INTRODUÇÃO: O Pênfigo Vulgar é uma doença bolhosa crônica que acomente pele e mucosas. A perda de adesão epitelial ocorre por agressão autoimune às desmogleínas presentes nos desmossomos, mediada por anticorpos IgG. Estudos sobre a gênese da autoimunidade no pênfigo indicam associação entre alelos do sistema HLA, especialmente dos loci DR e DQ. A população brasileira apresenta características favoráveis a estudos exploratórios em genética decorrente de sua origem mista e intensa miscigenação. PACIENTES E MÉTODO: O grupo em estudo incluiu trinta e seis pacientes não consanguíneos com diagnóstico de Pênfigo Vulgar comprovado por imunopatologia provenientes do estado de São Paulo, Brasil. Foram tipados para os loci HLA-A, HLA-B e HLA-DR utilizando-se oligonucleotídeos sequência-específica (PCR-SSO). As frequências alélicas e fenotípicas encontradas foram comparadas com as de um grupo controle composto de dados de 712 indivíduos doadores voluntários cadastrados no Registro Nacional de Doadores de Medula Óssea (REDOME) provenientes de São Paulo e tipados pelo mesmo método. O valor de P crítico foi corrigido utilizando-se o método False Discovery Rate. RESULTADOS: Os alelos HLA-DRB1*04:02, DRB1*08:04 e DRB1*14 estiveram associados à doença com riscos relativos de 44,6, 18,6 e 4,8, respectivamente (p<0,001). Não houve diferença estatisticamente significante entre as frequências de nenhum alelo dos loci HLA-A ou HLA-B entre os grupos. DISCUSSÃO: O alelo DRB1*04:02, diretamente, e o alelo DRB1*14, indiretamente por desequilíbrio de ligação com DQB1*05:03, estão associados com Pênfigo Vulgar em diversas populações ao redor do mundo, porém nenhum estudo semelhante observou associação com o alelo DRB1*08:04 em tamanha magnitude. Acreditamos que as associações encontradas em nosso estudo não sejam decorrentes de viés de estratificação populacional. É necessária, no entanto, a tipagem de loci adjascentes ao HLA-DR dos indivíduos do grupo em estudo para diferenciar se o risco à doença é inerente a estes alelos ou a algum outro nas proximidades, com o qual estariam em desequilíbrio de ligação. CONCLUSÕES: Os alelos HLA-DRB1*04:02, DRB1*08:04 e DRB1*14 estiveram associados ao Pênfigo Vulgar em pacientes brasileiros. / BACKGROUND: Pemphigus vulgaris is a chronic blistering disease affecting skin and mucous membranes. Autoimmune aggression to desmoglein in desmosomes, mediated by IgG antibodies, leads to loss of epithelial cell adhesion. Studies indicate association between some alleles of the HLA system and pemphigus vulgaris, mainly at the DR and DQ loci. Brazilian population characteristics are conducive to genetic exploratory studies because of its various origins and intense ethnically admixture. PATIENTS AND METHODS: The study group consisted of thirty-six unrelated patients with clinical and immunopathological diagnosis of pemphigus vulgaris from a tertiary hospital in Sao Paulo - Brazil. HLA allele typing at the A, B and DR loci was performed after DNA extraction using polymerase chain reaction and sequence-specific oligonucleotide probes (PCR-SSO). Allele and phenotypic frequencies were compared to those from a control group composed by 712 individuals volunteer donors registered in a national registry of bone marrow donors (REDOME) from Sao Paulo, typed using the same method. False Discovery Rate method was used to adjust level of critical P values. RESULTS: The HLADRB1* 04:02, DRB1*08:04 and DRB1*14 were associated with pemphigus vulgaris with relative risks of 44.6, 18.6 and 4.8, respectively (p <0.001). There was no significant difference between the frequencies of any allele of loci HLAA or HLA-B among the groups. DISCUSSION: The alleles DRB1*04:02 and DRB1*14 (indirectly through linkage disequilibrium with the DQB1*05:03) are associated with pemphigus vulgaris in several populations worldwide, however, no similar study reported such magnitude of association between pemphigus vulgaris and DRB1*08:04 allele. We consider that the association is not secondary to population stratification bias. HLA typing of nearby loci is required to differentiate if the association with pemphigus vulgaris is inherent to the HLA-DRB1*08:04 allele or to another gene which is in linkage disequilibrium. CONCLUSIONS: The HLA-DRB1*04:02, DRB1*08:04 and DRB1*14 were associated with pemphigus vulgaris in Brazilian patients

