台灣目前已邁入高齡化社會，因高齡人口持續攀升，面對中高齡者認知能力衰退，我們提議利用遊戲的方式進行注意力訓練。相較於一般以娛樂為主要目的的遊戲，悅趣化學習遊戲(Serious Game)是在遊戲設計除時以娛樂為目的外，另附加學習目標，這種遊戲設計方式常廣泛運用於教育、軍事、健康、都市規劃、宗教、工程與政治等領域上，以達成某種訓練或觀察目的。我們以心理學理論為基礎，透過悅趣化學習遊戲在平板電腦上設計了一個系統，邀請年長者分為兩組來擔任此一系統的受試者，並觀察使用我們所設計的遊戲系統前後其注意力變化的狀況。我們在此系統上進行了視覺搜尋(Visual Search)和注意力網絡作業(Attention Network Task, ANT)的前後測驗，並加入了自適應性(Adaptive)及導入干擾(Interference)以觀察受試者排除干擾的狀態。我們觀察此系統是否能影響測試者的認知能力與其影響的程度，並比較受試者之注意力在實驗前後變化是否因遊戲系統而改變。而經過實驗後共有21位高齡受試者完成所有實驗流程，實驗組的受試者經過分析後發現他們在視覺搜尋的在正確率以及在注意力網絡作業中的正確率、警覺性分數和導向性分數皆有顯著的改變，而在實驗後透過問卷調查另可發現高齡受試者對於遊戲學習亦是給予正面的回饋且有意願繼續使用。因此我們認為我們所設計的悅趣化學習遊戲系統能提升高齡受試者的使用意願並進而有效提升其注意力。 / Since the last decade, Taiwan has entered the aging society. However, the proportion of the elderly population has continued to increase in recent years. Our primary purpose is to use serious game as a means of training the attention of the elderly and delay the decline of cognition. Serious game has a primary purpose other than pure entertainment and has been used in the past for various applications such as national defense, education, scientific exploration, healthcare, emergency management, city planning, engineering, religion, and politics. Our goal in this work is to design a customizable serious game based on cognition psychology on the Android tablet PC platform for the elderly. We invited 21 elderly subjects to play the game and perform tests done before and after the playing. In the pre- and pro-tests, we adopted a Visual Search task and the Attention Network Task (ANT) tests to study how the proposed serious game can affect the cognition abilities, especially attention, of a subject. The experimental results reveal that the accuracy of visual search, accuracy of attention network test, scores of alerting and orienting of the participants in the experiment group have significantly improved after the trainings on the serious game system. We also have received positive feedback on the gameplay from the participants, which shows that the proposed system is well accepted and can serve as an effective means for cognition training.

研究目的 本研究的目的是要藉由線索暴露的實驗典範,探索長期使用安眠藥物 之患者對於安眠藥物相關刺激的注意力偏誤現象,並根據 Baker 及其同事們 (2004)與其他學者所提出的「藥物動機理論的情感模型」,強調負向情感在長 期使用安眠藥物的失眠患者所扮演的角色,本研究另欲探討長期使用失眠藥物的 患者是否在負向的情緒下能引發其對安眠藥物有更多的注意力及反應偏誤,並以 oddball 實驗典範來引發測量大腦皮質 ERP 波的注意力偏誤現象,並試圖以主觀 渴求問卷來測量個案是否在負向情感下有較強烈的主觀渴求反應。 方法 研究之有效樣本為 13 人。其中男性 5 人,女性 8 人,年齡介於 23-54 歲 (34.15 ± 11.07),參與研究之受試者會進行兩晚之實驗及多頻道睡眠生理檢查, 實驗情境分成基礎情境及挫折情境,在挫折情境中,受試者在進行較困難之認知 作業的同時,研究者會給予負向之指導語以進行情緒之操弄;而在基礎情境則給 予中性之指導語。在認知作業進行之後,開始進行線索暴露之 ERP 測量,受試 者須判斷圖片是否含有動物(目標刺激),另包含中性圖片刺激(96 張)、睡眠 相關刺激(32 張)及藥物相關刺激(32 張)。另外在認知測驗及線索暴露的前後 也會測量受試者之情緒狀態及主觀渴求狀態。研究分析以多變量變異數分析進行 檢驗。 結果 長期使用安眠藥物的患者相較於中性刺激,其對於藥物圖片刺激及睡眠相 關刺激皆有較大之 P300 及 SPW 腦波振幅。未在研究中驗證 Baker 等人提出之負 增強處理模式之因果關係,但發現,在基礎情境中,當受試者的正向情緒減少愈 多,受試者在單一題項渴求程度減少愈少;而負向情緒與其他的渴求指標較具有 相關性,研究發現當負向情緒增加愈多,單一題項渴求程度增加愈多,對藥物效 果的期待也愈高,對藥物的欲求與所帶來欣快感也會愈高,顯示情緒的改變於主 觀渴求狀態的相關性。