Thesis (MA)--Stellenbosch University, 2012. / ENGLISH ABSTRACT: In the recent past, the large-scale production and marketing of e-reading devices, such as Amazon’s Kindle, and tablet computers, such as Apple’s iPad, have allowed literary works to be presented in a digital reading space, both in the form of standard e-books and, more recently, as enhanced or “amplified” e-books. Much of the position-taking on the matter is polarised: technologists continue to imagine the myriad possibilities of multimodal online “stories”, focusing on opportunities for interactive engagement, while the guardians of literary tradition fear the digital reading space might well cause fluency disruptions and break the hermeneutic immersion necessary for strong reading, irrevocably altering a traditional, paper-based reading experience known to promote a state of deep attention and imaginatively engaged reading. This thesis looks realistically at the current literary climate in which the so-called “digital native” operates, scrutinises the “print” versus “electronic” debate, paying careful attention to how an online environment may well prevent hermeneutic immersion, and then discusses recent enhanced literary products, such as the transmedia fiction title, Chopsticks (Penguin Group USA 2012), and the nonfiction titles released by online publisher Atavist. Then, in an attempt to bridge the gap between the technologists and the print-book purists, and based on what might be considered to be literature’s original value, the thesis proposes a digital reading product in which a formalised set of conventions and a strategic instructional design, or interface, attempts to protect the qualities of traditional, paper-based reading, while at the same time taking advantage of on-screen, online environments to reconnect digital natives with the relevance of past literatures. More specifically, the product presented herein is an attempt to demonstrate 1) how a new aesthetic of literary presentation might stimulate renewed interest in the humanities and liberal arts; 2) how fiction might be reinstated as one of the central components in the education process; 3) how works of fiction that have become increasingly obscure over time or inaccessible to young people might be re-energised; and 4) how what one might call “local” literatures might be “de-parochialised” within an increasingly globalised reading environment. / AFRIKAANSE OPSOMMING: Die produksie en bemarking op groot skaal van e-lesers soos Amazon se Kindle en tabletvormige rekenaars soos Apple se iPad het dit moontlik gemaak om letterkunde in ’n digitale ruimte aan te bied, hetsy in die vorm van e-boeke, of (meer onlangs) in versterkte en “aangevulde” e-boek vorm. Meningsvorming rondom die letterkundige toepaslikheid van e-boeke is sterk gepolariseerd: tegnoloë sien net die magdom moontlikhede raak wat multi-modale aanlyn stories en interaktiewe betrokkenheid inhou, terwyl tradisionele literêre kurators vrese koester oor hoe die digitale leesruimte inbreuk sal maak op die vloei en hermeneutiese onderdompeling nodig vir ’n grondige leeservaring; dit, meen hulle, sal dan ook lei tot die onherroeplike verlies van diep en verbeeldingryke aandag, eienskappe wat lees op papier veronderstel is om mee te bring. Hierdie proefskrif werp ’n realistiese blik op die huidige literêre klimaat, veral die omstandighede waarin die sogenaamde “digital native” deesdae funksioneer. Die debat rondom gedrukte teenoor elektroniese boeke word noukeurig ondersoek, veral met betrekking tot die mate waarin aanlyn lees dalk wel hermeneutiese onderdompeling onderdruk. Verder word versterkte literêre produkte soos die transmedia fiksie titel, Chopsticks (Penguin Group USA 2012), en nie-fiksie titels deur aanlyn-uitgewer Atavist, noukeurig bekyk. Voorts, in ’n poging om die gaping tussen tegnoloë en gedrukte-boek puriste te oorbrug, en op grond van wat mens die oer-waarde van letterkunde dalk kan noem, stel hierdie proefskrif ’n digitale leesproduk voor met ’n geformaliseerde stel konvensies en ’n strategiese instruksionele ontwerp, of koppelvlak (‘interface’). Dit word gedoen in ’n poging om die eienskappe van tradisionele, ‘papier’ lees te behou, maar terselfdetyd voordeel te trek uit die aanlyn-omgewing, en om sodoende die ‘digitale inboorling’ te herenig met die relevansie van vervloë letterkunde. Hierdie voorgestelde produk, dan, is meer spesifiek ’n poging om te wys 1) hoe ’n nuwe literêr-digitale aanbiedingsestetika hernieude belangstelling in die geesteswetenskappe en liberale kunste kan werk; 2) hoe fiksie weer ingestel kan word as kern-komponent in die opvoedingsproses; 3) hoe nuwe energie verleen kan word aan fiksie wat toenemend onbekend of ontoeganklik vir jongmense word; en 4) hoe die Suid-Afrikaanse letterkunde opgehef kan word binne die opset van ’n toenemend-globale leesomgewing.

