<p>For nearly twenty years people have been talking about Product models, but given that the building industry is so conservative, it is hard to implement new working methods. Product models are these days known as Building Information Modeling, BIM. People often say they work with BIM but they often forget the most important part, the information. A 3D model should be linked with characteristics and information. Information that can be invaluable for the facility manager.</p><p>We have a vision that in the best of worlds the facility manager would be able to "walk" into the model and see what kind of installations are inside the wall or in the roof. You should be able to point at an object and gain complete information about operation and maintenance off the installation. You should also be able to gain information such as the name of the product and article number if you have to buy a new one. That’s why in our thesis we want to highlight the possibilities for the facility manager.</p><p>In order to have high achievements with BIM, coordination is highly needed. All participants in the construction process have to work together at an early stage; they must have the possibility to affect the stage of inquiry. By having the facility manager connected to the process at an early stage, other members have the opportunity to understand what’s expected from them. In the same way the facility manager will understand if any of the requirements are unreasonable or difficult to solve. Planning must be allowed to cost money. A well planned project can later save a lot of money due to less problems at the building worksite. In a well planned project there will be less changes and less additional work. The key words are Coordination and review.</p><p>During the facility management stage there are great opportunities to save money with BIM. The benefits of BIM have been shown and larger facility companies demand a model that work in the facility management stage. The greatest advantages are gained by the visual model that gives a greater understanding and a better base for decisions. There are also great advantages in more effective processes, better quality and better documentation for maintenance, operation, future rebuilding and future sale.</p><p>To be able to get a good image of BIM, how it is used today and what expectations there are, we have interviewed facility managers, system manager and BIM experts. We have also researched information in reports and articles.</p> / <p>I snart 20 år har man pratat om Produktmodeller men i byggbranschen är det svårt att införa nya arbetsmetoder. Produktmodeller har senare fått namnet Building Information Modeling eller Byggnadsinformationsmodeller på svenska, fortsättningsvis kallat BIM. Många säger idag att de BIM:ar när de gör 3D modeller men de glömmer ofta den viktigaste delen, informationen. Till 3D modellen kan egenskaper och information kopplas till varje objekt. Information som sedan kan vara ovärderlig för förvaltaren.</p><p>Vi har en vision av att i de bästa av världar skall förvaltaren kunna ”gå” in i modellen och se vad för installationer som finns i t.ex. väggar och ovanför takplattor. Dessutom ska man bara kunna peka på  ett don och få all information om det vad gäller drift och underhåll samt produktnamn och artikelnummer för att köpa ett nytt. Därför försöker vi i examensarbetet lyfta fram förvaltaren och fördelarna för denne.</p><p>För att få ut det bästa med BIM krävs samordning. De olika aktörerna i processen måste börja arbeta tillsammans i ett tidigt stadium, d.v.s. vara med och påverka redan i utredningsstadiet. Kan man ha med förvaltningen redan i utredningen får övriga aktörer en bättre förståelse för vad som förväntas av dem. Samtidigt kan förvaltningen tidigt få veta om några krav är orimliga eller svårlösta.Projektering måste få kosta. Ett väl projekterat projekt kan senare spara massor med pengar på att inga problem behöver lösas på byggarbetsplatsen. I väl projekterade projekt minskar ÄTA-arbeten och kollisioner. Nyckelorden för detta är Samordning och Samgranskning.</p><p>I förvaltningsskedet finns det stora utsikter att spara kostnader med hjälp av BIM, fördelarna har börjat visa sig och en del större förvaltare har börjat ställa krav på en produktmodell som går vidare in i förvaltningsskedet. De största fördelarna är bl.a. visualiseringen som ger en bättre förståelse och ett bättre underlag för beslut, effektiviseringen som spar både tid och material, kvalitetshöjning och bättre dokumentation för underhåll, drift, uthyrning, framtida ombyggnad och framtida försäljning.</p><p>För att skapa oss en bild om BIM, hur det används idag och vilka förväntningar som finns branschen, har vi intervjuat förvaltare, systemansvariga och BIM-experter. Vi har även sökt information i rapporter och tidsskrifter.</p>

