För att klara av den befolkningsökning som sker i städerna projekteras nybyggnadsområden. Innan byggnation av bostäder kan ske måste ett beslut tas om val av spillvattensystem. I nuläget saknas enkla hjälpmedel för att jämföra och göra val baserat på systemens totala kostnader under dess livslängd. Målet med detta arbete var att ta fram en beräkningsmall som kan göra en livscykelkostnadsanalys samt vara ett komplement vid projektering och val av spillvattensystem. Topografin och områdesspecifika kostnader bryts ner och förs in i beräkningsmallen för den sträcka där spillvattenledningen ska anläggas. Mallen kontrollerar därefter om områdets förutsättningar uppfyller de krav som finns för spillvattenledningar eller ej. Resultatet som erhålls av beräkningsmallen påvisar initiala-, årliga och ackumulerade kostnader för de båda systemen. Skillnader och eventuella brytpunkter mellan ackumulerad kostnad för de båda systemen redovisas och kan användas som underlag vid val av spillvattensystem. Arbetet visade att det finns ett stort b / In order to cope with the population increase that occurs in the cities, new construction areas are being planned. Before the construction of housing can take place, a decision must be made regarding the choice of sewerage system. At present there are no simple tools to compare and make choices based on the systems total lifetime cost. The aim of this thesis has been to develop a calculation template that can perform a life cycle cost analysis and to be a complement to the project planning and choice of sewerage systems. The topography and area-specific costs are broken down and entered into the calculation template for the distance where the wastewater pipeline is to be constructed. The template then checks whether the area's conditions meet the requirements for wastewater pipelines or not. The result obtained from the calculation template shows initial, annual, and accumulated costs for the two systems. Differences and possible breakpoints between the accumulated cost of the two systems are reported and can be used as a basis for decision. The work showed that there is a great need for supporting tools to facilitate the planning and decision making of water systems.

La nécessité de simulations précises d’un réacteur nucléaire et spécialement dans des cas de cœurs et de configurations de combustible complexes, a imposé un usage accru de Codes Neutroniques Stochastiques (CNS). De plus, une demande a émergé pour des CNS à capacité inhérente d’estimation en continu de la variation de la composition isotopique du cœur ainsi qu’à couplage thermo-hydraulique optimisé. Des capacités supplémentaires sont exigées pour ces codes au vu de leur utilisation pour l’étude de nouveaux concepts de réacteur comme les Réacteurs Conduits par Accélérateur (RCA). Plus précisément, le réacteur hybride comprenant un réacteur nucléaire conventionnel et un accélérateur, nécessite l’analyse des deux composantes (réacteur – accélérateur) par un outil capable de couvrir le spectre énergétique neutronique extrêmement étendu qui caractérise ce système hybride.Ce travail présente les principales caractéristiques et capacités du nouveau CNS ANET (Advanced Neutronics with Evolution and Thermal hydraulic feedback) développé en collaboration du NCSR Demokritos (Grèce) avec CNRS/IDRIS et UPMC (France) et couvrant autant que possible les exigences exposées ci-dessus. ANET est basé sur la version ouverte du code PHE GEANT3.21 et est destiné à effectuer des analyses de cœurs de réacteurs conventionnels de génération II et III ainsi que des RCA. ANET est construit avec la capacité inhérentea) d’effectuer des calculs d’évolution du combustibleb) de simuler le processus de spallation dans le cas des RCAtout en tenant compte de la thermo-hydraulique du système.La version actuelle d’ANET utilise les trois estimateurs standard Monte Carlo pour le calcul du facteur de multiplication neutronique effectif (keff), soit l’estimateur de collision, celui d’absorption et celui de longueur de trace. Pour ce qui est du calcul du débit de fluence neutronique et des taux de réaction, les estimateurs de collision et de longueur de trace sont implémentés dans ANET suivant la procédure standard Monte Carlo. Pour ce qui concerne les calculs d’évolution (par exemple la consommation du combustible), une approche purement stochastique est implémentée dans ANET. A noter que la procédure usuelle consiste à coupler le code neutronique stochastique avec un code déterministe qui calcule la consommation du combustible. Pour les besoins d’analyse des RCA, le module INCL/ABLA a été incorporé dans ANET de façon à ce que le processus de spallation soit