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No. of bitstreams: 1 SilviaReginaGroto_TESE.pdf: 2054580 bytes, checksum: 3099bc80643c665563f1301ac1a676e4 (MD5) Previous issue date: 2016-03-18 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Neste estudo, analisamos o debate evolu??o versus design inteligente ? luz da epistemologia de Ludwik Fleck (1896-1961), principalmente no que refere ?s categorias estilo de pensamento, coletivo de pensamento, c?rculos esot?rico e exot?rico, tr?fego intercoletivo de ideias e desvios de significado. A an?lise a partir desse referencial pretende contribuir para o ensino da evolu??o biol?gica - marcado por tens?es, disputas e pontos de vista discordantes nas salas de aula de ci?ncias e de biologia -, considerando a ?compreens?o? como objetivo ?ltimo do ensino de evolu??o. A recolha de dados envolveu a an?lise documental, predominantemente. A metodologia da An?lise Textual Discursiva (ATD) fundamentou a an?lise a partir de duas perspectivas: a sincr?nica, que foi realizada por meio de documentos produzidos por indiv?duos e/ou grupos espec?ficos vinculados ao debate evolu??o versus design inteligente, e a diacr?nica, que considerou o desenvolvimento de aspectos espec?ficos dos pensamentos desses grupos ao longo do tempo. Nossos resultados permitem caracterizar os grupos envolvidos no debate evolu??o versus design inteligente como portadores de estilos de pensamento pr?prios, constituindo distintos coletivos de pensamento. Apesar de o estilo de pensamento da evolu??o biol?gica (EP-EVO) e do estilo de pensamento do design inteligente (EP-DI) possu?rem certa sobreposi??o em seus objetos de estudo, adotam m?todos, explica??es, julgamentos e linguagem diferenciados para abord?-los. De forma semelhante, o coletivo de pensamento da evolu??o biol?gica (CP-EVO) e o coletivo de pensamento do design inteligente (CP-DI) apresentam diferen?as na configura??o de seus respectivos c?rculos esot?ricos e na forma como disseminam o conhecimento que produzem. O tr?fego intercoletivo de ideias evidencia ser assim?trico, ocorrendo, predominantemente, no sentido do CP-EVO ao CP-DI, assim como os desvios de significado. Nossos resultados apontam ainda, que uma an?lise fleckiana pode contribuir para a melhor caracteriza??o dos coletivos e estilos envolvidos no debate, subsidiando a discuss?o sobre a tem?tica em sala de aula quando esta se fizer necess?ria. Al?m disso, ela contribui para a elabora??o de pr?ticas e estrat?gias mais adequadas ao ensino da evolu??o biol?gica, sejam aquelas que evidenciam como esses estilos e coletivos se constitu?ram social e historicamente, sejam aquelas centradas na compreens?o da evolu??o e nos desvios de significado. / In this study, we analyzed the debate Evolution versus Inteligente Design by the point of view of Ludwik Fleck?s (1896-1961) epistemology, especially as regards the categories thought style and thought collective, esoteric and exoteric circles, intercollective communication and deviations of meaning. The analysis from this framework aims to contribute to the teaching of biological evolution - marked by tensions, disputes and conflicting points of view, during science and biology classes - considering the "understanding" as the ultimate goal of the teaching of evolution. Mainly, data collection involved the analysis of documents. The methodology of Discursive Textual Analysis (DTA) based the analysis from two perspectives: the synchronic one, which was performed by means of documents produced by individuals and/or groups linked to the evolution versus intelligent design debate, and the diachronic one, which considered the development of specific aspects of thinking of these groups over time. Our results characterize the groups involved in the evolution versus intelligent design debate as having own thought styles, constituting distinct thought collectives. Although the thought style of biological evolution (EVO-TS) and intelligent design thought style (ID-TS) have some overlap in their subjects, adopt methods, explanations, different judgments and language to address them. Similarly, the thought collective about biological evolution (EVO-TC) and the thought collective about intelligent design (ID-TC) differ in the configuration of their esoteric circles and the way they spread the knowledge they produce. The intercollective communication is asymmetrical, occurring predominantly in the direction from EVO-TC to ID-TC, as well as the deviations from meaning. Our results also indicate that a fleckian analysis can contribute to a better characterization of the collectives and styles involved in the debate, supporting the discussion on the subject in the classroom when it is needed. In addition, it contributes to the development of practices and most appropriate strategies to biological evolution education, both those that show how these styles and collectives were formed socially and historically, and those focused on understanding the evolution and deviations of meaning.

