que ocorrem no processo de recupera??o terci?ria de petr?leo, ou seja, as intera??es competitivas envolvendo mol?culas de tensoativos n?oi?nicos, o petr?leo e o quartzo da rocha onde o petr?leo est? acumulado. Os c?lculos foram desenvolvidos utilizando o m?todo semi-emp?rico PM3 (Parametric Model 3). Estudamos um conjunto de dez tensoativos n?o-ionicos, de origem natural e sint?ticos. O estudo das intera??es rocha-tensoativo foi realizado sobre a superf?cie do quartzo (001) completamente hidroxilada. Foram obtidos resultados energ?ticos e geom?tricos de v?rias orienta??es dos tensoativos sobre o quartzo. Atrav?s da QTAIM foi obtida a an?lise da densidade eletr?nica das intera??es, e assim, fornecendo detalhes sobre a forma??o de liga??es de hidrog?nio e hidrog?nio-hidrog?nio, nos sistemas estudados. Os resultados obtidos mostram que a adsor??o de tensoativos etoxilados na superf?cie da rocha ocorre atrav?s de liga??o de hidrog?nio do tipo C-H---O, e tensoativos derivados de poli?is ocorre por liga??es O-H---O. Para as estruturas de adsor??o estudadas, a grande dist?ncia do tensoativo para a superf?cie aliada com os baixos valores de densidade de carga, indicam que h? uma intera??o muito fraca, caracterizando uma adsor??o f?sica em todos os tensoativos estudados. Evidenciamos que tensoativos com o grupo polar constitu?do por unidades oxietileno, apresentaram a menor adsor??o sobre a superf?cie do quartzo, ao contr?rio dos derivados de poli?is

Made available in DSpace on 2014-12-17T13:56:56Z (GMT). No. of bitstreams: 1 RosaFSS_Capa_ate_apendices.pdf: 3131293 bytes, checksum: 7aea607310b47459763677ff1f6e35ff (MD5) Previous issue date: 2008-03-25 / The tertiary sector has been (re)defining and (re)qualifying, in an impacting way, the urban spaces in the cities, introducing new elements for the discussion of the relationship center/periphery. In Natal, as an inducing economic activity of its development, it conforms to the new needs of the capital, expanding, being materialized through several processes and spatial forms. We aim at analyzing one of those processes, which has taken its Northern Administrative Area to (re)define the design of its urban space, through the actions developed by the agents involved with the spatialization of the tertiary activities, at the same time as it redimensions its role as a periphery of Natal, contributing to the study of the recent and growing transformations of the Brazilian capitals. The studied district corresponds to 39.4% of the municipal area and, until recently, was composed by precarious reproduction spaces, unprovided of relevant economical activities. After the boom of the development of extensive housing complexes by SFH/BNH, the area, gradually stopped being a dependent area, and it imposed itself as an economically participant region, with the increase of the trade and services sectors, as well as a favorable place for the appearance of new activities. Its reflexes are noticeable in the achieved spatial configuration. As the main road to induct changes, Dr. Jo?o Medeiros Filho Avenue presents these new tendencies in the production of the intraurban space, concentrating the largest goods and services equipments of the area, through investments of the private and public sectors, which guarantee the capital allocation for the construction of a new centrality / O terci?rio vem (re) definindo e (re) qualificando espa?os urbanos de forma impactante nas cidades, introduzindo novos elementos para a discuss?o da rela??o centro/periferia. Em Natal, enquanto atividade econ?mica motor de seu desenvolvimento, adapta-se ?s novas necessidades do capital, expandindo-se, materializando-se atrav?s de diversos processos e formas espaciais. Objetivamos analisar um desses processos, que tem levado sua Regi?o Administrativa Norte a (re) definir o desenho de seu espa?o urbano, pelas a??es desenvolvidas via agentes envolvidos com a espacializa??o das atividades terci?rias, ao mesmo tempo em que redimensiona o seu papel como periferia de Natal, contribuindo para o estudo das recentes e crescentes transforma??es das capitais brasileiras. A regi?o estudada corresponde a 39,4% da ?rea municipal e at? recentemente era composta por prec?rios espa?os de reprodu??o, desprovida de atividades econ?micas relevantes. Ap?s o boom da constru??o de extensos conjuntos habitacionais via SFH/BNH, gradativamente deixou de ser ?rea dependente, e se imp?e como regi?o economicamente participativa, com amplia??o dos setores de com?rcio e presta??o de servi?os, assim como lugar prop?cio para o surgimento de novas atividades. Seus reflexos s?o percept?veis na configura??o espacial concretizada. Como principal via indutora das mudan?as, a Av. Dr. Jo?o Medeiros Filho apresenta essas novas tend?ncias na produ??o do espa?o intraurbano, concentrando os equipamentos de bens e servi?os de maior porte da regi?o, atrav?s de investimentos da iniciativa privada e setor p?blico, que garantem a aloca??o de capital na constru??o de uma nova centralidade