此外本研究結果顯示客觀的腦波指標與部分主觀感受顯著 相關,其中 P300 與其對藥物的渴求程度呈正相關。 結論 無論是在基礎情境或挫折情境,長期使用安眠藥物之患者對安眠藥刺激及 睡眠相關刺激皆有注意力偏誤之現象,且此注意力偏誤現象與其對藥物的渴求程 度具有一定程度之相關性。在挫折情境中,受試者對藥物之主觀渴求有較大的傾向。 / Introduction The major goal of this study is to examine the phenomenon of craving in hypnotic use. The Affective Processing Model of Negative Reinforcement (Baker, Piper, McCarthy, Majeskie, & Fiore, 2004) suggests that negative affect would influence drug use through the change of cognitive process to a “hot information processing” and therefore increase the craving for drug use. The study explores the effects of negative affect on attentional bias and subjective craving associated with hypnotic use to test this model. Method Thirteen long-term hypnotic users were included in this study. They came to the sleep laboratory for two nights for an experimental night in which negative affect was induced by giving negative comments on their performance on a cognitive task and a control night with exactly the same procedure except that the negative comments was replaced by neutral comments. For both nights, craving was assessed with subjective ratings and measure of attentional bias with recording of event-related potentials (ERPs) induced by pictures related to hypnotic use, sleep and neutral pictures. Result The amplitude of P300 and SPW for sleep related pictures and hypnotic related pictures are significant larger than the amplitude for neutral pictures in both conditions. Also, results show that the picture of P300 are positively correlated with subjective craving for hypnotic drugs. Moreover, the data shows the tendency of condition difference in subjective craving. Conclusion The hypnotic long-term users do show attentional bias for sleep related and hypnotic related pictures. However, the result does not show more attentional bias for hypnotic related pictures in stressful situation. On the other hand, the data shows a tendency that the subjective craving is stronger in stressful situation than in baseline situation. The findings show only partial support for the Affective Processing Model of Negative Reinforcement.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第18841号 / 理博第4099号 / 新制||理||1589(附属図書館) / 31792 / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 正高 信男, 准教授 後藤 幸織, 教授 岡本 宗裕 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

京都大学 / 0048 / 新制・課程博士 / 博士(人間･環境学) / 甲第20721号 / 人博第830号 / 新制||人||199(附属図書館) / 29||人博||830(吉田南総合図書館) / 京都大学大学院人間・環境学研究科共生人間学専攻 / (主査)教授 齋木 潤, 教授 月浦 崇, 教授 小村 豊 / 学位規則第4条第1項該当 / Doctor of Human and Environmental Studies / Kyoto University / DGAM

京都大学 / 新制・課程博士 / 博士(文学) / 甲第24332号 / 文博第906号 / 新制||文||727(附属図書館) / 京都大学大学院文学研究科行動文化学専攻 / (主査)准教授 森口 佑介, 教授 黒島 妃香, 特定講師 上田 祥行 / 学位規則第4条第1項該当 / Doctor of Letters / Kyoto University / DFAM

