創新生意模式 – 案例分析 LINE / As more people around the world start using smartphones, instant-messaging apps are emerging not only as an alternative to conventional mobile text-messaging, but also as a social network that could replace some of the roles played by Facebook Twitter and others. One of the fastest-growing messaging apps in the world is LINE, developed and operated by Tokyo-based LINE Corp. Just over the past year, LINE has seen the number of its users surge nearly fourfold to more than 500 million. In this paper, we will discuss the reason why LINE become so popular, and how is it new business model work. The main reason LINE become so successful is that LINE grasp the essential needs of users and it also look deeply insight the market. Each function LINE had was not innovative at that time, just like games, photo-sharing, and a Facebook-like home page and timeline, however a lot of people would find it convenient if one app can let them experience many different things, then it combine all the function to become a successful LINE. It also created a new way to communicate for boring text message. It create its virtual stickers often featuring cute and quirky cartoon characters that people can send as messages which change users communicate behavior to use stickers instead of text. By these cute character it also create new business model. The company’s revenue comes from the sales of virtual stickers as well as virtual items sold in games. Also generate with game title, which design with LINE character. The app also makes money by charging businesses that use official Line accounts to distribute promotional messages. In the future, LINE's ambition is to becoming a broader platform for social network and entertainment. The communication app category is crowded and competitive; therefore the company has to create its irreplaceable value to stand stable in this number one position.

Smartphones are becoming increasingly popular, with the result that customers prefer to carry out at least some customer services using an app on a mobile device. Among app users, smooth transfer to a live agent is seen as an important feature and this means that the company contact center need a solution to handle this as well as increasing numbers of interactions. The question this thesis tries to answer is "how can smartphone end user apps be included in the context of the company contact center"? To answer this question research was conducted regarding the possibilities of an Android smartphone, with the results of this research being used to define a use case, a state flow diagram and create a demonstration app. The thesis showed that it is possible to have an app as an online channel for customer service interactions. New possibilities in comparison to traditional telephony include that customer data such as topic, authentication, location and multimedia can be sent to the contact center before an actual interaction is started.

Mobile apps can make use of the rich data and sensors available on smartphones to offer compelling services. However, the use of sensitive resources by apps is not always justified, which has led to new kinds of privacy risks and challenges. While it is possible for app market owners and third-parties to analyze the privacy-related behaviors of apps, present approaches are difficult and tedious. I present two iterations of the design, implementation, and evaluation of a system, Gort, which enables more efficient app analysis, by reducing the burden of instrumenting apps, making it easier to find potential privacy problems, and presenting sensitive behavior in context. Gort interacts with apps while instrumenting them to detect sensitive information transmissions. It then presents this information along with the associated app context to a crowd of users to obtain their expectations and comfort regarding the privacy implications of using the app. Gort also runs a set of heuristics on the app to flag potential privacy problems. Finally, Gort synthesizes the information obtained through its analysis and presents it in an interactive GUI, built specifically for privacy analysts. This work offers three distinct new advances over the state of the art. First, Gort uses a set of heuristics, elicited through interviews with 12 experts, to identify potential app privacy problems. Gort heuristics present high-level privacy problems instead of the overwhelming amount of information offered through existing tools. Second, Gort automatically interacts with apps by discovering and interacting with UI elements while instrumenting app behavior. This eliminates the need for analysts to manually interact with apps or to script interactions. Third, Gort uses crowdsourcing in a novel way to determine whether app privacy leaks are legitimate and desirable and raises red flags about potentially suspicious app behavior. While existing tools can detect privacy leaks, they cannot determine whether the privacy leaks are beneficial or desirable to the user. Gort was evaluated through two separate user studies. The experiences from building Gort and the insights from the user studies guide the creation of future systems, especially systems intended for the inspection and analysis of software.

This thesis presents four case studies from the Finnish museum sector that are using mobile technologies in diverse ways to enhance the museum experience. At the National Museum of Finland, the mobile solution functions as an aid for providing translations in different languages and thus improving the aesthetic appearance of the exhibition. At Tampere Art Museum, the outdoors mobile tour extends the museum visit outside the physical walls of the building. At Helsinki City Museum the mobile phone is perceived as a communication tool. At Luostarinmäki Handicrafts Museum the Augmented Reality game combines digital narrative with real-world events, creating a solution that is both entertaining and informative.   These solutions are analysed in terms of the Contextual Model, developed by Falk and Dierking. The model divides the museum visit into three overlapping and interacting spheres – personal, social and physical. This thesis looks at how mobile solutions may enhance or hinder the museum experience in regards to each of these three spheres. Additionally, the model is compared with the results of a visitor research conducted at the National Museum of Finland in October 2013. The aim of the thesis is to identify the most successful features of these solutions and to explore how the field could be developed in the future.

