Étude du comportement d'un acier inoxydable 316L et d'un Inconel 718 dans le cadre d'un schéma thermomécanique à mémoire discrète constitué d'une équation multivoque, d'un critère d'inversion et d'un algorithme. Analyse détaillée des propriétés du comportement d'hystérésis pure. Etude des modules tangents aux courbes de charge. Mise en évidence de la restauration des propriétés du matériau après inversion et de la non-existence d'une discontinuité elastique-plastique dans le diagramme contrainte-déformation. Description de l'écrouissage en déformation à partir d'une analyse de la microstructure

Les bis-ylures peuvent être considérés comme des complexes de carbone(0). L'objectif de cette thèse consiste au développement de nouveaux modèles permettant de diversifier la réactivité de ce type d'espèces. Le premier chapitre de cette thèse dresse un état de l'art des complexes de carbone(0), basé sur l'étude de leur structure électronique, leur chimie de coordination, les applications en catalyse ainsi que leur potentiel en tant que source de carbone atomique. Le second chapitre est centré sur nos efforts pour préparer un nouveau modèle de bis-ylure de phosphonium-sulfonium cyclique. Nos principales approches y sont développées. Ces dernières ont permis l'obtention fortuite d'une nouvelle famille de précurseurs de bis-ylures P-chlorés, qui ont été entièrement caractérisés. Le troisième chapitre est consacré à une nouvelle famille de bis-ylures P,S stabilisés par des groupements sulfoxonium et phosphonium. Ces espèces ont été entièrement caractérisées par spectroscopie RMN et cristallographie. L'étude de leur réactivité met en exergue un potentiel important en tant que ligand pour les métaux de transition, de nombreux complexes organométalliques ont pu être préparés. La dernière partie de ce manuscrit présente l'étude des bis-ylures anioniques, connus également sous le nom d'yldiide. La synthèse d'un nouveau modèle est décrite ainsi que sa caractérisation, et sa réactivité vis-à-vis de composés carbonylés. Pour finir, une réactivité originale sous irradiation a été mise en évidence, permettant l'accès à de nouveaux complexes de C(0). / Bis-ylides can be viewed as carbon (0) complexes, also known as " Carbone ". The goal of this thesis is to develop new models of bis-ylides featuring original reactivities. The first chapter presents the state of the art of carbon(0) complexes. A study of their electronic and structural properties is described, as well as, their applications as ligands in organometallic chemistry and their uses as potential carbon atom sources. The second chapter records the different attempts to synthesize a new cyclic P,S bis-ylide. These efforts lead to the unexpected synthesis of new P-chlorinated mixed bis-ylide precursors. Some preliminary results allow us to class them in the family C(0) complexes. The third chapter consists in the synthesis of a new family of bis-ylides, stabilized by sulfoxonium group. These species were fully characterized theoretically, spectroscopically and by X-Ray diffraction. The reactivity studies demonstrate a high potential as ligand for transition metal, several organometallic complexes were prepared and characterized. The last chapter presents the study of anionic bis-ylides, also known as yldiide. The synthesis of a new model is described, as well as its reactivity towards carbonyls. Finally, original irradiation reactions of this yldiide allowed us to access new C(0) complexes.