INTRODUÇÃO: O Pênfigo Vulgar é uma doença bolhosa crônica que acomente pele e mucosas. A perda de adesão epitelial ocorre por agressão autoimune às desmogleínas presentes nos desmossomos, mediada por anticorpos IgG. Estudos sobre a gênese da autoimunidade no pênfigo indicam associação entre alelos do sistema HLA, especialmente dos loci DR e DQ. A população brasileira apresenta características favoráveis a estudos exploratórios em genética decorrente de sua origem mista e intensa miscigenação. PACIENTES E MÉTODO: O grupo em estudo incluiu trinta e seis pacientes não consanguíneos com diagnóstico de Pênfigo Vulgar comprovado por imunopatologia provenientes do estado de São Paulo, Brasil. Foram tipados para os loci HLA-A, HLA-B e HLA-DR utilizando-se oligonucleotídeos sequência-específica (PCR-SSO). As frequências alélicas e fenotípicas encontradas foram comparadas com as de um grupo controle composto de dados de 712 indivíduos doadores voluntários cadastrados no Registro Nacional de Doadores de Medula Óssea (REDOME) provenientes de São Paulo e tipados pelo mesmo método. O valor de P crítico foi corrigido utilizando-se o método False Discovery Rate. RESULTADOS: Os alelos HLA-DRB1*04:02, DRB1*08:04 e DRB1*14 estiveram associados à doença com riscos relativos de 44,6, 18,6 e 4,8, respectivamente (p<0,001). Não houve diferença estatisticamente significante entre as frequências de nenhum alelo dos loci HLA-A ou HLA-B entre os grupos. DISCUSSÃO: O alelo DRB1*04:02, diretamente, e o alelo DRB1*14, indiretamente por desequilíbrio de ligação com DQB1*05:03, estão associados com Pênfigo Vulgar em diversas populações ao redor do mundo, porém nenhum estudo semelhante observou associação com o alelo DRB1*08:04 em tamanha magnitude. Acreditamos que as associações encontradas em nosso estudo não sejam decorrentes de viés de estratificação populacional. É necessária, no entanto, a tipagem de loci adjascentes ao HLA-DR dos indivíduos do grupo em estudo para diferenciar se o risco à doença é inerente a estes alelos ou a algum outro nas proximidades, com o qual estariam em desequilíbrio de ligação. CONCLUSÕES: Os alelos HLA-DRB1*04:02, DRB1*08:04 e DRB1*14 estiveram associados ao Pênfigo Vulgar em pacientes brasileiros. / BACKGROUND: Pemphigus vulgaris is a chronic blistering disease affecting skin and mucous membranes. Autoimmune aggression to desmoglein in desmosomes, mediated by IgG antibodies, leads to loss of epithelial cell adhesion. Studies indicate association between some alleles of the HLA system and pemphigus vulgaris, mainly at the DR and DQ loci. Brazilian population characteristics are conducive to genetic exploratory studies because of its various origins and intense ethnically admixture. PATIENTS AND METHODS: The study group consisted of thirty-six unrelated patients with clinical and immunopathological diagnosis of pemphigus vulgaris from a tertiary hospital in Sao Paulo - Brazil. HLA allele typing at the A, B and DR loci was performed after DNA extraction using polymerase chain reaction and sequence-specific oligonucleotide probes (PCR-SSO). Allele and phenotypic frequencies were compared to those from a control group composed by 712 individuals volunteer donors registered in a national registry of bone marrow donors (REDOME) from Sao Paulo, typed using the same method. False Discovery Rate method was used to adjust level of critical P values. RESULTS: The HLADRB1* 04:02, DRB1*08:04 and DRB1*14 were associated with pemphigus vulgaris with relative risks of 44.6, 18.6 and 4.8, respectively (p <0.001). There was no significant difference between the frequencies of any allele of loci HLAA or HLA-B among the groups. DISCUSSION: The alleles DRB1*04:02 and DRB1*14 (indirectly through linkage disequilibrium with the DQB1*05:03) are associated with pemphigus vulgaris in several populations worldwide, however, no similar study reported such magnitude of association between pemphigus vulgaris and DRB1*08:04 allele. We consider that the association is not secondary to population stratification bias. HLA typing of nearby loci is required to differentiate if the association with pemphigus vulgaris is inherent to the HLA-DRB1*08:04 allele or to another gene which is in linkage disequilibrium. CONCLUSIONS: The HLA-DRB1*04:02, DRB1*08:04 and DRB1*14 were associated with pemphigus vulgaris in Brazilian patients

