Bien que les troubles du langage formel affectent une grande partie des enfants avec Trouble du Spectre Autistique (TSA), leur nature reste encore incertaine. Certaines études postulent que le trouble observable chez ces enfants est de même nature que celui dont souffrent les enfants avec trouble spécifique du langage (TSL), tandis que d’autres argumentent en faveur de deux troubles qui diffèrent dans leur étiologie. Au centre de ce débat réside la complexité à recueillir des données sur le langage chez les enfants avec TSA, notamment quand il s’agit de participer de manière active. Dans cette étude, nous explorons l’interprétation en temps réel des indices grammaticaux chez des enfants avec TSA monolingues francophones, en nous intéressant aux pronoms clitiques objets, dont la faible production en contexte obligatoire a été proposée comme marqueur du TSL pour le français. / It is well-known that children with Autism Spectrum Disorder (ASD) often have language impairment. However, the nature of this impairment is still largely unknown. Some studies hold that language impairment in children with ASD is of the same nature as impairment found in children with Specific Language Impairment (SLI), whereas others argue that SLI and language impairment in ASD may be different both in their structure and their etiology. At the heart of this debate lies the difficulty of assessing language abilities of children with ASD, especially when active participation is required. Moreover, to date, few studies have investigated formal aspects of language in children with ASD in languages other than English. In this study, we explore real-time interpretation of grammatical cues in French-speaking children with ASD, with a focus on object clitics.

La tomographie de cohérence optique plein champ est une technique de microscopie permettant d’imager un plan d’intérêt en profondeur dans un milieu diffusant. Cette technique a été utilisée pour l’examen de pièces opératoires dans un but de diagnostic en cancérologie. L’utilisation de cette technique permettrait en effet de fournir un outil de diagnostic peropératoire rapide et fiable, évitant ainsi de nombreuses procédures de réopération. Ces réopérations peuvent survenir lorsque – lors du diagnostic final par analyse de coupes histologiques – le pathologiste décèle la présence de tissus cancéreux restant, non retirés au cours de l’opération.L’OCT plein champ a montré de bons résultats pour cette application. Néanmoins, cette technique ne fournit qu’un contraste morphologique des tissus, ne permettant pas d’utiliser des critères de qualification des pièces opératoires basées – par exemple – sur la morphologie ou la densité cellulaire.Nous avons développé une nouvelle modalité d’imagerie basée sur l’OCT plein champ permettant de révéler un contraste métabolique dans le tissu à une échelle subcellulaire. Ce contraste permet de révéler les cellules précédemment non distinguées en OCT plein champ. Nous avons également utilisé la mesure quantitative de cette modalité pour réaliser des outils d’aide au diagnostic utilisant des approches d’apprentissage par ordinateur. / Full filed optical coherence tomography is a microscopy imaging technique allowing to image a specific slice in a scattering medium, in depth. This technique has been used for the diagnosis of biopsy in cancerology. This technique could be an efficient and fast way to diagnose excised tissues during surgery. This would avoid numerous reoperations procedures. These reoperations are necessary when a pathologist suspects cancerous tissue to still be present in the patient, based on histological slide examination.FFOCT has shown promising results for that purpose. Nevertheless, this technique only gives a morphological contrast of tissues, which is not enough for applying some diagnostic criteria such as cell morphology or cell density.We developed a new imaging modality based on FFOCT allowing to reveal metabolic contrast in tissues at the subcellular scale. This contrast reveals cells previously indistinguishable with FFOCT. We also used this quantitative metric to propose tools to facilitate diagnosis, using machine learning approaches.