Le groupe de Cremona de rang 2 est le groupe des transformations birationnelles du plan projectif. Le but de cette thèse est d'étudier et de construire des espaces hyperboliques sur lesquels le groupe de Cremona agit et qui permettent de mettre en œuvre des méthodes provenant de la théorie géométrique des groupes. Il est connu depuis une dizaine d'année que le groupe de Cremona agit sur un espace hyperbolique H analogue au plan hyperbolique classique mais de dimension infinie. Dans un premier temps, nous montrons que le groupe de Cremona défini sur un corps quelconque n'est pas simple en le faisant agir sur cet espace hyperbolique. Ceci prolonge un résultat déjà connu dans le cas d'un corps de base algébriquement clos. Nous nous intéressons ensuite à un graphe construit par D. Wright sur lequel agit le groupe de Cremona. Nous montrons qu'il ne possède pas la propriété que nous souhaitions, à savoir qu'il n'est pas hyperbolique au sens de Gromov. Nous construisons également un domaine fondamental pour l'action du groupe de Cremona sur H via la méthode des cellules de Voronoï. Nous caractérisons les applications du groupe de Cremona qui correspondent à un domaine adjacent au domaine fondamental. Cela nous permet de prouver que le graphe de Wright est quasi-isométrique au graphe dual à ce pavage. Nous obtenons ainsi une manière de retrouver le graphe de Wright dans H. Nous montrons enfin qu'en modifiant ce graphe dual, nous obtenons un graphe hyperbolique au sens de Gromov. Dans une dernière partie, nous nous intéressons à une autre propriété naturelle qui est la propriété CAT(0). Nous construisons un complexe cubique CAT(0) de dimension infinie muni d'une action naturelle du groupe de Cremona. / The Cremona group of rank 2 is the group of birational transformations of the projective plane. The aim of this thesis is to study and build some hyperbolic spaces with a natural action of the Cremona group. We want these spaces to have good geometric properties in order to use methods coming from geometric group theory. It is known that the Cremona group acts on a hyperbolic space H which is similiar to the classical hyperbolic plane but in infinite dimension. First, using this action, we show that the Cremona group is not simple over any field. This extends previous results over an algrebraic closed field. Then we study the Wrigth's graph. We show that it doesn't have the property we are looking for, in the sense that it is not Gromov hyperbolic. We build a fundamental domain for the action of the Cremona group on H 8 via Voronoï's cells. We characterize birational tranformations that correspond to adjacent domains of the fundamental domain. This allows us to prove that the Wright's graph is quasi-isometric to the dual graph of this tessellation. It's give us a way of realizing the Wright's graph inside H. Finally, we show that by modifying the dual graph we obtain a Gromov hyperbolic graph. In the last part, we are interested in another classical property which is the CAT(0) property. We build an infinite dimensional CAT(0) cubical complex which comes with a natural action of the Cremona group.

L'objet de cette thèse est l'étude de revêtements ramifiés V' to V de variétés hyperboliques compactes V cubiques, c'est-à-dire dont le groupe fondamental pi_1(V) opère proprement et cocompactement sur un complexe cubique CAT(0). Notre première approche consiste à construire un complexe cubique localement CAT(0) comme revêtement ramifié du complexe obtenu par cubulation de V. La difficulté est alors de vérifier que ce complexe a le même groupe fondamental que V’. On réalise ce programme dans le cas ou V’ est une « variété de Gromov-Thurston ». Notre seconde approche concerne plus généralement le cas où le lieu de ramification du revêtement V' to V est contenu dans une sous-variété convexe de codimension 1. La préimage de cette variété dans V’ puis dans le revêtement universel X’ de V’ fournit un système naturel de « murs ». La difficulté consiste alors à montrer que ces murs séparent linéairement X’ afin d'utiliser les théorèmes classiques de cubulation. / The goal of this thesis is to study of branched covers V' to V of closed hyperbolic manifolds that can be cubulated, i.e. Whose fundamental group pi_1(V) acts properly and cocompactly on a CAT(0) cube complex. We give sufficient conditions for pi_1(V') to be cubic as well.We tackle this question in two different ways. In a first approach we build a negatively curved cubical complex as a ramified cover of a cubical complex obtained by cubulating V. Then the main issue is to check that the fundamental group of this complexe is isomorphic to the fundamental group of V'. We manage to do so when V' is so called “Gromov-Thurston manifold “. Our second approach deals with the more general case where the branched locus of V' to V is contained in a codimension 1 convex submanifold. The preimage of this submanifold on V' and on the universal cover X' of V' provides a natural system of “walls”. Then the main issue is to show that these walls linearly separate X'. This enables us to use classical cubulation theorems.