京都大学 / 新制・課程博士 / 博士(法学) / 甲第24863号 / 法博第296号 / 新制||法||179(附属図書館) / 京都大学大学院法学研究科法政理論専攻 / (主査)教授 塩見 淳, 教授 髙山 佳奈子, 教授 安田 拓人 / 学位規則第4条第1項該当 / Doctor of Laws / Kyoto University / DFAM

本研究探討高齡者在視覺搜尋作業中，其由上而下（Top-down）與由下而上（Bottom-up）的注意力運作對於情緒刺激的反應，是否會因為注意力功能退化而與年輕成人的表現不同。過去研究指出，雖然高齡者注意力功能衰退，但是高齡者的由上而下注意力運作，仍可以幫助高齡者的表現。為了解由上而下注意力運作是否對於高齡者的反應有所幫助，本研究以兩個實驗分別探討內因與外因線索以及操弄訊息量所造成的影響。 實驗一包括80％有效的內因線索與25％有效的外因線索兩階段，外因線索階段為由下而上注意力運作，內因線索階段則為由上而下注意力運作，獨變項為年齡（高齡者、年輕成人）、情緒（生氣、快樂）以及線索有效情況（有效線索、中性線索、無效線索），記錄反應時間與正確率。實驗二的兩階段使用不同訊息量的外因線索（80％有效比例為高訊息量、25％有效比例為低訊息量），其餘操弄都與實驗一相同，低訊息量為單純的由下而上注意力運作，而高訊息量兼具由下而上與由上而下注意力運作。 研究結果發現，兩實驗高齡者與年輕成人都對於生氣情緒反應較快，符合威脅優勢。高齡者較年輕人更需要借助由上而下的注意力運作幫助反應，高訊息量的線索對於高齡者幫助也較年輕成人大。另外，實驗一增益效果的結果顯示，有效線索在高齡者搜尋生氣臉孔幫助較大，在年輕成人則搜尋快樂臉孔幫助較大，但是實驗二結果則顯示，有效線索在高齡者與年輕成人搜尋快樂臉孔的幫助都較生氣臉孔大，兩實驗的年齡與情緒的交互作用結果不同可能與高齡者異質性有關。由研究結果可知，由上而下注意力運作對於高齡者在情緒臉孔反應有幫助，在未來實務上，可以多運用由上而下注意力運作的線索幫助高齡者反應。 / This research is aim to understand attention in visual search of emotional faces in aging. Two types of attention process, that is top-down and bottom-up attention, were concerned in this study. In past researches, there are empirical evidences showing age-related declination in attention function, especially in bottom-up attention. But top-down attention is still playing an important role in doing task for the older adults. In order to understand the effect of top-down attention in aging, two experiments using endogenous or exogenous spatial cues were designed. Participants have to respond whether there is a different emotional face or not in a visual search task. The independent variables are age（aging and young）, emotional face（happy and angry）, and cue（valid, neutral, and invalid）. Dependent variables are reaction times and accuracy. In Experiment 1, there are two stages: 80％ valid endogenous cues and 25％ valid exogenous cues. The endogenous cues stage and exogenous cues stage were designed to probe top-down attention and bottom-up attention, respectively. In Experiment 2, there are two stages: 80％ valid exogenous cues（highly informative cues）and 25％ valid exogenous cues（non-informative cues）. Using highly informative exogenous cues involve both top-down and bottom-up attention. In contrast, non-informative exogenous cues only trigger bottom-up attention. The major results of this study support threat advantage hypothesis that both older and young adults respond to angry face target quicker than happy face. Benefit from top-down attention was larger in older adults than young adults. Highly informative cues help older adults more in searching emotional faces than young adults. The cuing effects in two emotional face conditions were different between Experiment 1 and 2. This inconsistent result maybe relates to aging heterogeneity. In conclusion, top-down attention can help older adults search for emotional faces.