La présente thèse a pour sujet la question du système des prépositions en latin vulgaire, ainsi que des morphèmes liés à ces dernières dans les langues indo-européennes (préverbes et préfixes). Notre objectif a été d’évaluer quelles ont pu être les spécificités relatives à l’emploi des prépositions (et des morphèmes connexes) dans la langue ordinaire, sur le plan sémasiologique comme onomasiologique. Est bâti pour ce faire le corpus le plus large possible de documents « autographes », c’est-à-dire de pièces portant une inscription directement réalisée par un latinophone (graffites, ostraca, tablettes de cire, defixiones, papyri documentaires), rédigés entre 1 et 395 p.C. La construction même de ce corpus et l’établissement d’une référenciation stable ont constitué un objectif secondaire de ce travail. La première partie établit les outils terminologiques nécessaires. Sont donc passées en revue toutes les théories relatives aux prépositions et à leur sémantisme depuis l’Antiquité, dans le but de souligner les manques et les imprécisions de la tradition terminologique. L’attention est ensuite portée sur le problème récurrent du « latin vulgaire », appellation nécessairement tolérée, même si elle demeure insatisfaisante et embarrassante. La question est spécifiquement posée au regard de la particularité du corpus, sur le plan matériel comme théorique. La notion « d’autographie » est en effet très floue, du fait de l’immixtion d’intermédiaires humains (comme les scribes, professionnels ou non), de la question de la « formularité » et des text types, et des problèmes complexes liés aux différentes formes de littératies à travers les provinces romaines. Cette partie se clôt sur les choix terminologiques et méthodologiques opérés, relativement au processus sous-jacent de collecte des données. La seconde partie présente les données. Celles-ci sont d’abord traitées sous l’angle quantitatif, avec prudence ; il s’agit d’abord d’établir quels sont les morphèmes encore en usage, quels sont ceux qui déclinent et quels sont ceux qui ont déjà disparu. Il s’agit également de comprendre quels écarts peuvent se manifester entre les données et nos attentes. On souligne ce faisant les différents processus de développement, en synchronie ou en diachronie, de certains morphèmes ou usages ; la notion de « préfixation pré-nominale », jusqu’ici peu envisagée dans les études latines, et ainsi étudiée. Le second chapitre de cette partie étudie ce matériel, sur un plan phonétique, morphosyntaxique et lexical. Il s’agit alors non seulement de découvrir les signes d’un possible renouvellement dans certaines zones de la langue (il est fait ici usage du concept de sermo castrensis, mais aussi de celui – encore peu envisagé – de sermo mercatorius) ; il s’agit en outre de comprendre pourquoi ce corpus manifeste une véritable résistance à l’égard des vulgarismes, et pourquoi l’on ne constate aucun véritable fossé entre la langue normée et celle du corpus.Le dernier chapitre se concentre sur le problème déjà ancien, mais complexe, de la chute des <-m> (et accessoirement, des <-s>) en latin vulgaire, et sur la conséquence de celle-ci au sein des groupes prépositionnels. Ce problème a une histoire (depuis Diehl), qui est rappelée afin d’expliquer comment se mélangent ici les niveaux graphiques, phonologiques et grammaticaux. Il s’agit de comprendre dans quels cas la disparition de <-m> peut être attribuée à une pure convention graphique, dans quels cas elle est relative à l’analphabétisme ou à la faible littératie des scripteurs, et dans quels cas elle