The purpose of this study was to investigate the statistical literacy of 8th grade students and their attitudes towards statistics. Moreover, the relationship between their statistical literacy and attitudes towards statistics was examined. The study was conducted in Yenimahalle district of Ankara in the Spring semester of 2011-2012 academic year. The sample of this study was obtained through cluster random sampling. Nine schools were randomly selected for the study. A total of 1074 eighth grade students in these schools participated. The scales used in the data collection were Statistical Literacy Test (SLT) adapted from Probability Attitudes Scale previously developed for Turkish students (Bulut, 1994) and Attitude towards Statistics Questionnaire (ATSQ) developed by the researcher based on Watson&rsquo / s (1997) three tier framework. The analysis of the mean scores of statistical literacy in terms of content domains revealed that although sample, graphs, and chance contents had closer mean scores to each other which was around moderate value / average, inference, and variation content domains had lower mean scores. A one-way within subjects ANOVA indicated that there were significant differences between Tier 1, Tier 2 and Tier 3 aspects of statistical literacy. The pairwise comparisons indicated that students performed lowest in third tier of statistical literacy where students were required to evaluate inappropriate statistical claims. Although, students performed slightly higher in the first tier where they showed their ability in understanding statistical terminology / their performance was the highest in the second tier which was interpreting statistical claims in context. Eighth grade students&rsquo / attitudes towards statistics were positive with a mean score of 3.52 in five point scale. The correlation analysis indicated that there were positive and significant relationship between students&rsquo / attitudes towards statistics and statistical literacy scores.

This study includes examination of the machinability characteristics of two medium carbon steel types (SAE 1040 and SAE 1050) as a result of spherodizing treatment. Both steel types were handled into four categories according to their spherodizing treatment parameters (temperature and time). Microstructural investigation, hardness and ultrasonic sound velocity measurement (with both longitudinal and transverse waves) of these steels were performed, and effect of applied heat treatments on microstructure, hardness and ultrasonic sound velocity was investigated. Pulse-echo method has been used for ultrasonic sound velocity measurements, and measurements were performed with 5 and 10 MHz longitudinal and 5 MHz transverse wave probes. Tool life criterion was used for determining the machinability characteristics of the steels. For this purpose, flank wear land measurements were performed on the cutting tools. Results have showed that, by appliying heat treatment it is possible to change the microstructure, hardness, ultrasonic sound velocity and machinability characteristics of a steel.

The aim of this study is to present a design approach for compliant bistable four-link mechanisms. The design constraints are the two positions of the mechanism, the force required to snap between the positions and the fatigue life of the designed mechanism. The theory presented here will be applied to the door lock mechanism used in commercial dishwashers, which is originally designed as a rigid inverted slider crank mechanism snapping between two positions with the force applied by a spring. The mechanism is re-designed as a compliant bistable four-link mechanism and a prototype has been manufactured.

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Die Anwendung von Hochintensitätslasern zur Beschleunigung von Teilchen bietet eine Alternative zu klassischen Teilchenbeschleunigern und den von diesen erzeugten Strahlenqualitäten. Nach großen Fortschritten auf dem Gebiet der Laser-Teilchenbeschleunigung wurde die Anwendung der neuen Technologie in der klinischen Ionentherapie vorgeschlagen und diskutiert. Bevor es dazu kommen kann, muss aber neben der Verbesserung der Strahleigenschaften, wie z. B. der Erhöhung der Energie, und der Stabilität der Teilchenbeschleunigung auch eine geeignete physikalische und dosimetrische Charakterisierung entwickelt und die biologische Wirksamkeit dieser neuartigen, ultrakurz gepulsten Strahlenqualität mit extrem hoher Pulsdosisleistung untersucht werden. Dies erfordert eine ganze Reihe von umfangreichen Experimenten der notwendigen Translationskette, angefangen von in vitro Zellbestrahlungen über in vivo Studien bis hin zu präklinischen Untersuchungen und ersten klinischen Studien. Hierzu wurden das Verbundprojekt onCOOPtics gegründet und in einem ersten Schritt in vitro