I den här studien intervjuas fem personer som är yrkesverksamma inom verksamheter med konstnärligt skapande som inriktning för personer med neuropsykiatriska funktionsvariationer (NPF) och/eller utvecklingsstörning. Syftet med studien är att belysa konstnärligt skapande som verktyg kopplat till ökade krav på evidensbaserad praktik i gruppverksamheter riktade till personer med NPF och/eller utvecklingsstörning. Forskningsfrågorna avser därför att ge svar på vilka funktioner metoden konstnärligt skapande fyller som verktyg i gruppverksamheter riktade till personer med NPF och/eller utvecklingsstörning, hur dessa funktioner kan förstås samt om de kan/bör leva upp till krav på evidensbaserad praktik. Resultatet bygger på fem semistrukturerade intervjuer som har kodats och analyserats med fenomenologisk tematisk analys. Det teoretiska ramverket består av den salutogena modellen med fokus på ”en känsla av sammanhang” och Jonna Bornemarks perspektiv om ”att mäta det omätbara”.   Metoden konstnärligt skapande används frekvent i verksamheter riktade till målgruppen men samtidigt finns brister när det kommer till kvantitativ forskning för att stödja metodens effekter. Informanterna menade att den subjektiva upplevelsen av metoden är svår att mäta men att de själva upplever att konstnärligt skapande har många fördelar för den specifika målgruppen. Under studiens gång beskrev informanterna aspekter som väl stämde överens med vad som ryms inom den salutogena modellen. De gav uttryck för att det konstnärliga skapandet som metod bidrog till inkludering, kognitiv förstärkning, ökad självkänsla samt att det kunde fungera som ett alternativt kommunikation- och samtalsverktyg. / In this study, five people are interviewed who work professionally in activity groups with creative arts as a focus for people with neurodevelopmental disorders (DSM-5) and / or developmental disorder. The purpose of the study is to investigate the professionals' view of creative arts as a method in the work with the target group, and also their view of creative arts linked to the increased requirement for evidence-based practice. The questions of this research therefore intend to provide answers to what functions creative arts as a tool can have in group activities for people with DSM-5 and / or developmental disorder. We also intend to research how we can understand creative arts as a method and if/how the method should be mesured in relation to an increased requirement for evidence-based practice. The result is based on five semi-structured interviews that have been coded and analyzed with phenomenological thematic analysis. The theoretical framework is based on the salutogenic model and Jonna Bornemarks perspective on "measuring the immeasurable". The method of creative arts is frequently used in group activities for the target group, but at the same time there are deficiencies in the quantitative research bass to support the effects of the method. The respondents argued that the subjective experience of the method is difficult to measure, but that they themselves feel that creative arts has many advantages for the specific target group. During the study, the respondents described aspects that were well in line with what is included in the salutogenic model. The practitioners expressed that creative arts as a method contributed to community, cognitive reinforcement, increased self-esteem and that it could function as an alternative means of expression.

L'utilisation de franges d'interférence en lumière blanche comme une sonde optique en microscopie interférométrique est d'une importance croissante dans la caractérisation des matériaux, la métrologie de surface et de l'imagerie médicale. L'Interférométrie en lumière blanche est une technique basée sur la détection de l'enveloppe de franges d'interférence. Il a été démontré antérieurement, la capacité des approches 2D à rivaliser avec certaines méthodes classiques utilisées dans le domaine de l'interférométrie, en termes de robustesse et de temps de calcul. En outre, alors que la plupart des méthodes tiennent compte seulement des données 1 D, il semblerait avantageux de prendre en compte le voisinage spatial utilisant des approches multidimensionnelles (2D/3D), y compris le paramètre de temps afin d'améliorer les mesures. Le but de ce projet de thèse est de développer de nouvelles approches n-D qui sont appropriées pour une meilleure caractérisation des surfaces plus complexes et des couches transparentes. / The use of white light interference fringes as an optical probe in microscopy is of growing importance in materials characterization, surface metrology and medical imaging. Coherence Scanning Interferometry (CSI, also known as White Light Scanning Interferometry, WSLI) is well known for surface roughness and topology measurement [1]. Full-Field Optical Coherence Tomography (FF-OCT) is the version used for the tomographic analysis of complex transparent layers. Both techniques generally make use of some sort of fringe scanning along the optical axis and the acquisition of a stack of xyz images. Image processing is then used to identify the fringe envelopes along z at each pixel in order to measure the positions of either a single surface or of multiple scattering objects within a layer.In CSI, the measurement of surface shape generally requires peak or phase extraction of the mono dimensional fringe signal. Most of the methods are based on an AM-FM signal model, which represents the variation in light intensity measured along the optical axis of an interference microscope [2]. We have demonstrated earlier [3, 4] the ability of 2D approaches to compete with some classical methods used in the field of interferometry, in terms of robustness and computing time. In addition, whereas most methods only take into account the 1D data, it would seem advantageous to take into account the spatial neighborhood using multidimensional approaches (2D, 3D, 4D), including the time parameter in order to improve the measurements.The purpose of this PhD project is to develop new n-D approaches that are suitable for improved characterization of more complex surfaces and transparent layers. In addition, we will enrich the field of study by means of heterogeneous image processing from multiple sensor sources (heterogeneous data fusion). Applications considered will be in the fields of materials metrology, biomaterials and medical imaging.