simulé par le code. La capacité d’ANET de simuler des configurations classiques a été démontrée en utilisant des résultats de mesures et des simulations de vérification effectuées en utilisant d’autres codes bien établis, ainsi qu’il est montré par la suite.Des données provenant de plusieurs installations et des analyses de problèmes-type internationaux ont été utilisés pour vérifier et valider les capacités d’ANET.Pour conclure, les résultats obtenus lors des comparaisons avec des mesures ou avec des simulations effectuées en utilisant d’autres codes neutroniques stochastiques ou déterministes, montrent qu’ANET possède la capacité de calculer correctement d’importants paramètres de systèmes critiques ou sous-critiques. Par ailleurs, l’application préliminaire d’ANET à des problèmes dépendant du temps fournit des résultats encourageants. ANET produit des estimations de consommation de combustible raisonnables, compte tenu que des incertitudes dans ce domaine sont souvent de l’ordre de 20% ou plus. Finalement, les performances du code dans le cas de KUCA montrent qu’ANET peut analyser des RCA de façon satisfaisante. / The necessity for precise simulations of a nuclear reactor especially in case of complex core and fuel configurations has imposed the increasing use of Monte Carlo (MC) neutronics codes. Besides, a demand of additional stochastic codes’ inherent capabilities has emerged regarding mainly the simulation of the temporal variations in the core isotopic composition as well as the incorporation of the T-H feedback. In addition to the above, the design of innovative nuclear reactor concepts, such as the Accelerator Driven System (ADSs), imposed extra requirements of simulation capabilities. More specifically, the combination of an accelerator and a nuclear reactor in the ADS requires the simulation of both subsystems for an integrated system analysis. Therefore a need arises for more advanced simulation tools, able to cover the broad neutrons energy spectrum involved in these systems.This work presents the main features and capabilities of the new MC neutronics code ANET (Advanced Neutronics with Evolution and Thermal hydraulic feedback), being developed in NCSR Demokritos (Greece) in cooperation with CNRS/IDRIS and UPMC (France) and intending to meet as effectively as possible the above described modelling requirements. ANET is based on the open-source version of the HEP code GEANT3.21 and is targeting to the creation of an enhanced computational tool in the field of reactor analysis, capable of simulating both GEN II/III reactors and ADSs. ANET is structured with inherent capability of (a) performing burnup calculations and (b) simulating the spallation process in the ADS analysis, while taking T-H feedback into account.The current ANET version utilizes the three standard Monte Carlo estimators for the neutron multiplication factor (keff) calculation, i.e. the collision estimator, the absorption estimator and the track-length estimator. Regarding the simulation of neutron fluence and reaction rates, the collision and the track-length estimators are implemented in ANET following the standard Monte Carlo procedure. For the burnup calculations ANET attempts to apply a pure Monte Carlo approach, adopting the typical procedure followed in stochastic codes. With respect to code improvements for the ADS analysis, so far ANET has incorporated the INCL/ABLA code so that the spallation process can be inherently simulated. The ANET reliability in typical computations was tested using observational data and parallel simulations by different codes as described in the following chapters.Various installations and international benchmarks were considered suitable for the verification and validation of all the previously mentioned features incorporated in the new code ANET. The obtained results are compared with experimental data from the nuclear infrastructures and with computations performed by well-established stochastic or deterministic neutronics codes and show satisfactory agreement with both measurements and independent computations, verifying thus ANET’s ability to successfully simulate important parameters of critical and subcritical systems. Also, the preliminary ANET application for dynamic analysis is encouraging since it indicates the code capability to inherently provide a reasonable prediction for the core inventory evolution taking into account the uncertainties of the order of 20% and even higher that are traditionally expected in core inventory evolution calculations. Lastly, the code performance in the KUCA case was found satisfactory demonstrating thus inherent capability of analyzing ADSs.

