• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 483
  • 98
  • 56
  • 15
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 13
  • 11
  • 8
  • 6
  • 6
  • Tagged with
  • 876
  • 876
  • 876
  • 876
  • 272
  • 245
  • 163
  • 132
  • 91
  • 90
  • 86
  • 78
  • 73
  • 72
  • 69
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
321

ADHD-diagnostisering under förskoleåren : En systematisk litteraturstudie hur forskning ställer sig till diagnostisering av ADHD hos barn i förskoleåldern / ADHD diagnosis during the preschool years : A systematic litterature review on how research focuses on the diagnosis of ADHD in preschool children

Persson Coyne, Cecilia January 2019 (has links)
Syftet med denna studie är att undersöka hur forskning från olika vetenskapliga fält och länder resonerar kring diagnostiseringen av ADHD hos förskolebarn. Som metod har en systematisk litteraturstudie använts, där de 22 vetenskapliga artiklar som framkommit vid den noggranna systematiska sökningen har granskats och analyserats genom en innehållsanalys. Vidare har the Relational Developmental System theory (RDS) använts som det teoretiska perspektivet för att analysera resultatet ytterligare. Resultatet från studierna visar på att en tidig diagnos med tillhörande behandling kan vara värdefullt för utvecklingen av barnets sociala förmågor och senare akademiska framgångar. Däremot finns det risk för feldiagnostisering och onödig behandling om diagnos ställs i tidig förskoleålder, därför bör noggrann utredning göras och en provisorisk diagnos kan vara att föredra om misstanke finns att symtomen skulle kunna vara åldersrelaterade. Forskningen har även visat att förskollärarnas kunskap om ADHD-relaterad problematik är betydelsefull för bedömningen vid utredning inför diagnostisering, men även att förskollärarnas inställning och utbildning påverkar arbetet med barn som uppvisar ADHD-symtom eller som har diagnosen. Enbart forskning från det senaste decenniet är med i denna studie, detta för ADHD-diagnostisering har ökat kraftigt och forskningen gått snabbt framåt.
322

Análise comparativa do desenho da figura humana em crianças diagnosticadas com transtorno de déficit de atenção e hiperatividade: um estudo exploratório / Comparative analysis of human figure design in children diagnosed with attention deficit hyperactivity disorder: an exploratory study