旅遊手機應用程式創業計畫 / This is a business plan of travel planning app that will be launched bilingual, Mandarin and English, focusing on its first target market—Taiwan. The world travel market had a total contribution of GPD over 9.5% in 2013, as for Taiwan the travel market GDP contribution had reached 5.3% in the same year. According to World Travel & Tourism Council (WTTC), the travel market will continue the growth at 4% year by year. As for Taiwan, estimation of travel market will increase 3.6% until 2020. The mobile device has dominated the market since 2012 when smartphone/tablet market share was 70% against 30% of desktop/portable PC and will continue a 15% growth until 2017, according to IDC report. Current major mobile app categories are gaming, social medial and messaging apps. Mobile travel app market share is still low. Considering more tendency that travelers rely on mobile technology and the growing travel market, this report will discuss and find a strong competing position for the travel planning app startup. From finding the right segment, targeting the real stakeholder and position its value proposition. This report will also so cover how it make revenue to be real and a forecast until year 2020. Keywords: Mobile travel, Taiwan travel, Travel app, Mobile app), Travel market

Alzheimer's disease (AD) is the leading cause of dementia. Amyloid plaques in the brain remain a pathological feature of AD. These plaques are primarily composed of amyloid β-protein (Aβ). It has been postulated that glycogen synthase kinase-3β (GSK3β) activity might exert a central role in the development of AD. GSK3β activity has been implicated in tau phosphorylation, APP processing, Aβ production and neurodegeneration. Quetiapine is frequently used to treat psychoses in AD patients at the late stage and has inhibitory effects on GSK3β activity in mouse brains after acute/subchronic treatment. Therefore, the proposed hypothesis is that chronic quetiapine administration after amyloid plaque onset reduces AD like pathology and alleviates AD like behaviours in APP/PS1 transgenic mice by inhibiting GSK3β activity. APP/PS1 transgenic mice were treated with quetiapine (2.5, 5 mg/kg/day) in drinking water starting from 3.5 months of age, for a period of 8 months. One week after behaviour testing, mice were sacrificed at 12 months of age. Half of the hemispheres were rapidly frozen for immunoblot and ELISA analyses and the other half were fixed with 4% paraformaldehyde for histological analyses. Quetiapine treatment reduced amyloid plaques formation in the cortex and hippocampus of AD mice. It also improved the behavioural deficits in these mice, including attenuating impaired memory and anxiety-like phenotypes. In addition, chronic quetiapine administration inhibited GSK3β, which resulted in reduced production of Aβ in cortices and hippocampi of transgenic mice. Quetiapine treatment also significantly decreased the activation of astrocytes and attenuated synapse integrity impairment in transgenic mice. These findings suggest that early application of quetiapine can alleviate memory deficits and pathological changes in the APP/PS1 transgenic mouse model of AD, and further support that modulation of GSK3β activity by quetiapine may be a therapeutic option for AD.

Increased amyloid-β (Aβ) load in the brain, neurite degeneration, neuronal loss, and decreased levels of several neurotrophins are among the characteristics of Alzheimer’s disease (AD). Generation of Aβ occurs when the amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases in the amyloidogenic pathway. However, Aβ formation is prevented if APP is cleaved by α- and γ- secretases in the non-amyloidogenic pathway. The normal function of APP is still not fully known. It seems clear that the different fragments that are produced during proteolytic processing have different bioactive properties. APP and its metabolites have been implicated in neurite outgrowth, synaptogenesis, cell adhesion, neuroprotection and apoptosis. The aim of this thesis was to investigate how neurotrophic factors affect the synthesis and processing of APP and its two mammalian paralogues the APP-like protein-1 and-2 (APLP1 and APLP2). We also wanted to determine how the expression levels of α- and β- secretases were affected in response to these factors. In addition, we wanted to analyze if the levels and function of the most well characterized APP adaptor protein, Fe65, was regulated during neuronal differentiation. Our results show that retinoic acid (RA), insulin-like growth factor-1 (IGF-1), and brain derived neurotrophic factor (BDNF) all regulate expression levels and processing of the APP protein family. Interestingly, the increased processing of the APP family involves different signaling pathways. The PI3-K/Akt pathway is involved in IGF-1-induced APP and APLP1, but not APLP2, processing. In addition, RA-induced expression of the α-secretase, a disintegrin and metalloproteinase (ADAM) 10 is dependent on PI3-K, whereas PKC is involved in RA-induced expression of another α-secretase, ADAM17/TACE. Furthermore, we present evidence that maturation of the adaptor protein Fe65, as well as its docking to APP, increases concomitant with neuronal differentiation. / At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 4: Manuscript.