為了探討注意力與年齡因素對計時行為的影響，本實驗選用事前知道計時派典（prospective paradigm）與不涉及人為時間單位之知識的計時複製方式。針對注意力的因素，本研究採用雙重作業以操弄注意力資源集中或分散，檢測其對計時作業的影響。另針對年齡的因素，本研究比較低年級小學生、高年級小學生、及大學生成人三種不同年齡組的受試。 本研究利用四種計時作業，針對三個不同年齡層的受試進行對兩種不等的時距計時資料收集。計時作業及年齡因子的實驗設計採受試者間設計，而時距因子則採受試者內設計。研究結果發現（1）低年級組的計時準確性較高年級組或成人組差；（2）受試在雙重作業的計時表現的確較單一作業差，這個計時受干擾的結果，在複雜的雙重作業又較在簡單雙重作業明顯，且年紀愈小的受試所受干擾影響愈大；（3）三年齡層受試在雙重作業中皆有低估目標時距的現象，其中以低年級在複雜雙重作業中的低估程度最明顯；（4）低年級組的計時能力之穩定性較高年級或成人組低；（5）在無需對不斷出現之無意義刺激作偵測反應時，三年齡受試的計時準確性未受影響。 這些結果顯示計時的誤差的確隨著注意力需分派於非時間作業的增加，受試所複製的時距也隨之縮短。這項由於注意力分散所致的計時誤差在國小低年級組最明顯，但隨著年齡的成長及腦發展愈臻成熟，這項影響效果愈趨式微，致使計時的表現愈正確。 關鍵詞：時間複製、年齡與發展、雙重作業、注意力、小學生、純量計時 / The purpose of this study was to investigate the effects of the attention and age on time estimation based on the prospective timing paradigm. Four timing tasks, with different degrees of attentional requirement, were utilized to test timing of reproducing the target intervals in three groups of different ages including the lower-grade (M= 7.5 years), higher-grade (M= 11.2 years) elementary school students and adult (M= 20.1 years). The subjects in this work were asked to estimate a stimulus duration lasting for 7 or 14 s, during which they are required to either do or do not perform a concurrent non-temporal task. Thus, the experimental design for the present study was mixed with between-subject factors (age and task) and a within-subject factor (target interval). The results showed (1) the lower-grade children performed less accurate than the higher-grade children; (2) all subjects had worse timing performance in the dual-task condition than the single-task or control condition, which effect was most evident in the lower-grade children; (3) all subjects reproduced shorter interval as compared to the target interval, which effect was most apparently observed from the dual-task for the lower-grade children; (4) the lower-grade children had less reliability in timing; and (5) the effect of age on the single-task and control condition is not significant. Together, these data indicate that concurrent non-temporal task cause temporal reproduction shorter, especially under high attention demand in lower-grade children. In addition to the influence by the task complexity, the accuracy of timing estimation depends on the age. Keywords: time reproduction、age and development、dual task、attention、elementary school student、Scalar expectancy theory(SET)

面為基階段在視覺處理歷程中扮演重要角色，面表徵是高於視網膜影像的視覺表徵，本研究目的在於探討以「面表徵」為選擇基礎之注意力運作。參考過去研究者所採用的面材料，本研究改為同時呈現二個交叉斜面並進行線索提示作業，以同面優勢效果作為面為基注意力運作之指標。 本研究分成四項實驗，每項實驗皆由兩個子實驗構成，此二個子實驗分別使用「外因性線索提示作業」與「內因性線索提示作業」探討面為基注意力的運作。實驗一利用上述「面」的設計及兩種提示作業，得同面優勢效果，反映面為基注意力的運作參與其中。實驗二目的在於排除注意力根據「可能目標的斜度」進行選擇之混淆，因此將面改為擁有相同斜度且互相平行的二個斜面。注意力若根據可能目標的斜度進行選擇，則無法得同面優勢效果。結果顯示在實驗二的兩種提示作業中，仍得同面優勢效果。實驗三目的在於排除可能目標因空間排列而形成簡單的知覺組織，繼而影響注意力分配之可能性。結果顯示在外因性線索提示作業下，仍得同面優勢效果；在內因性線索提示作業下，SOA需延長至500毫秒，才展現同面優勢效果。實驗四則進一步確認在不同SOA下，面為基注意力的運作情況，結果發現：在外因性線索提示作業下，SOA為500毫秒展現同面優勢效果；內因性線索提示作業下， SOA為1000毫秒下展現同面優勢效果。 綜合而言，在外因性線索提示作業與內因性線索提示作業下皆得到同面優勢效果。當可能目標難以群聚後，在長SOA時距下，依然展現同面優勢效果。因此本研究的結果，對於面為基注意力提供了直接的支持證據。 / Surface-based stage plays an important role in visual information process. Surface representation means the representation that goes beyond 2-D image representation. The purpose of this study is on the exploration of attentional selection which is based on surface representation. Referring to the surface material used before, this study adopted two interlacing slant surfaces structured by random-dot stereogram to test the effect of “same-surface advantage”. There are four experiments and each experiment includes two sub-experiments which are exogenous cuing task and endogenous cuing task, respectively. In Experiment 1, the same-surface advantage was revealed. In Experiment 2, the confounding of “slant” was ruled out and the same-surface advantage was still kept. In Experiment 3, we reduced the possibility that candidate targets group together to form simple perceptual organization and then influence the allocation of attention. After rearrange the spatial positions of candidate targets, attention cannot select the simple perceptual organization easily. In exogenous cuing task, same-surface advantage was still revealed. In endogenous cuing task, SOA should be prolonged to 500ms, and it shows same-surface advantage. Furthermore, in Experiment 4, we manipulate three kinds of SOA and confirm the operation of surface-based attention. We found that in exogenous cuing task, SOA should be prolonged to 500ms, and it shows same-surface advantage.In endogenous cuing task, SOA should be prolonged to 1000ms, and it shows same-surface advantage. In conclusion, it shows same-surface advantage in exogenous cuing task and endogenous cuing task. When candidate cannot group together to be selected easily, SOA should be prolonged to longer, and it still shows same-surface advantage. The results provide the direct support evidences of surface-based attention.