Ligeiro, Jeferson Luís 10 May 2019 (has links)
O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) é um distúrbio bastante referido tanto na área da saúde quanto na área da educação, podendo resultar em inúmeros problemas presentes e futuros para seus portadores. A literatura apresenta variados fatores etiológicos para o desenvolvimento do transtorno, havendo certo consenso de que o problema se deve a uma predisposição genéticaque pode seatualizar em função de estímulos docontexto ambiental. O TDAH inclui sintomas de desatenção, agitação e impulsividade que ocorrem em frequência e intensidade inadequadas à faixa etária dos sujeitos, sendo diagnosticado, geralmente,por meio de escalas comportamentais a serem respondidas por familiares e/ou professores, as quais podem ou não ser acompanhadas de testes (neuro)psicológicos, além de observação do comportamento da criança. O teste do Desenho da Figura Humana(DFH)tem sido um dos instrumentos mais utilizados por psicólogos, tanto para analisar aspectos cognitivosquanto elementos da personalidadedo executor do desenho. Dessa forma, por meio de uma comparação do desempenho no referido teste entre crianças diagnosticadas e não diagnosticadas com o transtorno, este trabalho tevecomo objetivo identificar possíveis traços indicadores da presença do TDAH nos desenhos das crianças portadoras do transtorno, visando àobtenção de mais um recurso que possa auxiliar psicólogos na execução de um diagnóstico mais confiável para o TDAH. Participaram do estudo 20crianças, alunas do1º. Ciclo do Ensino Fundamental, divididas em Grupo Clínico, composto por 10crianças diagnosticadas como sendo portadoras de TDAH, e Grupo Controle, composto por 10crianças com idade, sexo, escolaridade e nível socioeconômicoequivalentes, porém que nãoapresentavam o problema. Após ambos os grupos serem submetidos ao DFH, análises comparativas do nível de maturidade cognitiva e dos indicadores emocionais,bem como de aspectos gerais dos desenhos dos participantes (tamanho, traçado), foramefetuadas, de modo a verificar a existência ou não de diferenças significativas entre os grupos.Os resultados obtidos sugerem um desempenho mais baixo dos portadores de TDAHem termos de maturidade cognitiva, bem como maior presença de indicadores emocionaise de problemas de coordenação motora no grupo clínico, embora sem atingir significância estatística. Sugere-se a necessidade de ampliação da amostra a fim de que se possa obter resultados mais conclusivos a respeito da possibilidade de uso do DFH como instrumento auxiliar no diagnóstico do TDAH / Attention Deficit Hyperactivity Disorder (ADHD) is a disorder that is very much referred to in the health area as well as in the area of education, which can result in numerous present and future problems for the subjects. The literature presents a variety of etiological factors for the development of the disorder, with some consensus that the problem is due to a genetic predisposition that can be updated in function of stimuli of the environmental context. ADHD includes symptoms of inattention, agitationand impulsivity that occur in frequency and intensity that are inappropriate for the subject\'s age group and are usually diagnosed through behavioral scales to be answered by family members and / or teachers, which may or may not be followed by(neuro) psychological tests, as well as observation of the child\'s behavior. The Human Figure Drawing test (HFD) has been one of the instruments most used by psychologists, both to analyze cognitive aspects and personality elements of the executor of the drawing. Thus, through a comparison of performance in HFDtest between children diagnosed and undiagnosed with the disorder, this study aimed to identify possible indicative traits of the presence of ADHD in the drawings of children with the disorder, aiming to obtain an additional resource that can help psychologists to execute a more reliable diagnosis for ADHD. The participants of the research were20 children, students from the 1st. Elementary School Cycle, divided into a Clinical Group, composed of 10 children diagnosed as having ADHD, and Control Group, composed of 10 children with age, sex, education and socioeconomic level, but who did not present the problem. After both groups were submitted to HFD, comparative analyzes of the level of cognitive maturity and emotional indicators, as well as general aspects of the participants\' drawings (size, tracing), were performed, in order to verify the existence or not of significant differences between groups. The results suggest a lower performance of the ADHD patients in terms of cognitive maturity, as well as greater presence of emotional indicators and poor manual coordination in the clinical group, although not reaching statistical significance. We suggest the need to expand the sample in order to obtain more conclusive results regarding the possibility of using HFD as an auxiliary tool in the diagnosis of ADHD
323

Academic achievement in ADHD adolescents experiencing barriers to learning : perceptions of parents and learners.

Kruger, Michal 25 February 2014 (has links)
The aim of this research was to determine the perceptions of parents and learners are surrounding academic achievement and the factors which contribute to it, taking into consideration barriers to learning. The research also aimed to investigate what their perceptions are on the factors which contribute to academic achievement. There were a total of six dyads, six adolescents (middle to late adolescence) and eight parents. All of the adolescents had been diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Each of the adolescents took part in an interview and the parents took part in a separate interview. The interviews were semi-structured in nature. The findings of the study indicated that academic achievement was defined as being based on marks or on the ability of the learners to achieve their potential. The factors perceived to influence academic achievement such as peers, educators, school environment and the role of parents were found to be similar between parents and adolescents. The barrier to learning (ADHD) was not perceived as having a greater influence on academic achievement than any other factor.
324

Foundation phase educators' perceptions of Attention Deficit Hyperactivity Disorder (ADHD) at private and public schools.

