Economic cycle has significantly affected the national as well as the international labour market and has caused increased unemployment which primarily concerns endangered groups of people on the labour market. This Thesis is based on the hypothesis that persons older than 50 years are more prone to be socially excluded due to long-term unemployment and a more complex return to job than younger groups of people. With respect to the continuous aging population and prolongation of retirement age, it is necessary to analyse the obstacles and options leading to longer job engagement. The theoretical part of the Thesis characterises the labour market and its imperfections using a descriptive method. In the analytical part, effectiveness and purposefulness of the tool of active employment politics in Jindřichův Hradec are investigated. Evaluation of the analysis follows. The major aim of this Diploma Thesis is to identify the status of the social group in question in the Czech labour market via secondary analysis and also to evaluate to what extend active employment politics contributes to such a status in the regional labour market in Jindřichův Hradec.

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No. of bitstreams: 7 Dissertação-Daniella Medeiros Moreira Rocha - 2013 (1).pdf: 15801916 bytes, checksum: 0b05660a9e263c1da4204536b0e56871 (MD5) Dissertação-Daniella Medeiros Moreira Rocha - 2013 (2).pdf: 15676966 bytes, checksum: 14c5483474603d8a9d0511d3bceb46ac (MD5) Dissertação-Daniella Medeiros Moreira Rocha - 2013 (3).pdf: 13776768 bytes, checksum: fd1891ee713ec6ee3bd869c8b555b31c (MD5) Dissertação-Daniella Medeiros Moreira Rocha - 2013 (4).pdf: 15705470 bytes, checksum: f733031fb9deed4871424e7b1edd8bdc (MD5) Dissertação-Daniella Medeiros Moreira Rocha - 2013 (5).pdf: 16753983 bytes, checksum: 5c3116b2bb7bde75782d6a9bea854266 (MD5) Dissertação-Daniella Medeiros Moreira Rocha - 2013 (6).pdf: 12309120 bytes, checksum: f2daa3bc673f5f55b04314d2d1d2cd4a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2013-07-21 / This research seeks to highlight the history of architecture in Goiania, and its protected architectural heritage (historical and artistic), under art deco style look, which was manifested in hotel edifications of Goiania, in 1930 and 1940, and lately, in 1950, representing, at the time, a symbol of modernity. More specifically, it is a study of the three pioneering hotels with this style: Palace Hotel, Grand Hotel and Hotel Don Bosco. The study delimitation consisted on investigating the objects in three periods: at construction; at some of their most significant moments; at present days. Methodological proposal was based upon bibliographical and documental surveys, oral interviews, photographic survey, original plants and descriptive memorials surveys, updated architectural and photographic surveys, for composition of records, as well as descriptions and analysis of art deco modernity, under the following criteria: party and architectural program, volumetry and facades, materials, techniques and indoors. In bibliographical research were used references pertinent to the history of art, history of art deco, history of Goiania and considerations on the question of heritage. As to documentary research, the public agencies related with were: Institute of Historical and Artistic Heritage (IPHAN), the Board of Historical and Artistic Heritage, the Board of the Image and Sound Museum (MIS), both of the Agency of Culture Pedro Ludovico Teixeira in Goiania (AGEPEL), the Heritage Division of the Municipal Secretary of Culture, the Municipal Secretary of Sustainable Urban Development (SEMDUS) and its historical archives. The testimonies were collected by oral interviews of personae who were part of the story of the people of Goiania. / Esta pesquisa procura evidenciar a história da arquitetura de Goiânia e do seu acervo arquitetônico tombado (histórico e artístico) pelo viés do estilo art déco, que se manifestou nas edificações hoteleiras goianienses nas décadas de 1930 e 1940 e, mais tardiamente, em 1950, representando, à época, um símbolo de modernidade. Mais especificamente, constitui um estudo dos três hotéis pioneiros nesse estilo: o Palace Hotel, o Grande Hotel e o Hotel Dom Bosco. A delimitação do estudo consistiu em investigar o objeto em três tempos: no momento inicial da sua construção; alguns de seus momentos mais significativos; e os seus dias atuais. A proposta metodológica foi a do levantamento bibliográfico e documental, entrevistas orais, levantamento fotográfico, levantamento de plantas originais e memoriais descritivos, levantamentos arquitetônicos e fotográficos atualizados, para composição de registros, descrições e análise da modernidade do art déco a partir dos seguintes critérios: partido e programa arquitetônico, volumetria e fachada, materiaise técnicas e interiores. Na pesquisa bibliográfica foram utilizadas referências pertinentes à história da arte, à história do art déco, história de Goiânia e considerações sobre a questão do patrimônio. Quanto à pesquisa documental, os órgãos públicos relacionados foram: Instituto do Patrimônio Histórico e Artístico (IPHAN), a Diretoria do Patrimônio Histórico e Artístico, a Diretoria do Museu da Imagem e Som (MIS), ambas da Agência Goiana de Cultura Pedro Ludovico Teixeira (AGEPEL), a Divisão de Patrimônio Histórico da Secretaria Municipal de Cultura, Secretaria Municipal de Desenvolvimento Urbano Sustentável (SEMDUS) e arquivos históricos. Os depoimentos foram coletados por entrevista oral de personagens que fizeram parte da história goianiense.

