Base teórica: A meningite bacteriana é uma causa importante de morbidade e mortalidade na infância. Análise do líquido cefalorraquidiano (LCR) continua a ser a ferramenta de diagnóstico padrão ouro, porém novos biomarcadores para o diagnóstico e prognóstico ainda são necessários. Receptor Desencadeador Expresso nas Células Mielóides Tipo 1 (TREM-1) é um receptor transmembrana expresso em neutrófilos e monócitos, que desempenha um papel importante na modulação da resposta inflamatória. A sua fração solúvel (sTREM-1) também é aumentada na infecção, inflamação ou doenças imunológicas. Neste estudo nós avaliamos, prospectivamente, o valor do TREM-1 como um biomarcador de meningite bacteriana aguda em pacientes pediátricos e sua possível utilização como uma ferramenta de prognóstico neste cenário. Objetivos: O objetivo primário do presente estudo é caracterizar os níveis líquóricos solúveis de TREM-1 (sTREM-1) em pacientes admitidos por suspeita clínica de meningite. Analisamos também os níveis de sTREM-1 nos casos de meningite bacteriana e viral, além de medir a sensibilidade e especificidade deste biomarcador no LCR e estudar se esse biomarcador pode ser um fator associado ao prognóstico em meningite bacteriana aguda. Métodos: Sessenta e um pacientes pediátricos, de 0 a 10 anos foram avaliados quanto à meningite e foram prospectivamente incluídos neste estudo. Na admissão, após a suspeita clínica de meningite foram submetidos à análise do LCR para o diagnóstico e uma amostra do LCR inicial foi utilizado também para análise do sTREM-1. Os pacientes foram acompanhados durante a sua internação com o registro de seu tratamento e desfecho clínico para posterior análise dos dados. Resultados: Dentre os 61 pacientes, 38 (62%) foram negativos para a meningite, 7 (11%) pacientes foram diagnosticados com meningite viral e 16 (27%) pacientes foram diagnosticados com meningite bacteriana aguda e recebeu tratamento direcionado. Sexo (p = 0,15), presença de fatores de risco identificados (p = 0,17), presença de convulsões (p = 0,31), outras complicações clínicas (p = 0,11) e mortalidade (p = 0,66) não diferiram entre os grupos. Anormalidades sensoriais (p <0,0001) e presença de cefaléia (p = 0,003) foram mais prevalentes em pacientes com meningite. Como esperado, a contagem de leucócitos, glicose e proteína no LCR foram significativamente diferentes entre pacientes com meningite e pacientes sem meningite. As concentrações de sTREM-1 no LCR de pacientes com meningite bacteriana foi superior quando comparada com pacientes com meningite viral e com controles (1204,67 pg/ml, 39,34 pg/ml e 12,09 pg/ml, respectivamente; p <0,0001). Quando sTREM-1 foi usado como um determinante de diferenciação entre pacientes com ou sem meningite bacteriana, a análise da área sob a curva ROC foi de 0,95 (IC de 95% = 0,89-1,00; p <0,0001). A presença de fatores de risco para a meningite bacteriana (p = 0,04), anormalidades sensoriais (p <0,0001), contagem de leucócitos no LCR (p = 0,01), níveis de glicose no LCR (p = 0,002), níveis de proteína no LCR (p = 0,032) e os níveis de sTREM-1 no LCR (p = 0,004) foram associados com meningite bacteriana, incluindo os níveis sTREM-1 acima do ponto de corte estabelecido de 68,0 pg/ml (p <0,0001). A meningite bacteriana (p = 0,02) e os valores de sTREM-1 maior do que o ponto de corte (68,0 pg/ml) (p = 0,04) foram associados com sequelas neurológicas graves e morte neste grupo de pacientes. Conclusão: Avaliamos os níveis sTREM-1 de crianças com suspeita clínica de meningite. Os níveis de s-TREM-1 foram aumentados nos casos de meningite bacteriana e correlacionados com o prognóstico. Os nossos resultados sugerem que níveis elevados de sTREM-1 no LCR podem ser utilizados como um biomarcador para o diagnóstico de meningite bacteriana aguda em crianças e que pode ser útil na determinação do prognóstico do paciente nesse cenário. / Background: Bacterial meningitis is an important cause of morbidity and mortality in infancy. Cerebrospinal fluid (CSF) analysis remains the gold standard diagnostic tool, however new biomarkers for diagnosis and prognosis are still required. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane receptor expressed on neutrophils and monocytes that plays an important role on the immune response. Its soluble fraction (sTREM-1) is also increased in infection, inflammation or immune diseases. In this study we evaluate the value of sTREM-1 as a biomarker of acute bacterial meningitis in pediatric patients and its possible use as a prognostic tool prospectively. Methods: Sixty-one pediatric patients, from 0 to 10 years of age were evaluated for meningitis and were prospectively included in this study. At admission, following clinical hypothesis of meningitis patients were submitted to CSF analysis for diagnosis and a sample of initial CSF was also used for TREM-1 analysis. Patients were followed during hospitalization and clinical evaluation and treatment outcome were recorded for posterior analysis. Results: Thirty-eight (62%) out of 61 patients were negative for meningitis, 7 (11%) patients were diagnosed with viral meningitis and 16 (27%) patients were diagnosed with and received treatment for acute bacterial meningitis. Sex (p = 0.15), presence of identified risk factors (p = 0.17), presence of seizures (p = 0.31), other clinical complications (p = 0.11), and mortality (p = 0.66) did not differ among groups. Sensorial abnormalities (p<0.0001) and presence of headache (p= 0.003) were more prevalent in patients with meningitis. As expected, leukocyte count, glucose, and protein levels were significantly different between patients with meningitis and patients without meningitis. Concentrations of sTREM-1 in CSF from patients with bacterial meningitis was higher when compared to patients with viral meningitis and with controls (1204.67 pg/ml, 39.34 pg/ml and 12.09 pg/ml, respectively; p<0.0001). When sTREM-1 was used as a determinant to differentiate between patients with or without bacterial meningitis, the analysis of the area under the ROC curve (AUC) was 0.95 (95% CI=0.89-1.00; p<0.0001). Presence of risk factors for bacterial meningitis (p = 0.04), sensorial abnormalities (p<0.0001), CSF leukocyte count (p = 0.01), CSF glucose levels (p = 0.002), CSF protein levels (p = 0.032) and CSF sTREM-1 levels (p = 0.004) were all associated with bacterial meningitis, including sTREM-1 levels above the established cut-off point of 68.0 pg/ml (p<0.0001). Bacterial meningitis (p = 0.02) and values of sTREM-1 higher than the cut-off point (68.0 pg/ml) (p = 0.04) were associated with death and severe neurological disabilities in this patient cohort. Conclusion: We evaluated sTREM-1 levels in CSF of children with clinical hypothesis of meningitis. The sTREM-1 levels were increased in bacterial meningitis and correlated with prognosis. Our results suggest that CSF sTREM- 1 levels can be used as a biomarker for diagnosis of acute bacterial meningitis in children and it might be useful in determining patient’s prognosis in this scenario.

Base teórica: A meningite bacteriana é uma causa importante de morbidade e mortalidade na infância. Análise do líquido cefalorraquidiano (LCR) continua a ser a ferramenta de diagnóstico padrão ouro, porém novos biomarcadores para o diagnóstico e prognóstico ainda são necessários. Receptor Desencadeador Expresso nas Células Mielóides Tipo 1 (TREM-1) é um receptor transmembrana expresso em neutrófilos e monócitos, que desempenha um papel importante na modulação da resposta inflamatória. A sua fração solúvel (sTREM-1) também é aumentada na infecção, inflamação ou doenças imunológicas. Neste estudo nós avaliamos, prospectivamente, o valor do TREM-1 como um biomarcador de meningite bacteriana aguda em pacientes pediátricos e sua possível utilização como uma ferramenta de prognóstico neste cenário. Objetivos: O objetivo primário do presente estudo é caracterizar os níveis líquóricos solúveis de TREM-1 (sTREM-1) em pacientes admitidos por suspeita clínica de meningite. Analisamos também os níveis de sTREM-1 nos casos de meningite bacteriana e viral, além de medir a sensibilidade e especificidade deste biomarcador no LCR e estudar se esse biomarcador pode ser um fator associado ao prognóstico em meningite bacteriana aguda. Métodos: Sessenta e um pacientes pediátricos, de 0 a 10 anos foram avaliados quanto à meningite e foram prospectivamente incluídos neste estudo. Na admissão, após a suspeita clínica de meningite foram submetidos à análise do LCR para o diagnóstico e uma amostra do LCR inicial foi utilizado também para análise do sTREM-1. Os pacientes foram acompanhados durante a sua internação com o registro de seu tratamento e desfecho clínico para posterior análise dos dados. Resultados: Dentre os 61 pacientes, 38 (62%) foram negativos para a meningite, 7 (11%) pacientes foram diagnosticados com meningite viral e 16 (27%) pacientes foram diagnosticados com meningite bacteriana aguda e recebeu tratamento direcionado. Sexo (p = 0,15), presença de fatores de risco identificados (p = 0,17), presença de convulsões (p = 0,31), outras complicações clínicas (p = 0,11) e mortalidade (p = 0,66) não diferiram entre os grupos. Anormalidades sensoriais (p <0,0001) e presença de cefaléia (p = 0,003) foram mais prevalentes em pacientes com meningite. Como esperado, a contagem de leucócitos, glicose e proteína no LCR foram significativamente