Kern, Anwynne 28 June 2010 (has links)
This study investigated foundation phase educators’ perceptions of Attention Deficit Hyperactivity Disorder (ADHD). The educators’ views on the causes, appropriate interventions and incidence rates of ADHD were examined. A sample of 140 foundation phase educators from mainstream private and public schools participated in the study. The educators completed a self-developed questionnaire that had been piloted by the researcher. Descriptive statistics were used to analyze the quantitative data, in conjunction with t-tests to ascertain the differences in responses between public and private school educators. Thematic content analysis was used to identify the main categories and themes that emerged form the open-ended questions. The results revealed that the educators had a limited understanding of ADHD, in terms of what it is as well as its causes. In addition, it emerged that the educators preferred medication as the intervention method despite being aware of additional intervention methods. A comparison of the private and public school educators’ results indicated no significant difference in the educators’ perceptions regarding the cause, interventions or incidence rate of ADHD. These findings are discussed in relation to empirical studies and suggestions for future research are presented.
325

A comparative study of ADHD prevalence in 4 Gauteng schools and an exploration of the experiences of adolescents diagnosed with the disorder

Moss, Linda Louise January 2017 (has links)
A research report submitted to the Faculty of Humanities University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Arts (Research Psychology), 2017 / ADHD is one of the most prevalent disorders in child psychiatry today. Whilst the phenomenon of ADHD is well researched in Europe and North America, there are limited studies available in South Africa that explore the link between ADHD and different forms of schooling. Furthermore, few studies focus on the children who have been socially positioned in this way. This study focused on the prevalence of ADHD with a particular aim to explore how gender, race and class play out in an unequal schooling system. The secondary aim was to contribute to the knowledge about adolescents’ own understandings and experiences of ADHD. The research was conducted in two distinct phases, Phase 1 included the administration of a demographic questionnaire to determine the prevalence of the disorder within four different Gauteng schools. Phase 2 of the project included semi-structured interviews to explore the understandings, perceptions and experiences of children living with this diagnosis. This study explored the prevalence of ADHD across four different schools in Gauteng. Results of the study propose that the diagnosis and prevalence of this phenomena is strongly influenced by gender, race and class, as the majority of children diagnosed are boys (65%), more than half are from upper class families (61%) and most of the children are white (71%). The adolescents who were interviewed indicated that teachers were mostly the initiators of their diagnosis due to deviations from classroom behaviour and academic performance. While the children claimed that the diagnosis and the medication had certain benefits, they also identified distinct disadvantages with the most notable adverse effects on mood and interactions with their peers. The predominant biomedical view of the disorder seemed to be internalised by the children which positioned them in a subordinate relationship with health care professionals. A strong theme of disempowerment emerged, with medical experts and mothers, identified as gatekeepers to their sense of agency. / XL2018
326

Arbetsterapeuters kliniska resonemang vid arbetet med vuxna klienter med ADHD / Occupational therapists clinical reasoning when working with adult clients with ADHD