The aim of this paper is to propose a comprehensive revitalization of the side pond in the cadastral area of Skalička. As part of revitalization measures, the removal of mud from the pond, fortification of the banks and other modifications in connection with functional structures are proposed. In order to take water into the pond, a concrete diversion structure in the Hlubocky stream bed is designed, connected with pond via open canal with 2 pools, which will substitute the existing supply pipeline. As part of stabilization of the streambed and to overcome height difference, a boulder chute with stilling basin and related modifications are designed. The introductory part is a summary of knowledge from the issue and it explains important terms, historical context and description of basic principles. The next part describes the current situation and conditions in the surveyed locality. The following is a description of the methods and programs that were used for this work. The design part presents the proposed revitalization measures. An essential part of the work is also the varification of the proposed modification in the streambed, using 3D digital terrain model in Atlas DMT and subsequent 1D flow simulation in HEC-RAS.

Background: Novel intraoperative imaging techniques, namely, hyperspectral (HSI) and fluorescence imaging (FI), are promising with respect to reducing severe postoperative complications, thus increasing patient safety. Both tools have already been used to evaluate perfusion of the gastric conduit after esophagectomy and before anastomosis. To our knowledge, this is the first study evaluating both modalities simultaneously during esophagectomy. Methods: In our pilot study, 13 patients, who underwent Ivor Lewis esophagectomy and gastric conduit reconstruction, were analyzed prospectively. HSI and FI were recorded before establishing the anastomosis in order to determine its optimum position. Results: No anastomotic leak occurred during this pilot study. In five patients, the imaging methods resulted in a more peripheral adaptation of the anastomosis. There were no significant differences between the two imaging tools, and no adverse events due to the imaging methods or indocyanine green (ICG) injection occurred. Conclusions: Simultaneous intraoperative application of both modalities was feasible and not time consuming. They are complementary with regard to the ideal anastomotic position and may contribute to better surgical outcomes. The impact of their simultaneous application will be proven in consecutive prospective trials with a large patient cohort.

The performance of artificial nerve guidance conduits (NGC) in peripheral nerve regeneration can be improved by providing structures with multiple small channels instead of a single wide lumen. 3D-printing is a strategy to access such multi-channeled structures in a defined and reproducible way. This study explores extrusion-based 3D-printing of two-component hydrogels from a single cartridge printhead into multi-channeled structures under aseptic conditions. The gels are based on a platform of synthetic, anhydride-containing oligomers for cross-linking of gelatinous peptides. Stable constructs with continuous small channels and a variety of footprints and sizes were successfully generated from formulations containing either an organic or inorganic gelation base. The adjustability of the system was investigated by varying the cross-linking oligomer and substituting the gelation bases controlling the cross-linking kinetics. Formulations with organic N-methyl-piperidin-3-ol and inorganic K2HPO4 yielded hydrogels with comparable properties after manual processing and extrusion-based 3D-printing. The slower reaction kinetics of formulations with K2HPO4 can be beneficial for extending the time frame for printing. The two-component hydrogels displayed both slow hydrolytic and activity-dependent enzymatic degradability. Together with satisfying in vitro cell proliferation data, these results indicate the suitability of our cross-linked hydrogels as multi-channeled NGC for enhanced peripheral nerve regeneration.

No description available.