For nearly twenty years people have been talking about Product models, but given that the building industry is so conservative, it is hard to implement new working methods. Product models are these days known as Building Information Modeling, BIM. People often say they work with BIM but they often forget the most important part, the information. A 3D model should be linked with characteristics and information. Information that can be invaluable for the facility manager. We have a vision that in the best of worlds the facility manager would be able to "walk" into the model and see what kind of installations are inside the wall or in the roof. You should be able to point at an object and gain complete information about operation and maintenance off the installation. You should also be able to gain information such as the name of the product and article number if you have to buy a new one. That’s why in our thesis we want to highlight the possibilities for the facility manager. In order to have high achievements with BIM, coordination is highly needed. All participants in the construction process have to work together at an early stage; they must have the possibility to affect the stage of inquiry. By having the facility manager connected to the process at an early stage, other members have the opportunity to understand what’s expected from them. In the same way the facility manager will understand if any of the requirements are unreasonable or difficult to solve. Planning must be allowed to cost money. A well planned project can later save a lot of money due to less problems at the building worksite. In a well planned project there will be less changes and less additional work. The key words are Coordination and review. During the facility management stage there are great opportunities to save money with BIM. The benefits of BIM have been shown and larger facility companies demand a model that work in the facility management stage. The greatest advantages are gained by the visual model that gives a greater understanding and a better base for decisions. There are also great advantages in more effective processes, better quality and better documentation for maintenance, operation, future rebuilding and future sale. To be able to get a good image of BIM, how it is used today and what expectations there are, we have interviewed facility managers, system manager and BIM experts. We have also researched information in reports and articles. / I snart 20 år har man pratat om Produktmodeller men i byggbranschen är det svårt att införa nya arbetsmetoder. Produktmodeller har senare fått namnet Building Information Modeling eller Byggnadsinformationsmodeller på svenska, fortsättningsvis kallat BIM. Många säger idag att de BIM:ar när de gör 3D modeller men de glömmer ofta den viktigaste delen, informationen. Till 3D modellen kan egenskaper och information kopplas till varje objekt. Information som sedan kan vara ovärderlig för förvaltaren. Vi har en vision av att i de bästa av världar skall förvaltaren kunna ”gå” in i modellen och se vad för installationer som finns i t.ex. väggar och ovanför takplattor. Dessutom ska man bara kunna peka på  ett don och få all information om det vad gäller drift och underhåll samt produktnamn och artikelnummer för att köpa ett nytt. Därför försöker vi i examensarbetet lyfta fram förvaltaren och fördelarna för denne. För att få ut det bästa med BIM krävs samordning. De olika aktörerna i processen måste börja arbeta tillsammans i ett tidigt stadium, d.v.s. vara med och påverka redan i utredningsstadiet. Kan man ha med förvaltningen redan i utredningen får övriga aktörer en bättre förståelse för vad som förväntas av dem. Samtidigt kan förvaltningen tidigt få veta om några krav är orimliga eller svårlösta.Projektering måste få kosta. Ett väl projekterat projekt kan senare spara massor med pengar på att inga problem behöver lösas på byggarbetsplatsen. I väl projekterade projekt minskar ÄTA-arbeten och kollisioner. Nyckelorden för detta är Samordning och Samgranskning. I förvaltningsskedet finns det stora utsikter att spara kostnader med hjälp av BIM, fördelarna har börjat visa sig och en del större förvaltare har börjat ställa krav på en produktmodell som går vidare in i förvaltningsskedet. De största fördelarna är bl.a. visualiseringen som ger en bättre förståelse och ett bättre underlag för beslut, effektiviseringen som spar både tid och material, kvalitetshöjning och bättre dokumentation för underhåll, drift, uthyrning, framtida ombyggnad och framtida försäljning. För att skapa oss en bild om BIM, hur det används idag och vilka förväntningar som finns branschen, har vi intervjuat förvaltare, systemansvariga och BIM-experter. Vi har även sökt information i rapporter och tidsskrifter.

