- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 681 to 688 of 688 (0.042 seconds)Spelling suggestions: "subject:"endocrinology"" "subject:"endocrinolog""
| 681 |
Prediction of Radial Bending Strength by Cortical Porosity and DiameterEnsminger, Alyssa M. 04 May 2017 (has links)
No description available.
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| 682 |
The mechanisms of BPA exposure and in the developing mammary glandHindman, Andrea R. January 2017 (has links)
No description available.
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| 683 |
Simulation of Patient Flow in Type 1 Diabetes Clinics using Need-Based Booking Algorithms : Development of a Simulation Tool for Equitable Patient Population Management / Simulering av patientflöde inom diabeteskliniker med behovsstyrda bokningsalgoritmer : Utveckling av ett simuleringsverktyg för rättvis populationshanteringHugert, Fabian January 2024 (has links)
Current diabetes care practices provide the same amount of care to everyone, regardless of individual needs. The high coverage of continuous glucose monitors (CGMs) in the Type 1 Diabetes (T1D) population can facilitate the implementation of need-based care, which could potentially largely benefit both clinics and patients. This master’s thesis develops and evaluates a simulation model to explore patient flow in T1D clinics using need-based booking, as well as a user interface for running the simulation and collecting output data. The model also serves as a tool for optimizing input parameters for this system. Utilizing Agent-Based Modeling (ABM) and Discrete Event Simulation (DES), the study includes basic validation to ensure reliability. Findings suggest that the model has been perceived as useful as a tool to discover suitable configurations of a need based booking system when used in a T1D clinic, as well as to communicate and visualise potential benefits and effects of using a need-based system for T1D patients. / Nuvarande diabetesvårdsmetoder erbjuder samma vård till alla, oavsett individuella behov. Den höga täckningen av kontinuerliga glukosmätare (CGMs) i befolkningen med Typ 1-diabetes (T1D) kan underlätta införandet av behovsstyrd vård, vilket potentiellt kan gynna både kliniker och patienter i stor utsträckning. Denna masteruppsats utvecklar och utvärderar en simuleringsmodell för att utforska patientflödet i T1D-kliniker med behovsstyrd bokning, samt ett användargränssnitt för att köra simuleringen och samla in utdata. Modellen fungerar också som ett verktyg för att optimera inmatningsparametrar för detta system. Genom att använda agentbaserad modellering (ABM) och diskret händeslestyrd simulering (DES) inkluderar studien grundläggande validering för att säkerställa tillförlitlighet. Resultaten tyder på att modellen har uppfattats som användbar som ett verktyg för att upptäcka lämpliga konfigurationer av ett behovsstyrt bokningssystem i kliniker för T1D, såval som kommunicera och visualisera potentiella fördelar och effekter av att använda behovsstyrda bokningssystem för patienter med T1D diabetes.
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| 684 |
Analysis of mouse models of insulin secretion disordersKaizik, Stephan Martin January 2010 (has links)
No description available.
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| 685 |
Function of Vascular Endothelial Cells in Aging and Hypothermia: Clinical ImplicationsOsama, Mohammad January 2018 (has links)
No description available.
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| 686 |
The Development of the Anterior Inferior Iliac Spine: A Comparative Analysis Among Hominids and African ApesZirkle, Dexter 27 March 2015 (has links)
No description available.
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| 687 |
"That which was missing" : the archaeology of castrationReusch, Kathryn January 2013 (has links)
Castration has a long temporal and geographical span. Its origins are unclear, but likely lie in the Ancient Near East around the time of the Secondary Products Revolution and the increase in social complexity of proto-urban societies. Due to the unique social and gender roles created by castrates’ ambiguous sexual state, human castrates were used heavily in strongly hierarchical social structures such as imperial and religious institutions, and were often close to the ruler of an imperial society. This privileged position, though often occupied by slaves, gave castrates enormous power to affect governmental decisions. This often aroused the jealousy and hatred of intact elite males, who were not afforded as open access to the ruler and virulently condemned castrates in historical documents. These attitudes were passed down to the scholars and doctors who began to study castration in the late 19th and early 20th centuries, affecting the manner in which castration was studied. Osteometric and anthropometric examinations of castrates were carried out during this period, but the two World Wars and a shift in focus meant that castrate bodies were not studied for nearly eighty years. Recent interest in gender and sexuality in the past has revived interest in castration as a topic, but few studies of castrate remains have occurred. As large numbers of castrates are referenced in historical documents, the lack of castrate skeletons may be due to a lack of recognition of the physical effects of castration on the skeleton. The synthesis and generation of methods for more accurate identification of castrate skeletons was undertaken and the results are presented here to improve the ability to identify castrate skeletons within the archaeological record.