constitue effectivement le premier signe (mesuré) d’un effondrement des systèmes flexionnels, dans une perspective romane. Ce chapitre s’interroge ine fine sur la capacité des locuteurs semi-lettrés, à un moment de la diachronie, à faire usage d’un « système polymorphique » (Banniard), et à choisir ainsi, bien qu’ils fussent relativement conscients des règles morphologiques, de marquer ou non le cas accusatif. / In this thesis, we deal with the question of prepositional systems in Vulgar Latin, and the linguistic material wih which it is usually associated, in indo-european languages, i.e. preverbs and prefixes. Our work aims to evaluate how specific usages of prepositions (and related material) in colloquial speech may have been, in both semasiological and onomasiological ways. For this purpose, we draw on the largest corpus of « Autographical » documents, i.e. directly inscribed artifacts, such as graffiti, ostraca, wax tablets, defixiones, documentary papyri, etc., from 1 to 395 a.D. Moreover, as a second objective ot the dissertation, we set up a fully-ordered and well-referenced corpus of our archaeological material.The first part of the thesis tries to lay the methodological tools of such the said design. Theories of prepositions and prepositional meanings from Antiquity to present reviewed are reviewed, in order to understand the lack and fuziness of inherited terminological displays. We then consider the customary problem of utilising and defining the terme « Vulgar latin » (which we tolerate, as embarrassing and unsatisfying as it is) and most specifically the peculiarity of our corpus, in a theorical and practical ways : « autography » is indeed a messy concept, due to the involvement of human go-betweens (like professional or casual scribes), the question of formularity and « text types », and the complex pattern of literacy, throughout the Roman provinces. This chapter ends with terminological and methodological choices, referring to the undergoing process of the data report.In second part of the thesis we lay out the data itself. We first deal with this data quantitativly by cautiously using statistical approaches, we try to establish which morphemes were still in use, recessing, or had already disappeared. Furthermore, we examine what kind of discrepancies could arrise between our expectation and the data. We stress, by doing so, the synchonical and diachronical expansions of certain morphemes or usages, and more specifically the question of « Pre-nominal prefixation », on which little has yet been written in classical tradition. The second part of this chapter studies the dynamics of our material phonetically, morphosyntaxically and lexically. Not only do we try to catch sight of linguistic renewals in some areas of language (dealing with the concept of sermo castrensis, or the yet unexplored sermo mercatorius), but also the evidence of a structural dragging into vulgarisms and linguistical changes in our corpus, questioning the lack of an expected « gap » between litterary standards and the language that our documents are using.The third part of our thesis deals with the very well known but very intricate problem of falling /-m/ (and, casually, falling /-s/) in Vulgar Latin, and their consequences in the prepositionnal phrases. The problem’s history (from Diehl’s work) shows up, explaining the entanglement of graphical, phonological and grammatical levels in such an inquiry. We then try to establish which part of the disappearing <-m>, in prepositional phrases, could be assigned to graphical convention, which part goes to real illiteracy (or « low-level literacy ») and which part shows the evidence for a real (but limited) starting point toward a future collapse of nominal flection, from a romance perspective. We conclude this chapter by questioning the ability of semi-literate latin-speakers, at some point of the diachronic evolution of latin language, to deal with « polymorphic » systems (as proposed by Banniard), who ware quite aware of morphological rules but choosing to mark or not mark or to omit the accusative case.

