After the students in high school have learned to integrate a function, the calculation of the volume of a solid of revolution, like a rotated parabola, is taken as a good applied example. The next step is to calculate the volume of an object of reality which is interpreted as a solid of revolution of a given function f(x). The students do all these calculations in the same way and get the same result. Consequently the teachers can easily decide if a result is right or wrong. If the students have learned to work with a graphical or CAS calculator, they can calculate the volume of solids of revolution in reality by modelling a possible fitted function f(x). Every student has to decide which points of the curve that generates the solid of revolution can be taken and which function will suitably fit the curve. In Austrian high schools teachers use GeoGebra as a software which allows you to insert photographs or scanned material in the geometric window as a background picture. In this case the student and the teacher can control if the graph of the calculated function will fit the generating curve in a useful way.

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Submitted by Clebson Anjos (clebson.leandro54@gmail.com) on 2016-03-10T21:04:39Z No. of bitstreams: 1 arquivototal.pdf: 2589803 bytes, checksum: b920704887c22a48700cc509f77c8735 (MD5) / Made available in DSpace on 2016-03-10T21:04:39Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2589803 bytes, checksum: b920704887c22a48700cc509f77c8735 (MD5) Previous issue date: 2015-10-23 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Public and private organizations are both experiencing a moment when the intellectual capital has become a source of differentiation and success for them to achieve their goals, so that they can produce wealth and a more important value than those ones previously generated by capital and labor. This new point of view is influenced by Knowledge Management (KM), which has raised the knowledge to an important administrative role in the organizational routine activities. In public service, KM has changed the focus of the sectors that deal with knowledge. With it, favorable conditions for creating new skills to improve efficiency and quality of services provided to citizens and society are being raised among the newest concerns of the managers. Given the above, this study aims to analyze GC practices in the Attendance Center for Civil Servants (CAS) of the Dean of Human Resources Management (PROGEP) of the Federal University of Paraiba (UFPB), and to raise subsidies that promote KM improvement initiatives for carrying out their activities. The research consisted of a case study of applied nature, descriptive and bibliographic character, and its target population was all CAS servers involved in care processes. The method used to gather data collection was the Knowledge Management Diagnostic (KMD) elaborated by Bukowitz and Williams (2002), which consists of a questionnaire containing 140 questions with indicators for appreciation of seven sections of the knowledge. The result analysis was based on documentary evaluations associated to methodological procedures and metrics criteria established by KMD method. In view of this, the final results enabled the recognition of shortcomings and gaps in the areas of KM, as well as indicate some initiatives for building an action plan in the section ‘Evaluate’ which got the lowest score - 57%. For this, we can see that CAS develops in approximate proportions KM initiatives in the seven sections of KMD, with performances considered acceptable in all sections of the method and, in addition, it reached 63 percentile points in the overall result. This performance is higher than that found by Bukowitz and Williams in their field tests, 55%. Although the results are favorably disposed to GC practices, it is clear that much remains to be done, because there is no official, regular or continuous process to facilitate the engagement and learning conditions to be part of the organizational culture of CAS. / As organizações, tanto públicas quanto privadas, vivem um momento em que o capital intelectual tem se tornado fonte de diferenciação e de sucesso para que elas alcancem seus objetivos e, sobretudo, produzam riqueza e valor muito mais importantes do que aqueles antes gerados pelo capital e pelo trabalho. Essa nova visão é influenciada pela Gestão do Conhecimento (GC), que elevou o conhecimento a uma importante função administrativa nas atividades rotineiras das organizações e, no serviço público, tem mudado o foco dos setores que trabalham com o conhecimento, pois, através dela, condições favoráveis para criar novas competências e melhorar a qualidade dos serviços prestados ao cidadão e à sociedade estão sendo suscitadas nas novas preocupações dos gestores. Diante do exposto, objetivou-se, com este trabalho, analisar as práticas de gestão do conhecimento na Central de Atendimento ao Servidor (CAS) da Pró-Reitoria de Gestão de Pessoas (PROGEP) da Universidade Federal da Paraíba (UFPB) e levantar subsídios que promovam iniciativas de melhorias de GC no exercício de suas atividades. A pesquisa consistiu em um estudo de caso de natureza aplicada, de caráter descritivo e bibliográfico, e teve como população-alvo todos os servidores da CAS envolvidos nos processos de atendimento. Na coleta dos dados foi utilizado o instrumento KMD (Knowledge Management Diagnostic), elaborado por Bukowitz e Williams (2002), o qual é composto por um questionário estruturado com 140 questões, com indicadores para apreciação de sete seções do conhecimento. A análise dos resultados foi feita com base em avaliações documentais associadas aos procedimentos metodológicos e critérios de métricas estabelecidos pelo método KMD. À vista disso, os resultados finais possibilitaram reconhecer deficiências e lacunas nas áreas de GC da organização e indicaram iniciativas para construção de um plano de ação na seção ‘Avaliar’ que obteve menor pontuação – 57%. Para tanto, percebe-se que a CAS desenvolve em proporções aproximadas iniciativas de GC nas sete seções do KMD, com desempenhos considerados aceitáveis em todas as seções do método, além do que atingiu 63 pontos percentuais no resultado geral. Esse desempenho foi superior ao encontrado por Bukowitz e Williams em seus testes de campo, que foi de 55%. Apesar de os resultados se mostrarem favoráveis para as práticas de Gestão do Conhecimento, muito ainda deve ser feito, porquanto não existe um processo oficial, regular e contínuo para que condições facilitadoras de aprendizagem e envolvimento possam fazer parte da cultura organizacional da CAS.