Ce manuscrit de thèse rapporte quelques études méthodologiques sur la régionalisation du climat par l’approche dynamique. Le domaine géographique couvre une large zone allant du milieu de l’Atlantique Nord à l’Europe de l’Est, et du Sahel à l’Arctique. La quête à tout prix d’une amélioration du climat régional n’est pas au cœur du manuscrit. Pourtant, l’accent est mis sur trois points clefs, généralement rencontrés par toutes tentatives de régionalisation du climat. Le premier point concerne le schéma d’imbrication : imbrication du sens unidirectionnel du GCM vers le RCM (one-way nesting, OWN) ou bidirectionnelle entre le GCM et le RCM (two-way nesting, TWN). Le deuxième point examine la réalisation technique d’imbrication, qui est généralement une opération de relaxation newtonienne ajoutée aux équations pronostiques du modèle. Le troisième point est sur l’effet du raffinement de maille dans le RCM. L’esprit général du manuscrit consiste à conceptualiser et réaliser des simulations numériques pour traiter ces trois points avec astuces afin de les isoler et quantifier. Le modèle de circulation générale LMDZ est utilisé pour l’ensemble des expériences. Il joue à la fois le rôle du GCM et celui du RCM. Dans les deux cas, il conserve strictement ses paramétrisations physique et sa configuration dynamique, ainsi que tous les forçages ou paramètres externes. La stratégie d’expérimentation, qualifiée comme Master versus Slave, consiste à réaliser des simulations sous deux protocoles reliés l’un et l’autre : « DS-300-to-300 » désigne Downscaling du GCM à 300 km de résolution horizontale au RCM qui est identique au GCM, aussi à 300 km de résolution spatiale ; « DS-300-to-100 » désigne Downscaling de 300 km (GCM) à 100 km (RCM). Il est clair que « DS-300-to-300 » est un cadre idéalisé, particulièrement approprié pour évaluer l’effet de l’opération de relaxation. Le protocole « DS-300-to-100 », soustrait du « DS-300-to-300 », permet d’évaluer très précisément l’effet de la résolution du RCM augmentée. Dans chaque protocole, deux schémas de communication entre le RCM et le GCM ont été implémentés, l’un (OWN) est la méthodologie classique du sens unique qui consiste à piloter le RCM par les sorties du GCM, l’autre (TWN) est d’établir un échange mutuel entre les deux modèles. Le climat régional est sensible au choix des schémas de communication entre le RCM et le GCM, surtout aux moyennes latitudes. TWN apporte une nette amélioration sur la représentation des informations frontalières. Au niveau des modes régionaux de circulation atmosphérique, exprimés en structures d’EOF, OWN et TWN sont tous deux capables de les reproduire, mais avec de légères déformations dans l’espace. La relaxation newtonienne, largement utilisée dans la régionalisation du climat, permet au RCM de bien suivre la trajectoire synoptique du GCM. Pourtant, la concomitance temporelle et la ressemblance spatiale sont dépendantes des variables considérées, des saisons, des régimes de temps, et des échelles spatio-temporelles de circulations atmosphériques. Des cas de dé-corrélation sont remarquables quand la circulation dominante de la région est de petites échelles. Le raffinement de maille augmente la liberté du RCM à développer sa dynamique interne, surtout aux petites échelles, mais aussi à l’ensemble du spectre de la circulation à travers l’interaction des échelles. Ainsi le RCM devient plus indépendant et s’écarte davantage du GCM. Cette thèse, autour des aspects méthodologiques de la régionalisation du climat, aide à avoir une meilleure compréhension sur la pratique. Elle adresse aussi un message de précaution à la communauté RCM et l’invite à bien vérifier leur méthodologie de régionalisation. / The work developed in this thesis explores through methodological modelling studies the current techniques of climate regionalization. In this case, the regionalization focuses on a geographical domain covering from the North Atlantic to Eastern Europe longitudinal wise, and from the Sahel to the Arctic as a latitudinal interval. The aim of this thesis is not the improvement of regional climate modelling per se, but tackling three key questions that are commonly met by all attempts when trying to improve climate regionalization. Firstly, the choice and advantages of the nesting scheme: one-way nesting (OWN) versus two-way nesting (TWN). Secondly, the evaluation of the nesting method, which is generally a Newtonian relaxation operation added to the prognostic equations of the model. And finally, the consequences of the mesh refinement in Regional Circulation Models (RCM). The objective of this manuscript consists in conceptualizing and carrying out numerical simulations to answer these three questions by isolating each individual effect and quantifying the consequences of each of the effects. The general circulation model LMDZ is used for all experiments. It is able to play the role of the General Circulation Model (GCM) and the RCM, keeping the same physical parameterizations and the same dynamical configuration, as well as the same external forcings and model parameters. Our experimental set-up, referred as “Master versus Slave”, consists on two related protocols: “DS-300-to-300” and “DS-300-to-100”. The former implies the downscaling of the GCM at 300 km of horizontal resolution while the RCM has the identical resolution of 300 km. The latter implies the downscaling from 300 km (GCM) to 100 km (RCM). We have assumed the “DS-300-to-300” as an idealized framework, particularly appropriate to evaluate the relaxation operation effect. In parallel, the “DS-300-to-100” protocol, subtracted from the “DS-300-to-300”, allows assessing the effect of the increased resolution for the RCM. In each protocol, two communication schemes between the RCM and the GCM have been implemented. The first one -OWN- is the classic one-way methodology to control the RCM by the outputs of the GCM. The second one -TWN- is used to establish a mutual exchange between the two models (RCM and GCM). This thesis has found that climate regionalization is highly sensitive to the choice of the communication scheme between the RCM and the GCM, especially at mid-latitudes. TWN clearly improves the representation at the boundaries. For the regional atmospheric circulation modes, expressed in EOF structures, both OWN and TWN are able to reproduce them, but with a slight deformation in space. Newtonian relaxation, widely used in climate regionalization, allows the RCM to follow the GCM’s synoptic trajectory. However, temporal concomitance and spatial resemblance of the two depend on the variables considered, on the particular seasons selected, on the weather regimes, and on the spatiotemporal scales of atmospheric circulation. De-correlation cases are remarkable when the dominant circulation on a regional scale is small. Moreover, mesh refinement increases the freedom of the RCM to develop its internal dynamic circulation, especially at small scales, and also across the whole spectrum of circulation regimes through the scales in which the RCM operates. Thus, when resolution increases, the RCM becomes more independent from the GCM behavior and the model results deviate significantly from the GCM. Focused on the methodological aspects of climate regionalization, this thesis helps to gain a better understanding on the regionalization practice. Il also sends a precautionary message to the RCM community, kindly inviting to verify their regionalization strategy.

