Submitted by William Justo Figueiro (williamjf) on 2015-06-17T20:39:09Z No. of bitstreams: 1 28.pdf: 565889 bytes, checksum: 692a178a5e90d0450796ed3ddc637d61 (MD5) / Made available in DSpace on 2015-06-17T20:39:09Z (GMT). No. of bitstreams: 1 28.pdf: 565889 bytes, checksum: 692a178a5e90d0450796ed3ddc637d61 (MD5) Previous issue date: 2014 / Nenhuma / A xerostomia, conhecida como boca seca, pode ser uma consequência ou não do declínio ou interrupção da função das glândulas salivares com redução do fluxo salivar. A xerostomia possui variada etiologia e múltiplas consequências podendo comprometer o estado nutricional e a saúde do indivíduo e, poucas são as opções hoje existentes no mercado para amenizar seus sintomas. A proposta deste estudo foi desenvolver uma bala de goma mastigável acrescida de substâncias com potencial sialogogo em quantidades permitidas pela Legislação Brasileira. Foram desenvolvidas três balas nos sabores tangerina, morango e menta, as quais foram submetidas a análises microbiológicas, físico-químicas e sensoriais. Os resultados da análise sensorial foram obtidos através da aplicação do Teste de Aceitação com escala hedônica de nove pontos, variando de desgostei muitíssimo até gostei muitíssimo, cujos atributos considerados foram aparência, sabor, textura e aroma. Os resultados mostraram por meio da análise microbiológica que as balas estavam aptas para o consumo. Quanto às análises físico-químicas, a bala em estudo apresentou 308 kcal/100g sendo 75,90 % provenientes de carboidratos, 23,69 % provenientes de proteínas e 0,41 % provenientes de lipídeos. Com relação à análise sensorial, não houve diferença quanto aos atributos aparência e textura. Quanto ao atributo aroma, a bala de sabor morango diferiu estatisticamente entre as demais balas e em relação ao atributo sabor todas as balas foram diferentes, sendo a de sabor morango a de melhor aceitação pelo painel. O desenvolvimento de uma bala como um produto inovador que atenda às necessidades de pacientes com xerostomia pode ser uma alternativa na contribuição da melhoria na qualidade de vida, pois além do potencial sialogogo, a bala pode ser saborosa e um interessante veículo de nutrientes essenciais à saúde humana. / Xerostomia, known as dry mouth, may be a consequence, or not, of the decline or interruption of salivary gland function with reduced salivary flow. Xerostomia has a varied etiology and multiple consequences which may compromise the nutritional status and health of the individual, and there are few options in the market to minimize its symptoms. The purpose of this study was the development of a jelly candy with addition of sialogogue substances with amounts in accordance to the Brazilian law. Three jelly candies were developed in tangerine, strawberry and mint flavors, and they were submitted to physicochemical, microbiological and sensory analysis. The results of sensory analysis were obtained by applying the Acceptance Test with a nine-point hedonic scale ranging from dislike extremely to like extremely, whose considered attributes were appearance, flavor, texture and aroma. The microbiological analysis results showed the jelly candies were suitable for the consumption. Regarding the physicochemical analysis, the jelly candies presented 308 kcal/100g, being 75.90% from carbohydrates, 23.69% from proteins and 0.41% from lipids. In the sensory analysis, there was no difference in the appearance and texture attributes. As to aroma attribute, the strawberry jelly candy differed from the others and as flavor attribute, all of them were different, being the strawberry jelly candy the best accepted. The development of a jelly candy as an innovative product that answers the needs of patients with xerostomia may be an alternative to improve the quality of life, because besides the sialogogue effect, the jelly candy can be a tasty vehicle for essential nutrients to the human health.

