Title: Comparison of the game performance efficiency on the 2014 World Championship for woman in Turkey. Objectives: Compare and describe the effectiveness of selected performance gaming indices in all matches played during the 2014 World Championship in Turkey. The partial aim of the thesis is to find out the relation of the game indicators and the result of the match, which has a difference of 10 or less points. Methods: The main method is the secondary analysis of data that was obtained by direct observation during a match. These data are available to the public on the fiba.com web site in clear tables. Their values were analyzed and subsequently described and evaluated. Results: Using quantitative data processing, we have confirmed the improved efficiency of winning cooperatives in most of the tracked gaming indicators. We also confirmed the inadequate interdependence between one game factor and the result in a match. Keywords: team game performance, indicators, shooting, success, comparison, individual game activities, shooting success, rebounds

The diploma thesis is concerned with the education of officials of local government. The introductory part of the thesis summarizes theoretical knowledge about the education of employees of private corporations and analyses requirements on the education of officials of local government under the act No. 312/2002. The practical part of the thesis presents empirical knowledge based on original research in a selected local government office. The current education framework of officials of the office is examined, strengths and weaknesses are identified and specific recommendations for its enhancement are offered. Based on the acquired knowledge an improved comprehensive concept of education of local government officials is recommended.

The diploma thesis focuses on company management systems, which could be set up by specified standards. The thesis specifies document administration system of integrated company management system. The thesis includes theoretical findings and practical instructions on how to create effective company document management system.

論文摘要 本研究想探討策略及策略執行力對經營績效之影響，經由因素分析萃取出五個策略及流程構面，分別為策略運用、研發策略執行力、製造策略執行力、出貨策略執行力及物流策略執行力; 在經營績效方面萃取出營運績效及財務績效兩個構面。 經由典型相關分析發現在投入項(X組)策略及流程構面，分別為策略運用、研發策略執行力、製造策略執行力、出貨策略執行力及物流策略執行力五個構面(因素)對於產出項(Y組)營運績效及財務績效兩個構面有顯著相關。 本研究採取多元迴歸分析，分別就策略及策略執行力的構面包括策略運用、研發策略執行力、製造策略執行力、出貨策略執行力及物流策略執行力等構面對營運績效及財務績效構面探討分析，結果發現在策略運用、研發策略執行力、製造策略執行力、出貨策略執行力及物流策略執行力等構面對營運績效具有正向影響; 同樣的財務績效上亦同樣受策略運用、研發策略執行力、製造策略執行力、出貨策略執行力及物流策略執行力等構面的正向影響。 本研究旨在探討企業策略的運用可謂是企業的思考，對於企業整體外在環境的變遷及經營實況都要在策略規 劃中確實考量分析，將成功關鍵因素能夠融入在策略中來運用，真正根據事實來做決策。 而企業策略是指引流程運作的藍圖，企業在流程運作及績效訂定須與策略規劃要能夠精準的連結，流程能有效執行策略的規劃，如此方能展現企業執行力與策略的一致性。 企業須知策略是否能有效地貫穿在整個組織中來運作須藉由流程有效的運作來實現，故企業在執行流程時應有效界定策略執行力指標，來做為流程日常運作量測及監控，並做為流程持續改善相當重要的來源。 企業平時若能有效執行策略執行力的監控與改善則不論在成本及效率上更具有競爭力，並且能有效達成企業經營策略上的要求。

Protonentherapie ist eine wichtige Behandlungsmodalität in der Radioonkologie. Aufgrund einer vorteilhaften Dosisverteilung im bestrahlten Volumen kann diese Bestrahlungsmethode das tumorumgebende Normalgewebe schützen. Dadurch können Nebenwirkungen in bestimmten Patientenpopulationen, zum Beispiel Kindern oder Patienten mit Gehirntumoren, verringert werden. Trotzdem können nach Protonenbestrahlung von Gehirntumorpatienten Normalgewebsschäden auftreten. Gründe dafür können der notwendige klinische Sicherheitssaum im Normalgewebe, der Einfluss der relativen biologischen Wirksamkeit RBE sowie eine erhöhte Strahlensensitivität bestimmter Gehirnregionen sein. Um diese Aspekte zu beleuchten, werden geeignete präklinische Modelle für die Normalgewebsreaktion im Gehirn nach Protonenbestrahlung benötigt. Darüber hinaus kann eine Risikostratifizierung der Patienten durch die Vorhersage von Nebenwirkungswahrscheinlichkeiten oder der Tumorantwort den Behandlungserfolg erhöhen. Auch hier können präklinische Modelle helfen, um neue prädiktive Biomarker zu finden und um die zugrunde liegenden Mechanismen strahleninduzierter Gehirnschäden besser zu verstehen. Das Ziel dieser Dissertation war die Etablierung und Charakterisierung von adäquaten präklinischen Modellen für die Untersuchung von strahleninduzierten Normalgewebsschäden im Gehirn. Diese Modelle bilden die Grundlage