Os gliomas são tumores cerebrais intracraniais caracterizados pelo seu rápido crescimento e pela sua resistência à quimioterapia e radioterapia atuais. Assim, a procura por novos agentes terapêuticos com múltiplos mecanismos de ação têm identificado o ácido <font face=\"symbol\">g-linolênico (GLA), antiinflamatórios não esteroidais (AINEs) e compostos contendo rutênio como possíveis candidatos. Dessa forma, a principal proposta deste projeto foi entender melhor o mecanismo de ação dessas drogas sobre as células C6 de glioma de rato. Foram analisadas proteínas envolvidas no controle do ciclo celular, apoptose, angiogênese, invasão e migração através de RT-PCR e Western Blotting após tratamento in vitro e in vivo. Alterações da expressão de ciclina D1, E2F-1, pRb, p27, p21, p16, p65, c-myc, ERK1/2, nm23 e <font face=\"symbol\">b, MMP-2, Brevican GPI e Secretado, Tenascina-R, Tenascina-C, VEGF-A, Flt1, Flk1, Bax, PPAR<font face=\"symbol\">g, p53, COX-2, EP1, 2, 3 e 4, Ku70 e 80 foram encontradas. Em conclusão, o GLA e o complexo Rutênio-Ibuprofeno possuem múltiplos alvos que levam à inibição da proliferação celular. / Gliomas are intracranial tumors of cerebral origin characterized for its rapid growth and resistance to both conventional chemotherapy and radiotherapy. The search for new therapeutics agents with multiple mechanisms of action has identified <font face=\"symbol\">g-linolenic acid (GLA), nonsteroidal anti-inflammatory drugs (NSAIDs) and ruthenium containing compounds as possible candidates. The aim of this study was to better know the mechanism of action of these drugs on C6 rat glioma cells. Expression of proteins involved in control of the cell cycle, apoptosis, angiogenesis, invasion and migration was analyzed using RT-PCR and Western Blotting methods after treatment in vitro and in vivo. Alterations in cyclin D1, E2F-1, pRb, p27, p21, p16, p65, c-myc, ERK1/2, nm23 e <font face=\"symbol\">b, MMP-2, GPI and Secreted Brevican, Tenascin-R, Tenascin-C, VEGF-A, Flt1, Flk1, Bax, PPAR<font face=\"symbol\">g, p53, COX-2, EP1, 2, 3 and 4, Ku70 and 80 expression were observed. In conclusion, GLA and Ruthenium-Ibuprofen complex has multiple target wich translate into the inhibition of proliferation.

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} Automatization is higly used in stock traiding. The thesis try to exploid optimalization principles and machine learning. Developed and tested stock traiding system proces financial time series and generate optimal strategy

Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico / Os hidrocarbonetos policÃclicos aromÃticos (HPAs) sÃo considerados poluentes orgÃnicos persistentes e apresentam propriedades mutagÃnica, carcinogÃnica e teratogÃnica, contudo existe uma grande carÃncia em dados da distribuiÃÃo de HPAs em centros urbanos e costeiros brasileiros. Assim o presente trabalho tem o intuito de gerar dados da situaÃÃo de HPAs nos ecossistemas costeiros da cidade de Fortaleza. Os principais objetivos foram: validaÃÃo da metodologia para a extraÃÃo e anÃlise de HPAs em Ãgua e sedimento; distribuiÃÃo atmosfÃrica de HPAs no perÃodo chuvoso; avaliaÃÃo da poluiÃÃo promovida por HPAs nos rios de Fortaleza e estimativa do tipo de fonte emissora de HPAs. O programa de temperatura elaborado para a separaÃÃo e resoluÃÃo dos picos foi eficiente para separar os HPAs em estudo, exceto acenafteno e acenaftileno. Para a determinaÃÃo de HPAs em sedimento estuarino observou-se mais vantagens utilizando a tÃcnica de ultra-som, hexano/acetona como solvente de extraÃÃo, e clean-up com hexano/acetato de etila. A recuperaÃÃo proveniente das matrizes aquosas ambientais fortificadas com HPAs variou de 63,7 a 93,1% para precipitaÃÃo lÃquida atmosfÃrica, de 38,3 a 95,1% para Ãgua superficial de rio e de 70,2 a 89,4% para Ãgua marinha. A distribuiÃÃo espacial de HPAs mostrou que a pluma de maior concentraÃÃo à mais intensa na zona com grande fluxo automobilÃstico e topografia favorÃvel para a concentraÃÃo de poluentes emitidos. A razÃo molecular de alguns HPAs na atmosfera, embora preliminar, mostrou emissÃo proveniente da exaustÃo de gasolina, diesel, madeira e carvÃo. Os somatÃrios da concentraÃÃo de HPAs em sedimento(&#8721;HPAs) variaram de 3,04 a 2234.76 Âg.kg-1 (rio CocÃ) e de 3,34 a 1.859,21 Âg.kg-1 (rio CearÃ). Na maioria dos testemunhos de sedimentos coletados, os nÃveis do &#8721;HPAs diminuem em direÃÃo ao fundo dos testemunhos, confirmando que a poluiÃÃo à maior nos dias atuais. Os dados mostram que a cidade de Fortaleza apresenta nÃveis de HPAs nos sedimentos dos seus principais rios, prÃximos aos de cidades com grau de desenvolvimento industrial superior e que o produto da queima de combustÃveis fÃsseis e outras fontes de energia sÃo responsÃveis pela poluiÃÃo dos dois principais rios da cidade. / Polycyclic aromatic hydrocarbons (PAHs) are considered persistent organic pollutants possessing mutagenic, carcinogenic and teratogenic properties, but there is lack of data about PAHs distribution in Brazilian urban centers. The present work was performed to generate data about PAHs in coastal ecosystems of Fortaleza city. The main objectives were: validation of methodologies for extraction and analysis of PAHs in water and sediment; atmospheric distribution of PAHs in rainy period; evaluation of the pollution caused by PAHs in the rivers of Fortaleza city and estimation of PAHs sources. The temperature program elaborated for PAHs separation and resolution was efficient, except acenaphthene and acenaphthylene. The ultrasound technique was more advantages for the extraction of PAHs from sediments using hexane/acetone as extraction solvent and hexane/ethyl acetate for the clean-up. The recovery from environmental aqueous matrices fortified with PAHs varied from 63.7 to 93.1% for atmospheric liquid precipitation, from 38.3 to 95.1% for superficial river water, and from 70.2 to 89.4% for marine water. PAHs spatial distribution showed that the highest concentration plume is intense in the zone with larger automobile flow and favorable topography for the concentration of emited pollutant. The molecular ratio of some PAHs in atmosphere (preliminary), showed emission from gasoline, diesel, wood and coal exhaustion. The total concentration of PAHs in sediment (&#8721;PAHs) ranged from 3.04 to 2234.76 Âg.kg-1 (Cocà river) and from 3.34 to 1859.21 Âg.kg-1 (Cearà river). To the sediments cores &#8721;PAHs decrease towards the sediment deep layer, confirming that the pollution now days is larger. The data show that the sediments of the principal rivers of Fortaleza city have PAHs levels similar to other cities with a superior industrial development. The data also show that the burning product of fossil fuels and other sources of energy are responsible by the pollution of both rivers.

An intra-pulse Interaction Point fast feedback system (IPFB) has been designed for the Next Linear Collider (NLC), to correct relative beam-beam misalignments at the Interaction Point (IP). This system will utilise the large beam-beam kick that results from the beam-beam interaction and apply a rapid correction to the beam misalignment at the IP within a single bunch train. A detailed examination of the IPFB system is given, including a discussion of the necessary electronics, and the results of extensive simulations based on the IPFB concept for fast beam correction are presented. A recovery of the nominal luminosity of the NLC is predicted well within the NLC bunch train of 266 ns. The FONT experiment - Feedback On Nanosecond Timescales - was proposed as a direct test of the IPFB concept and was realised at the NLC Test Accelerator at SLAC. As part of FONT, a novel X-band BPM was designed and tested at the NLCTA. The results of these tests with the NLCTA short and long-pulse beam are presented, demonstrating a linear response to the position of the 180 ns long-pulse beam: measurements show a time constant of ~1.5 ns and a precision of better than 20 microns. A novel BPM processor for use at X-band, making use of the difference-over-sum processing technique, is also presented in detail, with results given for both short and long-pulse beams. The FONT design concepts and modification of the IPFB system for use at the NLCTA are described. The design of a fast charge normalisation circuit, to process the difference and sum signals produced by the BPM processor, forming part of the FONT feedback circuit, is detailed extensively. Bench tests of the feedback electronics demonstrate the effectiveness of the normalisation and feedback stages, for which a signal latency of 11 ns was measured. These bench tests also show the correct operation of the normalisation and feedback principles. Finally, the results of a full beam test of the FONT system are presented, during which a system latency of 70 ns was measured. These rigorous tests establish the soundness of the IPFB scheme and show correction of a mis-steered bunch train within the full NLCTA pulse length of 180 ns.