Objetivo: Comparar os resultados obtidos com a sialoendoscopia na melhora do fluxo salivar aferido através cintilografia em pacientes com síndrome de Sjögren primária. Material e método: Pacientes provenientes do Ambulatório de Reumatologia do HCPA com diagnóstico de Síndrome de Sjögren Primária foram submetidos a cintilografia de parótidas previamente ao procedimento de sialoendoscopia. Durante o procedimento de sialoendoscopia, uma das glândulas parótida foi lavada com solução fisiológica e a outra com solução de corticóide, escolha esta predeterminado por randomização. Após completo um mês do procedimento, um novo exame de cintilografia de glândulas parótidas foi realizado visando observar o fluxo salivar para comparação. Resultados: Participaram e completaram a pesquisa 13 pacientes, todas do sexo feminino, com idade média de 53,38 anos (27 - 76 anos). Houve melhora dos resultados de excreção salivar com radiofármaco no exame de cintilografia, após a realização da sialoendoscopia, em 10 pacientes, perfazendo 76,92% da amostra. Analisando cada glândula tratada separadamente (26 glândulas), houve melhora após a sialoendoscopia em 18 glândulas (69,23%), 8 destas utilizaram dexametasona e 10 utilizaram solução fisiológica na lavagem. Não houve melhora em 8 glândulas (30,77%). Conclusão: Este estudo mostra a sialoendoscopia como importante ferramenta na melhora do fluxo salivar aferido por cintilografia em pacientes com Síndrome de Sjögren Primária, aumentando a excreção salivar através da dilatação e consequente desobstrução dos ductos. Sugere que não há diferença estatisticamente significativa entre as soluções de lavagem intraductal solução fisiológica e solução com dexametasona. / Objective: To compare the results utilizing sialendoscopy to improve salivary flow mensured by scintigraphy in Primary Sjögren’ Syndrome. Material and method: Patients from Rheumatology clinic of Porto Alegre’s Clinic Hospital with diagnose of Primary Sjögren' Syndrome were submitted to parotid’s scintigraphy previous to sialendoscopy of both parotid. During the perform of sialendoscopy, one of the parotid gland was wash down with saline solution and the other with dexamethasone solution. Previous determination of the sides was achieved by randomization. After one month of procedure, a new scintigraphy of parotid’s glands was performed to observe the salivary flow for further comparison. Results: Participated and completed the study 13 patients, all female, with average age of 53,38 years (17 - 76 years old). The improve of salivary excretion on scintigraphy was achieved in 10 patients, performing 76,92% of the sample. Analyzing each gland in separate (26 glands), the improve after sialendoscopy was achieved in 18 glands (69,23%), 8 of these used dexamethasone and 10 used saline solution in washing. There was no improve in 8 glands (30,77%). Conclusion: This study demonstrate the use of sialedoscopy as an important tool to improve salivary flow mensured by scintipraphy in Primary Sjögren’ Syndrome patients, increasing the salivary excretion due to the dilatation and consequently clearing of ducts. It suggests that is no statistically difference between the solutions saline versus dexamethasone.

Made available in DSpace on 2015-04-14T13:29:25Z (GMT). No. of bitstreams: 1 412615.pdf: 4933199 bytes, checksum: 35eff7948e1f5baae8ca1ae5f63d60c9 (MD5) Previous issue date: 2008-10-17 / A S?ndrome da Ard?ncia Bucal (SAB) caracteriza-se por sintomas de queima??o, ard?ncia, dor ou prurido na mucosa bucal, que n?o s?o acompanhados por altera??es cl?nicas. Embora haja evid?ncias para uma origem neurop?tica, outros fatores parecem estar envolvidos na etiologia da SAB, como a associa??o de transtornos psicol?gicos e altera??es hormonais. Com o objetivo de identificar fatores de risco para a s?ndrome, neste estudo foram analisadas as concentra??es salivares de desidroepiandrosterona (DHEA), a velocidade do fluxo salivar (VFS) e os escores de depress?o e desesperan?a de pacientes com essa doen?a. Foram selecionadas 30 pacientes do sexo feminino portadoras de SAB, com idade variando entre 42 a 81 anos, e 30 pacientes-controle do mesmo sexo e faixa et?ria, que n?o apresentassem les?es bucais nem utilizassem f?rmacos ansiol?ticos, antidepressivos ou corticoster?ides. Ap?s anamnese e exame f?sico, a VFS foi determinada em repouso e sob estimula??o e os sintomas de depress?o e de desesperan?a foram investigados pelos instrumentos The Beck Depression Inventory e The Beck Hopelessness Scale, respectivamente. Amostras de saliva foram coletadas pela manh? e ? noite para an?lise da DHEA pela t?cnica de radioimunoensaio. O grupocaso exibiu sintomas de disgeusia e de xerostomia numa freq??ncia significativamente superior ao controle (p=0,045 e p=0,003, respectivamente). A velocidade do fluxo salivar das pacientes com SAB foi inferior ? do grupo-controle, tanto em repouso, quanto sob estimula??o (p<0,001 e p=0,007, respectivamente). N?o houve diferen?a significativa entre os grupos quanto aos escores de desesperan?a (p=0,597) ou de depress?o (p=0,416). O grupo-caso obteve concentra??es salivares de DHEA significativamente inferiores ao controle nas amostras matinais (p=0,003), entretanto, nas amostras coletadas ? noite, n?o houve diferen?a entre os grupos (p=0,620). N?o foi observada correla??o entre as concentra??es salivares de DHEA e os escores de depress?o e de desesperan?a nas pacientes com SAB. A an?lise multivariada de regress?o log?stica demonstrou que a velocidade do fluxo salivar em repouso e as concentra??es salivares matinais de DHEA foram fatores associados ? SAB. Os resultados do presente estudo permitem concluir que: (1) pacientes com SAB exibem concentra??es salivares matinais de DHEA e VFS inferiores ?s de pacientes sem a doen?a; (2) os sintomas de depress?o e desesperan?a n?o diferem entre indiv?duos com a s?ndrome e os controle; (3) n?o h? correla??o entre as concentra??es salivares de DHEA e os escores de depress?o e desesperan?a em indiv?duos com a S?ndrome da Ard?ncia Bucal. Sendo este o primeiro estudo a investigar as concentra??es salivares de DHEA em pacientes com SAB, sugerem-se outras pesquisas para esclarecer esta associa??o e suas conseq??ncias.