für zukünftige Studien zur Untersuchung von RBE Effekten, der spezifische Strahlensensitivität einzelner Gehirnregionen und neuer Biomarker. Die getesteten Modellsysteme waren in vitro Kulturen von adulten organotypischen Gehirnschnitten, Tumorschnittkultur sowie in vivo Bestrahlung von Gehirnsubvolumina, jeweils mit dem Modellorganismus Maus. Die Etablierung eines Bestrahlungssetups in der experimentellen Protonenanlage und dessen dosimetrische Charakterisierung waren von großer Bedeutung für die Durchführung der biologischen Experimente. Ein weiteres Hauptziel war die Definition klinisch relevanter Endpunkte für frühe und späte Nebenwirkungen. Die Gewebsschnitte wurden durch Messungen des Zellüberlebens und der Entzündungsreaktion, sowie mittels in situ Analyse von Zellmorphologie und DNA Schäden untersucht. Als ergänzendes Modell wurde die Tumorschnittkultur etabliert und ähnliche Endpunkte analysiert. Adulte Gehirnschnitte stellten sich als ungeeignet für präklinische Experimente in der Radioonkologie heraus. Die Messungen von Zelltod und Entzündungswerten zeigten eine starke Zellreaktion auf die Inkulturnahme, aber keine auf die Protonenbestrahlung. In der Histologie wurden gestörte Zellmorphologie, reduzierte Vitalität und eingeschränkte Reparaturfähigkeit von DNA Schäden beobachtet. Daher sollten für strahlenbiologische Experimente andere 3D Zellkulturmodelle in Betracht gezogen werden, wie zum Beispiel Organoide oder durch Tissue Engineering hergestellte Kulturen. Durch die Publikation der Daten leistet diese Dissertation einen wichtigen Beitrag zur aktuellen Forschung, da so künftig die limitierten Ressourcen, die für strahlenbiologische Experimente mit Protonen zur Verfügung stehen, auf relevantere Modelle verwendet werden können. Die Bestrahlung von Gehirnsubvolumina in Mäusen wurde mit dem Ziel etabliert, klinisch vergleichbare Felder zu erreichen. Das gewählte Zielvolumen war der rechte Hippocampus; der Protonenstrahl sollte in der Mitte des Gehirns stoppen. Im Rahmen des Projekts wurde ein Arbeitsablauf für präzise und reproduzierbare Bestrahlung entwickelt. Zur Verifizierung wurde der induzierte DNA Schaden ausgewertet und anschließend mit Monte-Carlos Dosissimulationen korreliert. Die Maushirnbestrahlung lieferte wertvolle Ergebnisse für frühe Zeitpunkte (d.h. innerhalb 24 h nach Bestrahlung). Im Verlauf des Projekts wurde ein Algorithmus erstellt, der schnell und zuverlässig die räumliche Verteilung des DNA Schadens in Relation zur Gesamtzellzahl analysiert. Diese Auswertung zeigte, wie bei der Bestrahlungsplanung vorgesehen, ein Stoppen des Protonenstrahls im Gehirn. Eine anschließende Korrelation der Schadensverteilung mit der applizierten Dosis weist nach, dass das Modell einen wichtigen Beitrag zur Untersuchung des RBE leisten kann. In einer darauf folgenden Studie wurde der Dosis-Zeitverlauf der beobachteten Strahlenreaktion des Normalgewebes genauer beleuchtet. Dafür wurden Untersuchungen des Allgemeinzustands der Versuchstiere, regelmäßige Magnetresonanztomografie (MRI) Messungen über einen Zeitraum von sechs Monaten, sowie abschließende Histologie korreliert. Die Volumenzunahme des Kontrastmittelaustritts, die den Zusammenbruch der Blut-Hirn-Schranke anzeigt, wurde konturiert; aus diesen Daten entstand ein prädiktives Dosis-Volumen Modell. Die Pilotstudie konnte eine dosisabhängige Strahlenreaktion nachweisen, die sich im Zusammenbruch der Blut-Hirn-Schranke, einer Hautreaktion mit vorrübergehender Alopezie, Gewichtsabnahme und zelluläre Veränderung äußerte. Das von den MRI Messungen abgeleitete Modell konnte zuverlässig das Eintreten der Nebenwirkungen, den Krankheitsverlauf, sowie die geschätzte Überlebensdauer der Mäuse vorhersagen. Zusätzlich konnte ein Zusammenhang zwischen den MRI Bildänderungen und den pathologischen Gewebsveränderungen beobachtet werden. Durch die außerordentlich homogene Strahlenreaktion der Tiere können aus den vorliegenden Daten künftig zuverlässig geeignete Dosen für spezifische experimentelle Endpunkte bestimmt werden. Zusammenfassend wurden in dieser Arbeit zwei präklinische Modelle für die Protonengehirnbestrahlung etabliert, nämlich organotypische Gewebsschnitte als 3D Zellkulturmodell sowie in vivo Bestrahlung