In my diploma thesis "The Development of Urban Build-up Area and Urban Infrastructure in Benešov in the Years 1918 - 1939", I explore one chapter in the development of a small agricultural town during the era of the First Czechoslovak Republic. This thesis is a contribution to the history of Czech towns during the interwar period and its topic corresponds to the research project of the Institute of Economic and Social History at the Faculty of Arts, Charles University in Prague, within the frame of which I worked on this thesis. The thesis was written mainly based on research of the resources in the State District Archives in Benešov (a branch office of the State Regional Archives in Prague) and of a wide range of relevant specialized literature. The introduction consists of a chapter offering a complex summary of the most important moments and changes in the development of Benešov during the examined period. Apart from the history of Benešov, it also shows the role of the town in the region and the relation of its development to other municipalities in the country. The focal point of the thesis lays in the extensive yet lucid chapters examining architectural development of the town (the essential moments, context, but also particular interesting buildings) and the development of its infrastructure...

L’évolution des turboréacteurs vers des taux de dilution toujours plus importants est associée à de nouvelles problématiques. Parmi elles, le raccourcissement de l’entrée d’air et de la tuyère est associé à une diminution du gain apporté par les traitements acoustiques de nacelle. La contribution des traitements situés dans l’espace entre la soufflante et le stator redresseur (OGV) va donc prendre de l’importance par rapport à l’ensemble des traitements. Cette zone, également appelée “interstage”, est caractérisée par une forte giration de l’écoulement moyen due à l’entraînement du fluide par le rotor. L’objectif de ce travail est de développer un modèle analytique afin d’évaluer l’effet de la giration sur le comportement des traitements acoustiques dans l’interstage, ainsi que sur le bruit à large-bande rayonnant en amont dû à l’interaction de la turbulence en aval de la soufflante avec les aubes des stators (OGV). Dans un premier temps, l’évolution de petites perturbations dans écoulement moyen tournant et cisaillé dans un conduit rigide est étudiée. Après avoir introduit les équations ainsi que les hypothèses du problème, l’analogie acoustique de Posson & Peake [122] est présentée. L’effet de la giration sur le contenu modal dans un conduit rigide est mis en évidence pour plusieurs types d’écoulements tournants. En particulier, le décalage des fréquences de coupures est étudié. L’étude est ensuite étendue au cas d’un conduit annulaire traité acoustiquement. Une attention particulière est portée sur la condition aux limites à appliquer aux parois du conduit. Dans ce cadre, une correction due aux effets centrifuges est apportée à la condition aux limites de Myers [101]. Une extension du modèle de Brambley [24] est aussi proposée afin de prendre en compte l’effet de l’épaisseur de la couche limite aux parois du conduit dans le cas tournant. Les effets combinés de la rotation et de la condition aux limites sur le contenu modal sont ensuite étudiés. En outre, une relation de dispersion pour les modes de surfaces en présence d’écoulement tournant est développée. À partir des développements précédents, un modèle de transmission acoustique est proposé afin d’évaluer l’effet de la giration sur le comportement des traitements acoustiques. La méthode repose sur le principe de raccordement modal appliqué à la conservation du débit massique et de l’enthalpie totale aux interfaces séparant les sections rigides et traitées. Une nouvelle méthode de projection basée sur les propriétés des polynômes de Chebyshev est proposée. À partir de ce modèle, l’efficacité des traitements acoustiques est étudiée pour différents écoulements tournants. Enfin, un modèle de prédiction du bruit à large-bande d’interaction rotor-stator est établi à partir de l’analogie de Posson & Peake [122], dans le but de prendre en compte l’effet de la giration sur la puissance acoustique rayonnée en amont. Le terme source est calculé selon le formalisme de Posson et al. [120]. Le modèle ainsi développé permet de prendre en compte une évolution radiale des paramètres géométriques et des propriétés statistiques de la turbulence incidente. Le modèle est ensuite évalué sur le cas test NASA SDT pour différents régimes et géométries. / The advent of modern turbofan engines such as UHBR goes along with new issues. Amongst others, the shortening of the inlet and exhaust yield a relatively higher importance of the liners located inside the interstage, where the flow is highly swirling. The present work aims at developing analytical models to assess the effect of the swirl both on the behavior of the interstage liners and on the upstream radiation of the fan-OGV interaction broadband boise. The evolution of small fluctuations in a rigid annular duct containing a swirling and sheared mean flow are studied first. After having introduced the governing equations and the main assumptions, the acoustic analogy of Posson & Peake [122] tailored to an annular duct with swirl and shear is presented. The effect of the swirl on the modal content in a rigid annular duct is highlighted for different types of swirl. In particular the shift of the cut-on thresholds is studied. Then, the