句子的主題具備了串連訊息、引導文句發展的重要功能，然而資料顯示許多外語學習者常因為使用不適當的主題而影響語句的連貫性以及文章的流暢度。本研究透過觀察台灣高中生記敘文的主題類型，分析其在高、中、低分群學生文章中的使用情形來了解主題的選用對文章連貫性以及整體作文品質的影響。 本研究分成初步試驗以及正式研究兩階段，在初步試驗階段我們建立了分析的架構。在正式研究階段，我們採集111位高三學生於課堂上完成的記敘文並交由兩位經過訓練的閱卷老師進行評分，最後結果產生高、中、低分三組學生作文，接著再從每一組的文章中各抽樣10份進行主題類型之分析研究。 分析結果顯示，三組學生作文的主題類型及出現頻率大致雷同，整體而言，學生最喜好使用非標記的名詞主題，卻最少使用標記的分詞+名詞主題。然而進一步分析三組的主題發展情形，卻發現有顯著的組別差異，以高分群為例，其主題多具備銜接上文或有利推進文意的背景資料文字，相較之下，中等或低分群的作文比較容易出現和上下文不相關或中斷文意發展的新主題。 根據本研究的發現，我們建議在英語作文課中介紹句子主題的概念，幫助學生熟悉其類型和功能，期使學生能在記敘文文章中正確使用主題來達到語句連貫，文意流暢的溝通目標。 / Theme plays a significant role in guiding the information flow in text. Nonetheless, there is evidence indicating that many EFL learners often fail to make good choices of theme to secure sentential relationship or writing coherence. Through the observation on the occurrences and distribution of theme types in three levels of student compositions: the high, the middle and the low-rated narratives, the present study aims to investigate the establishment of theme in Taiwanese senior high school students’ narratives in order to gain understanding of theme’s effect on writing coherence and writing quality. The entire study consists of a pilot study and a formal one. The pilot study helps establish the criteria for the main study. In the main study, 111 student compositions were gathered and two raters were recruited and trained for the rating. Based on the rating system, the student compositions are divided into 3 levels. 10 samples from each level were randomly selected for thematic analysis. The result shows that the occurrences and distribution of theme types in the three levels of writing are alike. In general, unmarked NP theme is the most favored by all the students and marked theme Non-fi C + NP is the least desirable. Nonetheless, in terms of the establishment of theme, there are major differences between groups. In particular, the high-rated essays tend to establish a theme that is connected to the theme or the rheme in the preceding discourse or provides background information for the development of the event. In contrast, the mid-or low-rated essays are more likely to establish a theme that is unrelated or disruptive to the progression of the current discourse. Based on the findings of the present study, it is suggested that the notion of theme including its features and functions be incorporated into the teaching of English compositions to help Taiwanese senior high school students identify the characteristics of coherent writing and facilitate coherence in their English narratives.