Made available in DSpace on 2015-04-14T13:30:35Z (GMT). No. of bitstreams: 1 459313.pdf: 1355539 bytes, checksum: 3f86f9475d13797bdaa6dc5fdc2f3210 (MD5) Previous issue date: 2014-04-25 / Xerostomia and hyposalivation are important sequelae of head and neck radiotherapy and may have a negative impact on quality of life. The present study aimed to evaluate the effects of low level laser therapy (LLLT) on hyposalivation, xerostomia and quality of life related to oral health (QLROH) in irradiated patients. Were selected 23 patients with a history of head and neck malignancy, treated with fractioned teletherapy, whose therapeutic site had involved at least 50% of the major salivary glands. Patients should have completed radiotherapy for at least six months and present hyposalivation and xerostomia. The sample was randomly distributed in laser group (n=12) and control (n=11). A GaAlAs laser, at 830 nm (infrared) wavelength, 100 mW power, 2 J energy per point was used. Patients underwent twelve sessions of LLLT, applied in parotid, submandibular and sublingual glands. In the control group, the laser tool received a plastic tip that blocked radiation emission. Stimulated and unstimulated salivary flow rate was assessed at baseline, after the 6th and 12th session. Xerostomia was assessed by Visual Analogue Scale (VAS) and QLROH, through the Oral Health Impact Profile (OHIP - 14). The results showed no significant difference between the laser and control groups regarding the salivary flow rate, xerostomia or quality of life. However, at the end of the treatment, the xerostomia and the QLROH showed significant improvement in both groups compared to assessments carried out in baseline. Based on the results, we conclude that, in the parameters used, LLLT was not able to increase salivary flow rate or decrease xerostomia. The results may be associated to the late effects of radiotherapy on glandular structure such as fibrosis and acinar atrophy. The improvement in xerostomia and quality of life highlights the importance of advice given to the irradiated patients and their follow-up. / A xerostomia e a hipossaliva??o s?o importantes sequelas da radioterapia de cabe?a e pesco?o e podem ter impacto negativo na qualidade de vida dos pacientes. O presente estudo teve como objetivo realizar uma revis?o de literatura destas sequelas e avaliar o efeito da terapia laser de baixa pot?ncia (TLBP) na hipossaliva??o, xerostomia e qualidade de vida relacionada ? sa?de bucal de pacientes submetidos ? radioterapia em cabe?a e pesco?o. Foram selecionados 23 pacientes com hist?rico de neoplasia maligna em regi?o de cabe?a e pesco?o, tratados por meio de teleterapia fracionada, cujo portal tenha envolvido ao menos 50% das gl?ndulas salivares maiores. Todos deveriam ter finalizado a radioterapia h? pelo menos seis meses e apresentar hipossaliva??o e xerostomia. A amostra foi aleatoriamente distribu?da em grupos laser (n=12) e controle (n=11). Foi empregado laser de AsGaAl no comprimento de onda de 830 nm (infravermelho), pot?ncia de 100 mW e energia de 2 J por ponto. Os pacientes foram submetidos a doze sess?es de TLBP, aplicada pontualmente em ambas as gl?ndulas par?tidas, submandibulares e sublinguais. No grupo-controle foi adaptado ao aparelho de laser um dispositivo que impedia a emiss?o de radia??o. O fluxo salivar em repouso e sob est?mulo foi avaliado em baseline, ap?s a 6? e a 12? sess?o de TLBP. A xerostomia foi avaliada por meio de Escala Visual Anal?gica (EVA) e a qualidade de vida relacionada ? sa?de bucal, por meio do instrumento Oral Health Impact Profile (OHIP-14). Os resultados demonstraram n?o haver diferen?a significativa entre os grupos laser e controle quanto ? velocidade do fluxo salivar, xerostomia ou qualidade de vida. Por outro lado, em ambos os grupos ao final do tratamento, houve redu??o significativa da xerostomia e melhora da qualidade de vida relacionada ? sa?de oral. Com base nos resultados, pode-se concluir que a TLBP, nos par?metros utilizados, n?o foi capaz de promover eleva??o clinicamente detect?vel do fluxo salivar ou redu??o da xerostomia. Os resultados podem estar associados aos efeitos tardios da radioterapia na estrutura glandular tais como fibrose e atrofia acinar. A melhora dos ?ndices subjetivos xerostomia e qualidade de vida em ambos os grupos ressalta a import?ncia da orienta??o e acompanhamento dos pacientes irradiados.