本論文視莎士比亞的《量罪記》為詹姆士王朝城市喜劇。這齣喜劇勾勒出城市的郊區下流地圖誌。過去的批評家在討論此劇時，要不將此劇視為迎接英國新國王詹姆士一世的奉承之作，就是將此劇解讀成對新來統治者的政治批評。本論文試圖超越過去論述的簡單二元對立，以城市喜劇的角度重新切入《量罪記》，分析莎士比亞如何透過戲劇再現城市下流文化，以及此舞台再現如何連結台下底層市民，形成大眾展演政治。 論文第一部分分析《量罪記》與城市下流文化的再現。本劇將維也納城作為「崩壞之身」拉開序幕，此隱喻一方面沿襲自文藝復興時期的身體政治學，一方面又挑戰了它，因為此「崩壞之身」直到劇終仍然維持其「病態」。本劇讓觀眾體驗漫布於城市各個角落的下流文化，包括郊區的妓院群與監獄中的娼寮。本劇表面上似乎在鞏固文森提歐公爵對城市空間的掌控與管理權，另一方面卻又透過「下流」角色的身影，提供觀眾另類的閱讀，揭露城市下流文化的延續與崛起。 論文第二部分探索詹姆士王朝的城市慶典與本劇饒富興味的最後一幕之間的關係。最後一幕中，公爵的皇家入城儀式與詹姆士一世的王室慶典有許多相似之處。城市慶典許久以來便是君王用來展示自我權力的工具之一，詹姆士一世對於自己的王室慶典之抗拒，卻流露出他對公眾討論的恐懼與對自我名譽的管理。他對公眾形象的細心掌控也被再現於此劇的最後一幕中。不過，即使在這最後一幕，嫖客盧求不僅讓公爵淪為眾人笑柄，毀了他的聲譽，更勾起觀眾對城市下流文化之記憶。因此，觀眾目睹的反而不是一個可敬王者的回歸，反而是一個淫亂嫖客之崛起。 論文第三部分將本劇放置在原本的文化、社會與歷史背景中 。《量罪記》屬於1603年後冒出的一波「偽裝國王劇」，這一波戲劇風潮呼應伊莉莎白一世去世、詹姆士一世繼位的關鍵歷史時刻，反映出的是當時人民對於新王來臨產生的焦慮。《量罪記》特別之處在於呈現了城市「下流」人物對於未來生存與否的焦慮。另外，本劇亦與「假國王」的戲劇傳統相關。在此戲劇傳統中，劇作家會透過舞台上的「假國王」來做政治批評，展示適當的統治方式。本論文認為，本劇中影射詹姆士一世的公爵角色也可被視為一個舞台上的「假國王」，崛起的反而是城市「下流」人物。本劇透過丑角盧求邀請觀眾大方嘲弄公爵並且挑戰他早先建立起的權威。最後，盧求成為舞台上的底層大眾化身，透過情色的笑話與不馴的笑聲與台下的觀眾形成「下流」社群，共享大眾歡樂。正是這大眾愉悅的力量，讓此劇不再替統治者的權威背書，反而擁抱了底層下流市民。 / This thesis sees Shakespeare’s Measure for Measure as a Jacobean city comedy that maps an urban vulgar culture. Critics in the past often focused on whether the play should be read as a flattery to the new king, James I, or as a political criticism of the ruler. The thesis goes beyond the simple dichotomy offered by criticism in the past. It reads Measure for Measure as a city comedy and analyzes Shakespeare’s dramatic representation of the urban vulgar culture, which connects the lowlife figures onstage with the audiences offstage, ultimately forming a popular performative politics. The first part of the thesis analyzes Measure for Measure and its representation of an urban vulgar culture. Vienna in the play is represented as a “vile body,” which both confirms and unsettles the early modern body politic, since the vile body stays “ill” till the very end of the play. The play invites the audience to experience how this vulgar culture permeates every part of the city, including the houses of prostitution in the suburbs and a “bawdyhouse” in the prison. While the play seems to confirm Duke Vincentio’s control and regulation of the city, the bawdy figures provide us with an alternative reading of the play, revealing the survival and even the rise of the urban vulgar culture The second part of the thesis relates Jacobean civic pageantry to the play’s intriguing final scene, in which the Duke stages a royal entry that is not unlike James I’s civic pageantry. While civic pageantries had long been used by monarchs to demonstrate their power, James I’s resistance to participating in his own pageantry revealed his fear of public discourses and his careful management of reputation and honor. This careful management of public image is also represented in the play’s final scene. However, even during the final scene, Lucio not only turns the Duke into a mockable figure but also ruins the Duke’s reputation and honor. His stage presence also evokes a suburban vulgar culture. Thus, the audience does not witness the return of a respectable ruler, but the rise of a lascivious whoremaster. The third part of the thesis puts the play into its cultural, social, and historical backgrounds. Measure for Measure belonged to the wave of disguised ruler plays after 1603. The wave of drama was produced during the critical moment when Elizabeth I died and James I came to the throne. It reflected a popular anxiety of the arrival of the new king. Measure for Measure is unique in its dramatization of suburban bawdy figure’s anxiety of their future state. In addition, the play was also