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-10-20T10:56:20Z No. of bitstreams: 1 DIS_VANESSA_STANGHERLIN_MACHADO_COMPLETO.pdf: 9505213 bytes, checksum: c355721326b3d2f7c04de64104755fac (MD5) / Made available in DSpace on 2017-10-20T10:56:20Z (GMT). No. of bitstreams: 1 DIS_VANESSA_STANGHERLIN_MACHADO_COMPLETO.pdf: 9505213 bytes, checksum: c355721326b3d2f7c04de64104755fac (MD5) Previous issue date: 2015-08-26 / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / The prediction of protein tertiary structure is a problem of Structural Bioinformatics still unsolved by science. The challenge is to understand the relationship between the amino acid sequence of a protein and a three dimensional structure, which is related to the function of these macromolecules. Among the methods related to protein structure prediction is CREF (Central Residue Fragment-based Method) proposed by Dorn & Norbert Souza (2008) for prediction of proteins? or polypeptide?s approximate 3D structure. In this thesis we present the wCReF, the Web interface for the CREF method developed with a focus on usability. With this tool the users can enter the amino acid sequence of its target protein, and get as a result the approximate 3D structure of a protein in an automated manner without the need to install all the necessary tools for their use. To define the requirements for its development were conducted usability evaluations, guided by experts on both Human-Computer Interaction and bioinformatics domain areas, in three protein structures prediction servers - I-TASSER, QUARK and Robetta - all participants at CASP (Critical Assessment of Protein Structure Prediction) competition. The inspections were conducted through the Heuristic Evaluation method using Nielsens? 10 heuristics. As a result, violations were found in all heuristics resulting in 89 usability problems. They were classified into 5 severities, 29 scored as being of high priority solution and 25 as problems to be solved immediately. Assessment results serve as guiding orientation of the key features that wCReF must have compiled in a document software requirements for its implementation. From this step was carried out prototyping and glimpsing the detection of new usability problems with end users by adapting the Ssemugabi satisfaction questionnaire. As a final product we present the wCReF server, protein structure prediction server rooted in concern about the usability and interaction with its users. Furthermore, this study can contribute to improvement of usability of existing bioinformatics applications, the prediction servers analyzed and the development of new scientific tools. / A predi??o da estrutura terci?ria de prote?nas ? um problema da Bioinform?tica Estrutural ainda n?o solucionado pela ci?ncia. O desafio ? entender a rela??o entre a sequ?ncia de amino?cidos de uma prote?na e sua estrutura tridimensional 3D, que est? relacionada ? fun??o destas macromol?culas. Dentre os m?todos relacionados ? predi??o de estruturas de prote?nas est? o M?todo CReF (Central Residue Fragment-based Method), proposto por Dorn & Norberto de Souza (2008), para predi??o da estrutura 3D aproximada de uma prote?na ou polipept?dio. Nesta disserta??o, apresentamos o wCReF, a interface Web para o m?todo CReF desenvolvida com o enfoque em usabilidade. Com esta ferramenta o usu?rio informa a sequ?ncia de amino?cidos de sua prote?na alvo, e como resultado obt?m a estrutura 3D aproximada de uma prote?na, de forma automatizada, sem a necessidade de instala??o das ferramentas necess?rias para sua utiliza??o. Para definir os requisitos necess?rios para seu desenvolvimento foram realizadas avalia??es de usabilidade, realizadas por especialistas em Intera??o Humano-Computador e da ?rea de dom?nio, a bioinform?tica, em tr?s servidores de predi??o de estruturas de prote?nas - I-TASSER, QUARK e Robetta - todos participantes do CASP (Critical Assessment of protein Structure Prediction). As inspe??es foram realizadas atrav?s do m?todo de Avalia??o Heur?stica, utilizando as 10 heur?sticas de Nielsen. Como resultado, foram encontradas viola??es em todas as heur?sticas e detectados 89 problemas de usabilidade. Eles foram classificados em 5 severidades, 29 pontuados como sendo de alta prioridade de solu??o e 25 problemas de resolu??o imediata. Os resultados das avalia??es serviram como orienta??o norteadora dos principais recursos que o wCReF deveria possuir, compilados em um documento de requisitos de software, para sua implementa??o. A partir desta etapa foi realizada a prototipagem, vislumbrando a detec??o de novos problemas de usabilidade, com os usu?rios finais, atrav?s da adapta??o do question?rio de satisfa??o de Ssemugabi. Como produto final, apresentamos o servidor wCReF alicer?ado na preocupa??o com a usabilidade e intera??o com seus usu?rios. Al?m disso, este estudo pode contribuir para melhoria da usabilidade das aplica??es de bioinform?tica j? existentes, dos servidores de predi??o analisados e no desenvolvimento de novas ferramentas cient?ficas.