von Gehirnsubvolumina in Mäusen. Während Zellkulturexperimente die Erwartungen nicht erfüllen konnten, stellen sich die Tierexperimente als hervorragendes Modell für translationale Radioonkologie heraus, welches zusätzlich für andere Strahlenqualitäten eingesetzt werden kann. Darauf basierend können aktuelle und zukünftige Studien die Ursachen von strahleninduzierten Normalgewebsschäden im Gehirn beleuchten, RBE Effekte untersuchen und neue prädiktive Biomarker erforschen.:Contents Abstract i Zusammenfassung v Publications ix List of Figures xiii List of Acronyms and Abbreviations xiv 1 Introduction 3 2 Background 5 2.1 Proton therapy for brain cancer treatment 5 2.1.1 Fundamentals of radiobiology 5 2.1.2 Proton therapy 6 2.1.3 Tumors of the central nervous system 8 2.2 Radiation effects on brain cells 8 2.2.1 Neurons and myelin 9 2.2.2 Blood-brain barrier 9 2.2.3 Astrocytes 10 2.2.4 Microglia 10 2.3 Principles of histology 11 2.3.1 Hematoxylin & eosin staining 12 2.3.2 Immunohistochemistry 13 2.3.3 Bioimage analysis 13 2.4 Techniques in medical imaging 14 2.4.1 Projectional radiography 14 2.4.2 Computed tomography 14 2.4.3 Magnetic resonance imaging 15 2.5 Preclinical models for radiation injury 17 2.5.1 Technical requirements 17 2.5.2 In vitro models 17 2.5.3 Small animal models 18 3 Applying Tissue Slice Culture in Cancer Research – Insights from Preclinical Proton Radiotherapy 19 3.1 Aim of the study 19 3.2 Conclusion 19 3.3 Author’s contribution 19 3.4 Publication 21 4 High-precision image-guided proton irradiation of mouse brain sub-volumes 41 4.1 Aim of the study 41 4.2 Conclusion 41 4.3 Author’s contribution 41 4.4 Publication 43 5 Late side effects in normal mouse brain tissue after proton irradiation 51 5.1 Aim of the study 51 5.2 Conclusion 51 5.3 Author’s contribution 52 5.4 Publication 53 6 Discussion 71 6.1 Establishment of preclinical models for radiooncology 71 6.1.1 3D cell culture 71 6.1.2 In vivo irradiation of brain subvolumes 73 6.2 Current applications of the mouse model 75 6.2.1 Ongoing data analysis 75 6.2.2 Innovating on-site imaging 76 6.2.3 RBE investigations 77 6.3 Future studies of radiation-induced brain tissue toxicities 79 Acknowledgement XV Supplementary Material XVII 1 Applying Tissue Slice Culture in Cancer Research – Insights from Preclinical Proton Radiotherapy XVII 2 High-precision image-guided proton irradiation of mouse brain sub-volumes XXVI 3 Late side effects in normal mouse brain tissue after proton irradiation XXXI / Proton therapy is an important modality in radiation oncology. Due to a favorable dose distribution in the irradiated volume, this treatment allows to spare tumor-surrounding normal tissue. Although this protection can lead to reduced side effects in certain patient populations, such as brain tumor or pediatric patients, normal tissue toxicities can occur to some extend. This could be due to clinical safety margins around the tumor that lead to dose deposition in the normal tissue. The underlying causes might also be related to relative biological effectiveness (RBE) variations or elevated radiosensitivity of certain brain regions. To address these issues, suitable preclinical models for normal brain tissue reaction after proton therapy are needed. In addition, patient stratification to predict the tumor response or the probability of side effects will contribute to increased treatment effectiveness. Preclinical models can improve the process of finding new predictive biomarkers and help to understand underlying mechanisms of radiation-induced brain injury. The aim of this thesis was to establish and characterize suitable preclinical models of brain tissue irradiation effects and set the base for future studies designed to reveal RBE effects, brain region specific radiation sensitivities, and novel biomarkers. The tested model systems were in vitro organotypic brain slice culture (OBSC) and in vivo irradiation of brain subvolumes, both on mouse brain tissue. Setup establishment at the experimental proton beam line and subsequent dosimetry built the foundation for conducting the biological experiments. Additionally, one main goal was defining clinically relevant endpoints for both short- and long-term effects. For