diferentes entre pacientes com meningite e pacientes sem meningite. As concentrações de sTREM-1 no LCR de pacientes com meningite bacteriana foi superior quando comparada com pacientes com meningite viral e com controles (1204,67 pg/ml, 39,34 pg/ml e 12,09 pg/ml, respectivamente; p <0,0001). Quando sTREM-1 foi usado como um determinante de diferenciação entre pacientes com ou sem meningite bacteriana, a análise da área sob a curva ROC foi de 0,95 (IC de 95% = 0,89-1,00; p <0,0001). A presença de fatores de risco para a meningite bacteriana (p = 0,04), anormalidades sensoriais (p <0,0001), contagem de leucócitos no LCR (p = 0,01), níveis de glicose no LCR (p = 0,002), níveis de proteína no LCR (p = 0,032) e os níveis de sTREM-1 no LCR (p = 0,004) foram associados com meningite bacteriana, incluindo os níveis sTREM-1 acima do ponto de corte estabelecido de 68,0 pg/ml (p <0,0001). A meningite bacteriana (p = 0,02) e os valores de sTREM-1 maior do que o ponto de corte (68,0 pg/ml) (p = 0,04) foram associados com sequelas neurológicas graves e morte neste grupo de pacientes. Conclusão: Avaliamos os níveis sTREM-1 de crianças com suspeita clínica de meningite. Os níveis de s-TREM-1 foram aumentados nos casos de meningite bacteriana e correlacionados com o prognóstico. Os nossos resultados sugerem que níveis elevados de sTREM-1 no LCR podem ser utilizados como um biomarcador para o diagnóstico de meningite bacteriana aguda em crianças e que pode ser útil na determinação do prognóstico do paciente nesse cenário. / Background: Bacterial meningitis is an important cause of morbidity and mortality in infancy. Cerebrospinal fluid (CSF) analysis remains the gold standard diagnostic tool, however new biomarkers for diagnosis and prognosis are still required. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane receptor expressed on neutrophils and monocytes that plays an important role on the immune response. Its soluble fraction (sTREM-1) is also increased in infection, inflammation or immune diseases. In this study we evaluate the value of sTREM-1 as a biomarker of acute bacterial meningitis in pediatric patients and its possible use as a prognostic tool prospectively. Methods: Sixty-one pediatric patients, from 0 to 10 years of age were evaluated for meningitis and were prospectively included in this study. At admission, following clinical hypothesis of meningitis patients were submitted to CSF analysis for diagnosis and a sample of initial CSF was also used for TREM-1 analysis. Patients were followed during hospitalization and clinical evaluation and treatment outcome were recorded for posterior analysis. Results: Thirty-eight (62%) out of 61 patients were negative for meningitis, 7 (11%) patients were diagnosed with viral meningitis and 16 (27%) patients were diagnosed with and received treatment for acute bacterial meningitis. Sex (p = 0.15), presence of identified risk factors (p = 0.17), presence of seizures (p = 0.31), other clinical complications (p = 0.11), and mortality (p = 0.66) did not differ among groups. Sensorial abnormalities (p<0.0001) and presence of headache (p= 0.003) were more prevalent in patients with meningitis. As expected, leukocyte count, glucose, and protein levels were significantly different between patients with meningitis and patients without meningitis. Concentrations of sTREM-1 in CSF from patients with bacterial meningitis was higher when compared to patients with viral meningitis and with controls (1204.67 pg/ml, 39.34 pg/ml and 12.09 pg/ml, respectively; p<0.0001). When sTREM-1 was used as a determinant to differentiate between patients with or without bacterial meningitis, the analysis of the area under the ROC curve (AUC) was 0.95 (95% CI=0.89-1.00; p<0.0001). Presence of risk factors for bacterial meningitis (p = 0.04), sensorial abnormalities (p<0.0001), CSF leukocyte count (p = 0.01), CSF glucose levels (p = 0.002), CSF protein levels (p = 0.032) and CSF sTREM-1 levels (p = 0.004) were all associated with bacterial meningitis, including sTREM-1 levels above the established cut-off point of 68.0 pg/ml (p<0.0001). Bacterial meningitis (p = 0.02) and values of sTREM-1 higher than the cut-off point (68.0 pg/ml) (p = 0.04) were associated with death and severe neurological disabilities in this patient cohort. Conclusion: We evaluated sTREM-1 levels in CSF of children with clinical hypothesis of meningitis. The sTREM-1 levels were increased in bacterial meningitis and correlated with prognosis. Our results suggest that CSF sTREM- 1 levels can be used as a biomarker for diagnosis of acute bacterial meningitis in children and it might be useful in determining patient’s prognosis in this scenario.