Discute a construção de um conjunto de edifícios e galerias comerciais em meio ao processo de metropolização e modernização da cidade de São Paulo no século XX. Produtos de um momento de desenvolvimento acelerado da indústria imobiliária, no qual a verticalização na área central era incentivada e ao mesmo tempo controlada pela administração municipal, estes edifícios, datados dos anos 50 e 60 em sua maioria, foram empreendidos por grupos de investidores brasileiros associados a imigrantes europeus, escritórios de arquitetura e construtoras. Considerando sua origem histórica, ao investigar as referências européias, norte-americanas e principalmente a história paulistana, propõe-se a compreensão de sua produção pelo viés arquitetônico, social e mercadológico. O trabalho identifica as especificidades da construção dos edifícios e galerias comerciais resgatando o momento de constituição do centro novo como uma nova área de investimentos, em especial, no setor terciário. Contribui também para as pesquisas sobre os novos programas e novas tipologias ligadas às demandas da metrópole paulistana na segunda metade do século XX. / The construction of a set of commercial buildings and galleries is discussed as part of the metropolization and modernization of the city of São Paulo in the 20th century. Products of a period of accelerated development of the real estate industry, during which the verticalization in the downtown area was encouraged and at the same time controlled by the municipal administration, these buildings, most of them dating back to the 50 and 60\'s, were the enterprise of groups of brazilian investors associated with european immigrants, architectural offices, and builders. Considering their historical origin, when investigating the european and north american references and mainly the history of the city, we propose the understanding of their production from an architectural, social, and marketing viewpoint. The present work identifies the specificities of the construction of the commercial buildings and galleries by recovering the time when a new downtown area was constituted as a new area of investment, especially in the tertiary sector. It also contributes to research about the new programs and typologies linked to the demands of the São Paulo metropolis in the second half of the 20th century.

No description available.

Durant la dernière décennie, les études de la décroissance bêta des isotopes 69,71,73Cu ont mis en évidence le net abaissement de l'orbitale proton 1f5/2 lors du remplissage de l'orbitale neutron1g9/2. Ce phénomène peut être interprété comme le résultat des forces tensorielles entre ces orbitales proton et neutron. Un argument similaire prédit l'affaiblissement du gap N=50 quand on s'approche du noyau 78Ni du fait de l'attraction entre les configurations 1g9/2 et1d5/2 avec l'orbitale 1f5/2 et de la répulsion entre les états 1g7/2 et 1f5/2. Ainsi, les noyaux au voisinage de noyau 78Ni, sont les meilleurs candidats pour étudier l'évolution de la fermeture de couche N=50 et les autres aspects du modèle en couches à grand rapport N/Z. De telles études nécessitent des appareillages performants comme la combinaison d'un spectromètre de noyaux de recul de grande acceptance (PRISMA) couplé à un multidétecteur gamma à grande granularité, CLARA à Legnaro (Italie). Lors d'une récente expérience, des résidus exotiques ont été produits via des réactions profondément inélastiques entre un faisceau de 82Se (Elab = 515 MeV) et une cible d'Uranium. Je me suis principalement penchée sur les systématiques des isotopes de Ge et Zn. Dans le but de compléter ces données, une expérience de décroissance bêta, réalisée auprès d'ISOLDE au CERN, des isotopes impairs riches en neutrons de Cu a également été étudiée. Les schémas de décroissance pour les isotopes 71,73,75Cu ont été construit, pour la première fois pour l'élément le plus exotique. La complémentarité des données issues de ces deux mécanismes ouvre de nouvelles perspectives en vue de l'étude des noyaux riches en neutrons.