OBSC, assays for cell death and inflammation, as well as in situ analysis of cell morphology and DNA damage induction were tested. As comparative model to OBSC, tumor slice culture was established and the results were also used for proton investigation. Adult OBSC turned out as inadequate model for preclinical experiments in radiation oncology. The assays measuring cell death and inflammation indicated a severe reaction during the first days in culture, but no response to irradiation. Histology revealed deficient cell morphology, reduced vitality and impaired DNA damage repair. In conclusion, other 3D cell culture models, such as organoids or tissue engineered constructs, should be considered for radiobiological experiments with protons. By publishing the observations, this thesis contributes to conserving the limited resources of proton radiobiology for more meaningful models. A methodology for irradiation of mouse brain subvolumes was established with a focus on creating fields comparable to clinical practice. The chosen target was the right hippocampus and the goal was to stop the proton beam in the middle of the brain. The project included a workflow for this precise irradiation in a robust and reproducible manner. Evaluation of the induced DNA damage and its correlation to Monte Carlo dose simulations were used for verification. Irradiation of mouse brain subvolumes yielded valuable results for early (i.e. within 24 h after irradiation) time points. An evaluation algorithm was designed for fast and robust analysis of spatial DNA damage distribution in relation to the total cell count. This ratio showed that the beam stopped in the brain tissue, in accordance to the treatment planning. Furthermore, the DNA damage could be reliably correlated with the dose simulation, which proves the value of the presented model for future RBE studies. In a follow-up experiment, the dose-time relationship of induced normal tissue reactions was analysed. For this, scoring of the animals' health status was combined with regular MRI measurements over the course of up to 6 months, and final histopathology. The volume increase of contrast agent leakage - representing breakdown of the blood brain barrier (BBB) - was contoured and the data was used to create a dose-volume response model. This pilot study on long-term radiation effects revealed dose-dependent normal tissue toxicities, including breakdown of the BBB, a skin reaction with temporary alopecia, weight reduction and changes on the cellular level. The model derived from MRI data reliably predicts onset of side effects, volume of brain damage as well as the expected animal survival. In addition, MRI image changes could be correlated to underlying tissue alterations by histopathology. Due to the uniform radiation response of the animals this data set enables to determine endpoint-specific dose values in future experiments. In conclusion, two preclinical models for proton brain irradiation were established, namely OBSC as 3D cell culture model and in vivo irradiation of mouse brain subvolumes. While the former could not yield the anticipated results, the latter emerged as excellent model for translational radiooncology, which can also be applied for experiments with other radiation types. Ongoing and future studies will focus on revealing the causes of normal brain tissue toxicities, studying RBE effects, and investigating new predictive biomarkers.:Contents Abstract i Zusammenfassung v Publications ix List of Figures xiii List of Acronyms and Abbreviations xiv 1 Introduction 3 2 Background 5 2.1 Proton therapy for brain cancer treatment 5 2.1.1 Fundamentals of radiobiology 5 2.1.2 Proton therapy 6 2.1.3 Tumors of the central nervous system 8 2.2 Radiation effects on brain cells 8 2.2.1 Neurons and myelin 9 2.2.2 Blood-brain barrier 9 2.2.3 Astrocytes 10 2.2.4 Microglia 10 2.3 Principles of histology 11 2.3.1 Hematoxylin & eosin staining 12 2.3.2 Immunohistochemistry 13 2.3.3 Bioimage analysis 13 2.4 Techniques in medical imaging 14 2.4.1 Projectional radiography 14 2.4.2 Computed tomography 14 2.4.3 Magnetic resonance imaging 15 2.5 Preclinical models for radiation injury 17 2.5.1 Technical requirements 17 2.5.2 In vitro models 17 