L’objectif de ce travail consiste d’une part à étudier la plasticité dans le dioxyde d’uranium en décrivant à l’échelle atomique le mécanisme de glissement des dislocations, et d’autre part à étudier l’oxyde sur-stœchiométrique en déterminant les configurations atomiques et les relations structurales des phases se formant sur le diagramme en fonction de la stœchiométrie O/U et de la température. Nous réalisons pour cela des simulations à l’échelle atomique par minimisation d’énergie et par dynamique moléculaire à l’aide d’un potentiel empirique complexe à charges variables, autorisant des modifications de charges d’ions en fonction de leur environnement local. Cette étude nous a permis dans un premier temps de caractériser la plasticité dans les monocristaux d’UO₂ en montrant qu’elle est produite dans les plans de glissement principaux {100} par glissement thermiquement activé de dislocations coin à basse température par un procédé de germination et de croissance de paires de décrochements sur ces dislocations. Dans un second temps, le même potentiel empirique nous a permis de préciser à l’échelle atomique la structure de la phase désordonnée UO₂₊ₓ à haute température et l’évolution en fonction de la température de la structure de la phase ordonnée U₄O₉₋ᵧ. Nous donnons alors une description atomistique d’une partie du diagramme de phase. Ainsi, l’outil que nous utilisons, un potentiel à charges variables, nous a permis de mieux comprendre les propriétés de l’UO₂ et d’une façon plus générale, nous prouvons que ce type d’outil est prometteur complémentaire aux potentiels empiriques classiques et aux méthodes ab-initio pour modéliser des systèmes atomiques complexes. / The aim of this work is to study on the first hand plasticity in uranium dioxide by the mean of an atomic scale characterization of dislocations glide mechanisms, and on the other hand to study hyper-stoichiometric uranium dioxide by the determination of atomic configurations and their relations that appear on the phase diagram as a function of O/U ratio and temperature. To achieve this, we perform atomic scale simulations by energy minimization and molecular dynamics using a complex variable charge empirical potential, which let the ionic charges vary as the local atomic environment is modified. We firstly characterize plasticity in UO₂ single crystals and show that it is governed in the {100} main glide planes by thermally activated edge dislocations glide at low temperatures by a mechanism of nucleation and growth of kink pairs on these dislocations. Then, the same empirical potential let us derive at the atomic scale the structure of the high temperature disordered UO₂₊ₓ phase and the evolution with temperature of the ordered structure U₄O₉. This gives an atomistic description of part of the U-O phase diagram. So, the tool we use, a variable charge empirical potential, let us understand more precisely UO₂ properties, and more generally we prove that this kind of tool is a promising alternative to classical empirical potentials and ab-initio methods to model complex atomic systems.

Memoria para optar al título de Geógrafo / El planeta se enfrenta a nuevos escenarios climáticos, y Chile no se encuentra ajeno. Aumentos de temperatura y disminución en las precipitaciones son algunos de los fenómenos que se están dando con mayor frecuencia, en donde la isoterma 0°C toma un rol importante al encontrarse vinculado estrechamente con las variaciones de temperatura. Es así como se propone un método de determinación de isoterma 0°C mediante datos de radiosonda lanzados en territorio chileno, así como también una validación de sus resultados. Los datos de radiosonda son limpiados y llevados a una macro, en donde se automatiza el cálculo de la altura de la isoterma 0°C mediante una regresión polinómica, cuyos resultados son espacializados en el territorio chileno a nivel estacional. Por otro lado, estos datos son analizados temporalmente según Makesens y contrastados con resultados arrojados por un modelo alternativo, utilizando datos de una base mundial denominada Terraclimate. La isoterma 0°C se ubica principalmente en la cordillera de Los Andes, abarcando mayor superficie en la zona norte y centro del país. A grandes rasgos, las tendencias señalan un aumento en la altura de isoterma 0°C en la zona norte, centro y sur, siendo en los meses de verano en donde existe un mayor grado de significancia. La altura de la isoterma 0°C en días de precipitación presenta un alza en la zona norte y centro del país, mientras que en la zona austral se destaca la tendencia negativa. / The planet is facing to new climate stages, and Chile isn't so far of that. Temperature increase, decrease in rainfall, are just some of the phenomenon that happens more frequently, where 0°C isotherm takes an important role to be closed linked with temperature variations. This Is how a 0°C isotherm variations method is proposed using radiosonde data launched in Chilean territory, as well as a validation of their results. The radiosonde data are cleaned and taken to a macro, where the calculation of the 0°C isotherm height is automated by a polynomial regression, the results of which are spatialized in Chilean territory at the seasonal level. On the other hand, these data are temporarily analyzed according by Makesens and contrasted with results produced by an alternative model, using data from a global database called Terraclimate. The 0°C isotherm is located mainly in the Andes mountain range, covering a larger area in the northern and central part of the country. Broadly speaking, the trends indicate an increase in the height of 0°C isotherm in the north, center and south zone, being in the summer months where there is more significance. The height of the 0°C isotherm on rainy days shows an increase in the north and center of the country, while in the southern zone the negative trend is noted.