Thesis magic of the written word is concerned with the changing letters in historical context. It is divided into two parts. The theoretical part informs about the development and use of fonts, writing techniques and cultural influences. It also describes the types described that most influenced the view of the future font. The practical part shows a set of twelve ceramic wall reliefs. Individual reliefs represent the most significant architect in writing and given time stage. The layout concept is based on the perception of the general public.

Two novel contributions to Content Based Image Retrieval are presented and discussed. The first is a search engine for font recognition. The intended usage is the search in very large font databases. The input to the search engine is an image of a text line, and the output is the name of the font used when printing the text. After pre-processing and segmentation of the input image, a local approach is used, where features are calculated for individual characters. The method is based on eigenimages calculated from edge filtered character images, which enables compact feature vectors that can be computed rapidly. A system for visualizing the entire font database is also proposed. Applying geometry preserving linear- and non-linear manifold learning methods, the structure of the high-dimensional feature space is mapped to a two-dimensional representation, which can be reorganized into a grid-based display. The performance of the search engine and the visualization tool is illustrated with a large database containing more than 2700 fonts. The second contribution is the inclusion of color-based emotion-related properties in image retrieval. The color emotion metric used is derived from psychophysical experiments and uses three scales: activity, weight and heat. It was originally designed for single-color combinations and later extended to include pairs of colors. A modified approach for statistical analysis of color emotions in images, involving transformations of ordinary RGB-histograms, is used for image classification and retrieval. The methods are very fast in feature extraction, and descriptor vectors are very short. This is essential in our application where the intended use is the search in huge image databases containing millions or billions of images. The proposed method is evaluated in psychophysical experiments, using both category scaling and interval scaling. The results show that people in general perceive color emotions for multi-colored images in similar ways, and that observer judgments correlate with derived values. Both the font search engine and the emotion based retrieval system are implemented in publicly available search engines. User statistics gathered during a period of 20 respectively 14 months are presented and discussed.

Denna uppsats behandlar frågorna om hur och varför ett typsnitt kan förmedla ett visst intryck, en känsla eller tonalitet på en webbsidas rubriker. Samt betydelsen av, som designer eller annan yrkesverksam inom området, att ha kännedom och medvetenhet kring typsnitt. Vi valde en kvalitav metod utifrån våra frågeställningar. Genom intervjuer och en fokusgrupp ämnar vi undersöka tre typsnitt från tre olika typsnittsfamiljer. Typsnitten vi specificerat oss på är Roboto (sans serif), La Parisienne (regular skript) samt Fifty four (display/dekorativ). Teoretiska utgångspunkter hämtas från tidigare studier inom ämnet, litteratur av sakkunniga samt data från empirisk undersökning som vi samlat in från intervjuer och en fokusgrupp. En webbsida, utvecklad i WordPress har varit ett praktiskt moment och har fungerat som en plattform för vår undersökning genom att presentera våra olika rubrikers typsnitt. Resultatet från vår undersökning visade att våra valda typsnitt på rubrikerna tolkades likvärdigt och att det är främst formen som avgör. Studien tydliggör även att typsnitt kan tolkas utifrån person och personlighetsdrag, genom grundkänslor, tidigare associationer, konnotation och majoritetens överensstämmande svar. Vi ser att kunskap om typsnitt har en central roll i den tidiga designprocessen. Med detta i åtanke blir det viktigt för designern att kunna behärska typografi och förstå dess kraft. / This essay addresses the questions about how and why a font can convey a certain impression, feeling or tonality on a website's headings. As well as the importance of being a designer or other professionals in the field, to have knowledge and awareness of fonts. We have chosen a qualitative method based on our questions. Through interviews and a focus group, we intend to study three fonts from three different fontfamilies. Roboto (sans serif), La Parisienne (regular script) and Fifty four (display /decorative). Theories are obtained from previous studies in the subject, we refer to literature by experts and the data comes from our empirical research that we have collected from our interviews and the focus group. We have developed a website in WordPress, that has been a practical element and has served as a platform for our research by presenting the fonts of our various headings. The results of this study showed that our selected fonts of the headlines were interpreted equally by our informants and everyone answers that it depends on what kind of a typeface it is. Fonts can be interpreted from many different perspectives, the form of a font affects people's interpretation a lot but also interpreted based on personality traits, through basic feelings, past associations, connotation and the majority's response which was consistent. The knowledge of fonts plays a central role in the early design process and it becomes important for a web designer to be able to master typography and understand its powers.