2.5.3 Small animal models 18 3 Applying Tissue Slice Culture in Cancer Research – Insights from Preclinical Proton Radiotherapy 19 3.1 Aim of the study 19 3.2 Conclusion 19 3.3 Author’s contribution 19 3.4 Publication 21 4 High-precision image-guided proton irradiation of mouse brain sub-volumes 41 4.1 Aim of the study 41 4.2 Conclusion 41 4.3 Author’s contribution 41 4.4 Publication 43 5 Late side effects in normal mouse brain tissue after proton irradiation 51 5.1 Aim of the study 51 5.2 Conclusion 51 5.3 Author’s contribution 52 5.4 Publication 53 6 Discussion 71 6.1 Establishment of preclinical models for radiooncology 71 6.1.1 3D cell culture 71 6.1.2 In vivo irradiation of brain subvolumes 73 6.2 Current applications of the mouse model 75 6.2.1 Ongoing data analysis 75 6.2.2 Innovating on-site imaging 76 6.2.3 RBE investigations 77 6.3 Future studies of radiation-induced brain tissue toxicities 79 Acknowledgement XV Supplementary Material XVII 1 Applying Tissue Slice Culture in Cancer Research – Insights from Preclinical Proton Radiotherapy XVII 2 High-precision image-guided proton irradiation of mouse brain sub-volumes XXVI 3 Late side effects in normal mouse brain tissue after proton irradiation XXXI

The diploma thesis discusses the evaluation and financing of investment in a shopping centre in the city of Hradec Králové. The first part of the thesis contains theoretical background focused mainly on the issue of investment decisions and determinig methods for evaluating the effectivness of investments, including their financing. The second part of the thesis is focused on performing strategic analysies to determine the current market situation and the current state of investment. The main part of the thesis consists of proposals aimed at renting shopping centers with a high quality mix of tenants to achieve adequate profitability and return of investment.

Main goal of this thesis is to theoretically describe and analyze evaluation of economic efficiency of business plan. Business plan is reconstruction old farm building to 5 apartments. In variant of using govermant plan for supporting social house building. And compare efficiency while using datas from pre-investment phase and datas after realization.

This paper will focus solely on the effectiveness of AV (antivirus) in detecting Metasploit payloads which have been encapsulated with different encapsulation modules. There seems to be a significant knowledge gap in the evaluation of commercial antivirus's software and their ability to detect malicious code and stop such code from being executed on IT systems. Therefore we would like to evaluate the capabilities of modern AV software with the use of penetration testing tools such as Metasploit. The research process is heavily reliant on a case study methodology as it can be argued that each payload generated reflects a case in itself. Firstly the payloads are generated and encapsulated through the self developed software, secondly they are uploaded to VirusTotal to be scanned with the use of their publicly available API, third the results are obtained from VirusTotal and stored locally. Lastly the results are filtered through with the software which in turn generates graphs of the results. These results will provide sufficient data in comparing encapsulation methods, payload detection rates, draw conclusions regarding which operating system may be most vulnerable as well as the overall state of modern AV software's capabilities in detecting malicious payloads. There are plenty of noteworthy conclusions to be drawn from the results, one of them being the most efficient encapsulation method powershell_base64 which had amongst the lowest detection rates in regards to the amounts of payloads it encoded, meaning that its encapsulation hid the malicious code from the AV at a higher degree than most the other encapsulation modules. The most noteworthy conclusion from the results gathered however is the encapsulation methods which obtained the absolute lowest detection rates, these were x86_nonalpha, x86_shikata_ga_nai, x86_xor_dynamic as well as payloads without any encoding at all, which had a few payloads reach among the lowest detection rates across the board (<20%).