Dissertação (mestrado)—Universidade de Brasília, Centro de Desenvolvimento Sustentável, 2008. / Submitted by Jaqueline Oliveira (jaqueoliveiram@gmail.com) on 2008-12-02T17:30:39Z No. of bitstreams: 1 DISSERTACAO_2008_HildaLedouxVargas.pdf: 1808279 bytes, checksum: 893984bbb9f494be9550811c2be336bb (MD5) / Approved for entry into archive by Georgia Fernandes(georgia@bce.unb.br) on 2009-01-22T12:10:35Z (GMT) No. of bitstreams: 1 DISSERTACAO_2008_HildaLedouxVargas.pdf: 1808279 bytes, checksum: 893984bbb9f494be9550811c2be336bb (MD5) / Made available in DSpace on 2009-01-22T12:10:35Z (GMT). No. of bitstreams: 1 DISSERTACAO_2008_HildaLedouxVargas.pdf: 1808279 bytes, checksum: 893984bbb9f494be9550811c2be336bb (MD5) / Este trabalho tem como objetivo analisar a ocupação irregular das áreas de preservação permanente urbanas a partir da percepção de vários atores sociais (órgãos públicos, comunidade local e ambientalistas), tendo como foco a Lagoa do Prato Raso, em Feira de Santana, Bahia. O estudo foi realizado a partir do exame das normas jurídicas que protegem as áreas de preservação permanente, no contexto urbano, e da percepção dos atores acerca dos conflitos que envolvem a ocupação irregular dessas áreas. Para atender ao objetivo do trabalho, foram realizadas entrevistas individuais com a aplicação de roteiro de pesquisa semiestruturado, que buscou levantar a percepção dos atores com relação aos seguintes ítens: i) a ocupação irregular na Lagoa do Prato Raso; ii) a percepção dos moradores e ambientalistas sobre a necessidade de preservar o meio ambiente para a presente e as futuras gerações; iii) a percepção dos moradores e ambientalistas sobre a importância da conservação da Lagoa do Prato Raso para a cidade; iv) a percepção dos moradores, ambientalistas e órgãos públicos acerca dos conflitos decorrentes da ocupação irregular da Lagoa do Prato Raso; v) a percepção dos órgãos públicos acerca da eficiência da lei para solucionar o conflito existente e garantir o direito de todos ao ambiente equilibrado. As informações obtidas foram analisadas, comparativamente entre os integrantes, no interior de cada categoria de entrevistados, resultando na conclusão tanto a comunidade que habita o entorno da Lagoa do Prato Raso como os órgãos públicos e os ambientalistas, em geral, reconhecem a necessidade da preservação do equilíbrio do ambiente. Desconhecem, entretanto, os invasores, a importância da Lagoa do Prato Raso para a conservação do ambiente na cidade e, ao contrário dos ambientalistas, defendem a ocupação total da lagoa, destruindo-a por completo. Essa é a solução que apontam para os conflitos decorrentes da ocupação irregular. Os ambientalistas e órgãos públicos não vêem uma solução fácil ou adequada à realidade financeira do município e perdem-se diante da ineficiência dos meios jurídicos em garantir a proteção a essas áreas. O descaso e inoperância dos órgãos públicos estimulam e reforçam as ocupações irregulares que se alastram como pragas, destruindo o que ainda resta daquele manancial. _______________________________________________________________________________ ABSTRACT / This study aims at examining the illegal occupation of the areas of urban permanent preservation from the perception of many actors of all social performers public agencies, local communities, and environmentalists, with a focus on the Prato Raso Lagoon, in Feira de Santana, Bahia . The study was conducted from analysis of legal standards that protect the permanent preservation areas in the city and the perception of the actors on the conflict involving illegal occupation of these areas. To meet the goal of the work, individual interviews were conducted with the use of forms for semi-structured. The research in question sought to raise the perception of actors on: i) irregular occupation in the Lagoon of Prato Raso, ii) on the perception of residents and environmentalists about the need to preserve the environment for present and future generations, iii) the perception of residents and environmentalists about the importance of the conservation of the Lagoon of Prato Raso to the city, iv) the perception of residents, environmentalists and public agencies about the conflicts arising from the illegal occupation of the Lagoon of Prato Raso, v) the perception of public authorities about the effectiveness of the law to resolve the conflict and ensure the right of all to a balanced environment. Information obtained was analyzed, compared among members, within each category of interviewees. This work then concludes that the community of the Prato Raso Lagoon, public agencies and the environmentalists in general, recognize the need to balance the preservation of the environment. The invaders, however do not know the environmental and cultural importance of the Prato Raso Lagoon to the conservation of the environment in the city and unlike the environmentalists, defend the total occupation of the lagoon, destroying it entirely. This is the solution that lead to the conflicts arising from the irregular occupation. Environmentalists and public agencies do not see an easy solution or tailored to the financial realities of the municipality get lost before the inefficiency of the legal means to ensure the protection of these areas. The neglect and failure of public agencies stimulates and strengthens the irregular occupations that expand as pests, destroying completely, what remains of that wealth.