Zellbestrahlungen zur Untersuchung der biologischen Wirksamkeit laserbeschleunigter Teilchen durchgeführt. Dazu wurden Dosis-Effekt-Kurven für humane Tumor- und Normalgewebs-Zelllinien jeweils für mehrere biologische Endpunkte bestimmt. Begonnen wurde dabei mit der umfangreichen Untersuchung laserbeschleunigter Elektronen am JeTi-Lasersystem in Jena, auf welche zum Zeitpunkt der Verfügbarkeit des DRACO-Lasersystems in Dresden die dosimetrische und strahlenbiologische Charakterisierung laserbeschleunigter Protonen an diesem Lasersystem folgte. Dabei stellte die Entwicklung einer präzisen Dosimetrie zur Bestimmung der applizierten Dosis aufgrund der Strahleigenschaften laserbeschleunigter Teilchen eine große Herausforderung dar. Sie ist aber sowohl im Hinblick auf eine spätere klinische Anwendung als auch für die Durchführung quantitativer strahlenbiologischer Experimente obligatorisch. Diese Arbeit, die im Rahmen des Verbundprojektes entstanden ist, leistet dazu in vielfacher Hinsicht einen wesentlichen Beitrag: Erstens wurden geeignete Detektoren zur präzisen dosimetrischen Charakterisierung laserbeschleunigter Elektronen und Protonen entwickelt, optimiert und charakterisiert sowie präzise kalibriert. So wurden umfangreiche Studien zu verschiedenen Eigenschaften der auch in der klinischen Dosimetrie angewandten radiochromischen Filme durchgeführt und die Filme entsprechend kalibriert. Dabei wurden neue Erkenntnisse u. a. über deren Energieabhängigkeit gewonnen, die für zahlreiche Anwendungen der Filme von Bedeutung sind. Weiterhin wurden verschiedene Ionisationskammern zur Echtzeit-Strahlmonitorierung von laserbeschleunigten Elektronen und Protonen ausgewählt und dosimetrisch charakterisiert. Zudem wurde der Einsatz von CR-39 Festkörperspurdetektoren zur spektroskopischen Untersuchung laserbeschleunigter Protonen etabliert, indem die Nachverarbeitung und Auslesung der Detektoren charakterisiert und optimiert wurden und außerdem eine retrospektive Filterprozedur der detektierten Krater entwickelt und angewendet wurde. Ferner wurde ein Faraday Cup, der auf die speziellen Eigenschaften derzeitiger laserbeschleunigter Protonen-Strahlenqualitäten abgestimmt ist, entwickelt, charakterisiert und mit drei voneinander unabhängigen Methoden kalibriert. Die radiochromischen Filme und der Faraday Cup konnten daraufhin als Referenzdosimeter sowohl an den konventionellen als auch an den neuartigen Laser-Teilchenbeschleunigern erfolgreich eingesetzt werden. Zweitens bildete die durchgeführte Echtzeit- und Referenzdosimetrie laserbeschleunigter Elektronen die Grundlage für die weltweit ersten systematischen Zellbestrahlungsexperimente dieser Strahlenqualität. Dabei konnten trotz großer Pulsdosisschwankungen alle Anforderungen bezüglich Dosishomogenität, Strahlstabilität, präziser Deposition einer vorgegebenen Dosis und Unsicherheit der bestimmten applizierten Dosis, die für eine quantitative Auswertung der radiobiologischen Daten notwendig sind, erfüllt werden. Exemplarisch sei die bestimmte Gesamt-Dosisunsicherheit von unter 10% genannt. Drittens wurden auch laserbeschleunigte Protonen so präzise dosimetrisch monitoriert und charakterisiert, dass auch mit dieser Strahlenqualität quantitative strahlenbiologische Untersuchungen durchgeführt werden konnten. Herausgefordert durch die kurze Reichweite der Protonen im Submillimeterbereich und das breite Energiespektrum dieser Strahlenqualität, gelang dies neben der Charakterisierung und Kalibrierung der einzelnen Detektoren durch die Konzeption und Realisierung eines integrierten Dosimetrie- und Zellbestrahlungssystems (IDOCIS).Weltweit erstmalig wurde eine Echtzeit-Strahlmonitorierung während der Zellbestrahlungen mit laserbeschleunigten Protonen durchgeführt, die sowohl zur kontrollierten Applikation einer vorgegebenen Dosis und zur Strahlüberwachung als auch zusammen mit der durchgeführten Referenzdosimetrie zur hochpräzisen Bestimmung der absolut in den Zellen deponierten Dosis diente. Außerdem trug die parallele und redundante Verwendung zweier voneinander unabhängiger Referenzdosimetrie-Systeme erheblich zur Erreichung einer hohen Zuverlässigkeit und Sicherheit bei. Die Unsicherheit in der bestimmten deponierten Dosis betrug entsprechend für den Endpunkt der residualen DNS-Doppelstrangbrüche 24h nach Bestrahlung, für den eine vollständige Dosis-Effekt-Kurve ermittelt wurde, nur ca. 10%. Die Unsicherheit liegt damit schon fast in dem Bereich, der an klinisch angewandten Beschleunigern zulässig ist (3-5%). Dagegen konnte zu Beginn dieser Arbeit die Dosis laserbeschleunigter Protonen nur mit einer Ungenauigkeit von mehr als 50% abgeschätzt werden. Viertens wurden die zur Bestimmung der relativen biologischen Wirksamkeit notwendigen Vergleichsbestrahlungen mit konventionellen Elektronen- und Protonenstrahlenquellen und die zur Vergleichbarkeit