L’objectif de cette thèse consiste à déterminer si le Traité sur le commerce des armes (TCA) est effectif en ce qui concerne les dispositions relatives au transfert (art. 6) et à l’exportation (art. 7) dans leurs applications aux ventes d’armes à l’Arabie saoudite. Cette effectivité est appréciée en mesurant l’applicabilité du TCA dans les ordres juridiques des principaux fournisseurs d’armes à l’Arabie saoudite, à savoir, la Belgique, le Canada, la France et le Royaume-Uni. L’applicabilité du TCA comprend deux volets : l’examen de la justiciabilité du TCA, à savoir, comment le juge national lui donne-t-il concrètement effet; et l’examen de son opposabilité, à savoir, comment déterminer si les individus peuvent se prévaloir de ses dispositions devant un juge national. Notre thèse vise à démontrer que le TCA en ce qui concerne les obligations relatives au transfert (art. 6) et à l’exportation (art. 7) n’est effectif que partiellement. Cette ineffectivité s’explique par le fait qu’il ne soit pas applicable dans les ordres juridiques des principaux fournisseurs d’armes à l’Arabie saoudite, notamment, ceux de Belgique et de France. Dans l’ensemble, la situation ne tend pas à s’améliorer vu l’inefficacité même du TCA et les multiples obstacles placés par les autorités administratives. Cela n’empêche cependant pas le déclenchement d’un processus de renforcement de cette effectivité portant principalement sur la suppression des obstacles artificiels placés sur la voie de son applicabilité. Ainsi, l’applicabilité directe du TCA, dans les ordres juridiques belge et français, ne doit pas être interprétée de façon à ce qu’elle l’empêche de déployer pleinement ses effets en droit interne. Le renforcement peut également se faire, dans les ordres juridiques britannique et canadien, par une incorporation intégrale des dispositions de ce traité en droit interne et par une attitude des juges qui soit favorable à l’utilisation de celui. / The objective of this thesis is to determine whether the Arms Trade Treaty (ATT) is effective with respect to the transfer (Art. 6) and export (Art. 7) provisions as they apply to arms sales to Saudi Arabia. This effectiveness is assessed by measuring the applicability of the ATT in the legal orders of the main arms suppliers to Saudi Arabia, namely Belgium, Canada, France and the United Kingdom. The applicability of the ATT is twofold: the examination of its justiciability, namely, how does the national judge give practical effect to it; and the examination of its enforceability, namely, how to determine whether individuals can rely on its provisions before a national judge. Our thesis aims to demonstrate that the ATT with regard to the obligations on transfer (Art. 6) and export (Art. 7) is only partially effective. This ineffectiveness is explained by the fact that it is not applicable in the legal orders of the main arms suppliers to Saudi Arabia, namely those of Belgium and France. Overall, the situation does not tend to improve given the very ineffectiveness of the ATT and the multiple obstacles placed by the administrative authorities. This does not, however, prevent the initiation of a process of reinforcing its effectiveness, mainly by removing the artificial obstacles placed in the way of its applicability. Thus, the direct applicability of the ATT in the Belgian and French legal orders must not be interpreted in such a way as to prevent it from having full effect in domestic law. In the British and Canadian legal orders, reinforcement can also be achieved by a full incorporation of the provisions of this treaty into domestic law and by an attitude of the judges that is favorable to the use of the treaty.

Dans cette thèse, nous dépassons le cadre binaire de l’évaluation et nous nous plaçons dans celui de plusieurs traitements, à l’instar de Brodaty et al. [2001], Larson [2000], Imbens [1999]. Les estimations effectuées portent sur les politiques de l’emploi en vigueur en France pendant la période 1997-1999. Trois programmes sont étudies : CIE (Contrat Initiative Emploi) emploi subventionné dans le secteur marchand, CES (Contrat Emploi-Solidarité) création d’emploi dans le secteur non marchand et SIFE (Stage d’Insertion par la Formation et l’Emploi). L’efficacité de ces dispositifs est évaluée non seulement sur le taux de retour à l’emploi des bénéficiaires mais aussi sur divers autres critères qui répondent à différentes questions intéressantes économiquement et économétriquement : i) la politique active de l’emploi atteint-elle les demandeurs d’emploi les plus prioritaires parmi les prioritaires ? ii) Comment les entreprises utilisent-elles les programmes de la politique active (effet d’aubaine, de substitution,...) ? iii) Pouvons-nous mesurer la qualité d’un contrat aidé ? Comment évaluer l’efficacité relative d’un contrat aidé (plus spécifiquement) non marchand comparativement à celui du secteur marchand ?, impact marginal, effet propre, bien-être, , etc. / We evaluate the ALMP’s with a particular attention to the differentiation of impacts by categories of programmes and categories of beneficiaries. These two forms of heterogeneity can in fact lead to erroneous evaluations or too partial:i) The heterogeneity of programmes proposed, in particular their characteristics (type of contract, duration, remuneration, training, etc.) are an important source of complexity in behavior of self-selection of job seekers: behaviors can be multiples and strategic.ii) The heterogeneity of target-populations (low-skilled, youth, women, priority category, first-job seekers, etc.) is an important source of complexity in the behavior selection of employment advisor.There is finally no reason that different types of programmes have the same average effect on various public as well. We evaluate so ALMP’s on multiple criteria of effectiveness (heterogeneity of criteria).