This master‘s thesis deals with the design of a software solution for the AURIX TC234 microcontroller by Infineon Technologies which enables a user to start sampling of the signal at any required moment. A sampling time should be set to the lowest possible value. This solution is then added to the application which is used for a field oriented control of the brushless direct current motor. The obtained values can be further used, for example, for analyzing the waveform of motor currents from which it might be possible to determine the condition of the transistor inverter.

Human immunodeficiency virus (HIV) infection has reached epidemic proportions in South Africa. The availability of highly active anti-retroviral therapy (HAART) prolongs life in HIV-infected persons, who may subsequently present with chronic manifestations of HIV-infection. The respiratory morbidity attendant to HIV-infection, even in the presence of HAART is high, the aftermath of which is lung tissue destruction and bronchiectasis. As a consequence of the political decision not to offer HAART to HIV-infected children, a number of children in South Africa have been left with severe consequences of uncontrolled HIV-infection. Bronchiectasis is one of those and because children with this devastating condition were numerous in the Pretoria region, the author and her colleagues began a Chronic Lung Disease Clinic in that region. This prompted the idea of investigating both the epidemiological profiles of these children and an attempt to intervene with both standard bronchiectasis guideline care and the use of a form of therapy commonly employed in other forms of bronchiectasis. This thesis explores those ideas. Important new and novel findings that were consequent were; that bronchiectasis is diagnosed late in HIV-infected children at a mean age of 6.9 years. The predominant organisms cultured from the airways are Haemophilus influenzae and parainfluenzae in 49% of samples. Pseudomonas aeruginosa (PA), common in cystic fibrosis (CF)-bronchiectasis is an uncommon pathogen in HIV-related bronchiectasis; isolated in only 2% of specimens. Tuberculosis (TB), at least as reported, is a significant antecedent of bronchiectasis, reported in 48.5%of children. A further 21.2% of the patients had received more than two courses of anti-TB treatment. However, proof of TB infection has been lacking. Respiratory morbidity is significant with the mean forced expiratory flow in one second (FEV1) of 53%, in this cohort at the time of presentation. Thirty-six percent of all children were exposed to environmental tobacco smoke, although this was not correlated with disease severity or HIVdisease progression. There is elevation of immunoglobulins in HIV-related bronchiectasis, with a mean IgE of 79 kU/l. This was not, though, associated with HIV disease progression as previously described in adult studies, nor with the presence of allergic bronchopulmonary aspergillosis (ABPA). The elevation in IgE was also not associated with an elevation of T helper-2 mediated cytokines, confirming the lack of association with atopy. The predominant cytokine, identified is interleukin (IL)-8, both systemically and locally (in airway secretions). There was elevation of other T helper-1 driven cytokines, reflecting an ability to mediate adequate inflammatory responses, which was independent of the level of immunosuppression. With the presence of HAART, there was a decline in the pro-inflammatory cytokines over time, which may be attributed to the ongoing effect of HAART that ties in to, or goes beyond the restoration of T cell numbers. Soluble triggering receptor expressed on myeloid cells (sTREM), an innate immune marker, is elevated in children with HIV-related bronchiectasis when compared to a control group of children with cystic fibrosis-related bronchiectasis. sTREM is not associated with the presence of exacerbations and the level of immunosuppression. The use of an anti-inflammatory drug erythromycin also did not impact the sTREM values. There was also no relationship between sTREM and pro and antiinflammatory cytokines and chemokines. Fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) could not reliably predict the presence of pulmonary exacerbations. Its diagnostic value was limited to identifying disease activity in acute pneumonia. 18F-FDG PET also had no significant correlation with CRP, inflammatory cytokines or markers of HIV disease activity. In a randomised controlled trial of erythromycin, a cost-effective immunomodulatory drug, compared to placebo, erythromycin was ineffective in reducing the number of pulmonary exacerbations. Erythromycin also failed to demonstrate any effect on systemic and local pro- and anti-inflammatory cytokines/chemokines. With access to anti-retroviral therapy, airway clearance, nutritional rehabilitation and vigilant follow up there was an improvement in pulmonary function parameters and stability of the degree of bronchiectasis that we propose is probably in keeping with an organ system disease modifying effect that may be, an as yet, undefined and undescribed byproduct of HAART. / Thesis (PhD)--University of Pretoria, 2012. / Paediatrics and Child Health / unrestricted