modal analysis is extended to a duct with lined walls. A particular attention is paid on the boundary condition. Notably, a correction of the classical Myers boundary condition [101] is proposed to account for the centrifugal effects. An extension of Brambley’s boundary condition [24] is also derived to account for the boundary layer thickness to first order. The effect of both the swirl and the boundary condition on the modal content are studied. Besides, a dispersion relation for the surface waves is derived for the corrected Myers boundary condition. Based on the previous modal analyses, a transmission tool is developed to assess the effect of the swirl on the efficiency of a liner. The method, which relies on the mode-matching approach, is based on the conservation of the total enthalpy and the mass flow at the interfaces between the rigid and the lined sections. Due to the nature of the eigenfunctions, a new projection method based on the Chebyshev polynomial properties is proposed. Thanks to this model, the absorption is assessed for different types of swirl. Finally, a rotor-stator interaction broadband noise prediction model is derived from Posson & Peake’s acoustic analogy [122], to account for the effect of the swirl on the upstream radiated acoustic power. The source term is computed according to Posson et al.’s model [120]. It allows considering a radial variation of the geometry and the statistical properties of the incident turbulence. The model is assessed on the NASA SDT test case and the effect of the swirl is evaluated for several stator geometries and regimes.

Dans le but de réduire la consommation en carburant et les émissions de CO2 des moteurs à combustion interne, un des leviers, qui a intéressé diffèrent acteurs dans le secteur automobile, est la récupération de l’énergie thermique disponible dans les gaz d’échappement. Malgré différents technologie ont été investigués dans le passé; les transferts de chaleur qui apparient dans les gaz d’échappement n’ont pas encore étés suffisamment étudiés. Le fait que les échanges de la chaleur apparent dans des conditions pulsatives, notamment due aux conditions de fonctionnement moteur, rende les connaissances acquis jusqu’à présent limités et ne pas exploitables. A l’état actuel on n’est pas capable de pouvoir prédire le transfert thermique convectif des écoulements pulsé. Les travaux de cette thèse s’instaurent dans la continuité de ce besoin, l’objectif principal est donc l’étude expérimentale du transfert thermique convectif des écoulements turbulent pulsés dans un conduit cylindrique. La première partie de ce travail a été consacrée à le dimensionnement d’un moyen d’essais permettant la création d’un écoulement pulsé type moteur; en suite différents méthodes de mesures ont étés développes afin de connaitre les variations instantanés de vitesse et température de l’écoulement. Plusieurs essais ont été reproduits afin de caractériser l’impact de la pulsation sur le transfert de la chaleur. Les résultats expérimentaux ont été analysés avec deux approches différentes: dans un premier temps une approche analytique 1D a permis de mettre en évidence le mécanisme principal responsable de l’amélioration du transfert thermique convectif,ainsi, il a fourni des éléments supplémentaires pour le futur développement de modèles mathématiques plus adaptés à la prédiction des transferts d’énergie. En suite une approche 2D, supporté d’une phase de modélisation numérique, a permis de caractériser le mécanisme de transport radial d’énergie thermique. / Waste Energy Recovery represents a promising way to go further in fuel saving and greenhouse emissions control for Internal Combustion Engine applications. Although several technologies have been investigated in the past few years, the convective heat transfers, playing an important role in the energy exchanges at the engine exhaust, has not receive enough attention. Heat transfers, in such applications, occur in pulsating conditions because of the engine operating conditions, making thus the actual knowledge of the heat transfer phenomena limited and not exploitable. Nowadays there is not any model capable to predict convective heat transfers for pulsating flows. In this context, the present thesis addresses the purpose to study the convective heat transfer phenomena, by an experimental approach, occurring for turbulent pulsating flows in pipes. In the first part of this work, an experimental apparatus has been designed to reproduce an exhaust type pulsating flow in fully managed conditions, as well as, several measurement techniques have been developed to know the instantaneous profiles of air temperature and velocity. Many experiments have been performed in order to characterize the impact of the flow pulsation on the convective heat transfers. In the second part of this work, the experimental results have been analyzed with two different approaches: firstly, with a 1D assumption the time-average convective heat transfers has been computed, and the major mechanism responsible of the heat transfer enhancement has been pointed out. Furthermore, it has been possible to highlight the mathematical term representative of such mechanism, which should be accounted in future to define a more adapted numerical model for the heat transfer prediction. In a second phase with a 2D assumption, and, with an energy and a fluid-mechanic computational phase, the radial transport of thermal energy has been characterized for a pulsating flow.