der konventionellen und laserbeschleunigten Strahlenqualitäten erforderlichen Referenzbestrahlungen mit 200kVp Röntgenröhren im Rahmen dieser Arbeit ebenfalls dosimetrisch optimiert und genau charakterisiert. Die dosimetrischen Ergebnisse der vorliegenden Arbeit waren eine notwendige Voraussetzung für die im Rahmen anderer Arbeiten vollzogene strahlenbiologische Auswertung der durchgeführten Zellbestrahlungen. Dabei wurde insgesamt kein signifikanter Unterschied in der strahlenbiologischen Wirksamkeit zwischen laserbeschleunigten, ultrakurz gepulsten und konventionellen, kontinuierlichen Strahlenqualitäten weder für Elektronen noch für Protonen festgestellt. Durch die Konsistenz dieser Ergebnisse für beide Teilchenarten und unterschiedliche biologische Endpunkte ist damit die nächste Stufe auf dem translationalen Weg hin zur klinischen Anwendung laserbeschleunigter Teilchen begehbar: Die Durchführung von in vivo Untersuchungen. Dabei muss zwar von einer zweidimensionalen (Zell-Monolayer) auf eine dreidimensionale Zielvolumenbestrahlung (Tumor) übergegangen werden, wobei aber die im Rahmen der vorliegenden Arbeit entwickelten Dosimetrieverfahren und Detektoren auch bei den Tierbestrahlungen angewendet und eingesetzt werden können. / The application of high-intensity lasers for particle acceleration provides an alternative to conventional particle accelerators and also alternative beam qualities. Soon after the recent progress in the field of laser particle acceleration, its application in clinical ion therapy was proposed and discussed widely. Besides the improvement of the beam properties (increasing of beam energy and stability of particle acceleration process, e. g.) a capable physical and dosimetric characterization has to be developed before the technology can be applied in cancer therapy. The same is true for investigation of the biological effectiveness of this new, ultra-short pulsed beam quality with extremely high pulse dose rate. Hence, the whole translational chain, beginning from in vitro cell irradiation over in vivo studies to the point of preclinical investigations and first clinical trials, is necessary. For this reason, in a first step the joint research project onCOOPtics was founded and in vitro cell irradiation experiments were performed to study the biological effectiveness of laser accelerated particles. Therefore, dose-effect-curves for tumor and normal tissue cell lines were determined for different biological endpoints. Starting with extensive experiments with laser accelerated electrons at the JeTi laser system in Jena, the investigations were continued with dosimetric and radiobiological characterization of laser accelerated protons at the DRACO laser system in Dresden shortly after the DRACO laser started its operation. In this process, the development of a precise dosimetry for determination of the applied dose posed a great challenge due to the beam properties of laser accelerated particles. However, this is a crucial and compulsive requirement for both, the future clinical application and also for the realization of quantitative radiobiological experiments. Compiled in the onCOOPtics framework, this paper contributed to this task in multiple key aspects: Firstly, capable detectors for precise dosimetric characterization of laser accelerated electrons and protons were developed, optimized and characterized as well as precisely calibrated. Thus, comprehensive investigations were performed studying different properties of radiochromic films which are also applied in clinical dosimetry. In addition, these films were precisely calibrated for different beam qualities. Thereby, new findings of the energy dependence of radiochromic films were obtained which are of importance for numerous applications of these films. Moreover, different ionization chambers for real-time beam monitoring of laser accelerated electrons and protons were selected and characterized. Furthermore, the application of CR-39 solid state track detectors was established for spectroscopic investigations of laser accelerated protons by characterizing and optimizing the postirradiation processing and the readout of the detectors. Also a retrospective filter procedure of the detected tracks was developed and applied. Moreover, a Faraday Cup adjusted to the special properties of current laser accelerated proton beam qualities was developed, characterized and precisely calibrated by means of three independent calibration methods. Finally, the radiochromic films and the Faraday Cup could be used as reference dosimeters both for conventional accelerators and also for novel laser particle accelerators. Secondly, the performed real-time and reference dosimetry of laser accelerated electrons was the prerequisite of the first systematic cell irradiation experiments with this beam