[pt] A competitividade no mundo corporativo tem se elevado consideravelmente e para se manterem competitivas, as empresas devem inovar seus processos produtivos constantemente. O lean manufacturing(LM) surgiu como uma filosofia que preza pela eliminação dos desperdícios no meio de produção. Atualmente, o mundo vivência a quarta revolução industrial ou Indústria 4.0 (I4.0), que é baseada em uma alta conectividade. Para se atualizarem, as empresas estão integrando o LM e a I 4.0. Para que a implementação das tecnologias da Indústria 4.0 seja um sucesso, é necessário analisar qual tecnologia se adapta melhor ao ambiente lean instalado. Neste contexto, a presente dissertação de mestrado tem por objetivo analisar os pontos de sinergia entre LM e I4.0 e melhorar a compreensão corporativa sob a implementação conjunta dessas duas vertentes na indústria de manufatura. Dois frameworks de integração entre o LM e a I4.0 são propostos, ambos com o intuito de auxiliar o processo de implementação conjunta dessas duas vertentes. Para atingir o objetivo de pesquisa, foram realizadas uma revisão sistemática da literatura e um Painel com Especialistas para o desenvolvimento e validação dos frameworks. São, também, apresentadas análises descritivas e de conteúdo sobre os temas propostos. Sugere-se, como pesquisa futura a realização de um estudo de caso em que esses frameworks sejam colocados em prática na indústria de manufatura. / [en] The competitiveness in the corporate world has increased considerably, and to keep competitive, companies must continuously innovate their production processes. Lean manufacturing (LM) emerged as a philosophy that replaces waste in the production environment. Currently, the world experiences the fourth industrial revolution or Industry 4.0, which is based on high connectivity. To keep themselves updated, companies are integrating lean and Industry 4.0. Towards the successful implementation of Industry 4.0 technologies, it is necessary to analyze which technology best adapts to the lean installed environment. Within this context, this Master s thesis aims to analyze the synergy points between LM and Industry 4.0 and to improve corporate understanding under the joint implementation of these two strands in the manufacturing industry. Two integration frameworks between the LM and I4.0 are proposed, both aiming to assist the process of joint implementation of these two strands. To achieve this objective, a systematic literature review and a Panel of Experts were carried out to develop and validate the frameworks. Descriptive and content analyses of the proposed topics are also presented. It is suggested for future research a case study in which these frameworks are used in practice in the manufacturing industry.