<p>Uppsatsen beskriver tiden kring 50-talet för att genom detta visa den ungdomskultur som då uppstod. När filmen Ung rebell hade premiär 1955 var den en föregångare inom filmbranchen genom att gestalta ungdomskulturen på ett nytt sätt. Uppstasen analyserar denna film, Sista natten med gänget (1973), samt Grease (1978) för att visa vilka verktyg som används för att visa ungdomskulturen under denna tid. En del av analysen är att påvisa bilens roll i ungdomskulturen i film gesaltad under och strax efter 50-talet.</p>

<p>I början av 1950-talet utvecklades en idé att flottan skulle bli lättare. Detta berodde delvis på ekonomiska faktorer samt att flottans större system såsom pansarskepp började bli föråldrade. Den tekniska utvecklingen bidrog även till att system som radarn gjorde intrång. Sjömålsroboten och den trådstyrda torpeden kunde skjutas från mindre plattformar vilket gjorde det möjligt med en lättare flotta. Hotet vid denna tid sågs som Sovjetunionen. Ytstridskrafterna skulle i händelse av krig vara beredda att möta en starkare motståndares landstigningsoperationer. Denna uppsats undersöker vissa områden av den taktiska utvecklingen som skedde under denna period. Detta görs genom en textanalys av litteratur på ämnet. Analysen behandlar områden som hotbild, teknik samt egna sjöstridskrafter, organisation samt uppgifter. Slutsatser som dragits är bl.a. tekniken utvecklades i snabb takt och spelade stor roll. Hotbilden var viktig vid utformandet av egen doktrin och strategi vilket ledde till förändringar inom taktiken. Egna sjöstridskrafters utveckling hämmades av ekonomiska styrningar vilket ledde till att kompromisser fick göras som påverkade kvaliteten på enheterna.</p> / <p>In the early fifties the Swedish Navy wanted to get lighter. This development took place mostly because of economical factors and the fact that bigger ships in the navy was getting old. Important systems such as radar were implemented in the Swedish Navy. The ship to ship missile and the wire guided torpedo could be fired from smaller vessels and this contributed to the development. The Soviet union was regarded as the main threat and the Swedish surface warfare units would in warface a stronger opponent and try to prevent him from landing on Swedish shores. This study tries to examine certain areas within the subject tactical development during this period. This is made by analyzing literature in the subject. The analyze is conducted in three predefined areas. The areas are: Threats, technological advances and own surface warfare units and their organisation and tasks. Some of the main conclusions are that the technology advanced in a rapid pace and was vital to the development of tactics. The threat of the Soviet union made differences in the naval doctrine and strategy which made changes in tactics. Economical factors forced the Swedish Navy to compromise when building new ships which affected the quality of the units.</p>

I början av 1950-talet utvecklades en idé att flottan skulle bli lättare. Detta berodde delvis på ekonomiska faktorer samt att flottans större system såsom pansarskepp började bli föråldrade. Den tekniska utvecklingen bidrog även till att system som radarn gjorde intrång. Sjömålsroboten och den trådstyrda torpeden kunde skjutas från mindre plattformar vilket gjorde det möjligt med en lättare flotta. Hotet vid denna tid sågs som Sovjetunionen. Ytstridskrafterna skulle i händelse av krig vara beredda att möta en starkare motståndares landstigningsoperationer. Denna uppsats undersöker vissa områden av den taktiska utvecklingen som skedde under denna period. Detta görs genom en textanalys av litteratur på ämnet. Analysen behandlar områden som hotbild, teknik samt egna sjöstridskrafter, organisation samt uppgifter. Slutsatser som dragits är bl.a. tekniken utvecklades i snabb takt och spelade stor roll. Hotbilden var viktig vid utformandet av egen doktrin och strategi vilket ledde till förändringar inom taktiken. Egna sjöstridskrafters utveckling hämmades av ekonomiska styrningar vilket ledde till att kompromisser fick göras som påverkade kvaliteten på enheterna. / In the early fifties the Swedish Navy wanted to get lighter. This development took place mostly because of economical factors and the fact that bigger ships in the navy was getting old. Important systems such as radar were implemented in the Swedish Navy. The ship to ship missile and the wire guided torpedo could be fired from smaller vessels and this contributed to the development. The Soviet union was regarded as the main threat and the Swedish surface warfare units would in warface a stronger opponent and try to prevent him from landing on Swedish shores. This study tries to examine certain areas within the subject tactical development during this period. This is made by analyzing literature in the subject. The analyze is conducted in three predefined areas. The areas are: Threats, technological advances and own surface warfare units and their organisation and tasks. Some of the main conclusions are that the technology advanced in a rapid pace and was vital to the development of tactics. The threat of the Soviet union made differences in the naval doctrine and strategy which made changes in tactics. Economical factors forced the Swedish Navy to compromise when building new ships which affected the quality of the units.