closely connected to the “mock king tradition,” in which the dramatists staged a mock king on the stage in order to show the proper way to rule. The thesis argues that Duke Vincentio, who resembled James I in many aspects, could possibly stand for a “mock king.” What the play actually shows is the rise of the suburban vulgar culture. The clown Lucio invites the audience to laugh at the Duke and challenges his authority established in earlier scenes. Lucio eventually stands for the general lowlife public on the stage, forming a “bawdy” community with the audience through bawdy jokes and unruly laughter. It is exactly this power of popular mirth that turns the play from an endorsement of the ruler’s authority to a celebration of the lowlife citizens.

Entre la fin des années 1860 et le milieu des années 1920, la philologie, la grammaire historique et l’histoire de la langue sont introduites dans l’enseignement supérieur français grâce à la création de postes et de chaires dans des établissements nouvellement fondés, comme l’École Pratique des Hautes Études et l’École normale supérieure de jeunes filles de Sèvres, ou profondément rénovés, comme la Faculté des lettres de Paris. La disciplinarisation de ces savoirs linguistiques de type historique participe du rapprochement entre enseignement et recherche et, ainsi, du renouvellement du système universitaire. En atteste la carrière dans les trois institutions citées de Gaston Paris, Arsène Darmesteter et Ferdinand Brunot, retracée à l’aide de correspondances privées et de documents d’archives d’ordre institutionnel. L’analyse de documents publiés par les établissements eux-mêmes (affiches, livrets, comptes rendus d’enseignements, ouvrages commémoratifs) met en évidence les difficultés que rencontrent ces trois enseignants pour s’adapter aux divers publics étudiants et aux préconisations officielles. Leurs notes de cours reflètent un travail de didactisation, qui passe par des pratiques d’écriture diverses dont on identifie les spécificités à l’aide des outils de la génétique textuelle. L’étude approfondie de deux objets de savoir met en lumière l’intérêt de ces notes en tant que sources pour l’histoire des idées linguistiques et de leur enseignement. D’abord, l’histoire de l’orthographe française, bien qu’absente des intitulés des cours, est présente dans les notes de cours. Ensuite, le « latin vulgaire » est un thème porteur d’enjeux idéologiques et épistémologiques majeurs invisibles dans les affichages institutionnels. / Between the late 1860s and the mid-1920s, philology, historical grammar and language history are introduced into the French higher education system with the creation of positions and tenures in newly founded schools, such as the École Pratique des Hautes Études and the girls’ École normale supérieure in Sèvres, and in deeply transformed institutions, like the Paris Faculty of Letters. Making history-oriented linguistic knowledge into disciplines contributed to bring teaching and research closer together and led to the rebirth of the university system. This is illustrated by the careers of Gaston Paris, Arsène Darmesteter and Ferdinand Brunot in these institutions as evidenced by private correspondence and institutional archive material. The analysis of documents published by the establishments (posters, booklets, teaching records, anniversary publications) casts light on the problems these teachers faced when attempting to adapt to various student populations and official guidelines. Their teaching notes reveal content adaptation through diverse writing practices, which we identify and characterize by using text genetics. The in-depth study of two knowledge contents demonstrates the use that can be made of these notes as sources for the history of linguistic thought and its teaching. Firstly with the history of French orthography which is present in teaching notes, although it does not appear in course titles. Secondly with vulgar Latin as a theme that pertains to major ideological and epistemological issues which are invisible in institutional display material.

