Orientador: Rui Seabra Ferreira-Júnior / Resumo: A sociedade contemporânea coloca aos indivíduos novos desafios no que tange suas vidas acadêmicas e profissionais, exigindo cada vez mais pessoas criativas, flexíveis e pró-ativas. O empreendedorismo acadêmico constitui um dos motores fundamentais para o crescimento econômico e geração de riqueza, incentivando discentes, docentes e pesquisadores na transformação de suas descobertas em patentes, spin-offs ou licenças tecnológicas e de negócios, ampliando, assim, a atividade universitária. A transposição do conhecido abismo, ou gap existente entre a pesquisa básica e a aplicada é uma problemática mundial. Grandes descobertas acadêmicas acabam morrendo na bancada do laboratório muitas vezes por falta de informação na área do empreendedorismo. Neste contexto, o presente estudo propôs o desenvolvimento de um curso não presencial, a ser disponibilizado aos alunos de pós-graduação do curso de Mestrado Profissional em Pesquisa Clínica da FMB - CEVAP - UNESP sobre “Empreendedorismo de Bioprodutos”. Vislumbrou também a sua validação, por meio do "Índice de Validade de Conteúdo (IVC)", método de validação de produtos ou cursos que utiliza especialistas, muito utilizado na área da saúde. O curso, desenvolvido por uma equipe multidisciplinar, foi dividido em seis módulos didáticos, cada qual contendo um vídeo introdutório, uma videoaula referente ao conteúdo do módulo e uma tarefa a ser desenvolvidas no ambiente virtual de ensino Moodle, totalmente customizado para o curso. Foi enviado pa... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

Administrative data is one of the most commonly used data sources for diagnosed diabetes surveillance within Canada. Despite their widespread use, administrative case definitions have not been validated in many minority populations on which they are commonly used. Additionally, previous validation work has not evaluated the effect of conditional covariance between data sources, which has been widely shown to significantly bias parameter (sensitivity, specificity, and prevalence) estimation. Using administrative data and data sources which contained gold standard cases of diabetes, this thesis examined (1) the validity of commonly used administrative case definitions for identifying cases of diagnosed diabetes within an Aboriginal population at the sub-provincial level, and (2) the effect of conditional covariance on parameter estimates of an administrative case definition used to identify cases of diagnoses diabetes within the general population of Nova Scotia. We found significant differences in the sensitivity and specificity of a commonly used administrative case when applied to an Aboriginal population at the sub-provincial level. For the general population of Nova Scotia, we found that including a parameter to estimate conditional covariance between data sources resulted in significant variation in sensitivity, specificity, and prevalence estimates as compared to a study which did not consider this parameter. We conclude that work must continue to validate administrative case definitions both within minority populations and for the general population to enhance diabetes surveillance systems in Canada. / Validation study for administrative case definitions to identify cases of diagnosed diabetes in Canada

INTRODUCTION Chronic kidney disease (CKD) affects 50 million people globally. Several studies show the importance of implementing interventions that enhance patients’ knowledge about their disease. In 2011 the Kidney Disease Knowledge Survey (KiKS) was developed: a questionnaire that assesses the specific knowledge about chronic kidney disease in pre-dialysis patients. OBJECTIVE To translate to Spanish, culturally adapt and validate the Kidney Disease Knowledge Survey questionnaire in a population of patients with pre-dialysis chronic kidney disease. METHODS We carried out a Spanish translation and cross-cultural adaptation of the Kidney Disease Knowledge Survey questionnaire. Subsequently, we determined its validity and reliability. We determined the validity through construct validity; and reliability by evaluating its internal consistency and its intra- observer reliability (test-retest). RESULTS We found a good internal consistency (Kuder-Richardson = 0.85). The intra-observer reliability was measured by the intra-class correlation coefficient that yielded a value of 0.78 (95% CI: 0.5-1.0). This value indicated a good reproducibility; also, the mean difference of -1.1 test-retest SD 6.0 (p = 0.369) confirms this finding. CONCLUSION The translated Spanish version of the Kidney Disease Knowledge Survey is acceptable and equivalent to the original version; it also has a good reliability, validity and reproducibility. Therefore, it can be used in a population of patients with pre-dialysis chronic kidney disease.

