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No description available.

[pt] A teoria da mente (ToM) é definida como a habilidade de inferir estados mentais internos de outras pessoas. Há consenso na literatura de que ToM é um marcador sociocognitivo do Transtorno do Espectro autista-TEA. A testagem é realizada, em grande parte, a partir de um paradigma denominado falsa crença. Contudo, verifica-se a necessidade de instrumentos de avaliação mais apurados, que compreendam: a complexidade do constructo, a relação com outros domínios cognitivos como funções executivas. O objetivo deste trabalho foi desenvolver e verificar evidências de validade de um novo instrumento que avalie os diferentes domínios de ToM para auxílio de diagnóstico em crianças com TEA. Este estudo foi registrado no Comitê de Ética em Pesquisa da Pontifícia Universidade Católica-PUC-Rio. O projeto foi dividido em quatro estudos, que englobavam desde uma revisão bibliográfica sobre as tarefas de ToM utilizadas em avaliações de crianças com diagnóstico de TEA, até mostrar evidências de validade do instrumento de nominado Bateria de avaliação em Teoria da Mente-BToM. Os resultados mostraram que BToM possui evidências de validade de conteúdo e de constructo, bem como de precisão. Além disso, identifica tarefas de Estados Mentais e Verbalizações, como possíveis marcadores sociocognitivos no diagnóstico de fenótipos mais leves do TEA. / [en] Theory of Mind (ToM) is defined as the ability to infer other s internal mental states. There is a consensus in the literature that ToM is a sociocognitive marker of Autism Spectrum Disorder-ASD. Performance is assessed in majority from false belief paradigm. However, there is a need for more accurate assessment tools, which include: complexity of the construct, interface with other cognitive domains as executive functions. The purpose of this work was to develop and verify validity’s evidences of a new instrument who evaluates differents ToM domains for diagnostic support in children with ASD. This study was registered in the Research Ethics Committee of Pontifical Catholical University of Rio de Janeiro-PUC-Rio. The project was divided into five studies, ranging from a literature review of ToM tasks used in assessments of ASD children, to show validity evidences of the instrument nominated Battery of Theory of Mind-BToM. The results showed BToM has evidence of content and construct validity as well as accuracy. In addition, it identifies Mental States and Verbalizations tasks as possible sociocognitive markers on diagnoses of lighter ASD phenotypes.

En analys av en studie gjord av Lorenz och Heinitz (2014) på autistiska personers uppfattning om sig själva, sina förmågor och behov och en kartläggningsrapport av Specialpedagogiska skolmyndigheten från 2013 har belyst hur det hos dessa individer finns en potential långt utöver det normala. Skolmyndigheten (2013) rapporterar om att lärare saknar verktyg för att förstå elever med neuropsykiatriska funktionsvariationer, framförallt vid autismspektrumtillstånd där sådana verktyg ofta behöver vara individanpassade och därför varierar från elev till elev. Önskan om att hitta metoder för att använda tillgängliga läromedel eller önskan om handledning för att förstå eleverna bättre är någonting som lyfts upp då lärare menar sig vara vilsna kring vad man ska göra i den egna undervisningen med de metoder som finns. Med detta som grund motiverades jag till att utforma ett fortbildningsmaterial för lärare inom matematik som förhoppningsvis ska kunna stötta lärarna i deras kommunikation med elever med autismspektrumtillstånd. Som ett led i utvecklingsarbetet gjordes djupintervjuer med två lärare inom matematik och teknik och med fyra personer diagnosticerade med AST. Därefter analyserades intervjuerna med hjälp av tematisk analys för att sedan användas som underlag för diskussion kring några faktorer som påverkar elevens lärande. Faktorer som framkom var lärarnas undervisningsform, föreställningar av sin och elevens roll i lärandet och hur lärarens relation till de övriga lärare i kollegieteamet påverkar kvalitén av lärarens undervisning. Resultatet från djupintervjuerna visade att det hos elever med AST finns behov av tydlighet, struktur och tidsplanering. Vill man som lärare säkerställa en bra kommunikation med dessa elever behöver en förståelse för hur läraren kan förmedla förväntningar uppmärksammas. Sådana förväntningar kan vara såväl implicita och explicita. Förväntningar som t.ex. kan vara att läraren tilldelar uppgifter som befinner sig på en lägre nivå än elevens egen föreställning av sin förmåga. Läraren behöver också vara införstådd i elevens problematik och för det krävs ett mer omfattande arbete inom kollegiet som läraren är en del av. Detta eftersom ett bra stöd för eleven inte kan förväntas ges enbart av elevens egna lärare då elevens behov av stöd kräver insatser från flera olika yrkesgrupper. Vidare visade resultat från djupintervjuerna hur det hos elever med AST finns ett behov av social inkludering, däremot var det mindre tydligt hur eleverna skulle uppnå detta. Man hänvisade till att läraren saknar kunskap om hur elevens personligheter och intressen måste beaktas tillsammans innan man sammanför grupper. Också underströks hur eleven behöver lära sig hantera vissa sociala situationer, vad den ska säga och hur. Om inte det sker vågar eleven sällan inleda samtal med övriga klasskamrater och det i sin tur har jag kunnat visa påverka elevens fortsatta förståelse av matematik. Utvärdering av det utvecklade fortbildningsmaterialet gav värdefull återkoppling för