quality worldwide. Despite high pulse dose fluctuations, all requirements were satisfied concerning dose homogeneity, beam stability, precise deposition of a prescribed dose and uncertainty of the applied dose, that are all necessary for a quantitative evaluation of the radiobiological data. Exemplary, a total dose uncertainty below 10% was reached. Thirdly, laser accelerated protons were precisely monitored and characterized allowing quantitative, well-founded radiobiological investigations with this beam quality. This task was very much challenged by the short range of the protons in the sub-millimeter range and the broad energy spectrum of the beam quality. It was succeeded not only due to the comprehensive characterization and precise calibration of the different detectors but also due to the conception and realization of an integrated dosimetry and cell irradiation system (IDOCIS). For the first time, a real-time beam monitoring during cell irradiation with laser accelerated protons was performed. This real-time monitoring was not only used for controlled application of the prescribed dose and beam monitoring and also – together with the performed reference dosimetry – for precise determination of the deposited dose at cell location. In addition, high reliability and safety was considerably ensured by using two independent reference dosimetry systems in parallel. Hence, the determined uncertainty of the deposited dose was only about 10% for the biological endpoint of the residual DNA double strand breaks 24h after irradiation. For this endpoint a complete dose-effect-curve was obtained. Therefore, the achieved uncertainty is almost as small as necessary at clinically applied accelerators (3

This thesis examines the rationale behind the work of Thomé H. Fang 方東美 (Fang Dongmei, 1899-1977) and Tang Junyi 唐君毅 (1909-1978), two of the most important Confucian thinkers in twentieth-century China, who appropriated aspects of the medieval Chinese Buddhist school of Huayan to develop a response to the challenges of ‘scientism’, the belief, widespread in their times, that quantitative natural science is the only valuable part of human learning and the only source of truth. As the status of Confucianism in China had declined from the mid-nineteenth century, non-Confucian ideas were appropriated by Chinese thinkers for developing responses to ‘scientism’, adopting the principle of fanben kaixin 返本開新 (going back to the origin and developing new elements). Buddhist ideas from a range of schools played an important role in this. Unlike other thinkers who turned to the schools of Consciousness-Only and Tiantai, Fang and Tang, for reasons of their own, saw the thought of the Huayan school as the apex of Buddhism and so drew on selected aspects to support and develop their own views. Fang regarded Huayan thought as a fine example of the idea of ‘harmony’, since in its vision of the perfect state all phenomena co-exist without contradiction. Interpreting the explanation of this given by Dushun 杜順 (557-640) in his own way, Fang argued that human beings are able to integrate physical, biological and psychic elements of the ‘natural order’ with values such as truth, beauty and goodness which belong to the ‘transcendental order’. He thus proposed that scientism’s view of humanity as matter could be incorporated without contradiction but also without excluding ‘non-scientific’ aesthetic, moral and religious values. By contrast, Tang stressed the characteristics of Huayan’s theory of ‘doctrinal classification’, as developed by Fazang 法藏 (643-712). Interpreting this to mean that different ideas could be applicable in different periods, Tang argued that the worldview of ‘scientism’ may indeed help solve problems in its own sphere, such as the desire for scientific development. Other paradigms, however, are preferable in discussing moral issues. In other words, this Buddhist theory allowed him to claim that both Confucianism and ‘scientism’ have their own value. Neither of them should be negated in principle. I argue that Fang’s and Tang’s selective appropriations of Huayan thought not only paid heed to the hermeneutical importance of studying ancient texts in order to be more responsive to modern issues, a concern hotly debated in the field of Chinese philosophical studies, but also helped confirm the values of Confucianism under the challenge of ‘scientism’. In short, by absorbing ideas from Huayan thought, both Fang and Tang, to different extents and in different ways, provided responses to the challenge of ‘scientism’ which gave a place to science without rejecting the importance of human faculties such as aesthetic appreciation and moral judgment or asserting the dominance of perception and cognition over other human faculties, the ultimate cause, as they saw it, of ‘scientism’.