Introduction—Chronic kidney disease (CKD) affects 50 million people globally. Several studies show the importance of implementing interventions that enhance patients' knowledge about their disease. In 2011, the Kidney Disease Knowledge Survey (KiKS) was developed, a questionnaire that assesses the specific knowledge about CKD in pre-dialysis patients. Objective—To translate to Spanish, culturally adapt and validate the questionnaire KiKS in a population of patients with pre-dialysis CKD. Methods—The translation and cultural adaptation of KiKS was performed. Subsequently, its validity and reliability were determined. The validity was evaluated by construct validity; and the reliability by its internal consistency and its intra-observer reliability (test-retest). Results—A good internal consistency was found (Kuder-Richardson = 0.85). Regarding intraobserver reliability, the intraclass correlation coefficient with a value of 0.78 (95% CI: 0.5–1.0) indicated a good reproducibility; the mean difference of −1.1 test-retest S.D. 6.0 (p = 0.369) confirm this.

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Student Number : 8609483Y - MA Dissertation - School of Human and Community Development - Faculty of Humanties / This study undertook to investigate the validity of the Sense of Coherence Scale (SOC Scale) for use in South Africa. The scale was developed by Antonovsky (1987) and is widely used in stress and health research. It measures three components: meaningfulness, comprehensibility, and manageability, which Antonovsky posited as being central to a person’s sense of coherence (SOC), which in turn facilitates coping and personal resilience. The current research utilised two samples, namely a group of disabled individuals and a group of undergraduate psychology students. It found that while the SOC Scale is indeed a useful psychometric instrument within a South African context, it would be advisable to develop a modified version of the scale for local use. Factor analysis suggested that a three-factor solution is more appropriate than a one-factor solution, a finding which is congruent with Antonovsky’s theory. Suggestions are made for modifications to some of the original 29 items, as well as the subscales, of the SOC Scale.

O desenvolvimento infantil é um processo complexo que começa na concepção e se estende por longo período, envolvendo vários aspectos como crescimento físico, maturação neurológica, comportamental, cognitiva, social e afetiva. De acordo com a Organização Mundial da Saúde - OMS, a presença de fatores negativos que intervém no desenvolvimento infantil afeta cerca de 10% da população infantil mundial. Existem evidências suficientes de que quanto mais precoce for a identificação de possíveis problemas de atraso no desenvolvimento com consequente intervenção adequada, menor será o impacto desses problemas na vida futura da criança. Entretanto, para que seja realizada futura intervenção precoce, os profissionais de atenção básica necessitam de instrumentos que possam de maneira rápida, alertar sobre sinais que signifiquem possíveis problemas no desenvolvimento da criança. Sendo assim, o objetivo deste estudo foi validar a Ficha de Acompanhamento do Desenvolvimento Infantil, proposta pelo Ministério da Saúde em 2002, em uso em muitos serviços de saúde no Brasil. Foi realizada a aplicação do instrumento em 269 crianças de 0 a 6 anos, no Ambulatório de Pediatria do Hospital Universitário da Universidade de São Paulo e realizado as análises estatísticas Análise AC1 e Alfa de Cronbach para verificar a validade e confiabilidade do instrumento.O instrumento apresentou boa validez e confiabilidade através das duas análises, necessitando revisão para o segundo, nono e décimo primeiro marco do desenvolvimento.Concluímos que o Instrumento Ficha de Acompanhamento do Desenvolvimento Infantil é um instrumento válido a ser recomendado para uso dos profissionais de Saúde Básica como instrumento de triagem para possíveis atrasos no desenvolvimento infantil de crianças de zero a seis anos / Child development is a complex process that begins at conception moment and extends for a long period, which involves a lot of points such as physical growth, maturation neurological, behavior/ cognitive, social and emotional. According to World Health Organization - OMS, there is a presence of negative factors that have affected around 10% of worldwide children population. There are a lot of enough evidences that as previous we identify these possible delays issues in the development, with appropriated intervention, lower will be the impact on child future life. In order we can held this previous future intervention, the primary care professional need tools can quickly warning them that potential problems in child development. For this reason, the goal of this study is to validate the Child Development Monitoring Chart, proposed by Ministry of Health in 2002, using in Brazil Health services. This instrument applications was performed in 269 children 0 - 6 years age at the Clinic of Pediatrics, University Hospital, São Paulo University and performed statistical analyses AC1 and Cronbach´s Alpha to check the validity and reliability of this instrument. The instrument presented good performance and reliability through two analyses process, but a review will be necessary for second, ninth and eleventh mark of development. We concluded that Child Development Monitoring Instrument Data Sheet is a valid instrument to be recommended to be used by Basic Health professional as a screening tool for potential delays in child development of children from 0 to 6 years age