Les glissements de terrains sous-marins, même de petite taille, représentent un risque majeur d’érosion littorale et de submersion marine lorsqu’ils sont déclenchés à proximité des côtes. Ce fut le cas à Nice (France) avec l’effondrement en mer d’une partie de la plateforme aéroportuaire, suivit d’un tsunami du fait d’un glissement sous-marin en octobre 1979. Du fait que la pente continentale niçoise soit abrupte, à proximité des côtes et soumise à une activité sismique modérée, elle constitue un véritable laboratoire naturel pour l’étude des glissements sous-marins de petite échelle. Ce travail repose sur une approche multidisciplinaire permettant une étude globale des processus de glissement dans la zone proximale. Il intègre des données issues de la géophysique marine, de la sédimentologie de la géotechnique et une phase préliminaire de modélisation numérique. Pour la première fois, la morphologie ainsi que l’architecture des dépôts du delta du Var ont été investigués à partir de données de très haute résolution. Elles ont permis d’identifier la signature de nombreux processus gravitaires de petite taille en surface (morphologie / taille / répartition spatiale) ainsi que leur imbrication en profondeur. Dans le cas du glissement de 1979, des éléments encore inconnus ont été identifiés tels que : 1) ses cicatrices Est et Ouest ; 2) des blocs et paquets glissés non évacués ; 3) la surface de glissement en profondeur ; 4) l’estimation d’un volume total déplacé différent du volume de sédiments évacués. Les carottes sédimentaires ont ensuite permis de discuter de la répartition en zone proximale des dépôts/érosion et de l’enregistrement de paléoglissement à partir de l’état de surconsolidation des dépôts. L’activité des glissements a été estimée dans le temps. Les plus grands glissements (V > 106 m3) ont des fréquences estimées ~50 ans, les glissements de taille moyenne (105 < V < 106 m3) autour de 3 à 25 ans, et les nombreux petits glissements (V < 105 m3) tous les 1-2 mois à 5 ans au cours des périodes actives des 50 dernières années. Ces glissements sont enregistrés dès la zone proximale à des fréquences de 3-7 ans au cours des périodes de plus forte activité depuis 400 ans. L’évolution de la morphologie suit des cycles successifs de déclenchement/quiescence/rechargement. À l’échelle de temps humaine deux cycles s’étendent de 1967-1999 et de 1999-2011 ; les ruptures se regroupent en cluster de 5-10 ans. À l’échelle pluriséculaire, les clusters de turbidites durent 20-40 ans et les périodes de quiescence ~100 ans. Enfin, cette étude apporte de nouvelles contraintes à propos des facteurs déclenchants ou préconditionnants agissant sur le delta du Var. L’état de stabilité de la zone semble être fortement préconditionné par la complexité de la topographie, l’état de consolidation des sédiments et l’importance des apports sédimentaires du Var. L’architecture des dépôts semble principalement contraindre la profondeur des instabilités. Parmi les forçages externes connus sur la zone, nous avons cartographié l’extension de la zone riche en gaz ainsi que des panaches de fluides dans la colonne d’eau. Notre analyse montre que l’amplitude des précipitations, des crues et du niveau de la nappe alluviale seraient trop faibles au cours des 50 dernières années pour agir en tant que facteur déclenchant de manière isolée. Afin de déstabiliser les pentes, ces forçages semblent devoir être couplés entre eux ou associés à l’action de séismes. Les analyses des bases de données en lien avec l’activité des glissements ainsi que les tests numériques permettent de suggérer que la sismicité régionale et que les séismes historiques sont soit 1) de magnitude trop faible, soit 2) à de trop grandes distances des zones de déclenchement, pour générer des PGA assez fort (0,2 g) et avoir individuellement un impact sur les pentes du Delta. / Small submarine landslides, when triggered near the coast represent a major coastal hazard due to erosion of the coastline and marine submersion. In October 1979, a submarine landslide generated a part of the airport platform of Nice (France) to collapse at sea and provoked a tsunami. Because the continental slope off this region is abrupt, close to the coast and subject to moderate seismic activity it is a natural laboratory to study small-scale submarine mass movements processes. This work is based on a multidisciplinary approach allowing a global study of landslide processes in the source area. It integrates data from marine geophysics, sedimentology, geotechnics and numerical modelling. For the first time morphology and architecture of the Var delta deposits are investigated using very high resolution data. It allows identification of numerous small-size gravitational processes signatures as well as their embedding at depth. In the case of the 1979 landslide previously unknown features are identified: 1) eastern and western scars, 2) in-situ blocks and lateral spreading’s traces, 3) in-depth sliding surface, 4) estimation of a total displaced volume, which is different from the evacuated sediment volume. The sedimentary cores are then used to