Orientador: André Leonardo Chevitarese / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciências Humanas / Made available in DSpace on 2018-08-24T06:57:00Z (GMT). No. of bitstreams: 1 Guerra_LolitaGuimaraes_D.pdf: 3272234 bytes, checksum: bc2f37f5088831937e035ad9b21cb6f3 (MD5) Previous issue date: 2014 / Resumo: Os Hieroì Lógoi de Élio Aristides, compostos ca. 170 da Era Comum, constituem uma narrativa autobiográfica dedicada a Asclépio, cujo santuário, em Pérgamo, foi frequentado pelo autor ao longo de sua vida. Este, ao voltar-se em direção ao deus em busca de suas famosas curas praticadas por meio de sonhos, é transformado em meio a uma relação de favorecimento e intimidade com Asclépio que, em última instância, identifica-o a ele. Essa identificação, dada a ver no corpo de Aristides e por ele sentida é atravessada por valores paradoxais e inapreensíveis do ponto de vista de uma elaboração sistemática. Ela é entendida, assim, como uma iniciação mistérica, a qual dialoga com a cultura material de Asclepeia como os santuários de Pérgamo e o de Epidauro. Nesses espaços circulam sentidos e práticas cuja dinâmica resulta, não apenas, na produção da própria materialidade, como dos indivíduos que, no ocupar-se dela, são também constituídos. Esta relação circular com o mundo material ultrapassa o contexto dos santuários e deve ser também observada no próprio texto dos Hieroì Lógoi como produto humano e, ao mesmo tempo, produtor do humano. A escrita autobiográfica oferece-se, assim, como locus privilegiado para a reflexão sobre os modos de produção e existência do Eu enquanto ser no mundo. Ao mesmo tempo, na medida em que esta autobiografia é composta por meio de discursos nos quais se combinam elementos sobrenaturais e de transformação do si mesmo em algo para além do humano, ela deve ser pensada como parte de um antigo ocupar-se do Eu em ambiente greco-romano. Esta forma de tratar o Eu, tomá-lo e ocupar-se dele, prescinde da elaboração sistemática de um saber teórico e, simultaneamente, fundamenta toda reflexão desenvolvida em torno do problema do si mesmo a partir da perspectiva da primeira pessoa. A identificação de Aristides a Asclépio dialoga com temas caros a esses questionamentos: a unidade, a continuidade e a impermeabilidade do Eu, muitas vezes contestadas por ideias de multiplicidade, fragmentação e abertura. Essas reflexões frequentemente lançam hipóteses sobre a autonomia do indivíduo e sua vulnerabilidade perante os imortais. Na medida em que a identificação de Aristides a Asclépio se dá, em grande parte, por meio da visualidade e dos encontros face a face, sinaliza-se a necessidade de questionar a mortalidade e a imortalidade como pares antitéticos tributários de noções de alteridade próprias da dicotomia sujeito / objeto. Assim, a partir do discurso paradoxal de Aristides sobre suas experiências, o qual reatualiza antigas perspectivas sobre os limites entre deuses e homens como flexíveis, contestáveis e, até mesmo, apenas virtualmente existentes, defendemos uma abordagem da mortalidade e da imortalidade como pares incomensuráveis os quais, nos Hieroì Lógoi, constituem o Eu. Essa abordagem nos permite pensar mortalidade imortalidade como expressão particular de uma dimensão de trato, tomada e ocupação do Eu anterior, não-tributária e não-fundadora de um saber sistematizado das relações de alteridade. Os Hieroì Lógoi apresentam-se, portanto, como materialidade narrativa das possibilidades-Eu emergidas no sonho e na devoção de um homem do segundo século de nossa Era / Abstract: The Hieroì Lógoi of Aelius Aristides, composed ca. 170 C.E., constitute an autobiographical narrative dedicated to Asclepius, whose sanctuary, in Pergamon, the author visited many times throughout his life. As he turns to the god in search of his famous dream cures, Aristides is transformed through a favoritism and intimacy relationship with Asclepius which ultimately identifies them. This identification, bodily seen and felt by Aristides, is permeated by paradoxical and inapprehensible values from the perspective of systematic elaboration. Therefore, it is understood as an initiation into a mystery which is in close relation to the Asclepieia¿s material culture, as in Pergamon and Epidauros. In these spaces there are available meanings and practices in circulation whose dynamics result not only in the