O objetivo deste estudo foi avaliar a efetividade de uma formulação farmacêutica experimental (solução com 1,54% de pilocarpina em spray) sobre o fluxo salivar (FS), experiência de boca seca e qualidade de vida (QV), comparado com placebo, em pacientes tratados com radioterapia (RTx) para câncer de cabeça e pescoço (CCP). Este ensaio clínico randomizado, controlado, duplo-cego e crossover foi realizado em pacientes com xerostomia (n=28). O FS foi medido pela sialometria estimulada (técnica do hálito fresco), a experiência de boca seca pelo Xerostomia Inventory (XI) e a QV pelo Oral Health Impact Profile (OHIP-14). As avaliações foram feitas antes do início da terapêutica - baseline (T0), um (T1), dois (T2) e três (T3) meses após iniciar o uso do spray, além da mensuração do FS uma hora após o baseline (T0+), seguido de período washout de 01 mês e após crossover, os mesmos períodos foram avaliados. O FS apresentou maior após uma hora (p=0,003 - teste de Wilcoxon) e dois meses (p=0,002 - teste de Friedman) de uso do spray com pilocarpina; melhoria na experiência de xerostomia, verificado pela diminuição significante (p<0,05 - teste de Friedman) dos escores em cinco itens do XI; melhoria na QV, verificado pela diminuição significante (p<0,05 - teste de Friedman) dos escores em três itens do OHIP-14, com o passar de alguns dos períodos de avaliação. A aplicação tópica da formulação de pilocarpina em spray melhoraram significantemente o FS, experiência de xerostomia e QV para os pacientes tratados com RTx para CCP. / The aim of this study was to evaluate the effectiveness of an experimental pharmaceutical formulation (1.54% pilocarpine spray solution) on salivary flow (SF), dry mouth experience and quality of life (QoL), compared to placebo, in patients treated with radiotherapy (RTx) for head and neck cancer (HNC). This randomized, controlled, double-blind, crossover clinical trial was performed in patients with xerostomia (n = 28). SF was measured by stimulated sialometry (fresh breath technique), dry mouth experience by Xerostomia Inventory (XI) and QoL by the Oral Health Impact Profile (OHIP-14). The evaluations were done before - baseline (T0), one (T1), two (T2) and three (T3) months after starting the spray, besides the measurement of FS one hour after the baseline (T0+), followed by a washout period of 1 month and after crossover, the same periods were evaluated. The SF presented higher after one hour (p=0.003 - Wilcoxon test) and two months (p=0.002 - Friedman test) of the use of the pilocarpine spray; improvement in the xerostomia experience, verified by the significant decrease (p<0.05 - Friedman test) of the scores in five items of XI; improvement in the QoL, verified by the significant decrease (p<0.05 - Friedman\'s test) of the scores on three items of the OHIP-14, with the passing of the evaluation of some periods. Topical application of the pilocarpine spray formulation significantly improved SF, xerostomia experience and QoL for patients treated with RTx for HNC.