Im Rahmen dieser Diplomarbeit entstand in Zusammenarbeit des Instituts für Kartographie der Technischen Universität Dresden und Archäologen der Universität Gent in Belgien ein dreidimensionales Landschaftsmodell einer Teilregion des Naturparks „Uch-Enmek“, gelegen in der Republik Altai. Diese Region beinhaltet die wichtigsten und größten bekannten Begräbnisstätten skythischen Ursprungs, für die es gilt, den Bekanntheitsgrad und das Bewusstsein dieses kulturellen Erbes durch diese Arbeit zu steigern. Im Zuge dessen wurden wichtige Geodaten, unter Berücksichtigung der prägenden Geoelemente einer Landschaft, in einem Geoinformationssystem zusammengetragen, um die Ausgrabungsstätten ergänzt und verfeinert und schließlich zu einem digitalen Landschaftsmodell ausgebaut. Die Wandlung zu einem dreidimensionalen Landschaftsmodell durch Hinzunahme von 3D-Objekten, wie Gebäuden oder Bäume, wurde in einer professionellen 3D-Software durchgeführt. Zur Visualisierung des Endproduktes wurden aus dem resultierenden 3D-Modell statische Bilder und eine Animation erstellt. Zukünftig können die Ergebnisse genutzt werden, um einen Internetauftritt des Naturparks zu ermöglichen. / Within the scope of this diploma thesis, a three-dimensional landscape model of a part of a region located in the nature park „Uch-Enmek“ (situated within the Altai Republic), was generated in cooperation with the Institut for Cartography of Dresden University of Technology and archaeologists of the University of Ghent in Belgium. The area of interest contains the most important and well-known burial mounds, that origin back to Scythian history. Aim of the thesis is to increase the degree of popularity and the awareness for this cultural heritage. In this case, important geodata were collected within a geo-informationsystem, with respect to characteristic geoelements of a landscape. The geodata were replenished and improved around the archaeological excavation and built up to a digital landscape model. The conversion to a three-dimensional landscape model by adding three-dimensional objects, like buildings and trees, was executed with the help of a professional 3D-software. To visualize the final product, static images and an animation were generated as results out of the 3D-model. Prospectively, the achievement can be used to establish an internet presentation of the nature park.

Les maladies cardiovasculaires sont la première cause de mortalité dans le monde chez les personnes âgées de plus de 65 ans. Parmi les maladies artérielles, l'anévrisme, maladie asymptomatique, est une dilatation localisée et permanente de la paroi d'une artère aboutissant à la formation d'une poche de taille variable. Soumis aux impulsions sanguines, l'anévrisme augmente progressivement et lorsqu'il se rompt, provoque une hémorragie interne pouvant entraîner la mort. Ce projet de recherche concerne le traitement endovasculaire des Anévrismes de l'Aorte Thoracique dont le traitement consiste à déployer une endoprothèse par voie fémorale. Actuellement, les chirurgiens planifient leurs interventions uniquement à partir d'informations issues de l'imagerie médicale. Cette procédure n'est pas totalement fiable et des limites liées à des configurations anatomiques complexes et à la difficulté du geste minimalement invasif persistent. Dans ce contexte, l'objectif est de développer un outil numérique réalisant des simulations virtuelles de ce traitement endovasculaire. Afin d'appréhender le comportement mécanique complexe du tissu artériel, des expérimentations avec une technique de corrélation d'images ont été réalisées sur des prélèvements humains d'aortes thoraciques. Des simulations d'écoulement sanguin dans l'aorte thoracique ont ensuite été réalisées chez un patient sain avec le logiciel OpenFOAM dans lequel un modèle rhéologique prenant en compte les effets viscoélastique et rhéofluidifiant du sang a été développé. En parallèle et en prévision de la modélisation complète de l'acte chirurgical, des calculs numériques sur la montée des outils chirurgicaux dans l'aorte thoracique ont été réalisés en se basant sur des travaux précédents au laboratoire sur la montée des outils dans l'aorte abdominale. L'approche envisagée s'inscrit ainsi dans le cadre des gestes médicaux et chirurgicaux assistés par ordinateur afin de proposer une solution personnalisée opérationnelle pour le choix d'un système de largage et d'une endoprothèse adaptés. / Cardiovascular diseases are the leading cause of death worldwide. Their analysis leads to multidisciplinary problems that require diversity, transversal and complementary approaches. This contribution is part of a research project in Computer Aided Surgery and intends to contribute to the improvement of TEVAR procedures in terms of accuracy and optimization of the operating strategy. In this study, stereocorrelation technique is used to measure the strain field under a human aortic arch in order to identify its mechanical behaviour. Blood flow simulations in the thoracic aorta were then carried out for a healthy patient using the open source OpenFOAM software. A rheological model derived from polymer rheology, considers viscous, shear thinning and other stress overshoot behaviours. In parallel and in anticipation of the complete modeling of the surgical procedure, numerical calculations ofthe rise of the surgical tools in the thoracic aorta were carried out based on previous work in the laboratory regarding the abdominal aorta. This study aims to virtually simulate the whole endovascular stent graft procedure for an aortic aneurysm. This procedure has a high rate of short-term success and its indication compared to open surgery is increasing. Despite many benefits such as reduced blood loss and reduced recovery time, the hindsight is insufficient and there are limitations related to complex anatomical configurations. This procedure therefore needs to be more reliable and secure. In this context, it is important to identify the mechanical behavior of the aorta for further numerical simulations.