The fact that we have entered turbulent times has been a central theme in the recent strategy literature. Turbulent environments are commonly described by increased competitive intensity, disruptive changes in the industry structure, volatility of demand, and unpredictability of customer behaviour, alongside instability of economic, social and political factors. In such a context, the adoption of traditional approaches to strategy, which assumes a relatively stable world, have been questioned by new approaches. Mixed strategy, which emerged as a contingency option to Porter's generic strategies model, defends that in a turbulent environment the simultaneous pursuit of the low-cost and differentiation approaches is fundamental for the short-term performance and long-term survival of the firm. A vast corpus of literature supports the benefits of adopting a mixed approach strategy: several empirical studies have proved that a combination of low-cost and differentiation strategic elements establishes a firm's performance superiority over the pure strategy choice. The mixed literature has concentrated on the performance linkage and on the debate countering the pure strategy approach, however very little attention has been paid to the challenges presented by the mixed strategy implementation. In fact, despite the rich empirical literature, it is still not clear how firms that adopt a mixed strategy may successfully integrate the inherent contradiction of the low-cost and differentiation approaches. The aim of this study is to investigate how a firm has been implementing the mixed strategy approach, unveiling its managerial characteristics and to generate a proposed managerial framework that could serve as a guide for further implementation. This study approaches the subject of mixed strategy implementation on three levels: environment, strategy definition and making process, and value chain activity. After having elucidated several ambiguities related to the concept of mixed strategy present in the literature and having proposed a normalized definition, this study investigates through a unique case study approach, an in-depth explorative process using causal process methods the managerial implication of the mixed strategy. Several characteristics are revealed from the unique case study and represent a major contribution to the field of strategy management. Furthermore, a managerial framework is proposed which could serve as support in the implementation of a mixed strategy.

Resumo: O cerrado é o considerado a savana mais rica em biodiversidade do mundo, possui uma flora estimada em 7000 espécies, sendo 44% endêmicas, além de ser um dos 25 "hotspots" globais. Devido a grande importância desse bioma, esse trabalho apresenta as características anatômicas macro e microscópicas de 97 espécies arbóreas e arbustivas que ocorrem no cerrado sensu lato (s.l.), procurando identificar padrões estruturais comuns na madeira, e peculiares às espécies que ocorrem nas diferentes fitofisionomias, cerrado sensu stricto (s.s.), cerradão e zona ripária. Adicionalmente, foi caracterizada a morfologia externa da casca dessas espécies. As características anatômicas macroscópicas da madeira aliadas as da morfologia externa da casca que facilitaram a separação das espécies em uma mesma família, principalmente espécies que pertencem ao mesmo gênero foram: arranjo de vasos, padrão de parênquima axial, largura de raios (TR), estratificação de raios, presença de exsudatos e a cor interna da casca. Para as espécies de cerrado s.l. foram observadas características que podem contribuir tanto para segurança quanto para eficiência na condução hídrica, como: alta ocorrência de vasos múltiplos e frequência de vasos por mm², pontoações intervasculares alternas pequenas, pontoações guarnecidas; placas de perfuração simples. O índice de vulnerabilidade foi de 1,6 e de mesomorfia 600. Apesar da maioria das características anatômicas das espécies do cerrado s.l. se enquadram nas tendências ecológicas para espécies que ocorrem em terras baixas dos trópicos, as espécies que ocorrem nas diferentes fitofisionomias possuem características anatômicas que mostram estratégias particulares para sobrevivência das mesmas. Quando comparando as fitofisionomias, de uma maneira geral, os espécimes da zona ripária apresentaram vasos de maior diâmetro... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The cerrado is considered the richest savanna in biodiversity in the world, its flora has about 7000 species, being 44% endemic, besides being one of the 25 global hotspots. Due to the great importance of this biome, this paper shows macro and microscopic wood anatomical features of 97 arboreal and shrubby species which occur in cerrado sensu lato, aiming to verify the common structural patterns in the wood, and peculiars to the species that occur in three different physiognomies, cerrado sensu stricto (s.s.), cerradão and riparian zone. Additionally, the external bark morphology of these species was characterized. Macroscopic wood features allied to bark surface features which facilitate separation of species within a family and, mostly species from the same genus were: vessel arrangement, axial parenchyma pattern, ray width (TR), storied rays, presence of exudates and bark internal colour. For cerrado s.l. species we observed anatomic features that may contribute to both safety in water flow and efficiency, such as: high incidence of