Introduction: Amyotrophic lateral sclerosis (ALS) is a deadly, progressive neuromuscular disease that affects individuals all over the world. About 10% of the patients have a familial predisposition (FALS) while the remainder of cases are isolated or sporadic (SALS) and of unknown cause. To date, the principal recognized risk factors for ALS are higher age, male gender, slim figure (BMI&lt;23) and a family history of ALS. In 1993, Rosen et al. observed that some FALS cases were associated with mutations in the gene encoding the CuZn superoxide dismutase enzyme (SOD1). Since then, several mutations in the SOD1 gene have been discovered, and mutations in more than 18 other genes have been associated with causing ALS. The aim of this thesis was to identify new mutations associated with ALS pathogenesis, and by comparing patients from different countries, were we also able to identify population-specific genetic variations. The studies are referred to as I–V. Methods: With written informed consent and adhering to the tenets of the Declaration of Helsinki, through a national network of ALS clinicians´, venous blood samples were collected from ALS patients and healthy subjects in Europe and the USA. The patients were diagnosed according to the El Escorial criteria, and as having FALS according to the criteria of Byrne et al. (2011). The DNA variations were amplified by various PCR techniques. (I, III and IV) The amplicons of ataxin 2 (ATXN2), profilin 1 (PFN1), and vesicle-associated membrane protein type B (VAPB) were characterised by direct sequencing. (II) After quantitative PCR, a genotype-phenotype correlation was performed to assess whether the survival motor neuron gene (SMN) modulates the phenotype of ALS. (V) The amplicons of the 50 base pair deletion in the SOD1 promotor (50 bp) were separated by electrophoresis on agarose. Results: (I) We observed a significant association between CAG expansions in the ATXN2 gene and ALS in a European cohort. (II) Abnormal copy number of the SMN1 gene was identified as a risk factor in France, but not in Sweden. Homozygosity of the SMN2 deletion prolonged survival among Swedish ALS patients, compared to French patients. (III) We identified two mutations in the PFN1 gene, the novel p.Thr109Met mutation and the p.Gln117Gly mutation, in two unrelated FALS patients. (IV) In our cohort, we identified five VAPB mutations p.Asp130Glu, p.Ser160del, p.Asp162Glu, p.Met170Ile, and p.Arg184Trp, two of which are novel. (V) The 50 bp deletion upstream of the SOD1 gene was found in equal frequencies in both the patient and control cohorts. The 50 bp deletion did not affect SOD1 enzymatic activity. Furthermore, we found no differences in age of onset or disease duration in relation to the 50 bp deletion genotype.VI Conclusions: (I) Our findings indicate that ATXN2 plays an important role in the pathogenesis of ALS, and that CAG expansions in ATXN2 are a significant risk factor for the disease. (II) We suggest that abnormal SMN1 gene copynumber cannot be considered a universal genetic susceptibility factor for ALS. We also propose that the effect of abnormal SMN2 gene copy number on ALS phenotype may differ between populations. (III) This work provides evidence that PFN1 mutations can cause ALS as a Mendelian dominant trait. The novel p.Thr109Met mutation also shows that disturbance of actin dynamics can cause motor neuron degeneration. (IV) We find it unlikely that the VAPB mutations cause ALS in our cohorts. (V) We find it unlikely that the 50 bp region contains important regulatory elements for SOD1 expression. This thesis supports the theory that ALS is a multigenetic disease, but there appears to be great genetic variation among apparently identical populations. These studies emphasise the importance of continuous genetic screening, to identify further mutations and genes involved in ALS disease, but it also highlights the importance of cooperation and comparison between countries. / On the aetiology of ALS: A comprehensive genetic study

本研究主係探討以投資者持有本國股票作為基礎投資組合，利用台灣五十成份股投資組合及金融期貨指數之月報酬率資料形成效率前緣，然後將本研究所選取之黃金產業GOX指數或以黃金現貨價格兩種黃金商品投資組合分別加入基礎投資組合中，觀察每個投資組合標的加入前後之投資機會集合之變化，是否基礎投資組合之效率前緣進一步向左偏移，並比較其優劣。此外進一步探討在兩種黃金投資組合加入基礎投資組合，分別在股市多頭及空頭市場時會不會產生相同的效果；並且藉由中央大學台灣經濟發展研究中心所調查訂定的消費者信心指數，以中位數區分為信心指數高或信心指數低兩組情境，並將兩種黃金商品投資組合在不同的情境依序分別加入基礎投資組合中，其基礎投資組合之效率前緣是否皆仍進一步向左偏移。實證結果發現，黃金現貨帶給基礎資產投資機會集合的貢獻，明顯優於黃金產業GOX指數，當檢定資產為黃金產業GOX指數時，「切點投資組合」差異W_1統計值上皆不具統計顯著性，整體而言當黃金產業GOX指數在加入投資組合之後，我們認為大部份的效果是來自分散原有的投資組合風險；然而黃金現貨在改善投資機會集合的貢獻上，來自「最小變異數投資組合」及「切點投資組合」的改善皆有顯著的效果。