Au niveau du cerveau et dans le plasma de malades atteints de maladie d’Alzheimer (MA), l’accumulation de C22:0 et d’acides gras à très longue chaîne (C24:0 ; C26:0), la diminution d’acide docosahexaenoique (C22:6 n-3) et les modifications quantitatives et qualitatives de plasmalogènes suggèrent l’implication de dysfonctions peroxysomales. En fonction de ces constatations, les activités biologiques de C22:0, C24:0 et C26:0 ont été recherchées sur des cellules neuronales humaines SK-N-BE. La lipotoxicité des acides gras (C22:0, C24:0 et C26:0) induit divers effets au niveau des mitochondries (modifications topographiques, morphologiques et fonctionnelles), conduit à une rupture de l’équilibre RedOx (surproduction d’espèces radicalaires de l’oxygène, modification de l’activité des enzymes anti-oxydantes : catalase, SOD, GPx), à une peroxydation lipidique et à une désorganisation du cytosquelette (microfilaments d’actine, tubuline, neurofilaments). Ces acides affectent aussi l’amyloïdogenèse et la tauopathie. L’amyloïde béta favorise aussi l’accumulation intracellulaire de C22:0, C24:0 et C26:0. A fortes concentrations, ces acides gras induisent une mort cellulaire non apoptotique. Par ailleurs, les données immunohistochimiques en relation avec l’expression de marqueurs peroxysomaux (ABCD1, ABCD2, ABCD3, ACOX1 et catalase) au niveau du cerveau de souris transgéniques APP PS1 ΔE9 ainsi que les profil d’acide gras obtenus sur le cerveau et le sang de ces souris suggèrent qu’elles pourraient constituer un bon modèle pour l’étude des relations entre MA et métabolisme peroxysomal. L’étude clinique réalisée sur plasma et érythrocytes de malades déments (MA, démences vasculaires, autres démences) montre une forte accumulation de C22:0, C24:0 et C26:0. Le C26:0 pourrait constituer un excellent biomarqueur de la MA. Le C18:0 à est aussi augmenté ainsi que les acides gras n-6. De forts indices de stress oxydant sont aussi révélés. Dans son ensemble, le travail réalisé suggère que les acides gras (C22:0, C24:0 et C26:0) ainsi que le métabolisme des acides gras en relation avec le métabolisme peroxysomal pourraient contribuer à la neurodégénéréscence associée aux démences incluant la MA / In the brain and in the plasma of patients with Alzheimer’s disease (AD), marked accumulation of C22:0 and of very long chain fatty acids (C24:0 ; C26:0) have been reported. Important decreases of docosahexaenoic acid (DHA; C22:6 n-3) have also been described as well as quantitative and qualitative modifications of plasmalogens. Altogether, these lipid modifications suggest an implication of peroxisomal metabolism disorders in the physiopathology of AD. Therefore, the biological activities of C22:0, C24:0 and C26:0 have been studied on human neuronal cells SK-N-BE. On these cells, the lipotoxicity of fatty acids (C22:0, C24:0 and C26:0) leads to various cellular modifications: topographical, morphological and functional changes at the mitochondrial level, rupture of RedOx equilibrium (overproduction of reactive oxygen species, modification of the activity of enzymes involved in anti-oxidant defenses: catalase, SOD, GPx), lipid peroxidation, cytoskeleton disorganization (actin microfilaments, tubulin, neurofilaments). These fatty acids also favor amyloidogenesis and tauopathy. At elevated concentrations, these fatty acids trigger a non apoptotic mode of cell death. Moreover, data obtained by immunohistochemistry with antibodies raised against peroxisomal components (ABCD1, ABCD2, ABCD3, ACOX1 and catalase) on histological tissue sections of the brain of transgenic mice APP PS1 ΔE9 as well as lipidomic analysis performed on the blood and the brain of these mice suggest that they could constitute interesting model to study the relationships between AD and peroxisomal metabolism. The clinical study performed on the plasma and on the erythrocytes of patients with dementia (AD, vascular dementia, other dementia) revealed an important accumulation of C22:0, C24:0 and C26:0. Hexacosanoic acid (C26:0) might constitute an excellent biomarker of AD. The fatty acid C18:0 and (n-6) fatty acids have also been found at increased concentrations. A strong oxidative stress has also been revealed. Altogether, our data support that the fatty acids (C22:0, C24:0 and C26:0) as well as the fatty acid metabolism depending on the peroxisome might contribute to neurodegeneration leading to various types of dementia including AD