production of materiality but, also, in the fashioning of individuals who, as they deal with it, are constituted by it. This circular relation with the material world trespasses the sanctuaries¿ context and may be also observed in the Hieroì Lógoi text itself as a human product and, at the same time, it's producer. Autobiography is offered, therefore, as a privileged locus for the reflection on the modes of existence and fashioning of the Self as being in the world. At the same time, as this autobiography is composed by discourses which combine supernatural features and elements which transform the Self into something beyond human, it must be approached as part of the ancient self-occupation in the Greco-Roman world. This taking and occupation of the Self dispenses the systematic elaboration of a theoretical knowledge and simultaneously grounds all reflection on the problem of the Self from the first-person perspective. Aristides¿ identification with Asclepius engages in important themes to these inquiries: unity, continuity and the Self¿s impermeability, often contested by ideas of plurality, fragmentation and openness. These reflections frequently construct hypothesis regarding individual agency and autonomy, on the one hand, and vulnerability towards the gods, on the other. As Aristides¿ identification with Asclepius occurs, mostly, trough face-to-face visuality, comes to light the necessity to question mortality and immortality as antithetical pairs dependent on notions about otherness peculiar to the subject / object dichotomy. Therefore, from Aristides¿ paradoxical discourse on his experiences, which reactualizes ancient perspectives on the limits between gods and men as flexible, contested and even virtually absent, we assert an approach towards mortality and immortality as incommensurable pairs which constitute the Self in the Hieroì Lógoi. This approach allows us to consider mortality immortality as a particular expression of treatment, taking and occupancy of the Self which is prior, independent and non-constituent of systematized and discursively built alterity. The Hieroì Lógoi present themselves, therefore, as the narrative materiality of Self-possibilities arisen in this second-century man's dream and devotion / Doutorado / Historia Cultural / Doutora em História

According to the National Institute of Neurological Disorders and Stroke, there are more than 600 neurologic disorders that affect approximately 50 million Americans each year. The $91 billion dollars spent by Medicare on Alzheimer's disease and other dementias in 2005 is projected to increase to $189 billion by 2015 [4]. The existence of neural stem cells (NSC's) and neurogenesis makes neural regeneration a viable option. The ethical barriers of using embryonic stem cells, rejection of the transplanted cells, and possible tumor formation, are only a few of the problems that face stem cell transplantation, a widely considered option to repopulate the brain with cells. A noninvasive pharmaceutical approach that can promote neuron regeneration and recovery would be the key to curing many neurodegenerative diseases. The development of MS-818 as a non-invasive enhancer of the proliferation process of NS Cs is revolutionary for the treatment of neurodegenerative diseases. Due to the fact that its mechanism of action remains unknown, the full pharmacological potential of MS- 818 has not been fully exploited [8]. Isolating protein targets of MS-818 is key in identifying the molecular pathways responsible for its mechanism of action. UV-Vis analysis of MS-818 showed absorbance at 275-nm, and this data was used to calculate coupling yield. MS-818 coupled to the NHS-activated sepharose beads of the affinity column with 83% efficiency. Proteins were isolated from human embryonic kidney cells (HEK 293 cells) and applied to the column. Bradford assay confirmed that bound proteins eluted in a concentration dependent manner when an MS-818 gradient was applied to the column. Polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate of the eluate revealed two sets of polypeptides migrating at 37-75 kDa and 100-150 kDa. In addition, some trace polypeptides in the sub-35 kDa region could be seen. Although we have not yet identified specific proteins that MS-818 interacts with, we were able to successfully to isolate such proteins.