Nesta pesquisa foram realizados levantamentos geofísicos utilizando os métodos eletromagnético indutivo - EMI (equipamento EM38) e GPR - Ground Penetrating Radar, visando localizar redes de interferências, tais como, tubulações metálicas, cabos elétricos e conduítes de plástico instalados nas linhas 6 e 7 do Sítio Controlado de Geofísica Rasa do IAG/USP. Os dados EMI foram afetados pelo drift instrumental devido à variação de temperatura. A sua correção foi efetiva por meio do uso de uma função quadrática, realçando os alvos mais profundos. A aquisição em distância permitiu detectar alvos metálicos no subsolo com boa precisão e a aquisição em tempo permitiu fazer um mapeamento regional de alvos metálicos no subsolo. Os melhores resultados foram obtidos com a aquisição em distância, com os sensores posicionados a 10 cm de altura, devido às anomalias ficarem mais nítidas, onde a influência da condutividade do background foi reduzida. Os perfis GPR 2D obtidos com a antena de 400 MHz permitiram detectar os alvos até 1 m de profundidade e com a antena de 200 MHz foi possível detectar quase todos os alvos metálicos e não-metálicos instalados nas linhas estudas do SCGR. Para o GPR quase-3D, na forma de depth slices, foram importantes para estimar as dimensões dos alvos e melhorar a visualização dos resultados. Os resultados obtidos com os métodos EMI e GPR são complementares, sendo ambos recomendados no mapeamento de interferências no subsolo, tendo aplicações diretas nas áreas de planejamento urbano e infra-estrutura nos grandes centros urbanos. / This research was conducted geophysical surveys using inductive electromagnetic - IEM (EM38 equipment) and GPR - Ground Penetrating Radar methods, to locate network interference, such as metal pipes, electric cables and plastic conduit installed in lines 6 and 7 of test site of the IAG/USP (SCGR). IEM data were affected by instrumental drift due to temperature variation. The correction was effective through the use of a quadratic function, highlighting the deeper targets. The acquisition targets identified in the distance underground metal with good accuracy and acquisition time allowed to make a survey of regional targets metal underground. The best results were obtained with the acquisition in distance with the sensors placed at 10 cm in height, due to deficiencies become more clear, where the influence of the background conductivity was reduced. The 2D GPR profiles obtained with the antenna of 400 MHz to detect the target by 1 m depth and the antenna of 200 MHz was possible to detect almost all metal targets and non-metallic lines installed in the study SCGR. GPR to the quasi-3D in the form of depth slices, were important for estimating the size of the targets and improve the visualization of results. The results obtained with the IEM and GPR methods are complementary, and both are recommended in mapping interference underground, with direct applications in the areas of urban planning and infrastructure in urban centers.