研究目的 失眠的過度激發是目前最廣為接受的失眠病因之一。無論在生理、認知、行為三不同層面上，多可觀察到失眠者有身心過度激發的狀態。根據失眠三因子模式，不同失眠病程階段，影響過度激發的背後成因有所差異。在慢性失眠部分，過 去累積了相當多的實證研究證實其過度激發的現象，但尚未進入慢性病程前之過度激發相關機轉，仍有待研究進一步探討。本研究嘗試以橫斷式的研究方法，並依據過去失眠病因發展推導，選擇從壓力反應特性 (包含壓力操弄後的壓力反應強度和 消退速度)、注意力偏誤 (包含警覺性注意力和注意力移除困難)、與睡前的睡眠監控行為三個面向切入，探討不同病程階段個體過度激發的背後機轉，並進一步檢驗上述之差異是否可用以預測在壓力操弄情境下，不同病程個體睡前的激發反應變化，藉此檢驗失眠病程發展之病因假說，並希望未來可據此發展有效之失眠防治與介入策略。 研究方法 本研究共計招募受試者 58 人，年齡介於 24-48 歲，包含符合 ICSD-3 慢性失眠者 18 人，以及以壓力下失眠反應量表( Ford Insomnia Response to Stress Test; FIRST)區分出急性失眠高危險組 19 人與低危險組 21 人。每位受試者皆需到睡眠實驗室進行兩階段的實驗，第一階段包含晤談評估、問卷填答、壓力反應的生理測量(以指溫與膚電為指標)、與包含威脅與睡眠刺激之點偵測注意力作業，之後需配戴腕錶與記錄睡眠日誌配合充足且規律作息一週後，再到睡眠實驗室進行第二階段的評量，包含睡前 2 小時、1 小時、關燈前生理指標 (指溫、膚電) 與腦波的測量和主觀身心激發狀態 (Pre-Sleep Arousal Scale, 簡稱 PSAS) 評量，於睡前填寫睡眠相關監測指標 (Sleep Associated Monitoring Index，簡稱 SAMI)，並完成一晚的 PSG 測量以排除其他睡眠相關疾患。 研究結果 首先，以單因子變異數分析比較不同組別間在壓力反應與回復和二因子變異數分析注意力警覺/移除困難指標的差異。在壓力生理反應表現上，慢性失眠組與高危險組在接受壓力操弄後的激發消退時間較低危險組來得長。在注意力層面，高危險組對壓力(威脅圖片) 刺激有顯著的警覺與移除困難注意力偏誤，慢性失眠組則是對睡眠刺激有顯著的移除困難注意力偏誤。在行為層面，慢性失眠組與高危險組睡前的注意力監控行為 (包含監測自身身體感覺訊息是否與入睡狀態不一致、鬧鐘 時間、環境) 均顯著較低危險組來得多。再者，以皮爾森相關探討注意力偏誤與睡前激發反應之關聯性，結果顯示高危險組的注意力偏誤現象與睡前高頻腦波與主觀生理激發的降幅呈現顯著負相關; 而慢性失眠組的注意力偏誤指標卻與膚電、主觀認知激發的降幅呈顯著正相關。 結論 本研究結果支持不同失眠病程背後的過度激發影響機制有所差異，生理層面較慢的激發消退能力與對壓力源的認知偏誤的前置因子，可能為急性失眠者易受日常壓力源誘發睡眠困擾之原因；而影響慢性失眠族群的持續因子主要在於其將睡眠視 為壓力源的認知歷程與行為轉變。此外，研究更進一步發現兩組分別對於壓力與睡眠的注意力轉移困難，使其在覺察壓力後易持續表現出過度激發現象。本研究結果除支持失眠過度激發理論之外，更釐清不同階段失眠的認知歷程的機制，並彰顯不 同失眠病程介入策略應有所差異，和急性失眠高危險族群及早介入預防之重要性。 / Introduction Hyperarousal has been recognized to be a major etiological factor of chronic insomnia. Cumulated research evidences have demonstrated that chronic insomnia patients are hyperaroused in somatic, cognitive, and behavioral aspects. According to Spielman’s 3P Model of Insomnia, there were different factors are involved at different points during the course of insomnia. However, there are seldom study to investigate the difference mechanism of hyperarousal in the course of the development of insomnia. The present study used cross-sectional design to compare the difference of good sleeper (low sleep vulnerability, LV), acute insomnia (high sleep vulnerability, HV), and chronic insomnia (CI) in stress reaction (eg. reactivity and recovery), attentional bias (eg. vigilance and disengagement), and sleep associated monitoring behaviors to investigate the underlying mechanism of hyperarousal. Furthermore, the study examined the correlation between attentional bias indices and subsequent pre-sleep arousal to investigate the impact of attentional bias on sleep in different groups. Method The present study recruited fifty-eight subjects, aged between 24-48. They included eighteen chronic insomniacs (CI) diagnosed ICSD-3, nineteen healthy individuals scoring high (HV) and twenty-one healthy individuals scoring low (LV) on the Ford Insomnia Response to Stress Test (FIRST). All subjects visited sleep lab