Hägglund, Ida January 2019 (has links)
Syftet med studien var att beskriva arbetsterapeuters kliniska resonemang vid arbetet med vuxna klienter med ADHD. Genom ett ändamålsinriktat urval identifierades åtta arbetsterapeuter inom psykiatrisk öppenvård som hade erfarenhet av att arbeta med vuxna klienter med ADHD. Data samlades in genom narrativa intervjuer och analyserades därefter med stöd av en paradigmatisk narrativ metod. Analys av data resulterade i tre teman som benämndes: Att möta personen där den är och skapa delaktighet i processen; Att möta en mångfacetterad problematik kräver samverkan; Att coacha klienten att etablera effektiva vanor. Arbetsterapeuternas kliniska resonemang ger indikationer på att det vid arbetet med berörd klientgrupp är viktigt att ta samtalets betydelse, klientcentrering och teamarbete i beaktning. Den visar på hur samtalet kan vara en intervention i sig och hur arbetsterapeuterna genom sitt resonemang kan möjliggöra klientcentrering genom att sätta klienten i fokus både i teamet och i det enskilda arbetet med klienten. Studiens resultat anses kunna bidra med kunskap för arbetsterapeuter som arbetat med vuxna klienter med ADHD och resultatet bör även gå att appliceras på andra klientgrupper inom området psykiatri eftersom denna studie tyder på att klienterna ofta har en mångfacetterad problematik som bidrar till utmaningar i dagliga aktiviteter. / The aim of the study was to describe the clinical reasoning of occupational therapists when working with adult clients with ADHD. Through a purposeful selection, eight occupational therapists were identified in psychiatric outpatient care who had experience working with adult clients with ADHD. Data was collected by narrative interviews and then analysed using a paradigmatic narrative method. Analysis of data resulted in three themes called: To meet the client where he or she is and promote participation in the process; To meet a multifaceted problem requires collaboration; To coach the client to establish effective habits. The clinical reasoning of occupational therapists gives indications that when working with the affected client group it is important to take into consideration the importance of the conversation, client centeredness and teamwork. It shows how the conversation can be an intervention in itself and how the occupational therapists can, through their reasoning, enable client centeredness by putting the client in focus both in the team and in the individual work with the client. The study's results can be considered to contribute knowledge for occupational therapists who work with adult clients with ADHD, and the result should also be applicable to other client groups in the field of psychiatry, as this study suggests that the clients often have  multifaceted problems that contributes to challenges in everyday occupations.
327

Desenvolvimento psicológico e estratégias de intervenção em crianças com Transtorno de Déficit de Atenção e Hiperatividade (TDAH) / Psychological development and intervention strategies with children with Attention Deficit Hyperactivity Disorder (ADHD)