discuss the proximal distribution of deposits, erosion and paleo-landslides records from the deposits overconsolidation. The landslide activity has been estimated over time in terms of return frequencies. The largest landslides (>106 m3) have return frequencies nearing 50 years; the medium-size landslides (105 > V > 106 m3) between 3 and 25 years; and the numerous small landslides (<105 m3) every 1-2 months to 5 years during the most active periods in the last 50 years. Landslides deposits recorded in the source area show return frequencies of 3-7 years during periods of greater activity over the last 400 years. The morphology’s evolution follows successive cycles of sliding/quiescence/reloading. In recent times, two main cycles can be observed (from 1967 to 1999 and from 1999 to 2011) during which triggering are clustered in 5-10 years. On a longer time scale, the turbidites clusters span 20-40 years and quiescence periods ~100 years. Finally, this study brings new constraints on preconditioning and triggering factors acting on the Var delta. The stability of the area seems to be strongly conditioned by the complexity of the topography, the sediments consolidation and the quantity of sediments brought by the Var river. The deposits architecture mainly constrains the depth of the instabilities. Among the external drivers known in the area the extension of the gas-rich zone as well as fluids plumes in the water column have been considered and mapped. Looking at other external drivers, the analysis shows that the magnitude of rainfall and floods, and the alluvial water level would be too low over the past 50 years to act as an isolated triggering factor. In order to destabilize slopes, these external drivers need to be tackled together or associated to earthquakes. Relationships between databases analyses, landslides activity and numerical tests suggest that regional seismicity and historical earthquakes are either too small or too distant from the source areas to generate sufficient peak ground acceleration (0.2 g) and to have an individual impact on the delta slopes.

Alla sinnen kan påverka vår matupplevelse och även hur vi upplever smak, men ett sinne som ofta glöms bort är hörseln. Olika ljud i omgivningen, men även matljuden i sig, har möjlighet att påverka hur vi upplever det vi äter. Hur vi upplever de olika matljuden kan ha en evolutionär bakgrund då krispiga ljud kan tala om för oss att maten är färsk eller innehåller mycket fett eller näringsämnen medan skrapande ljud och ljud av olika vätskor, såsom snörvlande påminner om sjukdom eller fara. På sistone har även fenomen som ASMR och streamande av ätande så kallat mukbang blivit populariserat där matljud lockar tittare. De ljud som är populära inom dessa genrer är dock ljud som kan bli triggande för personer med misofoni.     En enkätstudie utfördes med 100 deltagande respondenter varav 34 hade misofoni, 32 angav att de hade en nedsatt tolerans för olika ljud, 7 som inte visste (om de hade någon ljudöverkänslighet) och 27 som inte hade någon ljudöverkänslighet. Enkäten innefattade olika ljudklipp med matljud och ljud vid matbordet som respondenterna fick lyssna på samt fick olika frågor om hur de upplevde ljuden, ifall ljuden kunde påverka deras aptit, hur ljudkänsliga de är (via den så kallade noise sensitivity scale) samt vilka reaktioner som triggande ljud utlöser för personerna. I denna studie ställs frågan hur de olika grupperna skiljer sig åt gällande dessa frågor samt hur ljud upplevs och varför, samt om misofoni påverkar aptiten. Huruvida misofoni borde betraktas som en egen diagnos kommer att diskuteras.    Denna studie visar att personer med misofoni upplever matljud som signifikant värre än de utan någon ljudöverkänslighet. Ljudet av ett äpple som äts upplevs exempelvis som värre än ljudet av en gaffel skrapande mot en tallrik för personer med misofoni medan personer utan ljudöverkänslighet upplever skrapljudet som allra värst. Personer utan ljudöverkänslighet upplever ljudklippen i enkäten som betydligt mer aptithöjande än personer med misofoni. Studien visar även att personer med misofoni reagerar betydligt starkare på olika ljud i jämförelse med personer som svarat att de upplever att de har en nedsatt tolerans för olika ljud. / All our senses can affect our dining experience and how we perceive flavour. One of the senses that is often forgotten in the context of eating is our hearing. Different sounds in the environment, and even the sound of food itself, can affect the way we perceive our meal. How we experience the different sounds of food has an evolutionary background. Crispy sounds can tell us when something is fresh, has a high fat or nutrition content, while various liquid sounds such as snivelling or scraping noises remind us of sickness and danger. Recently phenomena such as ASMR and mukbang, online streaming of someone eating, has become popularized where food sounds attract many viewers. However the sounds that are popular within these genres are the sounds that can be triggering for people with misophonia.     