Το σύνδρομο Sjögren (ΣΣ) είναι μια αυτοάνοση νόσος που προσβάλλει κυρίως τους σιελογόνους και δακρυϊκούς αδένες οδηγώντας στην ξηρά επιπεφυκίτιδα και την ξηροστομία. Ιστοπαθολογικά χαρακτηρίζεται από λεμφοκυτταρική διήθηση Τ και Β κυττάρων, με επικράτηση των ενεργοποιημένων CD4 + Τ βοηθητικών κυττάρων. Οι ακριβείς παθογενετικοί μηχανισμοί που είναι υπεύθυνοι για το ΣΣ δεν είναι ακόμη πλήρως γνωστοί, ωστόσο φαίνεται ότι συμμετέχουν περιβαλλοντικοί, ορμονικοί και γενετικοί παράγοντες. Ακόμη, απορρύθμιση των κυτταροκινών που παράγονται από Th1, Th2 και Th17 κύτταρα εμπλέκονται στην ανάπτυξη του ΣΣ. Σκοπός: Σε αυτή τη μελέτη, αναλύσαμε την έκκριση κυτταροκινών από υποσύνολα Τ-κυττάρων από το περιφερικό αίμα ασθενών με πρωτοπαθές ΣΣ, χρησιμοποιώντας συνθετικά πεπτίδια τα οποία αντιστοιχούσαν σε επιτόπους Τ-κυττάρων των αυτοαντιγόνων La / SSB. Μέθοδοι: Μονοκύτταρα περιφερικού αίματος (PBMC) απομονώθηκαν από 23 ασθενείς με πρωτοπαθές σύνδρομο Sjogren (πΣΣ) και 14 από την ομάδα ελέγχου και καλλιεργήθηκαν παρουσία ή απουσία μιτογόνου διέγερσης (ΡΗΑ) και σε διάφορες συγκεντρώσεις των πεπτιδίων. Τo PBMC υποβλήθηκε σε κυτταρική ανοσοφαινοτύπιση και κυτταρομετρία ροής μετά από επώαση με το πεπτίδιο. ELISA χρησιμοποιήθηκε για τη μέτρηση της IL-2, IL-4, IL-5, IL-10, ΤGF-β και IFN-γ σε υπερκείμενα από καλλιέργειες κυττάρων των PBMC ή καθαρές ομάδες κυττάρων. Αποτελέσματα: Δεν παρατηρήθηκε σημαντική διαφορά στον κυτταρικό πολλαπλασιασμό στο περιφερικό αίμα των υγιών είτε παρουσία είτε απουσία PHA ενώ ανεστάλη ο κυτταρικός πολλαπλασιασμός σε ασθενείς με πΣΣ παρουσία PHA. Το ποσοστό των CD4 + CD25 + Τ λεμφοκυττάρων στο περιφερικό αίμα αυξήθηκε σε ασθενείς με πΣΣ σε σύγκριση με τους υγιείς. Οι IL-4, IL-2, ΙFΝ-γ και IL-5 δεν ανιχνεύθηκαν στα υπερκείμενα των υγιών και ασθενών, είτε τα κύτταρα καλλιεργήθηκαν μόνα ή υπό την παρουσία των πεπτιδίων. Η L-10 και ο TGF-β, έδειξαν μια διαφοροποίηση στην έκκριση τους σε σχέση με τους υγιείς. Συμπεράσματα: Το αυξημένο ποσοστό των CD4+CD25+ Τ κυττάρων δείχνει την ύπαρξη ανοσορυθμιστικού μηχανισμού που είναι παρόν στο ΣΣ, ενώ η αύξηση της IL-10 μπορεί τελικά να συμβάλλει στην παθογένεια της νόσου. / Sjögren’s syndrome (SS) is a common autoimmune disease mainly of salivary and lachrymal glands, leading το xerostomia and keratoconjunctivitis sicca. Histopathological findings in SS include focal lymphocytic infiltrates that contain T cells and B cells with a predominance of activated CD4+ helper T cells. The exact pathogenetic mechanisms responsible for SS are not yet fully known, however environmental, hormonal and genetic factors may be involved in SS pathogenesis. Dysregulation of several cytokines produced by the infiltrating Th1, Th2 and also Th17 cells have also been implicated in the development and progression of SS. Purpose: In this study, we analyzed the cytokine expression patterns of peripheral blood T-cell subsets in primary SS (pSS) patients using synthetic peptides that map to T-cell epitopes of the La/SSB autoantigen. Methods: Peripheral Blood Mononuclear Cells (PBMC) were isolated from 23 patients with pSS and 14 controls and were cultured in the presence or absence of mitogenic stimulation (PHA) and various concentrations of the peptides. PBMC were subjected to cell phenotyping and FACS analysis after incubation with peptide. ELISA was used to measure IL-2, IL-4, Il-5, Il-10, TGF-b and IFN-γ cytokine production in culture supernatants from cell culture of PBMC or purified cell groups. Results: No significant difference in cellular proliferation was observed in isolated PBMCs from healthy donors in the presence or absence PHA, whereas an inhibition of cellular proliferation was noticed in the presence of PHA in pSS patients. The percentage of CD4+CD25+ T lymphocytes in peripheral blood (PB) was increased in pSS patients compared with controls. IL-4, IL-2, IFN-γ and IL-5 were not detected in the supernatants of both controls and patients, whether the cells were cultured alone or in the presence of the peptides. IL-10 and TGF-b showed a differentiation in their secretion from controls. Conclusion: The increased percentage of the CD4+CD25+ T cells, shows that an enhanced immunoregulatory mechanism is present in SS and increased production of IL-10 in SS patients may contribute to the pathogenesis of the disease.