att förbättra materialet. Utvärderingen genomfördes bland tre verksamma lärare. En lärare hade förstått det avsedda syftet och angav att materialet gav hen idéer om hur undervisning kan genomföras, t.ex. genom att omformulera sina uppgifter eller addera material inför vissa moment som kan göra det lättare för AST-elever att sätta sig in i dem. För de andra två lärarna var syftet otydligt och de angav att det saknades tillräckligt med uppgifter som läraren kunde använda för sina elever med AST, men att de förslagen som gavs ändå var uppskattade. / A study conducted by Lorenz and Heinitz (2014) on the view that autistic people have of themselves, their attributes as well as a survey done by Specialpedagogiska Skolmyndigheten (2013) suggest that a lot of individuals on the spectrum may own a potential far beyond what is considered normal. The report from Skolmyndigheten (2013) paints an image of how present material for students with neuropsychiatric disorders are lacking, especially for those students who are on the autistic spectrum. These students are specially a challenge since every individual on the spectrum and thus a one-way solution is considered virtually impossible. Using this knowledge as a building block, I was motivated to construct an introductory material for teachers in mathematics to effectively communicate with students on the autistic spectrum. The material is based on surveys done in the form of deep interviews. These deep interviews were conducted with 2 teachers in math and technology and with 4 people diagnosed with ASD. Furthermore, the data from the interviews were analysed with the help of a tool called thematic analysis. Afterwards the data was used to discuss some of the factors that affect students learning. The factors involved in my discussion were the specific form of teaching, preconceptions about ones and students’ involvement in their own learning and how teacher interaction with the other teachers in the colleague team may impact the quality of student learning. Looking at the results from the deep interviews, we see that for people with ASD there is a desire for precision, structure and adequate time-planning. Good communication with these students requires the teachers’ understanding of how she can convey her conceptions, explicit as well as implicit, by her form of teaching, for example by recognizing how the distribution of lower level problems could downgrade a students’ perception of their own10ability. Teachers need to consider and understand the problems of specific students and in order to do that a more extensive cooperation is required with the rest of the team. Such cooperation is required since one need to consider how a complex diagnosis such as autism spectrum involves appropriate intervention regulated and influenced by people in different occupation groups. The final results concerned the opinions received by teachers regarding the realization of the introductory material. With regards to the intention to construct a material which can support understanding of the communication problems associated with autism, the results of evaluation from three teachers in mathematics and technology showed mix of responses. One of the three teachers had understood the purpose and commented on how the material inspired his own taking on how to teach for these students, for instance by reformulating problems or add material in the making of problems to make it easier for students on the autistic spectrum to engage with them. The other two teachers mentioned the lack of sufficient amount of math problems which could be of any use in their own teaching, although they saw how some of the parts were useful for other purposes. I suggest that the responses were mixed as an effect of misunderstanding of the real purpose of the introductory material. Since the making of a new introductory material given the feedback was not tested, the conclusions regarding how well this material meets the context cannot be properly validated.

Core symptoms of Autism Spectrum Disorder (ASD) impact the child's abilities to interact with others, especially with the primary caregivers. Most research has focused on investigating the mother-child dyad, but the paternal role in interaction with children with ASD is mainly unexplored (e.g., Rankin, Paisley, Tomeny & Eldred, 2019; Flippin & Crais, 2011). For this, the project's first aim is to examine paternal interactive characteristics and behaviors and compare father-child and mother-child interactions with children with ASD, delineating the strengths and weaknesses of both caregivers in a complementary system. Based on this investigation, we implemented a personalized and parent-specific early intensive intervention that may guarantee better developmental trajectories for children with ASD. Consequently, the project's second aim is to assess the impact of intervention with parental involvement through cognitive, socio-communicative, and dyadic behavioral measures using a longitudinal study with pre- and post-assessments. At this point, it is fundamental to evaluate how several traits of children and caregivers might impact the treatment response. To reach this aim, while assessing developmental trajectories, we wanted to identify a-priori individual differences at both child and caregiver’s level and dyad dynamics that may influence intervention outcomes. We identified markers of better developmental trajectories and discussed implications for clinical practice in providing practitioners with more information about areas to be targeted during the intervention.