Out of the 100 people surveyed 34 respondents reported that they had misophonia, 32 experienced increased noise sensitivity, 7 didn't know (if they had any increased noise sensitivity), and 27 were not noise sensitive. The survey consisted of different audio clips with food sounds and other sounds from the dinner table, as well as questions about how the respondents experienced the sounds, if the sounds affected their appetite, if they are sensitive to noise (according to the noise sensitivity scale) and what reactions occurred because of the triggering sounds. This study asks the question of how the different groups’ answers differentiate throughout these questions, how sound is perceived and why, and if misophonia has an effect on appetite. If misophonia should be considered as a separate diagnosis will be discussed.    This study shows that people with misophonia perceive sound of food as significantly worse than the people without noise sensitivity. For example, the sound of an apple being eaten is perceived as worse than the sound of a fork scraping against a plate for people with misophonia while people without noise sensitivity rate the scraping sound as the worst. People without sound sensitivity experience the audio clips as significantly more appetite enhancing than people with misophonia. This study also shows that people with misophonia respond significantly stronger to various sounds compared to the people with increased noise sensitivity.

No description available.

Made available in DSpace on 2016-04-26T20:23:03Z (GMT). No. of bitstreams: 1 Caio Cesar Nader Quintella.pdf: 696078 bytes, checksum: a44671ba498b295c279a835741074c8e (MD5) Previous issue date: 2014-08-19 / Complementary Law No. 104/2001 inserted the sole paragraph to Article 116 of the National Tax Code. Since such a provision was inserted in Chapter III of the Tax Codex, which deals with the triggering event and, specifically, in Article 116, for the regulation of the time of its occurrence, we would be facing a general rule that would affect the observation of occurrence of such a legal phenomenon. Given this legislative innovation of general application in the legal and tax relations, initially we analyze the interaction with the other elements that make up the national legal system, and verify its formal and material adequacy. Particularly given the immense thematic relevance of the topic and its regency in Tax Law as subsystem, we analyze the Principle of Legality, its scope and developments, to foster the engagement of provisions and effects brought with the insertion of the sole paragraph to Article 116 of the National Tax Code. Also, by the very result of such an analysis, we started to check the content, scope and consequences of the principle of legal certainty, which has an unquestionably great level abstraction and penetration into the national legal system in order to confront its corollary and impositions with the legal content and consequences of the instrument under investigation. Likewise, we address the institutes and subjects related to the central object of study, giving a greater depth to reflect on their compliance with the principles analyzed and on other general rules governing the Tax Law in Brazil. At the end, before all observations made on the subject, we promote the proper completion of the study / A Lei Complementar nº 104/2001 acrescentou ao artigo 116 do Código Tributário Nacional o seu parágrafo único. Posto que tal dispositivo foi inserido no Capítulo III do Codex tributário, que trata da ocorrência do fato gerador e, especificamente, no seu artigo 116, destinado à regulamentação do momento da sua ocorrência, estaríamos diante de uma norma geral que afetaria a constatação de ocorrência de tal fenômeno jurídico. Diante dessa inovação legislativa de alcance geral nas relações jurídico-tributárias, inicialmente analisa-se a sua interação com os demais elementos que compõem o sistema jurídico nacional, verificando sua adequação, formal e material. Particularmente, em face da imensa pertinência temática ao tema e à sua regência na seara do Direito Tributário como subsistema, analisa-se o Princípio da Legalidade, seu alcance e desdobramentos, para promover o confronto das prescrições e dos efeitos trazidos com a inserção do parágrafo único ao artigo 116 do Código Tributário Nacional. Igualmente, por decorrência da própria análise de tal instituto axiológico, passa-se a verificar o conteúdo, o alcance e os desdobramentos do Princípio da Segurança Jurídica, o qual inquestionavelmente possui grande abstração e penetração no sistema jurídico nacional, a fim de confrontar seu corolário e imposições com o conteúdo e os reflexos jurídicos do dispositivo sob investigação. Da mesma forma, abordam-se institutos e temas correlacionados ao objeto central de estudo, conferindo um maior aprofundamento à reflexão sobre a sua adequação aos princípios analisados e às demais normas gerais que regem o Direito Tributário no Brasil. Ao final, diante de todas constatações obtidas sobre tema proposto, promove-se a devida conclusão do estudo