Darbo tikslas Ištirti kserostomijos klinikos ypatumus ir juos lemiančius veiksnius sergant Šegreno sindromu, po radioterapijos kaklo ir galvos srityje bei vartojant triciklius antidepresantus ir pasiūlyti burnos sveikatos pagerinimo būdą. Darbo uždaviniai 1. Ištirti pagrindinius kserostomijos klinikos simptomus ir nustatyti juos įtakojančių veiksnių reikšmingumą. 2. Nustatyti kai kurių etiologinių kserostomijos veiksnių sąsają su pacientų amžiumi, lytimi ir pagrindiniais klinikos simptomais. 3. Ištirti didžiųjų ir mažųjų seilių liaukų funkcinę būklę sialometrijos ir sialoscintigrafijos metodais ir įvertinti jos įtaką klinikiniams simptomams. 4. Nustatyti kserostomijos trukmės sąsają su pagrindiniais kserostomijos simptomais. 5. Nustatyti sergančiųjų pacientų dantų, apydančio ir burnos higienos būklės sąsają su kserostomijos etiologija ir klinika. 6. Pasiūlyti kserostomijos stadijų klasifikaciją ir jos diagnostikos kriterijus. 7. Patobulinti dirbtinių seilių sudėtį ir pasiūlyti sergančiųjų kserostomija burnos sveikatos pagerinimo būdą. Medžiaga ir metodai Tyrimų medžiagą sudarė dvi grupės: I. KMU dantų ir burnos ligų klinikoje 2003 – 2005 metais 64 pacientai, pirmą kartą besikreipę konsultuotis dėl sausos burnos, buvo įtraukti į studiją. Iš jų 34 atrinkti dirbtinių seilių poveikiui tirti iš kurių 27 pacientam atliktas sialoscintigrafinis tyrimas; II. Iš KMUK archyvo atsitiktiniu būdu buvo atrinktos 481... [toliau žr. visą tekstą] / There is a continuous discussion about the basic xerostomia etiology and clinic problems in literature. Still individual authors have no unified opinion on how and to what extent the etiological factor of hyposalivation is relevant to manifestation of various aspects of xerostomia (Jensen SB et al.). There is no final objective data about the relationship of subjective patient complains with age, sex, psychological status and duration of xerostomia. There is an on-going discussion among certain authors in medical literature on when salivation should be considered as deficient, and what level of hyposalivation causes clinical xerostomia. Proper treatment of xerostomia is one of the most relevant problem. At the present, there is no unified treatment strategy that is towarded to stage or severity degree of xerostomia. However, objective criteria are not developed yet to classify xerostomia severity. Most authors, independently of absence of clear indications, recommend anticariesogenic, antibacterial treatment and to compensate the lack of saliva with artificial ones. Currently, there are not available saliva substitutes as one of the most important xerostomia treatment component on the market in our country. The study is also needed to evaluate the effectiveness of the treatment. 2. THE AIM AND THE GOALS OF THE STUDY The aim of the study was to evaluate the pecularities of xerostomia etiology and clinic and the... [to full text]

Thesis (M.Sc. (Maxillofacial Prosthetics))--Mahidol University, 2008.

Thesis--University of Turku, Finland, 2003. / Added t.p. with thesis statement inserted. Includes bibliographical references.

Thesis--University of Turku, Finland, 2003. / Added t.p. with thesis statement inserted. Includes bibliographical references.