Yes / A study has been carried out to investigate controlled release performance of caplet shaped injection moulded (IM) amorphous solid dispersion (ASD) tablets based on the model drug AZD0837 and polyethylene oxide (PEO). The physical/chemical storage stability and release robustness of the IM tablets were characterized and compared to that of conventional extended release (ER) hydrophilic matrix tablets of the same raw materials and compositions manufactured via direct compression (DC). To gain an improved understanding of the release mechanisms, the dissolution of both the polymer and the drug were studied. Under conditions where the amount of dissolution media was limited, the controlled release ASD IM tablets demonstrated complete and synchronized release of both PEO and AZD0837 whereas the release of AZD0837 was found to be slower and incomplete from conventional direct compressed ER hydrophilic matrix tablets. Results clearly indicated that AZD0837 remained amorphous throughout the dissolution process and was maintained in a supersaturated state and hence kept stable with the aid of the polymeric carrier when released in a synchronized manner. In addition, it was found that the IM tablets were robust to variation in hydrodynamics of the environment and PEO molecular weight. / The research was funded by AstraZeneca, Sweden.

[pt] Estudar como ocorre o desenvolvimento da criança diagnosticada com Transtorno do Espectro Autista, em espaços que não sejam somente o da escola, nos faz pensar como esta constrói suas interações sociais e também pode exercer os seus direitos e liberdades fundamentais como sujeito com deficiência, visando sua inclusão social e cidadania. Assim, o objetivo deste estudo foi investigar os modos e frequência de participação das crianças no TEA em espaços urbanos de lazer como fator relevante para seu desenvolvimento cognitivo, emocional e social. Realizou-se um estudo qualitativo que envolveu a análise do discurso de 16 cuidadores de uma clínica de Neuroreabilitação, localizada no Rio de Janeiro. Os resultados revelaram que as interações entre pais/cuidadores e filhos autistas quando são mútuas e colaborativas, juntamente com estratégias parentais igualitárias, são favoráveis e capazes de conduzir a criança a pensar a respeito de suas atitudes, logo, podem incentivar a conduta pró-social da criança. O estudo concluiu que a interação e a convivência entre pais/cuidadores e a criança autista em outros espaços, que não seja somente o da escola. Mostrou-se importante, mas que ainda existem muitos obstáculos e limitações impostos em relação ao TEA, no que diz respeito às suas potencialidades, resistências e preconceitos. Entretanto, apesar dos desafios, as iniciativas e a dedicação representam um enorme passo para encontrar maneiras dessas crianças se apropriarem do conhecimento e possivelmente desenvolverem suas habilidades. / [en] Studying how the development of children diagnosed with Autism Spectrum Disorder occurs, in spaces that are not only the school, makes us think about how they build their social interactions and also how they can exercise their fundamental rights and freedoms as a subject with disabilities, aiming at their social inclusion and citizenship. Thus, the objective of this study was to investigate the participation of children with Autism Spectrum Disorder (ASD) in urban spaces, as a relevant factor for their cognitive, social and emotional development. A qualitative study was carried out that involved the analysis of the speech of 16 caregivers of a Neurorehabilitation clinic, located in Rio de Janeiro. The results revealed that interactions between parents/caregivers and autistic children, when they are mutual and collaborative, together with egalitarian parenting strategies, are favorable and capable of leading the child to think about their attitudes, therefore, they can encourage prosocial behavior. of child. The study concluded that the interaction and coexistence between parents/caregivers and the autistic child in other spaces, other than the school, proved to be important, but that there are still many obstacles and limitations imposed in relation to ASD, in terms of concerns its potentialities, resistances and prejudices. However, despite the challenges, the initiatives and dedication represent a huge step towards finding ways for these children to appropriate knowledge and possibly develop their skills.

