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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 11 to 18 of 18 (0.034 seconds)Spelling suggestions: "subject:"44.81 - onkologie"" "subject:"44.81 - onkologiese""
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Reverse-Transkription-Polymerasekettenreaktion (RT-PCR) zum Nachweis von Parathormon-ähnlichem Protein (PTHrP) sowie Immunzytologie von Zytokeratin 18 (CK 18) zur Detektion disseminierter Tumorzellen im peripheren Blut und Knochenmark von Patientinnen mit Mammakarzinom / Reverse transcription-polymerase chain reaction (RT-PCR) for parathyroid-hormone-related protein (PTHrP) and immunocytology of cytoceratin 18 (CK 18) for the detection of disseminated tumour cells in bone marrow and peripheral blood of patients with breast cancerScharnberg, Peer 23 October 2008 (has links)
No description available.
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| 12 |
Der Hedgehog Rezeptor Patched bei der Tumorentstehung und in der Hämatopoese / The Hedgehog receptor Patched in tumorigenesis and hematopoesisUhmann, Anja 06 July 2006 (has links)
No description available.
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| 13 |
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur / Assessment of the Efficacy of Dacarbazine and Temozolomide in Melanoma Treatment in Association with DNA-RepairBöckmann, Lars 15 January 2010 (has links)
No description available.
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| 14 |
Entwicklung und Einsatz der Immun-SERS-Mikroskopie zur Gewebe-basierten TumordiagnostikSalehi, Mohammad 09 September 2013 (has links)
Surface-enhanced Raman scattering (SERS) microscopy is a novel method of optical imaging for the localization and quantification of target molecules in cells and tissue specimens. The major advantages of SERS over fluorescence are quantification and spectral multiplexing due to the small line width of vibrational Raman bands. The position of the plasmon band of both hollow gold/silver nanoshells and silica-encapsulated gold nanoclusters can be tuned for maximum SERS enhancement upon red laser excitation, which is optimal for minimizing the disturbing autofluorescence of tissue. In this work, silica-encapsulated and non-encapsulated SERS particles were used for the localization of target proteins in prostate tissue specimens. Two different biofunctionalization methods were established for each type of SERS particles. The cross-linking method based on s-NHS/EDC chemistry was modified for covalently conjugating proteins to hollow gold/silver nanoshells and gold nanostars in order to minimize the aggregation of SERS nanoparticles during and after cross-linking. As an alternative to covalent conjugation chemistry, the noncovalent binding of antibodies to the SERS particles via an adapter protein (protein A/G) was established. The influence of several factors that determine the quality of results obtained by SERS imaging, such as the number of immuno-SERS conjugates, incubation time, antigen retrieval and blocking buffer, were investigated. Rapid SERS microscopy with 30 msec acquisition time per pixel was enabled by using silica-encapsulated gold nanoclusters for the localization of p63 proteins on prostate tissue specimens from healthy donors. Two-color SERS experiments for the parallel localization of PSA and p63 were performed with silica-encapsulated and non-encapsulated nanoshells. The quality of the results depends less on the nature of the surface chemistry of the nanoparticles (with or without silica encapsulation), but more on the blocking buffer and the antigen retrieval method. Silica-encapsulated gold nanoclusters were also used for the simultaneous quantification of three cytokines (IL1, IL8 and TNF- α) in a SERS-based sandwich immunoassay with a detection limit of ca. 0.3 pM.
Keywords: Raman, SERS microscopy, biocompatibility of nanoparticles, cross-linking, antigen unmasking methods, antigen detection, immunohistochemistry, immunoassay.
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| 15 |
Platelet surface receptors and melanoma metastasis / Plättchen-Oberflächenrezeptoren und Melanom-MetastasierungErpenbeck, Luise 18 May 2011 (has links)
No description available.
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Die Wirkung von Valproat auf die Konochenmetastasenzellen (VCaP) des Prostatakarzinoms / The effect from valproic acid at the bone metastasis cells (VCaP) of the prostate cancerFrüchtenicht, Tanja 20 September 2011 (has links)
No description available.
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Progenitorzelleigenschaften bei myelodysplastischen Syndromen (MDS) mit Eisenüberladung / Iron overload influences the hematological stem cell function on patients with myelodysplastic syndromesHartmann, Julia 11 October 2011 (has links)
No description available.
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| 18 |
Oxidativer Stress als Biomarker für die (Neben-) Wirkungen von Strahlentherapie: Bestimmung von Isoprostanspiegeln und Genexpressionsprofilen in Patientenproben / Oxidative stress as a marker for effects and side effects of radiotherapy. Analysis of isoprostane levels and gene expression profiles in patients samplesKluge, Friedrich 29 November 2011 (has links)
No description available.
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