Folquitto, Camila Tarif Ferreira 13 December 2013 (has links)
O TDAH é um fenômeno de entendimento complexo e muitas vezes controverso, possuindo sintomas que, em certo grau, estão presentes em crianças de diferentes idades e contextos, reforçando a necessidade de pensar essa manifestação a partir de teorias que reflitam sobre o desenvolvimento da criança. Em estudo anterior (Folquitto, 2009), investigou-se o desenvolvimento de crianças diagnosticadas com TDAH. Os resultados sugeriram indícios de defasagens no desenvolvimento, e não foram observadas diferenças significantes no desempenho entre grupos de crianças com TDAH, fazendo ou não uso de medicamentos, durante a aplicação de provas piagetianas. Procurou-se, na presente pesquisa, elaborar estratégias de intervenção que possibilitem às crianças avançar em seu desenvolvimento, a partir da construção de novos procedimentos que conduzirão, progressivamente, a estruturações mais avançadas de pensamento. A hipótese foi verificar se é possível proporcionar, com base na teoria piagetiana, experiências facilitadoras para a construção de capacidades cognitivas e afetivas que favoreçam o desenvolvimento dessas crianças, bem como investigar suas crenças espontâneas sobre o tempo. Foi conduzido um estudo longitudinal, durante 12 meses, com intervenções utilizando jogos e situações problema, estimulando reflexões, aquisição de conhecimentos significativos, favorecendo a construção de procedimentos e consciência das ações. A mediação realizada pelos profissionais foi a principal estratégia de intervenção adotada, com o intuito de mobilizar processos de autorregulação nas crianças. Participaram da pesquisa 18 crianças, com idades entre 7 a 12 anos. Anteriormente, e posteriormente à intervenção, os participantes e seus pais foram entrevistados, para avaliação do desenvolvimento das noções operatórias, medidas neuropsicológicas e sintomas de TDAH. Foram utilizados os seguintes instrumentos: SNAP-IV, WISC-III (subtestes Vocabulário, Cubos, Código, Dígitos e Procurar Símbolos), Figura de Rey, e as seguintes provas piagetianas: Conservação das quantidades discretas, Mudança de critério/dicotomia, Noção de ponto e contínuo, O relacionamento das perspectivas, Sucessão dos Acontecimentos Percebidos, Simultaneidade e O tempo da ação própria e a duração interior. Perguntou-se também às crianças o que era o tempo, solicitando exemplos. Os participantes foram subdivididos em um grupo intervenção, que participou das atividades propostas (n=13), e grupo comparação (n=5). Foi escolhida a estratégia de composição dos grupos a partir de uma amostra definida por conveniência. Para o grupo intervenção, houve diferença estatisticamente significativa, na comparação entre as avaliações anterior e posterior à intervenção, em relação aos sintomas, QI, velocidade de processamento e funções executivas. Comparando-se os dois momentos, houve diferença significativa para as respostas das provas piagetianas como um todo (p=0,011), O relacionamento das perspectivas (p=0,024) e Simultaneidade (p=0,023). O grupo comparação não apresentou diferença estatisticamente significativa no desempenho nas avaliações, para as medidas analisadas. Sobre as crenças espontâneas sobre o tempo, constatou-se que a maioria das crianças conceituou o tempo como vinculado à própria ação, desconsiderando aspectos como a sucessão dos movimentos e a sensação de passagem do tempo. Os resultados indicam que as intervenções com jogos, em grupo e mediadas por profissionais, podem mobilizar o desenvolvimento de crianças com TDAH, diminuindo sintomas e melhorando suas funções executivas, e, principalmente, tais resultados demonstram que o método de intervenção realizado, pautado na utilização de jogos mediada por profissionais, foi efetivo para mobilizar processos de autorregulação e tomada de consciência por parte dos participantes, que assim puderam avançar em seu desenvolvimento, construindo procedimentos de melhor qualidade e estruturações cognitivas e afetivas mais adaptadas. Portanto, os resultados obtidos podem ser interpretados como um indício de que propostas de intervenções em longo prazo, envolvendo situações problema, reflexões sobre as ações e tomada de consciência, são fundamentais para que crianças com TDAH possam ter processos de aprendizagem e desenvolvimento mais significativos / ADHD is a complex disorder, whose understanding is often controversial. ADHD symptoms, to some degree, are present in children with different ages and backgrounds, reinforcing the need to study this phenomenon from a theoretical perspective that considers the development of children. In a previous study (Folquitto, 2009), it was investigated the development of children diagnosed with ADHD. They were also evaluated according to whether use psycho stimulant medications or not. Comparing subgroups, no significant differences were observed, indicating that the use of these medications has not contributed sufficiently to favour the development of ADHD children. In the present research, we aimed at developing intervention strategies that could enable children to enhance development, constructing new procedures who lead, progressively, to more advanced structures of thinking. The hypothesis of this work was to investigate if it is possible to provide, based on the Piagetian theory, experiences that facilitate the construction of cognitive and affective capacities that would favour the development of these children, as well as to investigate their spontaneous beliefs about time. This is a longitudinal study, performing interventions with games and problem-solving situations that stimulate children to analyse their activities and to acquire meaningful knowledge, favouring the construction of new procedures, awareness of actions and cognitive structuring. Participants were 18 children, aged 7-12 years old. Previously, and after the intervention, participants and their parents were interviewed to assess the development of operational notions, neuropsychological measures of Executive Functions and ADHD symptoms. We used the following instruments: SNAP-IV, WISC-III´s subtests \"Vocabulary\", \"Block Design\", \"Coding\", \"Digit Span\" and \"Symbol Search\", Rey Osterrieth Complex Figure (ROCF), and the Piagetian tasks Conservation of discrete quantities; Change of criteria - dichotomy; the tasks Three mountains, Succession of Events Perceived, The ideia of points and the ideia of continuity, Simultaneity, and The time of the action and the internal duration.Participants were divided into an experimental group, who took part in the intervention (n=13), and a control group (n=5), composed by ADHD children who did not take part in the intervention program. For the intervention group there were statistically significant differences when comparing the assessments before and after the intervention for symptoms, IQ, processing speed and executive functions. Comparing the two periods, there was significant difference in the responses of piagetian tasks as a whole (p=0.011), the Three mountains task (p=0.024) and Simultaneity (p=0.023). The comparison group showed no statistically significant difference in the performance evaluations for the measures analyzed. Regarding spontaneous beliefs about time, the majority of children conceptualized time as linked with action itself, not considering aspects like the succession of movements and sensation of time going by. Results indicate that interventions with games, mediated by professionals, can be useful tools to assist and enhance the development of children with ADHD, decreasing symptoms and improving executive functions. Specially, this results demonstrate that intervention method performed, based on use of games mediated by professionals, was effective in mobilizing self-regulation and awareness processes by participants. Thus, they were able to move forward in its development, building better procedures and affective and cognitive structuring more adapted. Results presented can be interpreted as an indication that long-term interventions, involving problem solving situations, reflections on the actions and awareness are fundamental to enable children with ADHD to have more meaningful learning processes and developing
328