multiple vessels and high vessel frequency per mm², small intervessel pits alternate, vestured pits, simple perforation plates. The vulnerability and mesomorphy index were 1.6 and 600, respectively. Despite of the majority of cerrado s.l. species anatomical features were framed in the ecological trends for species which occur in tropical lowlands, the specimens which occur in the different physiognomies have anatomical features that show particular strategies for survival in each physiognomy. When comparing the physiognomies, in a general way, riparian zone specimens have larger vessels, low frequency per mm² and larger intervessel pits diameter, what indicates better efficiency in conduction, while cerrado s.s. specimens were the opposite and showed low vulnerability and mesomorphy index, demonstrating greater safety under conditions... (Complete abstract click electronic access below) / Orientador: Carmen Regina Marcati / Coorientador: Claudia Franca Barros / Banca: Silvia Rodrigues Machado / Banca: Patricia Soffiatti / Banca: Veronica Angyalossy / Banca: Edenise Segala Alves / Doutor

Orientador: Ana Gabriela Sálvio / Resumo: A Doença Enxerto Contra o Hospedeiro (DECH) é uma das principais complicações em pacientes pós transplante de células tronco hematopoiéticas (TCTH), onde as células T do doador agridem os tecidos do receptor resultando em uma das principais causas de mortalidade e morbidade. Ocorre em cerca de metade dos pacientes que realizaram transplante de células tronco hematopoiéticas (TCTH). A pele é um dos órgãos mais acometidos. A DECH é dividida da forma aguda (DECH-a) e crônica (DECH-c), de acordo com o tempo de aparecimento dos achados clínicos e histopatológicos. A DECH de pele é classificada em graus variados, de I a IV, de acordo com o comprometimento. O presente estudo teve como objetivo avaliar a incidência de DECH-a cutânea entre os pacientes submetidos ao TCTH alogênico, aparentado, no Serviço de Transplante de Medula Óssea do Hospital Amaral Carvalho em Jaú/SP. Também foi objetivo do estudo a análise do perfil destes pacientes, a incidência e o impacto da doença na mortalidade precoce nos 100 primeiros dias pós TCTH. Os procedimentos metodológicos envolveram análise retrospectiva de dados retirados de planilhas do setor administrativo do Serviço de Transplante de Medula Óssea do Hospital Amaral Carvalho em Jaú/SP, contendo informações de 1113 pacientes que estiveram internados para a realização de transplante de medula óssea alogênico, aparentado, no período de agosto de 1996 a dezembro de 2013. Foram incluídos 582 pacientes cujas as doenças eram de linhagem mielóide - as ... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

Submitted by ANA LETICIA SGAVIOLLI null (ana.lsgaviolli@sp.senac.br) on 2016-10-25T21:37:48Z No. of bitstreams: 1 Submissão - 25.10.16.pdf: 954213 bytes, checksum: f27af9c710378005f768acd829e6aae3 (MD5) / Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-11-01T19:55:43Z (GMT) No. of bitstreams: 1 serignolli_als_me_bot.pdf: 954213 bytes, checksum: f27af9c710378005f768acd829e6aae3 (MD5) / Made available in DSpace on 2016-11-01T19:55:43Z (GMT). No. of bitstreams: 1 serignolli_als_me_bot.pdf: 954213 bytes, checksum: f27af9c710378005f768acd829e6aae3 (MD5) Previous issue date: 2016-09-02 / A Doença Enxerto Contra o Hospedeiro (DECH) é uma das principais complicações em pacientes pós transplante de células tronco hematopoiéticas (TCTH), onde as células T do doador agridem os tecidos do receptor resultando em uma das principais causas de mortalidade e morbidade. Ocorre em cerca de metade dos pacientes que realizaram transplante de células tronco hematopoiéticas (TCTH). A pele é um dos órgãos mais acometidos. A DECH é dividida da forma aguda (DECH-a) e crônica (DECH-c), de acordo com o tempo de aparecimento dos achados clínicos e histopatológicos. A DECH de pele é classificada em graus variados, de I a IV, de acordo com o comprometimento. O presente estudo teve como objetivo avaliar a incidência de DECH-a cutânea entre os pacientes submetidos ao TCTH alogênico, aparentado, no Serviço de Transplante de Medula Óssea do Hospital Amaral Carvalho em Jaú/SP. Também foi objetivo do estudo a análise do perfil destes pacientes, a incidência e o impacto da doença na mortalidade precoce nos 100 primeiros dias pós TCTH. Os procedimentos metodológicos envolveram análise retrospectiva de dados retirados de planilhas do setor administrativo do Serviço de Transplante de Medula Óssea do Hospital Amaral Carvalho em Jaú/SP, contendo informações de 1113 pacientes que estiveram internados para a realização de transplante de medula óssea alogênico, aparentado, no período de agosto de 1996 a dezembro de 2013. Foram incluídos 582 pacientes cujas as doenças eram de linhagem mielóide - as mielopatias malignas (Leucemia Mieloide Aguda, Leucemia Mieloide Crônica, Síndrome Mielodisplásica e Doença Mieloproliferativa Crônica) para que o grupo pesquisado se tornasse homogêneo em termos de drogas e condicionamento. Esses 582 pacientes englobaram 2 grupos: pacientes que apresentaram DECH-a exclusiva de pele e pacientes que não apresentaram nenhum tipo de DECH. Todos os dados foram revisados e submetidos a análise estatística univariada e multivariada. Na análise univariada, observa-se maior sobrevida em 10 anos para os indivíduos com DECH-a de pele grau I e II (p=0.039) e para os transplantados com células de Medula Óssea (0.018). Essa significância estatística foi