Made available in DSpace on 2015-03-13T17:10:42Z (GMT). No. of bitstreams: 1 JosearaLP_DISSERT_1-99.pdf: 2215047 bytes, checksum: 8ea5d48b8aca4151ba7b015646e9eeca (MD5) Previous issue date: 2010-11-11 / This work studies the territorial dynamics of the trade modern retailer in the North Zone of Natal/RN, undertaken by the expansion of that following of the tertiary section in the researched space. For so much, we accomplished bibliographical and documental research during whole the process of construction of the work and the field research based close to in interviews the responsible for the establishments of the modern retail and application of questionnaires with the residents and consumers of the area in subject. Leaving of the understanding that the territory is used by the society producing the movement of capitalist reproduction in the places, we inferred that the expansion of the modern retail in the North Zone has been promoting a new dynamics in your territory, fact that has been valuing the space and attracted investors to the place. Therefore, we organized the study in this dissertation in three chapters: the first, "North Zone: use and occupation of the soil ", brings us the process of historical and social formation of the North Zone inserted in the context of the urban expansion of Natal; the second chapter, " Expansion of the tertiary section: the growth of the modern retail trade in the North Zone", makes direct reference to the tertiary section and the expansion of the I trade modern retailer; and finally, the third surrender, " The territorial dynamics and the modern retail trade in the North Zone of Natal", in which we expose all the results of the field research, looking for to understand the territorial dynamics that the expansion of the modern retail trade has been producing in the study area / Este trabalho estuda a din?mica territorial do com?rcio varejista moderno na Zona Norte de Natal/RN, empreendida pela expans?o desse segmento do setor terci?rio no espa?o pesquisado. Para tanto, realizamos pesquisa bibliogr?fica e documental durante todo o processo de constru??o do trabalho e a pesquisa de campo fundamentada em entrevistas junto aos respons?veis pelos estabelecimentos do varejo moderno e aplica??o de question?rios com os moradores e consumidores da ?rea em quest?o. Partindo da compreens?o de que o territ?rio ? usado pela sociedade produzindo o movimento de reprodu??o capitalista nos lugares, inferimos que a expans?o do varejo moderno na Zona Norte tem promovido uma nova din?mica em seu territ?rio, fato que tem valorizado o espa?o e atra?do investidores para o local. Portanto, organizamos o estudo nesta disserta??o em tr?s cap?tulos: o primeiro, Zona Norte: uso e ocupa??o do solo , nos traz o processo de forma??o hist?rica e social da Zona Norte inserida no contexto da expans?o urbana de Natal; o segundo cap?tulo, Expans?o do setor terci?rio: o crescimento do com?rcio varejista moderno na Zona Norte , faz refer?ncia direta ao setor terci?rio e ? expans?o do comercio varejista moderno; e por fim, o terceiro capitulo, A din?mica territorial e o com?rcio varejista moderno na Zona Norte de Natal , no qual expomos todos os resultados da pesquisa de campo, buscando compreender a din?mica territorial que a expans?o do com?rcio varejista moderno tem produzido na ?rea de estudo

Made available in DSpace on 2014-12-17T14:46:56Z (GMT). No. of bitstreams: 1 DanieleVD_TESE.pdf: 4938953 bytes, checksum: ba81cf3eb020178b1818aa9393647bed (MD5) Previous issue date: 2014-06-06 / Universidade Federal do Rio Grande do Norte / Venous ulcers are lesions resulting from chronic venous insufficiency, venous valvular abnormalities and venous thrombosis. Its occurrence has been growing with the increase in life expectancy of the world population. Considered as fundamental aspects in the approach to the person with venous ulcer care with the interdisciplinary approach, adoption of protocol-specific knowledge, technical skill, coordination between levels of care complexity of the Health System and active participation of patients and their families, a holistic perspective. The construction of a clinical protocol for people with venous ulcers can help professionals of high complexity services in patient assessment and the establishment of quality care in a systematic way and focused on the factors that interfere with wound healing. Thus, this study aimed to analyze the evidence of validation of a clinical protocol for people with venous ulcers treated at high-complexity services. This is a methodological study with a quantitative approach, developed in three stages: literature