TDAH e infância contemporânea: um olhar a partir da psicanálise /

Schicotti, Rosana Vera de Oliveira. January 2013 (has links)
Orientador: Jorge Luis Ferreira Abrão / Banca: Audrey Setton Lopes de Souza / Banca: Diana Pancini de Sá Antunes Ribeiro / Banca: Mary Yoko Okamoto / Banca: Viviana Carola Velasco Martinez / Resumo: Segundo o Fórum sobre Medicalização da Educação e da Sociedade, de 2005 a 2010 houve um aumento da compra do metilfenidato pelos órgãos públicos em torno de 1400%. Deste modo, contextualizar e compreender o crescente número de diagnósticos do Transtorno do Déficit de Atenção/Hiperatividade, bem como o aumento da venda de medicamentos para este transtorno, tem sido uma empreitada comum de muitos autores que se dedicam ao tema da infância. O presente trabalho visa compreender os significados e as peculiaridades da sintomatologia do TDAH, elucidando a polissemia imbricada na singularidade de cada caso particular. Os objetivos específicos foram: identificar as experiências singulares de crianças, pais e professores e entender os sentidos comunicados por suas queixas e dificuldades; apontar algumas correlações entre certos traços da nossa cultura e a atual proliferação de diagnósticos do referido transtorno. Para tanto, realizei um trabalho de psicodiagnóstico com crianças que foram encaminhadas para atendimento psicológico em uma cidade do interior paulista. Foram atendidos três casos de crianças diagnosticadas com TDAH, todas medicadas com metilfenidato e/ou outros medicamentos, as quais foram acompanhadas por médicos neuropediatras e psicólogos. Deste modo, optei por trabalhar com o método psicanalítico. Este se enquadra em um modelo de pesquisa qualitativa, visto que neste enquadre o conhecimento tem um caráter interpretativo, na medida em que é construído em um processo de atribuição de sentidos. Assim, partindo da bibliografia estudada, dos casos atendidos e do olhar psicanalítico, pude constatar que na contemporaneidade, tornou-se cada vez mais raro abster-se das tecnologias medicamentosas/biológicas para educar crianças e adolescentes. Foi frequente a... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: According to the Forum of Education and Society Medicalization, from 2005 to 2010, there was an increase in the purchase of methylphenidate by public agencies, around 1400%. Thus, contextualizing and understanding the growing number of diagnoses of Attention Deficit Hyperactivity Disorder, as well as the increasing of sales of drugs for this disorder, it has been an ordinary venture of many authors who dedicate themselves to the theme of childhood. This study aims to understand the meanings and the peculiarities of the symptoms of ADHD, explaining the different meanings embedded in the uniqueness of each individual case. The specific objectives were: identifying the unique experiences of children, parentes, and teachers as well as understanding the meanings communicated by their complaints and difficulties; demonstrating some correlations between certain traits of our culture and the current proliferation of the diagnoses of the said disorder. Therefore, I performed a work of psychodiagnostic with children who were referred for psychological care in an inland city of São Paulo state. Three cases of children diagnosed with ADHD were seen, all of them medicated with methylphenidate and / or other drugs, which were accompanied by neuropediatricians and psychologists. Thus, I chose to work with the psychoanalytic method. This fits itself into a model of qualitative research, since knowledge has an interpretive character frame, as it is built on a process of assigning senses. Thus, based on the literature studied, the cases treated, and psychoanalytical study, I found out that, nowadays, it has become increasingly rare to abstain from drug/biologic technologies to educate children and teenagers. It was common the observation of lack of discrimination between parents‟ and children‟s places. The family dynamics... (Complete abstract click electronic access below) / Doutor
329