mantida na análise multivariada. A principal causa da mortalidade nos primeiros 100 primeiros dias do transplante foi a recidiva da doença de base, sendo a DECH aguda responsável por 6% dos óbitos nesse período. Não houve diferença significativa para os outros dados pesquisados. Conclui-se então que uma escolha adequada de doadores, além do uso de fonte de medula óssea como principal escolha para realização de transplante de medula óssea, podem diminuir a incidência de DECH-a de pele, além de aumentar a sobrevida dos pacientes transplantados. / Graft versus host disease (GVHD) is a major complication occurred in patients posttransplantation hematopoietic stem cell transplantation (HSCT), where the donor's T cells attack the recipient's tissues resulting in a major cause of mortality and morbidity.This is a recurrent and severe event, which occurs in about half of patients who underwent hematopoietic stem cell transplantation (HSCT), the skin is one of the most affected organs. GVHD is divided as acute (GVHD) and chronic (chronic GVHD), according to the time, clinical and histopathological findings. This study aimed to evaluate the incidence of GVHDskin among patients undergoing allogeneic HSCT, akin in Marrow Transplant Service Bone Amaral Carvalho Hospital, Jaú / SP, the profile of this patient and the impact of the disease in early mortality in the first 100 days after HSCT. The methodological procedures involved retrospective analysis of data from spreadsheets in the administrative sector of the Bone Marrow Transplant Service, Hospital Amaral Carvalho - Jau, containing information of 1,113 patients who were hospitalized for performing allogeneic bone marrow transplantation, related in the period August 1996 to December 2013. to equalize the analysis were included only 582 patients whose diseases were of myeloid lineage - malignant myelopathy (Acute myeloid Leukemia, Chronic myeloid Leukemia, Myelodysplastic Syndrome and Chronic myeloproliferative disease) so that the study group became homogeneous in terms of drugs and conditioning. These 582 patients were divided into 2 groups: patients with GVHDexclusive skin and patients without any GVHD. All data were reviewed and subjected to statistical analysis. In univariate analysis, there is greater survival at 10 years for patients with GVHD to skin grade I and II (p = 0.039) and the transplanted cells Bone Marrow (0018). This significance was maintained in multivariate analysis. The main cause of mortality in the first 100 early days of transplantation was the recurrence of the underlying disease, and acute GVHD responsible for 6% of deaths in this period. There was no significant difference for the other surveyed data. It was concluded that a suitable choice of donors, and the use of bone marrow source as the primary choice for bone marrow transplantation, can reduce the incidence of GVHD, the skin, and increase the survival rate of transplant patients.

Made available in DSpace on 2016-12-06T17:07:26Z (GMT). No. of bitstreams: 1 Anna Quialheiro.pdf: 4792596 bytes, checksum: d8f954e7807dbb62634090379eff89a7 (MD5) Previous issue date: 2010-03-03 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The rheumatoid arthritis (RA) is an auto-immune illness with incapacity potential mainly in the joints of the hands. The handgrip (FPM) is one of the forms of evaluation of the manual function and one of most common quantifying the manual muscular function and can be used as a general pointer of force and functionality. The objective of the study was to analyze the force of manual hold in women with RA being compared the parameters of the curve force versus time of isometric handgrip of the individuals with and without RA between dominant and not dominant hand and also to verify if isometric handgrip exists association between the parameters of the curve force versus time of handgrip and the disease activity index (DAS28) in the group with RA. In this study participated 28 women being 16 with RA (GA) and 12 without RA (GC), with age between 35 and 75 years. All the participants had told the right hand as dominant hand. They had been carried through: test of blood for calculation of the VHS, the demographic data, the vital signals and the anthropometry, these verify before the FPM. For the FPM test a system of dinamometria with load sensor was used with handle adjustable to the anthropometry of the hand of each participant. A protocol elaborated specifically for this study was followed that consisted of the accomplishment of the FPM isometric continues maximum. After the FPM, was carried through the counting of the pain joints, swollen joints and general evaluation of the health for composition of the disease activity index. In the group with RA it was verified that the pathology has statistical significant influence in the variables Fmax, TFmax, TDF and AFPM in both the hands, presenting significant difference does not enter the groups in the variable %Fmax however a trend to a decline of the Fmax biggest in the GA was verified. AIR significantly influenced four of the five parameters of the curve force versus time evaluated in this study. However, it did not have influence of the changeable dominância in the same parameters amongst the groups. In DAS28, this was correlated only with the Fmax 0 variable in the not dominant hand between the groups, however it not found correlate between DAS28 and dominance and disease variables in the others