twice. During the first visit, the subjects filled in a package of questionnaires, and went through psychophysiological recording (including) of stress reaction, and a visual dot-probe task. They then were required to keep a sleep log and wear actigraphy at home for one-week to make sure they followed a regular sleep schedule. During the second visit, subjects went through a pre-sleep physiological recording (including peripheral temperature, skin conductance, and EEG) and filled in two questionnaires (Pre Sleep Arousal Scale [PSAS] and Sleep Associated Monitoring Index[SAMI]) at three time points and had a PSG recording to screen for sleep disorders. Result One-way ANOVAs were conducted to compare the differences of stress reaction/recovery among three groups. Two-way ANOVAs were used to compare the differences in attentional bias (vigilance/ disengagement) of threatening and sleep-related stimulus among three groups. In stress related physiological activity, CI and HV showed slower recovery rate than LV. Considering attentional bias, HV had significant vigilance and disengagement bias to threatening pictures, and CI had significant disengagement bias to sleep-related pictures. CI and HV also showed more prevalent sleep-associated monitoring behaviors than LV. Furthermore, Spearman’s correlation was used to examine the association between attentional bias and pre-sleep arousal. The result shows the attentional bias of HV had negative correlation with reduction of high frequency EEG and somatic sub-score on the PSAS. In contrast to our prediction, CI showed positive correlation between decrease of skin conductance and the cognitive sub-score on the PSAS. Conclusion The study showed that stress recovery ability and stress-related attentional bias were the major differences between individuals with low and high sleep vulnerability, indicating that increased information processing to threats and stress-related stimulus as well as decreased recovery ability of autonomic arousal in reacting to stress may predisposed an individual to stress-related sleep disturbances. On the other hand, the attention shift from threat toward sleep can differentiate chronic insomnia from those individual with frequent acute insomnia. Moreover, the difficulty in disengagement from sleep-related stimulus, rather the vigilance, might explain the cause of hyperarousal that perpetuate insomnia. The results support the transition of arousal from general treat to sleep-related stimulus in the development of chronic insomnia. The study not only further the understanding of the etiological mechanism of insomnia, but also imply that different strategies should be applied in the treatment of acute and chronic insomnia. It also highlights the importance of preventive intervention for individuals with high sleep vulnerability