Submitted by Vasti Diniz (vastijpa@hotmail.com) on 2017-09-21T12:22:55Z No. of bitstreams: 1 arquivototal.pdf: 1624295 bytes, checksum: 67f6cdb16480494b2e1703d40fb8cda8 (MD5) / Made available in DSpace on 2017-09-21T12:22:55Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1624295 bytes, checksum: 67f6cdb16480494b2e1703d40fb8cda8 (MD5) Previous issue date: 2016-08-04 / The appropriation of digital technology and its tools make the public television able to increase the offers of contents, setting up a wide number of options, beyond the interactive resource and attending the necessities of information for an ample public more and more segmented, such as elderly. In this context, we proposed a development of an interactive TV show for the news program at TV UFPB, channel 43, partner with Brazil TV, approaching themes related to health care for old people and its relation with social way. We presented a theoretical board resulted from an exploratory research within works that relate experiences of digital TV implementation around Brazil, in especial the project Brazil 4D, it was done with together with TV UFPB. From a wide biography, we presented an interactive interface to guide the TV audience to choose the offering contents. The menu prototype that will conduct the audience to the distinct contents based in usability principles already tested with success in the process Brazil 4D execution. The applicability of the model here proposed depends on the digitalization from TV UFPB signals, which is going to happen in 2018, when the federal government will conclude the unlinked of the analogical TV in cities with more than 11 thousand inhabitants. / A apropriação da tecnologia digital e suas ferramentas tornam as televisões públicas aptas a ampliarem a oferta de conteúdos, apresentando um leque maior de opções, através do recurso da interatividade, e atendendo às necessidades de informação de públicos cada vez mais segmentados, a exemplo dos idosos. Nesse contexto, propusemos o desenvolvimento de um quadro interativo para o telejornal da TV UFPB, canal 43, afiliada da TV Brasil, abordando temas relacionados à saúde dos idosos e suas relações com o meio social. Apresentamos um quadro teórico resultante de uma pesquisa exploratória em obras que relatam experiências de implementação da TV digital no país, em especial o Projeto Brasil 4D, que foi realizado em parceria com a TV UFPB. A partir das incursões em vasta bibliografia, apresentamos um modelo de interface interativa para guiar os telespectadores na escolha dos conteúdos ofertados. O protótipo do menu que conduzirá a audiência aos distintos conteúdos baseou-se em princípios de usabilidade já testados com sucesso na execução do Projeto Brasil 4D. A aplicabilidade do modelo de interatividade, aqui proposto, depende da digitalização dos sinais da TV UFPB, o que deverá ocorrer em 2018, quando o Governo Federal concluirá o desligamento das transmissões analógicas de TV em cidades com mais de 100 mil habitantes.

Neste trabalho foi realizado um levantamento GPR 4D em laboratório no qual foi simulado o vazamento de óleo de uma ETD - Estação de Transmissão e Distribuição de Energia Elétrica. Os estudos consistiram em derramar 15 litros de óleo em três experimentos: tanque contendo areia seca, tanque contendo areia úmida mais gradiente hidráulico e tanque contendo areia úmida. Em todos os experimentos o objetivo foi detectar a pluma de contaminação e avaliar a migração desse óleo com o tempo. Os dados GPR 4D foram adquiridos utilizando-se uma antena blindada de 400 MHz modelo SIR-3000 equipamento da GSSI. O monitoramento no tempo de aquisição dos dados variou de 2 minutos até 12 dias. No experimento com o tanque preenchido com areia seca não foi possível determinar a pluma de contaminação devido ao baixo contraste entre as propriedades físicas do meio e a pluma contaminante. No experimento em que o tanque foi preenchido com areia úmida e havia a presença de um gradiente hidráulico, foi possível determinar a migração da pluma de contaminação a partir do 5º dia. Para finalizar, o 3º experimento onde o tanque estava cheio de areia úmida também não foi possível identificar a pluma, devido ao baixo contraste entre as propriedades físicas. Nesta pesquisa também foram realizadas modelagens numéricas 2D utilizando o método FDTD, onde foram simulados os três experimentos, considerando posições intermediárias da pluma de contaminação em função do tempo. Os resultados das modelagens foram concordantes com os resultados obtidos com dados reais e ajudaram a definir o padrão de reflexão da pluma contaminante. Os promissores resultados indicam que a determinação efetiva da pluma contaminante de óleo numa ETD é possível desde o meio que esteja saturado com água. Portanto, para garantir o sucesso das