[pt] Esta pesquisa propõe um estudo com objetivo de validação clínica do Sistema Brasileiro de Avaliação Qualitativa da Figura de Rey (BRAS-ROCF). A partir de uma amostra total de 80 crianças e adolescentes foram verificados critérios quantitativos e qualitativos da cópia do teste Figura Complexa de Rey (ROCF), comparando o desempenho de dois grupos: (1) Grupo com diagnóstico prévio de TEA (GTEA) e (2) um grupo sem diagnóstico de TEA (GST). O primeiro estudo analisou os resultados quantitativos da ROCF, encontrando diferença significativa (t (77) = 3.457, p .037) entre os grupos. O segundo estudo analisou a validade clínica do BRS-ROCF sendo a estratégia de elementos idiossincráticos mais utilizada (21 por cento) pelo GTEA e uma das menos utilizadas pelo grupo GST (5 por cento). A estratégia de desenho com início por metades ou quadrantes foi mais utilizada (36 por cento) pelo GST. Comparando os dois grupos quanto a estratégia aplicada para cópia da figura de Rey foi detectada uma relação forte (r = .702, p < .001) entre os critérios de correção qualitativa da ROCF e os critérios propostos pelo BRS-ROCF. A partir dos achados, conclui-se que a análise qualitativa BRAS-ROCF tem utilidade clínica como medida de funcionamento executivo. / [en] This research proposes a study aiming to clinically validate the Brazilian System of Qualitative Assessment of the Rey Figure (BRAS-ROCF). From a total sample of 80 children and adolescents, quantitative and qualitative criteria of the Rey Complex Figure Test (ROCF) copy were verified, comparing the performance of two groups: (1) a group with a previous diagnosis of Autism Spectrum Disorder (ASD) (GTEA) and (2) a group without a diagnosis of ASD (GST). The first study analyzed the quantitative results of the ROCF, finding a significant difference (t(77) = 3.457, p .037) between the groups. The second study examined the clinical validity of the BRS-ROCF, with the idiosyncratic element s strategy being the most utilized (21 percent) by the GTEA and one of the least utilized by the GST (5 percent). The strategy of drawing with beginning by halves or quadrants was more utilized (36 percent) by the GST. Comparing GTEA and GST, a strong relationship (r = .702, p < .001) was observed in this modality between the qualitative correction criteria of the ROCF and the criteria proposed by the BRS-ROCF. From these findings, it is concluded that the qualitative analysis of BRAS-ROCF has clinical utility as a measure of executive functioning.

Den här studien handlar om grundskolans interna samverkan kring elever med neuropsykiatriska funktionsnedsättningar (NPF). Syftet med studien var att belysa hur samverkan mellan olika professioner i grundskolan kan utvecklas för att skapa en tillgänglig lärmiljö för elever med NPF. De frågeställningar som besvaras är: Hur beskriver lärare sin samverkan med andra professioner i grundskolan när det gäller skolsituationen för elever med NPF? Vad behöver enligt lärarna utvecklas när det gäller samverkan kring elever med NPF? Studien utgick från verksamhetsteori som bidrog till att samverkan kunde studeras på ett djupare plan. Sex grundskollärare intervjuades med halvstrukturerade intervjuer. Med tematisk- och verksamhetsteoretisk analys på studiens empiri framkom att samverkan mellan lärare och skolans övriga professioner inte sker i den utsträckning som lärare önskar. Kunskapsmässiga svårigheter är det vanligaste motivet för samverkan mellan lärare och andra professioner i skolan, där stöd av elevers sociala svårigheter och skolans förebyggande arbete får stå tillbaka. Det som enligt lärarna behöver utvecklas är att rektorn blir delaktig i skolans specialpedagogiska processer; Skolors organisatoriska arbete kring elever med NPF behöver förtydligas, både gällande motivet för samverkan, professioners ansvarsområden och att skolor skapar forum och rutiner för skolans professioner att mötas kring elever med NPF. / This study is about the primary school's internal collaboration around pupil with neurodevelopmental disorders (NDD). The aim of this study was to highlight how cooperation between different professions in primary school can be developed to create an accessible learning environment for students with NDD. The questions that the study sets out to answer is: How do teachers describe their collaboration with other professions in elementary school regarding the school situation for students with NDD? According to the teachers, what needs to be developed in terms of collaboration around students with NDD? The study was based on an activity theory, which contributed to the fact that cooperation could be studied on a deeper level. Six primary school teachers were interviewed using semi-structured interviews. With a thematic- and activity theory analysis of the study's empirical data, it emerged that collaboration between teachers and the school´s other professions does not take place to the extent that teachers wish. Knowledge-related difficulties are the most common motive for teachers´collaboration with other professions in the school, here support of students´ social difficulties and the school´s preventive work may take a back seat. According to the teachers, what needs to be developed is for the principal to be involved in the school´s special education processes. Schools´ organizational work around students with NDD needs to be clarified, both regarding the motive for collaboration, professions´ areas of responsibility and that schools create forums and routines for the school´s professions to meet around students with NDD.