La partie ouest du rift de Corinthe, en Grèce, s'ouvre à une vitesse d'environ 15 mm par an générant un taux de déformation parmi les plus élevés au monde, quelques séismes destructeurs de magnitude M>6 par décennie, et une forte activité microsismique irrégulière spatialement et temporellement. Afin de mieux comprendre les mécanismes liés à cette déformation crustale et de préciser les structures majeures actives, ce travail de recherche exploite la base de données sismologiques du Corinth Rift Laboratory de 2000 à 2015 en analysant finement les microséismes et leur évolution spatio-temporelle. La relocalisation globale des sources sismiques ainsi que leur classification en multiplets ont permis de préciser la géométrie des failles et d'identifier des comportements mécaniques différents. La zone ouest, au milieu du golfe, est affectée par des variations de pressions de fluides dans une couche géologique, entraînant des migrations des essaims de microséismes à des vitesses d'environ 50 m par jour. Les multiplets profonds de la partie centrale, près de la côte nord, sont persistants et semblent déclenchés par des épisodes de glissements lents asismiques sur un détachement immature pouvant atteindre la croûte ductile. Le faible pourcentage de déclenchement dynamique par les ondes sismiques suggère que l'état global du système de failles n'est pas au seuil critique de rupture. La magnitude des séismes est corrélée à l'impulsivité initiale de la rupture. Ces résultats précisent la dynamique de déformation du rift, les interactions sismique-asismiques, et permettront d'améliorer les modèles d'aléas sismiques de la région / The western part of the Corinth Rift in Greece is opening at about 15 mm per year, generating one of the highest deformation rates in the world, some destructive earthquakes of magnitude M>6 per decade, and high microseismic activity irregular in space and time. In order to better understand the mechanisms related to this crustal deformation and to specify the major active structures, this research work makes use of the seismological database of the Corinth Rift Laboratory from 2000 to 2015 by finely analyzing microearthquakes and their spatio-temporal evolution. The global relocation of the seismic sources and their classification into multiplets enable to refine the geometry of the faults and to identify different mechanical behaviors. The western zone, in the middle of the gulf, is affected by fluctuations of fluid pore pressures in a geological layer, resulting in microseismic swarm migrations at a velocity of about 50 m per day. The deep multiplets of the central part, near the northern coast, are persistent and appear to be triggered by episodes of slow aseismic slip along an immature detachment, which can reach the ductile crust. The low percentage of dynamic triggering by passing seismic waves suggests that the overall state of the fault system is not at the critical breaking point. The magnitude of earthquakes is correlated with the initial impulsiveness of the rupture. These results specify the dynamics of the rift deformation, the seismic-aseismic interactions, and will make possible the improvement of the seismic hazard models of the region

Volcanic activity, and the resultant deposits and structures at the Earth's surface, are the outcome of the inner workings of underground magmatic plumbing systems. These systems, essentially, consist of magma reservoirs which supply magma to the surface through volcanic conduits feeding volcanic eruptions. The mechanics and structure of plumbing systems remain largely unknown due to the obvious challenges involved in inferring volcanic processes occurring underground from observations at the surface. Nevertheless, volcanologists are beginning to gain a deeper understanding of the workings and architecture of magmatic plumbing systems from geophysical observations on active volcanoes, as well as from geological studies of the erosional remnants of ancient volcanic systems. In this work, I explore the relationship between the structure and mechanics of shallow plumbing systems and the volcanic eruptions these systems produce. I attempt to contribute to the understanding of this complex relationship by linking geological and geophysical observations of an eroded basaltic subvolcanic system, and the eruptive and tectonic activity of an active volcano, with mathematical models of magma ascent and stress transfer. The remarkable exposures of the Carmel outcrop intrusions, near the San Rafael swell, southeast Utah, U. S. A., allow detailed geological and geophysical observations of the roots of volcanic conduits that emerge from a subhorizontal magma feeder reservoir. These observations reveal a new mechanism for magma ascent and eruption triggering through gravitational instabilities created from an underlying feeding sill, and shed light on the mechanics of sill emplacement. Geophysical and geological observations of the 1999 and xii 1992 eruptions of the Cerro Negro volcano, Nicaragua, are used to explore the coupling between changes in the stress field and the triggering of volcanic eruptions, and magma ascent through the shallow crust. Modeling results of stress transfer and conduit flow highlight the importance of the surrounding stress field and geometry of the volcanic conduits that comprise shallow plumbing systems.