In diesem Text geht es um eine vergleichende Recherche zwischen dem deutschen Philosophen Ernst Cassirer und dem chinesischen Philosophen Laozi in Bezug auf ihr Verständnis für die kultur. Der Unterschied verdankt sich ihrem unterschiedlichen Verständnis für den Begriff „Nichts“. Das 1. Kapitel behandelt die Interpretation Cassirers und Laozis vom Begriff Nichts. Cassirer hat in drei Fragebereichen den Spielraum des Nichts beschränkt, und zwar erstens in der Frage nach dem verbindenden Band für die Ganzheit der Welt, zweitens nach der Einheit der Welt, und drittens nach dem ethischen Wert der Kultur. Im Vergleich dazu gibt Laozi dem Nichts einen positiven Spielraum in diesen drei Fragebereichen. Folglich dienen die drei Fragebereiche als die Basis der Vergleichbarkeit zwischen Cassirer und Laozi in den folgenden drei Kapiteln. Das 2. Kapitel erläutert, wie Cassirer und Laozi auf unterschiedliche Weise die Vielfältigkeit und gleichzeitig die Ganzheit der Welt erklären. Der erstere hebt ein repräsentierendes Verhältnis hervor, während der letztere ein genetisches Verhältnis behauptet. Es handelt sich beim 3. Kapitel um das Problem der Einheit. Cassirer und Laozi beide haben die Einheit in einem Prozess gesucht. Dieser Prozess ist für Cassirer der lebendige Prozess der Formung, während er für Laozi der lebendige Prozess der Entformung ist. Dazu redet Cassirer von einer Rückkehr von der forma formata zur forma formans. Laozi hingegen redet von einer Rückkehr vom Sein zum Nichtsein. Das 4. Kapitel behandelt die Wertfrage in Hinsicht der Kultur. Cassirer und Laozi weisen der Freiheit unterschiedliche Definitionen zu. Folglich weist Cassirer der Kultur eine positive Beurteilung zu, und Laozi fällt ein ethisch negatives Urteil über die Kultur. Die Möglichkeit einer Kombination von Cassirers positiver Einstellung zur Kultur und Laozis negativer Einstellung zur Kultur besteht in der praktischen Bedeutung eines subjektiven Zustands des Selbstvergessens bei der Arbeit. / The text deals with a comparative research between the German Philosopher Ernst Cassirer and the Chinese Philosopher Laozi in relationship with their understanding of the culture. The differences between them are owed to their different understanding of the concept “nothingness”. The Chapter 1 is about the interpretation of Cassirer and Laozi of the concept “nothingness”. Cassirer limits the play space of the nothingness in three areas of questions: first the question about the connecting bond for the entirety of the world, secondly about the unity of the world, and thirdly about the ethical value of the culture. In comparison with this Laozi gives the nothingness much positive play space within these three areas of questions. Therefore the three question areas serve as the basis of the comparability between Cassirer and Laozi in the following three chapters. The Chapter 2 describes how Cassirer and Laozi explain the variety and at the same time the entirety of the world in different ways. The former emphasizes a representing relationship, while the latter maintains a genetic relationship. The Chapter 3 deals with the problem of the unity. Both Cassirer and Laozi search for the unity during a process. For Cassirer this process is the living process of shaping of form, while for Laozi the living process of releasing from form. For it Cassirer talks about a return from forma formata to forma formans. However Laozi talks about a return from being to nonbeing. The Chapter 4 treats the value question in regard to the culture. Cassirer and Laozi assign different definition to the freedom. Therefore Cassirer gives the culture a positive evaluation, while Laozi makes an ethically negative judgment over the culture. The possibility of a combination of Cassirer’s positive attitude to the culture and Laozi’s negative attitude to the culture exists in the practical meaning of a subjective self-forgetting status at work.