Ce mémoire présente une étude expérimentale des fluctuations spatiales d'origine quantique de l'intensité dans des images en amplification paramétrique optique (OPA). Dans un premier temps nous avons caractérisé la réponse d'une caméra CCD lors de la mesure du bruit de photons dans le plan transverse de l'image. Pour cela, nous avons montré la pleine aptitude des capteurs silicium pour le domaine visible (527 nm) et leur mauvaise réponse dans le proche IR (1055 nm). Puis nous avons calibré le capteur sur toute sa dynamique afin d'éliminer l'inhomogénéité de réponse des pixels et ainsi mesurer le bruit de photons dans des images faibles ou intenses. D'autre part, nous avons étudié les aspects quantiques des OPA. L'amplification à l'aide d'un cristal de BBO de type I d'images (527 nm) dominées par le bruit quantique à l'aide d'une pompe UV (264nm) s'est imposée comme le meilleur compromis expérimental. Nous avons mis au point un montage et un protocole de mesure permettant la comparaison entre l'amplification sensible à la phase (PSA) et l'amplification insensible à la phase (PIA). Dans le cas d'une PIA, nous avons mis en évidence la dégradation du rapport signal à bruit. Pour la configuration PSA, nous avons réalisé la première amplification paramétrique d'images sans bruit spatial. Pour ces deux cas, les valeurs expérimentales sont en accord avec la figure de bruit attendue. De plus, nous avons étudié la distribution des fluctuations spatiales de la fluorescence paramétrique. L'emploi d'impulsions brèves et un fort filtrage des longueurs d'onde ont permis la caractérisation directe de la distribution de Bose-Einstein pure.

<p>According to the salutogenic theory put forth by Antonovsky, an individual’s sense of coherence (SOC) is central for maintaining health. The present study used data from middle-aged women being part of a longitudinal research program to investigate how SOC relates to health status (in terms of self-rated health and medicine consumption) and a set of lifestyle factors (physical exercise, alcohol consumption, nicotine consumption and dietary habits). Women with a strong SOC were hypothesized to exhibit better health profiles, consume less medication, and lead a healthier lifestyle than women with a weak SOC. The findings partly confirmed the hypotheses in showing that women with a strong SOC had better self-rated overall health, better psychological well-being, fewer self-reported diseases and lower medicine consumption. Contrary to the hypothesis, women with stronger SOC had more self-reported psychological and physical symptoms. Of the lifestyle factors, only dietary habits were significantly associated with SOC. The study shows that SOC is related to differences in health and medicine consumption in a homogeneous group of middle-aged women, while the association between SOC and lifestyle was found to be less prominent.</p>

<p>Vårt syfte med uppsatsen var att ta reda på om KASAM-begreppet, trots att det har några år på nacken, fortfarande ses som betydelsefullt. Vi utgick från personalens perspektiv gällande KASAM's betydelse för barn 0-12 år, placerade på institution eller med någon form av insats från öppenvården. Genom kvalitativa intervjuer tog vi del av personalens erfarenheter av KASAM's betydelse för barnen, hur de arbetar och om de metoder de använder sig av , ger möjlighet att skapa en känsla av sammanhang för barnen. Vid tolkningen av vårt intervjumaterial utgick vi från tre teman baserade på våra frågeställningar. Det som framkom av materialet var att KASAM har stor betydelse för barnens välbefinnande. KASAM-begreppet är högst närvarande i de metoder som används inom verksamheterna, även om personalen inte talar om det i termer av KASAM.</p><p> </p>