parameters. The comparative statistical tests had shown significant differences that confirm and validate the benefits of the FPM as the best form to foresee the force manual being able to produce a difference between healthful individuals and pathological individuals. / A artrite reumatóide (AR) é uma doença auto-imune com potencial incapacitante principalmente nas articulações das mãos. A força de preensão manual (FPM) é uma das formas de avaliação da função manual e uma das mais comuns para quantificar a função muscular manual e pode ser utilizada como um indicador geral de força e funcionalidade. O objetivo do estudo foi de analisar a força de preensão manual em mulheres com artrite reumatóide comparando os parâmetros da curva força versus tempo de preensão manual isométrica máxima dos indivíduos com e sem AR entre mão dominante e não dominante e também verificar se existe associação entre os parâmetros da curva força vs tempo de preensão manual isométrica máxima e o índice da atividade da doença (DAS28) no grupo com AR. Participaram deste estudo 28 mulheres sendo 16 com AR (GA) e 12 sem AR (GC), com idade entre 35 e 75 anos. Todas as participantes relataram a mão direita como mão dominante. Foram realizados: coleta de sangue para cálculo do VHS, dos dados demográficos, dos sinais vitais e da antropometria, estes mensurados antes da FPM. Para o teste de FPM foi utilizado um sistema de dinamometria com sensor de carga com empunhaduras ajustáveis à antropometria da mão de cada participante. Foi seguido um protocolo elaborado especificamente para este estudo que consistiu na realização da FPM isométrica continua máxima. Após a FPM, foi realizada a contagem das articulações doloridas, edemaciadas e avaliação geral da saúde para composição do índice da atividade da doença. No grupo com AR foi verificado que a patologia tem influência estatisticamente significativa nas variáveis Fmax, TFmax, TDF e AFPM em ambas as mãos, não apresentando diferença significativa entre os grupos na variável %Fmax porém verificou-se uma tendência a um declínio da Fmax maior no GA. A AR influenciou significativamente quatro dos cinco os parâmetros da curva força versus tempo avaliados neste estudo. Entretanto, não houve influência da variável dominância nos mesmos parâmetros dentre os grupos. Quanto ao DAS28, este correlacionou-se apenas com a variável Fmax na mão não dominante entre os grupos, porém não foi encontrado correlação do DAS28 com as variáveis dominância e grupo nos demais parâmetros. Os testes estatísticos comparativos mostraram diferenças significativas que confirmam e validam os benefícios da FPM como a melhor forma de prever a força manual podendo produzir uma diferença entre indivíduos saudáveis e indivíduos patológicos.

This scientific essay is based on a self experienced situation from my work in after-school activities. Suddenly I find myself in a situation that is not thought through were the only goal is to transfer the students in the school area. I am asking them to stand in line to go to the lunch cafeteria. An obstacle occurs when the students fail or refuses to stand in line, which demands me to reflect over what just has happened. Through this I am stimulated to increase my understanding of the situation. The purpose of this essay is to investigate effects in the initially unreflected structure which is being used in afterschool activities. The standing in line is here used as a representation of that group-based structure. My three main focus areas for this research is learning, power and the tension between individuals and a group. To illustrate the effects in afterschool group-based structure I have chosen a hermeneutic writing. Foucault enriches my knowledge on the complexity of power perspectives that is being revealed in the situation. Through Asap Bartholdsson I am introduced to the concept of ”friendly power” (my translation). With the support of Gert Biestas ́s theories about ”qualification, socialization and subjectification”. I investigate the learning which is not immediately visible. Broadys view on the hidden curriculum shows me a new perspective on the structure and education in after-school activities as normative learning. By the analysis of the tension between individuals and the group I have made visible that the seeing made by the teacher has a big role to play. Also it has become clear that the students individuality and integrity sometimes has to take a step back in favour of the group and vice versa. But if this interaction is balanced it has an enriching effect on both perspectives. / Denna vetenskapliga essä har sin utgångspunkt i en egenupplevd situation från mitt arbete i fritidshemmet. Jag finner mig plötsligt i en situation som ger sig till känna som dittills oreflekterad med enda mål att förflytta eleverna. De blir tillbedda att ställa upp på led för att gå till mellanmålet i matsalen. Svårigheten uppstår när eleverna utmanar strukturen och min styrning vilket väcker stort intresse för att analysera händelsen vidare. Syftet med denna essä är att undersöka effekter av den gruppbaserade strukturen i fritidshemmet som ledbildandet här får stå som representant för. Jag fokuserar främst på tre områden som behandlar lärande, makt och spänningsfältet mellan individ och grupp. För att synliggöra effekter i fritidshemmets gruppbaserade struktur har jag valt ett hermeneutiskt essäskrivande. Jag tar hjälp av Foucaults maktperspektiv för att tolka pluraliteten av maktrelationer som uppenbarar sig. Med hjälp av Åsa Bartholdsson närmar jag mig begreppet vänlig maktutövning och med understöd av Biestas begrepp kvalificering, socialisation och subjektifiering utforskar jag det underliggande lärandet. Broadys syn på den dolda läroplanen synliggör de normerande kunskaper som eleverna förvärvar i ledbildandet. Vid analys av individ kontra grupp har det gjort sig tydligt att pedagogens seende har stor roll. Det har också visat sig att elevens subjekt- och integritetsskapande ibland får stå tillbaka för gruppen och vice versa. Dock är det viktigt för båda perspektiv att de får lika stor del utrymme och genom detta sker en berikande sammanflätning.