A Study of an ADHD Experience Video Game's Effect on Users' Attention

Jessica R. Balfe (5930531) 10 June 2019 (has links)
<div>Although some literature suggests that video games improve attention skills within the game-play, this study addressed translating this effect on attention in the real world. Research has shown video games can help people focus. Yet, there is lack of evidence displaying whether video games improve or diminish attention skills. The video game “The Inattentive Mind”, a game created for this study, used a method of overstimulation in the form of user interfaces, sound, and environmental interaction to try and help participants to empathize or improve their attention skills outside of the game. Using an experimental design of pre-test, video game intervention, and post-test, results were expected to show improved attention skills. These results did not show conclusive evidence of significant changes in attention skills. However, the results did show an increase in ADHD understanding.<br></div>
330

Farmakologisk långtidsbehandling vid ADHD : Hur skiljer sig substanserna metylfenidat, lisdexamfetamin och atomoxetin? / Pharmacological long-term treatment in ADHD : How do the substances methylphenidate, lisdexamfetamine and atomoxetine differ?

Andersson, Lea January 2019 (has links)
Attention Deficit Hyperactivity Disorder (ADHD) is a neuropsychiatric disability  characterised by difficulties in paying attention, excessive activity and actions without thinking about the consequenses. Symptoms vary among different individuals in how the disability expresses. Symptoms also vary among different age groups. The cause of ADHD is not yet known, but the main theory seems to be due to disturbed dopaminergic transmisson in the regions of the brain that controlls attention, activity control and impulses. Clinical studies show that there seems to be a connection between the etiology of the disability and genetic- and environmental factors. ADHD can’t be cured but a multimodal treatment has been proven to be effective in symptom reduction. The multimodal treatment consist of psychoeducation, psychotherapy and medical treatment. In Sweden methylphenidate is the first choise of drug and if it is not tolerated well by patients in terms of respons or side effects lisdexamfetamine or atomoxetin is choosen. The mechanism of action for these three substances is not completly known but in general they presume to block the reuptake of dopamine and norepinephrine in the presynaptic neurons. This leads to an enhanced transmission at the dopaminergic neurons that in turn stimulates the executive funtions that seem to be deficient in ADHD patients. The aim of this literature study is to investigate how the three substances methylphenidate, lisdexamfetamine and atomoxetine differ in therapeutic effects and side effects profile during long-term treatment for ADHD. Five scientific articles were choosen from the database Pubmed, which analysed the therapeutic effects and side effects of the above choosen drugs during a period of atleast 24 weeks. Participants in the selected studies had a definite diagnosis of ADHD and the participants included were children, adolescents and also adults. Therapeutic efficiency of selected drugs was measured by using different diagnostic scales such as ADHD-RS-IV, CAARS-Inv:SV, AISRS, CGI-S or CGI-I. Therapeutic efficiency was measured by the total reduction of the mean value in the rating scale from start to end of the study. Safety was measured at each follow up session by evaluating the side effects profile and measurements of vital parameters. These studies show statistically significant symptom reductions for all three selected drugs. The results also show differences in therapeutic effects among different drugs. Participants treated with lisdexamfetamine showed greater symptom reduction and thereby the greatest effect. There may be a difference in therapeutic effect between methylphenidate and atomoxetine but more studies are needed to conclude the results. The adverse effects were similar between lisdexamfetamine and methylphenidate but more serious effects were found during treatment with lisdexamfetamine.

Page generated in 0.1592 seconds