pesquisas GPR para fins de mapeamento e delineamento de plumas de contaminação em ETDs recomenda-se que a aquisição dos dados seja feita após um período de chuvas. / In this work a 4D GPR survey was accomplished in a laboratory in which a oil leak from a ETD Estação de Transmissão e Distribuição of electric energy was simulated. The studies consisted in an oil spill (15 liters) in three different experiments: i) tank containing dry sand, ii) tank containing wet sand with a hydraulic gradient and iii) tank containing wet sand. In all experiments the objective was detect the contamination plume and evaluate the migration of the oil with the time. The 4D GPR data was acquired using a shielded antenna of 400 MHz model SIR-3000 of the GSSI equipment. The time monitoring of the data acquisition ranged from 2 minutes up to 12 days. In the experiment-1 with the tank filled with dry sand wasnt possible to determine the plume contamination due to the low contrast of the physical properties between the environment and the plume. In the experiment-2 where the tank filled with the dry sand in the presence of a hydraulic gradient, was possible to determine the migration of the plume from the fifth day. Finally, the experiment-3 where the tank was filled with wet sand wasnt possible to identify the plume, due to the low contrast between the physical properties. This research also conducted 2D numerical modeling using the FDTD method, where the three experiments were simulated, considering intermediary positions of the contamination plume with respect with time. The results of the modeling were consistent with the results obtained with real data and helped to define a pattern of reflection of the contamination plume. The promising results indicate that the effective determination of the contaminating plume of oil in an ETD is possible provided that the environment be saturated with water. Therefore, to guarantee the success of researches with GPR for mapping and delineation of contamination plumes in ETDs its recommended that the data acquisition be realized in the rainy season.

As metaloproteinases de matriz (MMP) são enzimas superexpressas em quase todos os tumores humanos, sendo que os subtipos MMP-2 e MMP-9 têm sido associados ao potencial metastático e prognóstico desfavorável em neoplasias malignas como, por exemplo, melanoma metastático e glioma. Compostos capazes de inibir a atividade destas enzimas podem representar potenciais agentes terapêuticos. O composto 4-nerolidilcatecol (4-NC), isolado de plantas do gênero Pothomorphe, apresentou resultados promissores para o tratamento do melanoma e glioma e foi capaz de atuar em várias etapas bioquímicas importantes envolvidas na progressão dessas patologias, inclusive inibindo MMP-2 e MMP-9. No entanto, o mecanismo de ação do 4-NC não está completamente elucidado. O presente estudo envolveu a aplicação de métodos de modelagem molecular e de formalismos do planejamento de novas moléculas auxiliado por computador, CAMD (Computer-Aided Molecular Design) a fim de explorar a interação entre esta molécula e as enzimas MMP-2 e MMP-9, além de planejar novos inibidores para estes alvos. Análise exploratória de dados, que compreende a análise de agrupamentos hierárquicos e de componentes principais. foi desenvolvida para um conjunto de hidroxamatos (N=64) descritos como inibidores de MMP-2 e MMP-9, a fim de identificar as propriedades moleculares que mais influenciavam o processo de discriminação dos compostos. As propriedades termodinâmicas, eletrônicas e estéricas foram importantes para descrever os compostos mais ativos no conjunto de dados da MMP-2. Para a MMP-9, o coeficiente de distribuição (ClogD) em pH 1,5 foi relevante no processo de discriminação do conjunto. A presença de substituintes volumosos na porção R3 parece ser crucial para o conjunto de inibidores investigados. Esta região está envolvida em interações moleculares com a cavidade S1 de ambas as enzimas, mas há um limite de volume a ser considerado para estes substituintes. O formalismo QSAR-4D independente do receptor (IR) foi aplicado ao mesmo conjunto de dados e permitiu estabelecer o mapeamento do farmacóforo, além de explorar diferentes alinhamentos para a obtenção da hipótese de conformação bioativa prevista pelo melhor modelo de QSAR. OS modelos QSAR apresentaram boa capacidade de previsão, auxiliaram na proposição de novos inibidores e estimaram a atividade do 4-NC. Com o melhor modelo QSAR para MMP-9 (N=64), a atividade prevista para o 4-NC foi classificada na faixa dos inibidores com atividade moderada. Entretanto, o melhor modelo QSAR obtido para MMP-2 (N=38) não foi capaz de prever, de forma adequada, a atividade de compostos com arcabouço químico diferente daqueles utilizados na construção dos modelos. Estudos de ancoramento