A cultura da segurança do paciente cirúrgico está em evidência devido ao crescente número de erros e eventos adversos, os quais poderiam ser prevenidos. A avaliação pré-operatória permite que o enfermeiro do Centro Cirúrgico junto com os demais enfermeiros e o anestesiologista, elabore um plano de cuidados para reduzir e prevenir as complicações pós-operatórias. Com os dados obtidos com a avaliação pré-operatória, e as dúvidas dos pacientes esclarecidas, identificam-se as necessidades de cada um, traçando intervenções que buscam solucionar os problemas que possam dificultar o procedimento cirúrgico. Acredita-se que a vivência dos pacientes relacionada aos questionamentos, muitas vezes repetida e dispersa, decorra da coleta efetuada por diversos profissionais envolvidos com as avaliações, da inexistência de um instrumento transdisciplinar de avaliação pré-operatória que na maioria das vezes, está associada uma falha na comunicação entre os profissionais. Objetivo: elaborar e validar um instrumento de avaliação pré-operatória transdisciplinar para garantir a segurança do paciente cirúrgico no período transoperatório. Método: estudo metodológico com técnicas psicométricas baseado na revisão dos guidelines da Associação Brasileira de Enfermeiros de Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização (SOBECC), Association of periOperative Registered Nurse (AORN), American Society of Anaesthesiologists (ASA) e European Society of Anaesthesiology (ESA), sendo realizado através da etapa de validação de conteúdo de um instrumento de avaliação pré-operatória transdisciplinar. Resultado: o instrumento desenvolvido foi elaborado com base na revisão dos guidelines relevantes das áreas de enfermagem perioperatória e anestesiologia. Foram encontradas semelhanças nos guidelines preconizados pela SOBECC e AORN em quatro categorias. Já os guidelines preconizados pela ASA e ESA eram similares em três categorias. Em relação a validação de conteúdo, o instrumento apresentou índices satisfatórios na validação de conteúdo pelo coeficiente de conteúdo total, variando de 0,83 a 0,99. Recomenda-se a aplicação-piloto informatizada deste instrumento. Conclusão: Nas fases de validação, o instrumento apresentou resultados significativos, tornando-se uma importante ferramenta para garantir a segurança do paciente no período perioperatório. / The safety of the surgical patient is at the forefront of society due to the increasing number of incidents and adverse events that have been extensively documented and could have been otherwise prevented. The preoperative evaluation allows the nurse of the Surgical Center, along with the other nurses and the anesthesiologist, to develop procedures to reduce and prevent postoperative complications. Using the data obtained from the preoperative evaluation and clarifying the doubts of patients, the needs of each patient are identified, tracing interventions that seek to solve the problems that may hinder the surgical procedure. It is believed that the current practice of asking repetitive questions to patients, often exaggerated and dispersed throughout the medical record, results from the uncoordinated actions of several professionals involved in the evaluation and the lack of a transdisciplinary preoperative evaluation instrument, which more often than not leads to miscommunication among professionals. Objective: elaborate and validate a transdisciplinary preoperative evaluation instrument to guarantee the safety of the surgical patient in the transoperative period. Method: a methodological with psychometric techniques study based on the revision of the guidelines of Brazilian Association of Nurses of Surgical Center, Anesthetic Recovery and Material and Sterilization Center (SOBECC), Association of periOperative Registered Nurse (AORN), American Society of Anaesthesiologists (ASA) and European Society of Anaesthesiology (ESA), being carried out through the validation stage of content of a transdisciplinary preoperative evaluation instrument. Result: the developed instrument was elaborated based on the revision of the relevant guidelines of the areas of perioperative nursing and anesthesiology. Similarities were found between the guidelines recommended by SOBECC and AORN in four categories. In turn, the guidelines favored by ASA and ESA were similar in three categories. With regards to content validation, the instrument presented satisfactory contents indexes for coefficient of total content, ranging from 0.83 to 0.99. The pilot application of this computadorized instrument is recommended. Conclusion: In the validation phases, the instrument presented significant results, consisting in an important tool to guarantee patient safety during the perioperative period.