The content of this work is the design and implementation of HW supported by SW for viewing subtitles into the movie, which translates from the projection equipment on 16 mm film, synchronizing subtitles with the movie, at the same time the work also addresses the issues of principle changes the distance of the canvas. Subtitles are loaded by using the SD card slot control by using the control, which is used to display graphics monochrome buttons that are also used for setting the device and its modifications.

Typography is one of the most important elements of web design and marketing. Good typography makes web design more appealing, which is important for readers in evaluating titles and the quality of text. The aim of this thesis is to provide a characterization of good and bad typography. I will use this characterization to identify modern typographical trends in a digital background. In the theoretical part, I will describe the basic features of typography. In the practical part, I will distinguish appealing typography and visual smog, and find specific examples demonstrating typographical trends in web design.

Denna undersökning genomfördes tillsammans med Marie Gustavsson, ägare av frisörföretaget Studio M. Målet var att skapa en grafisk profil, som ska hjälpa företaget att förmedla nedanstående värdeord och värderingar: Rofyllt Personligt Lyhört Kvalitet Familjärt Yrkesstolthet Allas lika värde För att få kännedom om hur logotyper hos frisörer ser ut idag, genomfördes en visuell innehållsanalys. I analysen undersöktes 11 stycken frisersalonger. Detta för att se hur logotyper kan skilja sig åt. Denna visade att företagens logotyper hade vissa specifika designelement som återkom i flertalet logotyper, som exempelvis företagsmärke, typsnitt och färg. Utifrån resultaten från analysen skapade jag logotypen. De typiska designelementen i logotyperna har jag i åtanke vid skapandet av designen. Litteraturstudien visade vad en grafisk profil bör innehålla. Litteraturstudien, innehållsanalysen samt företagets värdeord som ska speglas i den grafiska profilen fanns i åtanke vid skapandet av den grafiska profilen. Tre alternativ på logotyper, tre alternativ på färger samt två alternativ på typsnitt testades mot målgruppen i en enkätundersökning, för att komma fram till vilka designelement som attraherade målgruppen mest. Vinnande logotyp, färg och typsnitt applicerades sedan i den grafiska profilen. Resultatet blev en grafisk profil innehållande logotyp, företagsmärke, färger, mallar och regler, som vid korrekt användande under skapandet av den visuella identiteten, ska attrahera Studio M:s målgrupp. / This survey was carried out together with Marie Gustavsson, owner of Studio M. The aim was to create a graphic profile, which should help the company to convey the following words and values:Peaceful  Personal  Sensitive  Quality  Familiar  Pride  Everyone´s equal valueTo get to know how logos at hairdressers look today, a visual content analysis was carried out. The analysis examined 11 hairdressing salons. This was to see how logos can differ. This showed that the company logos had some specific design elements that came back in most logos, such as corporate branding, font and color. Based on the results of the analysis, I created the logo. The typical design elements in the logos were in mind when creating the design.The literature study revealed what a graphic profile should contain. The literature study, the content analysis and the company values that should be reflected in the graphic profile were in mind when creating the graphic profile.Three options on logos, three options on colors and two options on typefaces were tested against the target group in a questionnaire survey, in order to arrive at which design elements attracted the target group the most. The winning logo, color and font were then applied to the graphic profile.The result was a graphic profile containing the logo, company brand, colors, templates and rules, which, when properly used during the creation of the visual identity, will attract Studio M's target audience.