molecular foram desenvolvidos para investigar a orientação do 4-NC no sitio catalítico das duas enzimas e as interações que poderiam ser estabelecidas nestes complexos. Duas conformações favoráveis foram encontradas. Simulações computacionais de dinâmica molecular foram desenvolvidas com os complexos mais promissores selecionados nos estudos de ancoramento, a fim de obter informações mais detalhadas e de maior confiabilidade. sobre suas interações intermoleculares. O 4-NC tende a se orientar no sítio de forma a acomodar sua cadeia lateral no bolso S1 adjacente ao sítio catalítico em ambas as enzimas. Ensaios de zimografia também foram realizados com o objetivo de elucidar possíveis contribuições da cadeia lateral e do núcleo catecólico do 4-NC na atividade inibitória frente às enzimas em estudo. O núcleo catecólico parece ser o responsável por sua atividade, pois o composto 1,2dimetoxibenzeno, que possui as hidroxilas bloqueadas por grupos metil, não foi capaz de exercer atividade inibitória significante frente à MMP-2 e MMP-9. Estudos de voltametria reforçaram a hipótese de que o 4-NC tem a capacidade de quelar os íons zinco presentes no tampão de incubação. / Matrix metalloproteinases (MMP) enzymes are overexpressed in almost all human tumors, and MMP-2 and MMP-9 subtypes have been associated with metastatic potential and poor prognosis in malignant tumors, such as metastatic melanoma and glioma. Compounds capable of inhibiting the activity of theses enzymes would be considered as potential therapeutic agents. The 4-nerolidylcatechol compound (4-NC), isolated from plants of genus Pothomorphe, has showed promising results in the treatment of melanoma and glioma, and was able to act in several important biochemical steps involved in the progression of these diseases, as well as inhibiting MMP-2 and MMP-9. However, the 4-NC mechanism of action is not completely understood. This study has involved the application of molecular modeling methods and formalisms of computer-aided molecular design (CAMD) in order to explore the interaction between 4-NC and MMP-2/MMP-9, and to design new inhibitors for these targets. Exploratory data analysis, which comprises hierarchical cluster analysis and principal components analysis, was performed to a set of hydroxamates (N=64). previously reported as MMP-2 and MMP-9 inhibitors, in order lo identify the molecular properties that is most critical for the discrimination process regarding the investigated compounds. The thermodynamic, electronic, and steric properties were: quite important to describe the highly active compounds in the data set of MMP-2, whereas the apparent partition coefficient (ClogD) at pH 1.5 was the property more relevant for MMP-9 data set. The presence of bulky substituents on the R3 moiety seems to be crucial for this set of inhibitors due to the molecular interaction with the S1 subsite of both enzymes. However, there is a limit regarding the substituents volume in this region. Receptor independent (RI) 4D-QSAR analysis was applied lo the same data set and it was possible to establish the pharmacophore mapping, besides to explore different alignments in order to generate the hypothesized bioactive conformation through the best QSAR model. The QSAR models have presented good predictability, assisted in proposing new inhibitors, and estimated the activity of 4-NC. Regarding the best QSAR model for MMP-9 (N=64), the 4-NC predicted activity was classified in the range of the moderate active inhibitors. The best QSAR model obtained for MMP-2 (N=38), however was not able to properly predict the activity for compounds with different chemical scaffold from those used to build up the QSAR model. Molecular docking studies have been developed to investigate the 4-NC binding mode into the catalytic site of the two enzymes and the interactions that could be established in those complexes. The results have shown two favorable conformers regarding the MMP inhibition. Molecular dynamics computational simulation were combined to molecular docking studies in order to obtain more detailed and reliable information regarding the intermolecular interactions of each complex. The 4-NC molecule tends to accommodate the side chain in the S1 pocket adjacent to the catalytic site in both enzymes. Experimental zymography assays were also performed to elucidate the possible contribution of the side chain and the catechol core in the 4-NC inhibitory activity against the MMP-2 and MMP-9 enzymes. The catechol core seems to be responsible for its activity, since the 1,2 dimethoxybenzene compound, which has the hydroxyl blocked by a methyl group, was not able to exert any significant inhibition on enzymes. Voltametric assays confirmed the hypothesis that 4-NC chelates zinc ions present in the incubation buffer.