Introdução: As doenças neuromusculares (DNM) abrangem diversas afecções que se caracterizam pela presença de fraqueza muscular. Idealmente, os instrumentos de medida da habilidade motora funcional devem ser validados para a faixa etária na qual o diagnóstico é realizado, ocorrendo escassez de medidas funcionais para avaliação da função motora em crianças pequenas com DNM. A Medida da Função Motora (MFM-32), no Brasil validada como MFM-P, é um instrumento desenhado para monitorar a gravidade e progressão da função motora em pacientes de seis a sessenta anos de idade com DNM. Como a mesma não foi validada em crianças menores de seis anos de idade, os pesquisadores do Serviço de Reeducação Pediátrica L\'Escale, (França) criadores da versão original, desenvolveram a versão reduzida desta escala, denominada \"Motor Function Measure - Short Form (MFM-20) \", adaptada à faixa etária de dois a sete anos de idade. Objetivos: Realizar o estudo de confiabilidade e validar a escala \"Medida da Função Motora - Versão Reduzida (MFM-20) \" na língua portuguesa do Brasil. Métodos: Foi realizada a tradução literária e conceitual da MFM-20. A versão em português foi denominada \"Medida da Função Motora- Versão Reduzida (MFM-20) \" e posteriormente foi realizada a tradução reversa. Um comitê revisou todas as versões. Após pré-teste numa amostra de cinco sujeitos, não houve necessidade de modificações, e a versão final da MFM-20 foi aplicada a vinte e seis crianças com diagnóstico de DNM. Para avaliar a reprodutibilidade intraexaminador, o Teste de Wilcoxon foi empregado para as duas aplicações da escala, as quais tiveram um intervalo de uma semana. A fim de avaliar a reprodutibilidade interexaminador na aplicação da escala por duas fisioterapeutas, no primeiro dia de avaliação, os escores foram comparados com o Teste t de Student. Para verificar as validades de constructos convergente entre a MFM-20 e a Escala Motora Funcional Hammersmith (EMFH), o Índice de Barthel (IB) bem como a Escala de Vignos e Brooke (EVB), e a validade de constructo discriminante, entre a MFM-20 e a escala MRC (força muscular), foi utilizado o Coeficiente de Correlação de Pearson. Resultados: Fizeram parte do estudo vinte e seis sujeitos, com média de idade de 4,6 ± 1,5 anos, com os seguintes diagnósticos: distrofia muscular de Duchenne (n=9), distrofia muscular congênita (n=5), miopatia congênita (n=6) e amiotrofia espinhal progressiva tipo II (n=6). Os itens da MFM-20 não necessitaram de nenhuma modificação em relação à adaptação cultural. A análise de confiabilidade demonstrou boa reprodutibilidade intraexaminador no dia 1 (35,88±8,80) e no dia 7 (36,96±8,99), p=0,065, além de boa reprodutibilidade interexaminador, sendo: examinador 1, 35,88±8,80 e examinador 2, 35,08±9,16, com p=0,747. A análise de validade convergente demonstrou boa correlação entre a MFM-20 e a EMFH (coeficiente de correlação =0,907), a EVB (coeficiente de correlação = - 0,918) e o IB (coeficiente de correlação =0,797), com p<= 0,05. A análise da validade discriminante demonstrou correlação positiva entre a MFM-20 e a escala MRC que avalia força muscular (coeficiente de correlação = 0,873), com p<= 0,05. Conclusões: A versão brasileira da MFM-20 foi devidamente validada, representando avanço na avaliação dos pacientes com DNM dos centros brasileiros, permitindo acompanhar a evolução motora a partir dos dois anos até os sessenta anos de idade (MFM-20 e MFM-P) / Introduction: Neuromuscular diseases (NMD) include a large number of conditions, whose main characteristic is a loss of muscular strength. Ideally, measurement tools should be validated for the age at which the diagnosis is made. There is a lack of tools to assess motor functional abilities in young children with NMD. The Motor Function Measure (MFM-32), validated in Brazil as MFM-P, is a tool designed to monitor the severity and progression of motor function in patients with NMD, aged six to sixty years. As this version was not validated in children under six years of age, the authors of the