Os programas de educaÃÃo a distÃncia que utilizam tecnologias digitais constituem possibilidades pedagÃgicas cada vez mais recorrentes no contexto educacional. Evidencia-se grande expansÃo de experiÃncias de ensino a distÃncia que complementam os sistemas convencionais, bem como o surgimento de formas hÃbridas de educaÃÃo que combinam atividades presenciais e a distÃncia que promovem o intercÃmbio e a integraÃÃo dos dois tipos de sistemas. As mÃdias digitais e as ferramentas da Web 2.0, por meio de plataformas colaborativas como o Moodle, possibilitam a comunicaÃÃo, interaÃÃo, colaboraÃÃo e formulaÃÃo coletiva dos conhecimentos, transformando os tradicionais papÃis de professores e alunos. Com base nesse cenÃrio, a pesquisa procurou identificar como as tecnologias digitais e as mediaÃÃes pedagÃgicas baseadas na co-autoria potencializam os saberes colaborativos - conhecimentos, habilidades e atitudes relacionadas à colaboraÃÃo - fundamentais para a aprendizagem ao longo da vida. A abordagem teÃrica procurou explorar teorias e pesquisas sobre colaboraÃÃo e aprendizagem colaborativa; definir o conceito de saberes colaborativos e eleger, entre estes, cinco mais fortemente aplicÃveis à dinÃmica colaborativa em programas de EAD: autonomia, comunicaÃÃo e compartilhamento, exploraÃÃo e resoluÃÃo de conflitos, engajamento colaborativo e verificaÃÃo e sÃntese. Buscou ainda reaver aspectos centrais da utilizaÃÃo das tecnologias digitais na EAD, como as caracterÃsticas das mÃdias digitais, integraÃÃo multimÃdia, hipertexto, interatividade, interfaces e Web 2.0. A pesquisa teÃrica destacou os aspectos teÃricos que norteiam o conceito de mediaÃÃo pedagÃgica como diÃlogo, elaboraÃÃo simbÃlica e cultural e possibilidade de comunicaÃÃo e crÃtica. A investigaÃÃo abordou os modelos de comunicaÃÃo relativos ao uso das tecnologias na educaÃÃo, com destaque para o modelo EMEREC e os conceitos de autoria e co-autoria nos processos de ensino e aprendizagem. A pesquisa de campo foi realizada na disciplina EducaÃÃo a DistÃncia, da FACED- UFC, de agosto a dezembro de 2007, utilizando a metodologia da etnografia virtual. A anÃlise de dados està organizada em trÃs categorias: saberes colaborativos, tecnologias digitais e mediaÃÃes pedagÃgicas esteadas na autoria e co-autoria. Os resultados indicam que os saberes colaborativos sÃo vivenciados e aprimorados em contexto de utilizaÃÃo de tecnologias digitais e de mediaÃÃes pedagÃgica baseadas na autoria e na co-autoria, que precisam ser aprimoradas. Indicam, tambÃm, que as ferramentas da web 2.0, ainda que insuficientemente exploradas, favorecem e induzem Ãs prÃticas colaborativas e que as mediaÃÃes pedagÃgicas baseadas na autoria e co-autoria requerem grande investimento na formaÃÃo docente. A pesquisa sugere a definiÃÃo de polÃticas pÃblicas em gestÃo e financiamento, acesso à internet das diversas camadas sociais e formaÃÃo docente voltada para aÃÃes crÃticas e autÃnomas. / The programs of distance learning that use digital technologies constitute pedagogical possibilities more and more frequent on the educational context. It is verified great expansion of experiences in distance learning that complement conventional systems, as well as the upcoming of hybrid forms of education that combine presence activities and distance activities, which promote the interchange e the integration of both systems. The digital media and the Web 2.0 tools, by collaborative platforms such as Moodle, possibilitate the communication, interactivity, collaboration and collective formulation of knowledge, transforming the traditional roles of teachers and students. Having this scenario as basis, the research tried to identify how the digital technologies and the pedagogical mediations based on co-authorship increases the collaborative knowledges - knowledge, abilities and attitudes related to collaboration - fundamental to life long learning. The theoretical approach tried to explore theories and researches about collaboration and collaborative learning; tried to define the concept of collaborative knowledge and to elect, among these, the five concepts most applicable to the collaborative dynamic in distance learning programs (EAD): autonomy, communication and sharing, exploration and resolution of conflicts, collaborative engagement and verification and synthesis. This study searched yet to retrieve central aspects of the use of digital technologies in EAD, such as digital media characteristics, hypertext, interactivity, interfaces and Web 2.0. The theoretical research highlighted the theoretic aspects that guide the concept of pedagogic mediation such as dialogue, symbolic and cultural elaboration and possibility of communication and critic. The investigation approached the relative communication models to the use of technologies in education, highlighting the EMEREC model and the concepts of authorship and co-authorship in the processes of distance teaching and learning. The field research was done in the discipline of Distance Education, of FACED-UFC, from august to December 2007, using the methodology of virtual ethnography. The data analysis is organized in three categories: collaborative knowledges, digital technologies and pedagogical mediations supported by authorship and co-authorship. The results indicate that the collaborative knowledges are lived and improved in context of use of digital technologies and pedagogical mediations based in authorship and co-authorship, which need to be improved. Indicate also that the Web 2.0 tools, although insufficiently explored, favors and induces collaborative practices and that pedagogical mediations based in authorship and co-authorship require great investment in docent formation. The research proposes the definition of public politics in management and financing, access to internet to different social segments and teacher formation towards critic and autonomy actions.