Building Information Modeling (BIM) är en relativt ny arbetsmetod i byggbranschen som allt fler företag anammar i sina olika projekt. Med hjälp av BIM kan projektets arbete effektiviseras redan i ett tidigt stadie. Då man till exempel kan utföra kollisions kontroller i skapade 3D modeller de olika aktörerna i mellan redan i projekteringsfasen och på så vis undvika problem när byggarbetet väl har startat. BIM processen består av tre delar. De kallas 3D, 4D och 5D vilket omfattar 3Dmodulering, tidplanering och kostnadskalkylering. I denna rapport riktas fokus på tidplaneringsfasen för att ge en bild av hur arbetet skulle kunna bli bättre om BIM användes för att tidplanera och dess hinder i utvecklingen i användningen av BIM. För att få en uppfattning av hur det var att planera utfördes en jämförelse av Gantt planering och Flowline planering. Där en Flowline planering upprättades från en befintlig Gantt planering för att se hur de olika metoderna skiljer sig åt. / Building Information Modeling (BIM) is a relatively new method of working in the construction industry that more and more companies embrace in various projects. With the help of BIM project work efficiency can be increased at an early stage. For example, I can perform collision checks in the created 3D models of the various players already in the planning phase, this can help avoiding problems when the construction work has started. BIM process consists of three parts. They are called 3D, 4D and 5D and include 3D visualization, scheduling and costing. In this report the focus is mostly on time planning phase to provide a picture of how the work could be better if the BIM was used to planning and its obstacles in the development of the use of BIM. To get an idea of how the planning was carried out as a comparison of the Gantt planning and Flowline planning was made. Where a Flowline plan was established from an existing Gantt planning , then to see how the methods are different from each other.

Clarus arkitekter som projekteringsföretag får ofta beställningar från entreprenörer och beställare där de efterfrågar en BIM-modell. I de flesta fallen så används inte BIM modellen helt utan man tar fram 3D-ritningar eller 2D-ritningar. Då ställs frågan “Har beställaren/entreprenören rätt uppfattning om vad BIM är?” Olika aktörer har olika riktlinjer och krav som projektören ska följa. Frågan som arbetet kommer svara på är “hur ska konsulten göra för att på bästa sätt kunna erbjuda rätt tjänst samt mot vilka mål ska konsulten jobba.” Syftet med den här fallstudien är att ta reda på hur BIM användningen skulle kunna underlätta arbetet samt kommunikationen mellan de olika aktörerna som är inblandade i ett byggprojekt. Att undersöka hur kompetensnivån ligger till hos Beställare, Entreprenör och projektörer/arkitekter och svara på frågan “Vad ligger bakom kompetensskillnaden som finns?” Arbetet inleddes med litteraturstudier för insamling och sammanställning av information. Frågor kommer att ställas upp för att senare kunna användas under intervjuerna med olika personer från olika företag. Intervjuerna kommer att ske med bland annat med individer från konsult-, entreprenör- och beställare företag. Intresset att använda BIM är stort i branschen men tyvärr så finns det stor kompetensbrist. Beställare och entreprenörer har planer att börja använda sig av BIM mer vilket kommer att ske de kommande åren, men i nuläget så vill man inte ta nya risker och föredrar att använda sig av traditionella metoder som är mer säkra. För att man skulle kunna tillämpa BIM mer i byggbranschen så behövs det mer kunskap. / Clarus Arkitekter as design companies often receive orders from contractors and clients asking for a BIM model. In most cases, the BIM model is not fully used, but 3D drawings or 2D drawings are available. Then asks the question "Does the client / contractor have the correct understanding of what BIM is?" Different players have different guidelines and requirements that the projector should follow, which can be perceived as defective by the projector just to know what is demanded from each client. The question the thesis will answer is "How should the consultant do the best to offer the right service and what goals the consultant will do. The purpose of this master thesis is to find out how BIM usage could facilitate the work as well as the communication between the various actors who is involved in a construction project. To investigate how the level of competence lies with the Client, Entrepreneur and Projectors / Architects and answerthe question "what is behind the skill difference that exists?". The work began with literature studies for the collection and compilation of information. Questions will be set up to later use them during interviews with different people from different companies. The interviews will take place with individuals from consultancy, contractor and client company. The interest in using BIM is high in the industry, but unfortunately there is a great deal of skills shortage. Customers and entrepreneurs plan to start using BIM more, which will happen in the coming years, but now, they do not want to take new risks and prefer to use traditional methods that are more secure. To be able to apply BIM more in the construction industry, more knowledge is needed.