review, evidence of content validity and evidence of validation in the clinical context. Approved by the Federal University of Rio Grande do Norte Research Ethics Committee (Opinion: 147.452 and CAAE: 07556312.0.0000.5537). The literature review was conducted in August and September 2012, becoming the basis for the construction of the protocol. Then the evidence of content validity, which included 53 judges (experts) selected by the Lattes platform to evaluate the protocol items was performed. The judges were contacted by e-mail and rated the protocol via Google Docs <docs.google.com>. After analyzing the ratios obtained in this step, which reported kappa between 0.75 and 0.96 and between 0.80 and 0.98 IVC, and the suggestions of the judges, the protocol was adjusted and subjected to empirical evidence to validate the clinical setting at the University Hospital Onofre Lopes in Natal / RN. Evidence of validation in the clinical setting involved 4 judges who acted in pairs (paired) evaluated 32 patients with venous ulcers in the clinical context of high complexity. In both stages, we used the Kappa Index and Content Validity Index to analyze the responses of the judges. The parameters set as acceptable for these indices were: Kappa &#8805; 0.61 and Content Validity Index > 0.80. Any evidence of content validity, as evidence of validation in the clinical context, the protocol items that have not reached Kappa and Content Validity Index established indices were excluded and some items were modified or added after suggestions. The process of content validation evidence and evidence of validation in the clinical setting allowed the improvement of the protocol for the care of people with venous ulcers initially proposed. The initial version of the protocol, built from the literature, contained 15 categories and 108 items; after evidence of content validity, remained the reduction to 15 categories with 91 items; the final version, clinically validated, is composed of the same 15 categories, 76 items. The protocol was validated in its content and in the clinical aspect, so we accepted the alternative hypothesis in the study. This protocol may contribute to the care system, allowing tailor behaviors and promote greater resolution in the treatment of people with venous ulcers in health services of high complexity / As ?lceras venosas s?o les?es resultantes da insufici?ncia venosa cr?nica, anomalias valvulares venosas e trombose venosa. Sua ocorr?ncia vem crescendo com o aumento da expectativa de vida da popula??o mundial. Consideram-se aspectos fundamentais na abordagem ? pessoa com ?lcera venosa a assist?ncia com atua??o interdisciplinar, ado??o de protocolo, conhecimento espec?fico, habilidade t?cnica, articula??o entre os n?veis de complexidade assistencial do Sistema ?nico de Sa?de e participa??o ativa dos pacientes e seus familiares, em uma perspectiva hol?stica. A constru??o de um protocolo assistencial para pessoas com ?lcera venosa pode auxiliar os profissionais dos servi?os de alta complexidade na avalia??o do paciente e no estabelecimento de uma assist?ncia de qualidade, de forma sistematizada e focada nos fatores que interferem na cicatriza??o da les?o. Assim, este estudo objetivou analisar as evid?ncias de valida??o de um protocolo assistencial para pessoas com ?lceras venosas atendidas em servi?os de alta complexidade. Trata-se de um estudo metodol?gico, com abordagem quantitativa, desenvolvido em tr?s etapas: revis?o da literatura, evid?ncia de valida??o de conte?do e evid?ncia de valida??o no contexto cl?nico. Aprovado pelo Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte (Parecer: 147.452 e CAAE: 07556312.0.0000.5537). A revis?o da literatura foi realizada em agosto e setembro de 2012, tornando-se a base para a constru??o do protocolo. Em seguida, foi realizada a evid?ncia de valida??o de conte?do, que incluiu 53 ju?zes (especialistas) selecionados por meio da plataforma Lattes, para avaliar os itens do protocolo. Os ju?zes foram contatados por e-mail e avaliaram o protocolo via Google Docs <docs.google.com>. Ap?s a an?lise dos ?ndices obtidos nesta etapa, que apresentaram Kappa entre 0,75 e 0,96 e IVC entre 0,80 e 0,98, e as sugest?es dos ju?zes, o protocolo foi ajustado e submetido ? evid?ncia de valida??o no contexto cl?nico, no Hospital Universit?rio Onofre Lopes em Natal/RN. A evid?ncia de valida??o no contexto cl?nico envolveu quatro ju?zes, que atuaram em duplas (pareados), avaliando 32 pacientes com ?lceras venosas no contexto cl?nico de alta complexidade. Nas duas etapas, utilizaram-se o ?ndice Kappa e ?ndice de Validade de Conte?do para analisar as respostas dos