Dissertação (mestrado)—Universidade de Brasília, Centro de Desenvolvimento Sustentável, 2008. / Submitted by Priscilla Brito Oliveira (priscilla.b.oliveira@gmail.com) on 2009-09-15T20:49:18Z No. of bitstreams: 1 2008_JoaoBastosNeto.pdf: 7539463 bytes, checksum: a0c860975a55626b1a8e07e57fa00484 (MD5) / Approved for entry into archive by Luanna Maia(luanna@bce.unb.br) on 2010-01-04T14:49:50Z (GMT) No. of bitstreams: 1 2008_JoaoBastosNeto.pdf: 7539463 bytes, checksum: a0c860975a55626b1a8e07e57fa00484 (MD5) / Made available in DSpace on 2010-01-04T14:49:50Z (GMT). No. of bitstreams: 1 2008_JoaoBastosNeto.pdf: 7539463 bytes, checksum: a0c860975a55626b1a8e07e57fa00484 (MD5) Previous issue date: 2008-05-23 / O trabalho estuda a pertinência e a compatibilidade dos dispositivos legais de proteção das áreas de preservação permanente, contidos no Código Florestal, Lei 4.771/65, com as práticas sócio-econômicas e culturais do Semi-Árido baiano. A área de estudo compreende um trecho do rio Itapicuru-açu, que passa pelos municípios de Filadélfia, Itiúba, Ponto Novo e Queimadas. Traz a evolução do conceito das áreas de preservação permanente antes e após o Código de 1934, comparando-o com o conceito atribuído à mata ciliar. Foi trazido para o estudo o conhecimento acerca das funções ambientais das áreas de preservação permanente, assim como a sua importância no contexto ambiental do Semi-árido baiano. Foram levantados os dados analógicos e digitais sobre a progressão do desmatamento nas áreas de preservação permanente, bem como o percentual de ocupação com pastagem e vegetação preservada, solo exposto, plantio de coqueiro e área queimada, objetivando analisar o estado de conservação dessas áreas. Foram utilizadas imagens de satélite IKONOS II, do ano de 2005 e fotografias aéreas de 1965, 1966 e 1970, tratadas pelo software ARQGIS, gerando mapas digitais que apresentam as classes de cobertura do solo pastagem (50,83%), vegetação preservada (41,18%), solo exposto (6,89%), plantação de coqueiros (0,91%), área queimada (0,13%) e estrada (0,06%). Foi identificado também, que a maioria dos desmatamentos nas áreas de preservação permanente, ocorreu antes mesmo da edição do Código Florestal de 1965. De posse desses dados, pôde-se comprovar o não cumprimento da Lei 4.771/65, no que se refere à manutenção das Áreas de Preservação Permanente, pelos produtores rurais, bem como os remanescentes florestais existentes nas áreas. As entrevistas com os diversos atores sociais, realizadas seguindo roteiros previamente definidos, demonstraram os diversos conflitos existentes na região do Itapicuru-açu, bem como o desconhecimento da legislação ambiental, concernente as áreas de preservação permanente, procedendo-se a análise do ponto de vista dos diversos atores sociais envolvidos no processo. Por fim, o estudo analisa a percepção dos produtores da região quanto à legislação ambiental, especialmente as áreas de preservação permanente do rio Itapicuru-açu, indicando que seria possível o desenvolvimento de algumas atividades de produção locais, com atendimento das expectativas social, econômica e ambiental nessas áreas. _______________________________________________________________________________ ABSTRACT / The work examines the relevance and compatibility of the devices legal protection of the areas of permanent preservation, in the Forest Code, Law 4.771/65, with the practices socioeconomic and cultural the Semi-árido baiano. The study area comprises a stretch of the river Itapicuru-açu, through the cities council of Filadélfia, Itiúba, Ponto Novo e Queimadas. Brings the evolution of the concept of permanent preservation areas before and after the Code of 1934, comparing it with the concept attributed to the riparian forest. It has been brought to study knowledge about the environmental functions of the areas of permanent preservation, as well as its importance in the context of environmental to the Semi-árido baiano. They were raised analogue and digital data on the progression of deforestation in the areas of permanent preservation, as well as the percentage of occupancy with pasture and vegetation preserved, exposed soil, planting of coconut and burned area, to examine the state of conservation of these areas. Satellite images were used IKONOS II, in the year 2005 and aerial photographs from 1965, 1966 and 1970, addressed by the software ARQGIS, creating digital maps that show the classes of soil cover pasture (50.83%), vegetation preserved (41.18%), exposed soil (6.89%), planting of coconut trees (0.91%), burned area (0.13%) and road (0.06%). It was also identified that most of the thinning in the areas of permanent preservation, occurred even before the edition of the Forestry Code of 1965. With such data, could itself prove the non-compliance of Law 4.771/65, as regards maintaining Areas of Conservation Permanent by farmers and the remaining forest existing in the areas. Interviews with the various social actors, performed following routes previously defined, demonstrated the various conflicts in the region of the Itapicuru-açu, and the lack of environmental legislation, concerning the areas of permanent preservation, in itself to analysis from the point of view of the various social actors involved in the process. Finally, the study examines the perception of producers in the region regarding environmental legislation, especially the areas of permanent preservation of the river Itapicuru-açu, indicating that it would be possible to the development of some activities of local production, with attendance expectations social, economic and environmental these areas.