<p>The present thesis follows an intensive care unit during four year of hard work and demanding organisational changes (1998-2001). The changes were mainly initiated by diminishing resources and a legislative claim to pay regard to the quality aspect of health care service. The process of implementing a quality system was the main focus for the thesis. Triangulation was used aiming at explore the process from different views. Two interviews studies were conducted one with the staff and another with the leadership. Both interviews were analysed thematically combined with a phenomenographic technique (e.g. using the how, and what aspect). A longitudinal quasi experimental time-series study was also accomplished. The correlation between staff variables and workload were measured once a year. The result show a 20 % increase in workload per staff and year. The staff judged the organisational climate for innovativeness stable over the period. Sick leave increased, and more so, than the general trend in the society. In spite of this increase the prevalence of stress related symptoms was the same. Two different systems emerged, a complex adaptive system and a mechanical system. The two systems exist and functions intertwined. Because of the construction of the patient register it is possible to see that the situation around a patients being admitted ≥ 5 days functions according to the complex systems character while the situation around the acute patients functions according to a mechanical system. Sick leave correlated with number of patient admitted ≥ 5 days (P=,000). It seemed the problem found had its root in the unawareness of the existing of a complex system. The result has implications for a need of increased awareness about how to manage the situation when the ICU is functioning according to the complex adaptive system.</p>

Since Galileo Galilei invented the first thermometer, researchers have tried to understand the complex dynamics of ocean and atmosphere by means of scientific methods. They observe nature and formulate theories about the climate system. Since some decades powerful computers are capable to simulate the past and future evolution of climate.<br><br> Time series analysis tries to link the observed data to the computer models: Using statistical methods, one estimates characteristic properties of the underlying climatological processes that in turn can enter the models. The quality of an estimation is evaluated by means of error bars and significance testing. On the one hand, such a test should be capable to detect interesting features, i.e. be sensitive. On the other hand, it should be robust and sort out false positive results, i.e. be specific. <br><br> This thesis mainly aims to contribute to methodological questions of time series analysis with a focus on sensitivity and specificity and to apply the investigated methods to recent climatological problems. <br><br> First, the inference of long-range correlations by means of Detrended Fluctuation Analysis (DFA) is studied. It is argued that power-law scaling of the fluctuation function and thus long-memory may not be assumed a priori but have to be established. This requires to investigate the local slopes of the fluctuation function. The variability characteristic for stochastic processes is accounted for by calculating empirical confidence regions. The comparison of a long-memory with a short-memory model shows that the inference of long-range correlations from a finite amount of data by means of DFA is not specific. When aiming to infer short memory by means of DFA, a local slope larger than $alpha=0.5$ for large scales does not necessarily imply long-memory. Also, a finite scaling of the autocorrelation function is shifted to larger scales in the fluctuation function. It turns out that long-range correlations cannot be concluded unambiguously from the DFA results for the Prague temperature data set. <br><br> In the second part of the thesis, an equivalence class of nonstationary Gaussian stochastic processes is defined in the wavelet domain. These processes are characterized by means of wavelet multipliers and exhibit well defined time dependent spectral properties; they allow one to generate realizations of any nonstationary Gaussian process. The dependency of the realizations on the wavelets used for the generation is studied, bias and variance of the wavelet sample spectrum are calculated. To overcome the difficulties of multiple testing, an areawise significance test is developed and compared to the conventional pointwise test in terms of sensitivity and specificity. Applications to Climatological and Hydrological questions are presented. The thesis at hand mainly aims to contribute to methodological questions of time series analysis and to apply the investigated methods to recent climatological problems. <br><br> In the last part, the coupling between El Nino/Southern Oscillation (ENSO) and the Indian Monsoon on inter-annual