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| 688 |
TARGETED DELIVERY OF BONE ANABOLICS TO BONE FRACTURES FOR ACCELERATED HEALINGJeffery J H Nielsen (8787002) 21 June 2022 (has links)
<div>Delayed fracture healing is a major health issue involved with aging. Therefore, strategies to improve the pace of repair and prevent non-union are needed in order to improve patient outcomes and lower healthcare costs. In order to accelerate bone fracture healing noninvasively, we sought to develop a drug delivery system that could safely and effectively be used to deliver therapeutics to the site of a bone fracture. We elected to pursue the promising strategy of using small-molecule drug conjugates that deliver therapeutics to bone in an attempt to increase the efficacy and safety of drugs for treating bone-related diseases.</div><div>This strategy also opened the door for new methods of administering drugs. Traditionally, administering bone anabolic agents to treat bone fractures has relied entirely on local surgical application. However, because it is so invasive, this method’s use and development has been limited. By conjugating bone anabolic agents to bone-homing molecules, bone fracture treatment can be performed through minimally invasive subcutaneous administration. The exposure of raw hydroxyapatite that occurs with a bone fracture allows these high-affinity molecules to chelate the calcium component of hydroxyapatite and localize primarily to the fracture site.</div><div>Many bone-homing molecules (such as bisphosphonates and tetracycline targeting) have been developed to treat osteoporosis. However, many of these molecules have toxicity associated with them. We have found that short oligopeptides of acidic amino acids can localize to bone fractures with high selectivity and with very low toxicity compared to bisphosphonates and tetracyclines.</div><div>We have also demonstrated that these molecules can be used to target peptides of all chemical classes: hydrophobic, neutral, cationic, anionic, short, and long. This ability is particularly useful because many bone anabolics are peptidic in nature. We have found that acidic oligopeptides have better persistence at the site of the fracture than bisphosphonate-targeted therapeutics. This method allows for a systemic administration of bone anabolics to treat bone fractures, which it achieves by accumulating the bone anabolic at the fracture site. It also opens the door for a new way of treating the prevalent afflictions of broken bones and the deaths associated with them.</div><div>We further developed this technology by using it to deliver anabolic peptides derived from growth factors, angiogenic agents, neuropeptides, and extracellular matrix fragments. We found several promising therapeutics that accelerated the healing of bone fractures by improving the mineralization of the callus and improving the overall strength. We optimized the performance of these molecules by improving their stability, targeting ligands, linkers, dose, and dosing frequency.</div><div>We also found that these therapeutics could be used to accelerate bone fracture repair even in the presence of severe comorbidities (such as diabetes and osteoporosis) that typically slow the repair process. We found that, unlike the currently approved therapeutic for fracture healing (BMP2), our therapeutics improved functionality and reduced pain in addition to strengthening the bone. These optimized targeted bone anabolics were not only effective at healing bone fractures but they also demonstrated that they could be used to speed up spinal fusion. Additionally, we demonstrated that acidic oligopeptides have potential to be used to treat other bone diseases with damaged bone.</div><div>With these targeted therapeutics, we no longer have to limit bone fracture healing to casts or invasive surgeries. Rather, we can apply these promising therapeutics that can be administered non-invasively to augment existing orthopedic practices. As these therapeutics move into clinical development, we anticipate that they will be able to reduce the immobilization time that is the source of so many of the deadly complications associated with bone fracture healing, particularly in the elderly.</div>
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