Doctorat en sciences psychologiques / info:eu-repo/semantics/nonPublished

Doctorat en sciences psychologiques / info:eu-repo/semantics/nonPublished

Doctorat en philosophie et lettres / info:eu-repo/semantics/nonPublished

Doctorat en sciences psychologiques / info:eu-repo/semantics/nonPublished

The diploma thesis introduces the obligations, details, links, contexts and circumstances of integration in relation to the technical aspects of accounting. It provides information on the motives that lead to decisions about company mergers and acquisitions, the phases and principles of these processes, analyzes possible risks, human factors, potential reporting issues, and other practical aspects of accounting management.

L‟épissage alternatif est un mécanisme de régulation de l‟expression des gènes ayant pris une importance croissante dans l‟étude du vivant. Si des méthodes existent pour déterminer les gènes qui y sont soumis, peu d‟outils sont disponibles pour suivre ces événements d‟épissage in vivo au cours du développement. Pourtant, la caractérisation des régulations sous-jacentes à ces évènements et la détermination des facteurs impliqués sont dépendantes de stratégies fiables pour les visualiser dans des conditions physiologiques.Nous avons développé un système adapté à l‟étude d‟événements d‟épissage basé sur un rapporteur fluorescent bicolore. Nous l‟avons appliqué à cinq gènes de l‟organisme modèle Caenorhabditis elegans et avons suivi leur épissage in vivo.Parmi les différents gènes suivis, deux d‟entre eux suivaient un modèle d‟épissage potentiellement stochastique, un autre une absence d‟épissage alternatif détectable. Les deux derniers gènes présentent un profil d‟épissage spécifique à certain types cellulaires mais ont un effet toxique sur l‟organisme lorsque nous les avons exprimés à partir de concatémères extrachromosomiques. Pour remédier à cela, nous avons choisi de mettre en place une méthode simplifiée d‟insertion en simple copie des rapporteurs utilisant le CRISPR-Cas.Nos résultats indiquent que le système rapporteur fonctionne avec succès. Cependant, il peut encore être amélioré pour se rapprocher des taux physiologiques de transcription grâce à une insertion en simple copie dans le génome de l‟organisme. Nous avons également révélé un événement sous le contrôle de régulations spatiales, temporelles et conditionnelles. De plus, nous avons créé une série de constructions capables de déterminer les éléments en cis impliqués dans la régulation du gène top-1. / Alternative splicing is a regulatory mechanism of gene expression which is increasingly studied in Life Science. Methods exist to study this mechanism but specific tools to follow each alternative splicing event in a spatio-temporal manner are lacking. Yet, the characterization of the regulation and the elements that determines them depends on valide strategies for visualising them in physiological conditions.We have developped a dual-fluorescent reporter-based system in order to follow alternative splicing event regulation in vivo. It has been applied to five different genes in the model organism Caenorhabditis elegans. Among the genes followed, two follow a potentially stochastic scheme, one show no visible sign of alternative splicing. The last display tissue specific splicing patterns but developed a toxic effect in the animal when expressed from a multicopy extrachromosomal array. To remediate this problem, we decided to develop a method that allows for simpler single copy insertion of fluorescent reporter using CRISPR-Cas.Our results indicates that the dual-fluorescent reporter works well. However, this system can be upgraded by getting close to physiological rates of transcription allowed by single-copy insertion in the genome of C.elegans. We also discovered an alternatiove splicing event which follows a spatial, temporal and conditionnal regulation. Moreover, we constructed a set of different reporter to unravel the regulation observed in the gene top-1.

La découverte de nouveaux procédés biotechnologiques remet en question la capacité de la loi de fournir une protection suffisante de l'être humain dès le commencement de sa vie. Ces nouvelles méthodes, comme la méthode CRISPR/Cas9, également connue sous le nom de « genome editing », le don de mitochondries et, finalement, la création de cellules souches pluripotentes induites humaines (cellules hiPS) permettent de manipuler et d'influencer de manière fondamentale la constitution génétique de la progéniture et des générations futures. En vue de ces développements, cette thèse vise à élaborer un projet de loi adressé au législateur allemand en prenant compte de deux aspects : d'un côté, sur la base d'une analyse comparative du droit allemand et français, il s'agit d'optimiser la législation allemande actuelle en identifiant des avantages éventuels de l'approche réglementaire en France. De l'autre côté, en admettant que les techniques en question pourront être appliquées un jour avec des risques gérables, il est examiné sur la base d'une étude de droit constitutionnel allemand si une telle application future pourrait en principe être justifiée, le résultat de cette étude étant également concrétisé sous forme d'une proposition de loi. / The discovery of new biotechnological processes calls into question the ability of the law to provide sufficient protection for human beings from the beginning of their lite. These new methods, such as the CRISPR/Cas9 method -also known as "genome editing" -mitochondrial donation, and the creation of human induced pluripotent stem cells (hiPS cells), make it possible to manipulate and influence in a fundamental way the genetic make-up of one's offspring and future generations. This thesis aims to prepare a draft law addressed to the German legislature. ln so doing, it takes into account two aspects : on the one hand, it aims to optimise, on the basis of a comparative analysis of German and French law, current German legislation by identifying possible advantages of the regulatory approach in France. On the other hand – assuming that the techniques in question can one day be applied with controllable risks – it examines, on the basis of an analysis of German constitutional law, whether such a future application could, in principle, be justified and implements these considerations by drafting a legislative proposal.