time scales is studied by means of Hilbert transformation and a curvature defined phase. This method allows one to investigate the relation of two oscillating systems with respect to their phases, independently of their amplitudes. The performance of the technique is evaluated using a toy model. From the data, distinct epochs are identified, especially two intervals of phase coherence, 1886-1908 and 1964-1980, confirming earlier findings from a new point of view. A significance test of high specificity corroborates these results. Also so far unknown periods of coupling invisible to linear methods are detected. These findings suggest that the decreasing correlation during the last decades might be partly inherent to the ENSO/Monsoon system. Finally, a possible interpretation of how volcanic radiative forcing could cause the coupling is outlined. / Seit der Erfindung des Thermometers durch Galileo Galilei versuchen Forscher mit naturwissenschaftlichen Methoden die komplexen Zusammenhänge in der Atmosphäre und den Ozeanen zu entschlüsseln. Sie beobachten die Natur und stellen Theorien über das Klimasystem auf. Seit wenigen Jahrzehnten werden sie dabei von immer leistungsfähigeren Computern unterstützt, die das Klima der Erdgeschichte und der nahen Zukunft simulieren. <br><br> Die Verbindung aus den Beobachtungen und den Modellen versucht die Zeitreihen­analyse herzustellen: Aus den Daten werden mit statistischen Methoden charak­teristische Eigenschaften der zugrundeliegenden klimatologischen Prozesse geschätzt, die dann in die Modelle einfliessen können. Die Bewertung solch einer Schätzung, die stets Messfehlern und Vereinfachungen des Modells unterworfen ist, erfolgt statistisch entweder mittels Konfidenzintervallen oder Signifikanztests. Solche Tests sollen auf der einen Seite charakteristische Eigenschaften in den Daten erkennen können, d.h. sie sollen sensitiv sein. Auf der anderen Seite sollen sie jedoch auch keine Eigenschaften vortäuschen, d.h. sie sollen spezifisch sein. Für die vertrauenswürdige Untermauerung einer Hypothese ist also ein spezifischer Test erforderlich. <br><br> Die vorliegende Arbeit untersucht verschiedene Methoden der Zeitreihenanalyse, erweitert sie gegebenenfalls und wendet sie auf typische klimatologische Frage­stellungen an. Besonderes Augenmerk wird dabei auf die Spezifizität der jeweiligen Methode gelegt; die Grenzen möglicher Folgerungen mittels Datenanalyse werden diskutiert.<br><br> Im ersten Teil der Arbeit wird studiert, wie und ob sich mithilfe der sogenannten trendbereinigenden Fluktuationsanalyse aus Temperaturzeitreihen ein sogenanntes langes Gedächtnis der zugrundeliegenden Prozesse herleiten lässt. Solch ein Gedächtnis bedeutet, dass der Prozess seine Vergangenheit nie vergisst, mit fundamentalen Auswirkungen auf die gesamte statistische Beurteilung des Klimasystems. Diese Arbeit konnte jedoch zeigen, dass die Analysemethode vollkommen unspezifisch ist und die Hypothese “Langes Gedächtnis” gar nicht abgelehnt werden kann. <br><br> Im zweiten Teil werden zunächst Mängel einer sehr populären Analysemethode, der sogenannten kontinuierlichen Waveletspetralanalyse diskutiert. Diese Methode schätzt die Variabilität eines Prozesses auf verschiedenen Schwingungsperioden zu bestimm­ten Zeiten. Ein wichtiger Nachteil der bisherigen Methodik sind auch hier unspezi­fische Signifikanztests. Ausgehend von der Diskussion wird eine Theorie der Wavelet­spektralanalyse entwickelt, die ein breites Feld an neuen Anwendungen öffnet. Darauf basierend werden spezifische Signifikanztests konstruiert.<br><br> Im letzten Teil der Arbeit wird der Einfluss des El Niño/Southern Oscillation Phäno­mens auf den Indischen Sommermonsun analysiert. Es wird untersucht, ob und wann die Oszillationen beider Phänomene synchron ablaufen. Dazu wird eine etablierte Methode für die speziellen Bedürfnisse der Analyse von typischerweise sehr unregel­mäßigen Klimadaten erweitert. Mittels eines spezifischen Signifikanztests konnten bisherige Ergebnisse mit erhöhter Genauigkeit bestätigt werden. Zusätzlich konnte diese Methode jedoch auch neue Kopplungsintervalle feststellen, die die Hypothese entkräften konnten, dass ein neuerliches Verschwinden der Kopplung ein beisspielloser Vorgang sei. Schliesslich wird eine Hypothese vorgestellt, wie vulkanische Aerosole die Kopplung beeinflussen könnten.