The thesis is presented in three papers format. Paper 1 presents the first bibliometric literature survey of its kind on aggregate production planning (APP) in presence of uncertainty. It surveys a wide range of the literatures which employ operations research/management science methodologies to deal with APP in presence of uncertainty by classifying them into six main categories such as stochastic mathematical programming, fuzzy mathematical programming and simulation. After a preliminary literature analysis, e.g. with regard to number of publications by journal and publication frequency by country, the literature about each of these categories is shortly reviewed. Then, a more detailed statistical analysis of the surveyed research, with respect to the source of uncertainty, number of publications trend over time, adopted APP strategies, applied management science methodologies and their sub-categories, and so on, is presented. Finally, possible future research paths are discussed on the basis of identified research trends and research gaps. The second paper proposes a novel decision model to APP decision making problem based on mixed chase and level strategy under uncertainty where the market demand acts as the main source of uncertainty. By taking into account the novel features, the constructed model turns out to be stochastic, nonlinear, multi-stage and multi-objective. APP in practice entails multiple-objectivity. Therefore, the model involves multiple objectives such as total revenue, total production costs, total labour productivity costs, optimum utilisation of production resources and capacity and customer satisfaction, and is validated on the basis of real world data from beverage manufacturing industry. Applying the recourse approach in stochastic programming leads to empty feasible space, and therefore the wait and see approach is used instead. After solving the model using the real-world industrial data, sensitivity analysis and several forms of trade-off analysis are conducted by changing different parameters/coefficients of the constructed model, and by analysing the compromise between objectives respectively. Finally, possible future research directions, with regard to the limitations of present study, are discussed. The third paper is to appraise the performance of different APP strategies in presence of uncertainty. The relevant models for various APP strategies including the pure chase, the pure level, the modified chase and the modified level strategies are derived from the fundamental model developed for the mixed chase and level strategy in paper 2. The same procedure, which is used in paper 2, follows to solve the models constructed for these strategies with respect to the aforementioned objectives/criteria in order to provide business and managerial insights to operations managers about the effectiveness and practicality of these APP policies under uncertainty. Multiple criteria decision making (MCDM) methods such as additive value function (AVF), the technique for order of preference by similarity to ideal solution (TOPSIS) and VIKOR are also used besides multi-objective optimisation to assess the overall performance of each APP strategy.