Le réalisme pictural peut être conçu, par-delà la pensée ontologique dualiste, comme expérience perceptive cognitive du spectateur d’avoir l’impression de voir le « réel » dans une configuration imagée picturale. Cette impression de réel n’est pas illusoire, mais subjectivement factuelle, sans être nécessairement consciente. Elle pourrait résulter de la facilité perceptive ou de la fluidité opérationnelle du processus perceptif cognitif. Lorsque l’activité perceptive cognitive opérante dans l’expérience du réalisme pictural est régulée par la valence hédonique immanente à cette fluidité opérationnelle sous-jacente à l’impression de réel, cette expérience « subjective » peut être également « esthétique » pour cette autosuffisance fonctionnelle de la « conduite cognitive » du spectateur. Cependant, l’expérience du réalisme pictural comporte une dimension anthropo-transculutrelle, comme on peut le constater notamment dans les récits littéraires des spectateurs coréens du 18e siècle qui illustrent leurs expériences visuelles des peintures occidentales « illusionnistes » réalisées par des missionnaires jésuites à Pékin. La culture est néanmoins opérante dans l’expérience « esthétique » du réalisme pictural. Son effet est double. D’une part, la culture fonctionne comme une des variables de la fonction complexe de l’apprentissage perceptif qui pourrait modifier la dynamique du processus perceptif cognitif ainsi que l’attention perceptive visuelle. D’autre part, elle pourrait opérer un effet dans la valence hédonique globale en participant à la modélisation de l’« affect idéal » distingué de l’« affect effectif ». / The pictorial realism can be conceived, beyond ontological dualistic thought, as beholder’s perceptual cognitive experience to have the impression of seeing the “real” in a picture. This impression or feeling of real is not illusory, but subjectively factual, without being necessarily conscious. It may result from perceptual easiness or from perceptual cognitive processing fluency. When the perceptual cognitive activity working in the pictorial realism experience is regulated by hedonic valence immanent in this processing fluency that underlies the impression of real, this subjective experience can also be “aesthetic” by functional self-sufficiency of beholder’s “cognitive conduct”. However, the experience of pictorial realism contains an anthropo-transcultural dimension, as we can observe especially in the stories written by 18th century Korean beholders, which illustrate their visual experiences of the western “illusionist” paintings produced by jesuit missionary painters in Beijing. Nevertheless, the culture comes into play in the “esthetic experience” of pictorial realism. Its effect is double. On the one hand, the culture acts as one of the variables of the complexe function of perceptual learning which could make difference in the perceptual cognitive processing dynamics and in the visual or perceptual attention. On the other hand, the culture might influence the global state of hedonic valence by participating in the modeling of “ideal affect” distinguished from “actual affect”.