In dieser Arbeit wurden nutzbringende Anwendungsmöglichkeiten für monoskopische und (auto)stereoskopische 3D-Anzeigen in Fahrzeugen theoretisch hergeleitet und empirisch überprüft. Zur Ableitung der Hypothesen wurde für jede Teilaufgabe anhand eines Fragenkatalogs zu den Vor- und Nachteilen von 3D-Anzeigen untersucht, inwieweit deren Bearbeitung davon profitiert, dass Informationen räumlich abgebildet werden. Die erwiesenen 3D-Vorteile wurden zu fünf Kategorien zusammengefasst: Integration, räumliche Kompatibilität, Aufmerksamkeitslenkung, Bildhaftigkeit und Attraktivität. Da der wesentliche 3D-Vorteil für Anzeigen in Fahrzeugen in einer räumlich kompatiblen Informationsdarstellung aus der Fahrerperspektive gesehen wurde, lag der Schwerpunkt der empirischen Arbeit auf 3D-Anzeigen für Fahrerassistenzsysteme (FAS). Am Beispiel einer 3D-Anzeige des Abstandsregeltempomaten (ART) wurde nachgewiesen, dass die Vorteile von 3D-Anzeigen für FAS in einer Erhöhung der Attraktivität und Akzeptanz sowie in einer Verbesserung des unmittelbaren Verständnisses im Vergleich zu 2D-Anzeigen liegen. Gleichzeitig wurden mit optimal gestalteten 3D-Anzeigen keine Nachteile in der Wahrnehmungssicherheit und Ablenkungswirkung festgestellt. Anhand der Literaturanalyse und der empirischen Ergebnisse wurden Gestaltungshinweise für 3D-Anzeigen in Fahrzeugen formuliert. Der erwartete 3D-Vorteil einer kompatiblen Darstellung stellte sich bei einer konstanten Anordnung der Informationen nicht ein, bleibt aber für Aufgaben mit einem kontinuierlichen Abgleich (z.B. Navigation) zu überprüfen. Die stereoskopische Darbietung erbrachte keinen besonderen Nutzen. Das fahrzeugtaugliche ASD erhöhte sogar die Reaktionszeiten. Insgesamt sprechen die Ergebnisse für eine gezielte Verwendung bildhafter monoskopischer 3D-Anzeigen für FAS und ausgewählte räumliche Funktionen, welche sich anhand von Begriffen und abstrakten Symbolen nur schwer erläutern lassen. / This thesis consists of the theoretical deduction and empirical evaluation of useful applications for monoscopic and (auto)stereoscopic 3D-displays in vehicles. For deducting hypotheses concerning the benefits and limits of 3D-displays, each subtask was tested for its potential benefits from a 3D-information presentation using a catalogue of confirmed advantages and disadvantages of 3D-displays. The proven 3D-advantages were summarized in five categories: integration, spatial compatibility, direction of attention, concreteness and attractiveness. Because it was presumed, that 3D-displays in vehicles are especially favorable for representing information about the vehicle surrounding in a 3D-perspective compatible to the drivers view, the empirical part was mainly focused on the application of 3D-displays for driver assistance systems. Using a 3D-display for adaptive cruise control (ACC), a general increase of attractiveness, acceptance and immediate comprehension for 3D-displays in comparison to conventional 2D-displays was confirmed. Simultaneously, well designed 3D-displays did not compromise perceptional safety and driver distraction. Design guidelines for 3D-displays in vehicles were concluded from the evaluation results and from literature analysis. Even though the expected 3D-benefit of spatially compatible information displays from the driver’s perspective was not confirmed for driver assistance systems like ACC with a constant layout of information, it still remains to be tested for continuous matching tasks like navigational checking in cars. The stereoscopic presentation of 3D-displays did not show advantages. On the contrary, an in-vehicle ASD even increased reaction times. In summery, the results suggest a distinctive application of well designed concrete and monoscopic 3D-displays for driver assistance systems and selected spatial functions which are difficult to explain using abstract notions or symbols.