ju?zes. Os par?metros estabelecidos como aceit?veis para esses ?ndices foram: Kappa &#8805; 0,61 e ?ndice de Validade de Conte?do > 0,80.Tanto na evid?ncia de valida??o de conte?do, como na evid?ncia de valida??o no contexto cl?nico, os itens do protocolo que n?o atingiram os ?ndices Kappa e ?ndice de Validade de Conte?do estabelecidos foram exclu?dos e alguns itens foram modificados ou inclu?dos ap?s sugest?es. Os processos de evid?ncia de valida??o de conte?do e evid?ncia de valida??o no contexto cl?nico permitiram o aprimoramento do protocolo para o cuidado ? pessoa com ?lcera venosa, proposto inicialmente. A vers?o inicial do protocolo, constru?do a partir da literatura, continha 15 categorias e 108 itens; ap?s a evid?ncia de valida??o de conte?do, mantiveram-se as 15 categorias com redu??o para 91 itens; a vers?o final, validada clinicamente, ? composta das mesmas 15 categorias, sendo 76 itens. O protocolo foi validado em seu conte?do e no aspecto cl?nico, sendo assim, aceitou-se a hip?tese alternativa no estudo. Esse protocolo poder? contribuir para a sistematiza??o da assist?ncia, permitindo adequar condutas e promover maior resolutividade no tratamento da pessoa com ?lcera venosa em servi?os de sa?de de alta complexidade

Made available in DSpace on 2015-03-13T17:10:57Z (GMT). No. of bitstreams: 1 RiceliaMMS.pdf: 3321311 bytes, checksum: de96c9c9d291e6ef67ae29f9db780343 (MD5) Previous issue date: 2006-10-04 / This work has as study object the tertiary sector and (the re)production of the urban space of Bayeux-PB. For in such a way, one became necessary to the construction of a theoretical boarding that context the national reality, to be able itself to understand the reality local. This way to construct allowed an opening of the field of vision how much to the relevance of if ahead studying the tertiary sector and its weight of the current configuration of the society in a country as Brazil, e especially in a city of a State northeastern, as it is the case of Bayeux. The theoretical boarding had as base the two circuits of the urban economy, the productive reorganization and the transformations in the world of the work, as well as, the space organization and the distinction between the economic and social space of the tertiary activities, from the logic of functioning of the establishments: the regulation. Besides working with referring official data to the tertiary sector, the empirical study it had as reference one hundred and sixty and establishments tertiary, located in four axles of circulation of the city of Bayeux - PB, which are: Av. Liberdade, Av. Engenheiro de Carvalho, Av. Francisco Marques da Fonseca and Av. Marechal Rondon, that they had appeared in such a way stimulated for the processes of urbanization and industrialization lived deeply from years 70 in the "Great Jo?o Pessoa" how much, in the countries of the underdeveloped capitalist world, as Brazil. Being thus, the objective of the work was to study the tertiary sector and its relation with (the re)production of the urban space, standing out the functioning logic / Esta disserta??o tem como objeto de estudo o setor terci?rio e a (re)produ??o do espa?o urbano de Bayeux-PB. Para tanto, fez-se necess?rio ? constru??o de uma abordagem te?rica que contextualizasse a realidade nacional, para se poder entender a realidade local. Essa maneira de construir permitiu uma abertura do campo de vis?o quanto ? relev?ncia de se estudar o setor terci?rio e seu peso diante da atual configura??o da sociedade num pa?s como o Brasil, e especialmente em um munic?pio de um Estado nordestino, como ? o caso de Bayeux. A abordagem te?rica teve como base os dois circuitos da economia urbana, a reestrutura??o produtiva e as transforma??es no mundo do trabalho, bem como, a organiza??o espacial e a distin??o entre o espa?o econ?mico e social das atividades terci?rias, a partir da l?gica de funcionamento dos estabelecimentos: a regulamenta??o. Al?m de trabalhar com dados oficiais referentes ao setor terci?rio, o estudo emp?rico teve como refer?ncia cento e sessenta e um estabelecimentos terci?rios, localizados em quatro eixos de circula??o do munic?pio de Bayeux PB, quais sejam: Av. Liberdade, Av. Engenheiro de Carvalho, Av. Francisco Marques da Fonseca e Av. Marechal Rondon, que surgiram impulsionadas pelos processos de urbaniza??o e industrializa??o vivenciados a partir dos anos 70 tanto na Grande Jo?o Pessoa quanto, nos pa?ses do mundo capitalista subdesenvolvido, como o Brasil. Sendo assim, o objetivo do trabalho foi estudar o setor terci?rio e sua rela??o com a (re)produ??o do espa?o urbano, ressaltando a l?gica de funcionamento