original version, from the Pediatric Reeducation Service L\'Escale (France), developed the Motor Function Measure - Short Form (MFM-20), designed for children with two to seven years of age. Objectives: The aim of this study was to verify the reliability and validity of the \"Medida da Função Motora - Versão Reduzida (MFM-20)\" in Brazilian Portuguese language of Brazil. Method: The literal and conceptual translation of the MFM- 20 was performed. The Portuguese version was called \"Medida da Função Motora - Versão Reduzida (MFM-20)\", and then the reversal translation was made. A committee revised all these versions. After a pretest in a sample of five subjects, no modification was necessary, and the final version of MFM-20 was applied to twenty-six children with NMD. To verify the intra-rater reliability, the Wilcoxon Test was utilized for the two scale applications within one-week interval. To verify inter-rater reliability concerning the scale application by two physical therapists at the first day of assessment, Student\'s t-Test was applied. To verify the converging construct validity between MFM-20 and Hammersmith Motor Functional Scale (HMFS), Barthel\'s Index (BI) and Vignos and Brooke Scale (VBS), as well as the discriminating construction validity between MFM-20 and MRC Scale (muscular force), Pearson Correlation was applied. Results: Twenty six patients with mean age 4,6 ± 1,5 years old were included in the study, with the following clinical diagnosis: Duchenne\'s muscular dystrophy (n=9), congenital muscular dystrophy (n=5), congenital myopathy (n=6) and Type 2 spinal muscular atrophy (n=6).MFM-20\'s items did not need any cultural adaptation. The reliability analysis demonstrated good reproducibility for intra-rater on day 1 (35,88±8,80) and day 7 (36,96±8,99), p=0,065, and good inter-rater reproducibility, as follows: examiner 1, 35,88±8,80 and examiner 2, 35,08±9,16, ?=0,05 e p=0,747. The converging validity analysis demonstrated good correlation between MFM-20 and HMFS, VBS as well as BI, with correlation\'s coefficients of 0,907, - 0,918 and 0,797, respectively. The discriminating validity analysis demonstrated positive correlation between MFM-20 and MRC Scale (muscular force) with a correlation\'s coefficient 0,873. Conclusions: The Brazilian Portuguese version of the MFM-20 had a proper validation, representing advances for patients from Brazilian\'s centers, diagnosed with NMD, allowing the follow-up of the motor functional evolution in patients from two to sixty years of age (MFM-20 and MFM-P)

This project analyzes the validity of theoretical models used to predict the duration (hold time) for which a halon-replacement suppression agent will remain within a protected enclosure. Two current models and one new formulation are investigated; the sharp descending interface model (as applied in NFPA 2001, Annex C), the wide descending interface model (implemented in ISO 14520.1, Annex E), and the thick descending interface model (introduced herein). The thick interface model develops the characteristic thickness as an additional input parameter. Experimental data from 34 full-scale tests designed to characterize the discharge and draining dynamics of seven clean extinguishing agents (CEA) is used to assess model validity. For purposes of model validation the characteristic thickness is regressed from the experimental data although further work may be required to establish the independence of this parameter to other system design and environmental variables. Results show that the wide and sharp interface models' validity is highly sensitive to the threshold of agent concentration decay being modeled; whereas the thick interface prediction method demonstrates increased robustness at any modeled threshold. When the hold time is defined as a 15% decay in agent concentration, experimentally obtained hold time values are roughly 10% shorter than sharp interface predictions, 60% longer than wide interface predictions, and 30% longer than the thick interface model predicts.