Bakgrund: Idag lever ca: 450 000 personer med diabetes i Sverige och det gör sjukdomen till en av de stora folksjukdomarna. Diabetes mellitus typ 1 är en kronisk autoimmun sjukdom och drabbar framförallt unga människor. I Sverige lever ungefär 7000 barn med sjukdomen och varje år insjuknar ca: 700 barn under 15 år. Detta gör sjukdomen till en av de vanligaste kroniska sjukdomarna hos barn i Sverige. Syfte: Syftet med denna litteraturstudie var att beskriva föräldrars upplevelse av att leva med ett barn (0–13 år) med diabetes mellitus typ 1. Samt att beskriva datainsamlingsmetoderna i de inkluderade artiklarna. Metod: En deskriptiv litteraturstudie som inkluderade 11 vetenskapliga artiklar varav nio artiklar av kvalitativ ansats, en av kvantitativ ansats och en mixad studie. Dessa analyserades objektivt av båda författarna. Sökningarna skedde i PubMed och Cinahl. Resultat: Resultatet visar att föräldrar upplevde en stor påfrestning och livsomställning när ens barn drabbades av diabetes. De upplevde en känsla av ständig oro och de hade svårt att överlåta ansvaret till någon annan. Stöd och information upplevdes som bristfällig vid olika situationer men ett diabetesteam eller en mentor upplevdes som positivt. Datainsamlingsmetoderna i de inkluderade artiklarna var till största delen intervjuer förutom en som tillämpat frågeformulär. Slutsatser: Föräldrar upplevde ständig oro, brist på stöd och information. Med rätt stöd och information skulle föräldrars oro minskas och det skulle även kunna stärka barnets egenvårdsförmåga. / Background: Today live about 450 000 people with diabetes in Sweden and it makes the disease one of the major diseases. Diabetes mellitus type 1 is a chronic autoimmune disease primarily affects young people. In Sweden live about 7000 children with the disease and fall ill every year approximately 700 children under 15 years. This makes the disease one of the most common chronic diseases in children in Sweden. Aims: The purpose of this study was to describe parents' experience of living with a child (0-13 years) with type 1 diabetes mellitus and to describe the data collection methods of the included articles. Methods: A descriptive literature study, which included 11 scientific articles, nine articles of qualitative approach, one quantitative and one mixed study. These were analyzed objectively by both authors. The searches took place in PubMed and Cinahl. Results: The results show that parents experienced stress and life adjustment when child get diabetes. They felt a sense of worry and they found it difficult to assign responsibility to someone else. Support and information perceived as flawed in different situations, but a healthcare team or a mentor perceived as positive. Data collection methods in the included articles were mostly interviews except one who applied the questionnaire. Conclusions: Parents experienced constant worry, lack of support and information. With the right support and information would reduce parents' anxiety and it could also strengthen the child's self-care ability.