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-04T00:00:44Z No. of bitstreams: 1 DaianeAlvesDosSantos_DISSERT.pdf: 1813161 bytes, checksum: e5c706d3daa94ed9aa2f3dbfc6df4854 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-07T22:42:13Z (GMT) No. of bitstreams: 1 DaianeAlvesDosSantos_DISSERT.pdf: 1813161 bytes, checksum: e5c706d3daa94ed9aa2f3dbfc6df4854 (MD5) / Made available in DSpace on 2016-06-07T22:42:13Z (GMT). No. of bitstreams: 1 DaianeAlvesDosSantos_DISSERT.pdf: 1813161 bytes, checksum: e5c706d3daa94ed9aa2f3dbfc6df4854 (MD5) Previous issue date: 2014-10-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / As Institui??es de Ensino Superior Privadas est?o inseridas em um mercado no qual a competitividade ? um fator determinante para a perman?ncia. Para manterem-se competitivas, as IES precisam ter estrat?gias claras, sobretudo, para atender aos seus principais clientes, os alunos, no que se refere ?s suas expectativas quanto ? qualidade da IES. O presente estudo tem como objetivo geral avaliar as institui??es de ensino superior privadas da cidade do Natal/RN, quanto ?s estrat?gias adotadas para permanecerem no mercado, tendo como base a percep??o de qualidade dos discentes. Para conduzir esta pesquisa, desenvolveu-se em duas IES privadas da cidade do Natal, por meio da aplica??o de um survey explorat?rio para a coleta de dados com o uso do instrumento do question?rio para ser aplicado nos discentes, sendo direcionado aos alunos do ?ltimo ano dos cursos de Administra??o, Ci?ncias Cont?beis e Direito. Esse instrumento de pesquisa aborda aspectos relevantes para mapear as dimens?es: (1) ensino, caracteriza as perspectivas relacionadas aos m?todos e instrumentos de ensino; (2) professores, especifica os atributos de qualidade relacionados aos professores; (3) estrutura f?sica, descreve o ambiente das IES; (4) servi?os, avalia os processos que atribuem qualidade ?s IES; e, (5) intang?veis, relaciona os aspectos cotidianos com a satisfa??o dos estudantes. Os resultados foram analisados por meio de t?cnicas de estat?stica descritiva com o uso da ferramenta Statistical Package for the Social Sciences (SPSS). A primeira etapa dos resultados caracteriza a an?lise descritiva da amostra geral e por IES e curso, al?m de uma construir a an?lise univariada das IES e a an?lise bivariada que apresenta a correla??o dos fatores por meio do coeficiente de Spearman. Os resultados da an?lise foram utilizados para compor a matriz de import?ncia versus desempenho e tamb?m comparar com os ?ndices do Minist?rio de Educa??o e Cultura (MEC). Por fim, essas compara??es possibilitaram a identifica??o dos fatores mais importantes para a qualidade das IES e o n?vel de desempenho das institui??es no desenvolvimento de cada um dos atributos das dimens?es de qualidade. / Private Higher Education Institutions are embedded in a market where competitiveness is a key factor. To remain competitive, HEIs needs to have proactive and innovative strategies, especially to understand their main customers, students, with regard to their expectations about the quality of HEI. This study is to evaluate the overall private institutions of higher education in the city of Natal / RN, as the strategies adopted to remain on the market , based on the perceived quality of students. For conduct this research, it has developed two private institutions in the city of Natal, through the application using exploratory research to guide the survey for data collection with questionnaire to apply the overview with students, being directed to senior students courses in Bussiness, Accounting and Law. This research tool addresses aspects relevant to map the dimensions: (1) teaching, perspectives related to methods and teaching tools; ( 2 ) teachers, specifies the quality attributes related to teachers; (3 ) Infrastructure, describes the environment of the HEI; ( 4 ) services , evaluates the quality processes that attach to the HEI; and ( 5 ) intangible relates aspects with student satisfaction. The results were analyzed using descriptive statistical techniques using the Statistical Package Tool for Social Sciences (SPSS). The first stage of results characterizes the descriptive analysis of the overall sample and by HEI and course, plus a build univariate analysis of the HEI and also bivariate analysis shows that correlation of the factors through Spearman correlation coefficient. The results were used to compose a matrix of importance versus performance that compare with the contents of the Ministry of Education and Culture (MEC). Finally, these comparisons allowed identification of the most important factors for the quality of the HEI and the level of performance from institutions in the development of each attributes of quality dimensions.