L'objectif de cette thèse est d'expliquer les avantages qu'offrent la reconstruction de l'architecture des unités géologiques, leurs déformations ainsi que leurs variations au cours du temps à l'exploration de ressources minérales, tout en appliquant des méthodes et outils de modélisation 3D et 4D. La modélisation et la restauration structurale sont utilisées ici pour estimer des attributs géologiques qui peuvent aider à la compréhension de la formation des gisements, et à l'identification des zones favorables aux minéralisations. Cette thèse est axée sur l'application de la modélisation 3D et 4D à des cas réels pour trouver le lien entre une minéralisation et des processus géologiques tel que l'exhumation des terrains, l'activité des failles et la fracturation résultant d'un évènement de déformation. Ce mémoire est organisé en trois parties : (i) la modélisation structurale ainsi que la restauration surfacique ont été appliquées au district minier de la Ceinture de Cuivre de Legnica-Glogów (sud-ouest de la Pologne), pour estimer les conditions favorables à la fracturation hydraulique. Cette fracturation est intervenue dans le nord de l'Europe lors d'une phase d'inversion à la fin du Crétacé et au début du Paléocène. Dans notre hypothèse de départ, la fracturation hydraulique développée au cours de cette période a joué un rôle important dans la distribution en cuivre observée aujourd'hui dans le district minier ; (ii) la courbure des surfaces triangulées, représentant les horizons de la région des Sudètes polonaises, permet de mettre en évidence les systèmes de failles dans le socle. En particulier, des méthodes de restauration surfaciques ont été utilisées pour évaluer l'activité de des failles au cours du temps, en se basant sur la courbure des surfaces obtenues à chaque étape de la restauration. Les zones de fortes activités sont ici associées aux processus de minéralisation cuprifère de la région ; (iii) la restauration mécanique de la région de Mount Pleasant (Australie occidentale), a permis de simuler un évènement de raccourcissement apparu dans l'Archéen et qui est lié à un processus de minéralisation aurifère. La restauration mécanique est appliquée pour estimer le champ des déformations de la région au moment du raccourcissement. Avec ce champ de déformation, il est possible de calculer les paramètres d'endommagement de la masse rocheuse qui semblent liés aux zones aurifères situées hors des systèmes principaux de failles. Cette thèse a ainsi permis de mettre en évidence l'aspect prometteur de la modélisation et de la restauration structurale pour identifier des zones potentiellement minéralisées, mettant en valeur leur utilisation pour l'exploration des gisements et des ressources minérales / The objective of this Ph.D. thesis is to apply 3D and 4D modeling methods to reconstruct the architecture and deformations over time of geological entities in a defined region. Structural restoration modeling is used here to estimate geological, physical and structural attributes for understanding the origin of ore-deposits, and for identifying potential mineralized areas. We focused this thesis on 3D and 4D modeling on real case studies with different geological contexts (e.g. uplifting, fault activity and shortening), demonstrating the advantages and drawbacks on their use for similar situations. This thesis is organized into three parts: (i) the application of structural modeling in the mining district of the Copper Belt of Legnica-Glogów (south-west Poland). A surface-restoration approach was applied to estimate favorable conditions for hydraulic fracturing during an inversion, occurred in the northern part of Europe at Late Cretaceous--Early Paleocene. In our hypothesis, hydraulic fracturing developed at that time played an important role in the distribution of copper content observed in present days in the mining district. (ii) The curvature calculated on triangulated surfaces that represent the stratigraphic horizons in the Fore-Sudetic region (Poland), are used to highlight the fault systems in the basement as well as their activity. High curvature values reveal the fault activity which is associated with the copper mineralization process in the region. (iii) Mechanical restoration of the Mount Pleasant, Western Australia, simulates an Archean shortening event which occurred in the area linked to the gold mineralization process. The mechanical restoration was used to estimate the strain field in the region at the time of shortening. This deformation field was used to estimate the damage parameters of the rock mass. They show new potential gold areas located in off-fault gold systems. In conclusion, it is shown that 3D modeling and structural restoration could be used to identify potential favorable zones for the presence of mineralization, and seem promising as a tool for the exploration of ore-deposits and mineral resources