This work is about reverberators as system for simulating space properties of sound and their implementation in game development software Unity. The goal of this thesis is to create a working plug-in module for this development software, which is capable of working in real time and also can change it's parameteres in real time.

The digital project at the intersection of the interactive installation and computer game.

This diploma thesis deals with the development of web 2D HTML5 game, which users can play through a web browser. For the wide availability of games for various game devices (personal computers, game consoles, smartphones), the game is developed using modern web technologies. At the end of the work, the web game (application) was deployed and tested on the web.

Squamous Cell Carcinoma of the Anus (SCCA) is a rare cancer that is heavily associated with high-risk human papillomavirus infection (HRHPV) of the squamocolumnar junction (SCJ) of the anus. Treatment of SCCA ranges from chemotherapy and radiation for early stage cancer, and surgical interventions such as abdominoperineal resection for later stage cancer. Patients who present with late-stage metastatic SCCA have a five-year survival rate of 32%, emphasizing the crucial need for early detection. Given its rarity in the general population (approximately 1 to 2 cases per 100,000 people), screening guidelines to allow for early detection of SCCA have not been fully established, and remains the subject of continuous debate amongst clinicians, researchers, and public health practitioners. A major challenge in establishing SCCA screening guidelines is slow progression of symptoms. 20-33% of patients diagnosed with SCCA were clinically asymptomatic at the time of their diagnosis. Patients who reported symptoms usually noted mild symptoms, which mimicked ones found in other anal disorders. For instance, early stage cases of SCCA frequently manifest as bleeding in the anus, but in the absence of other serious symptoms, patients and clinicians often assume hemorrhoids as a cause. As SCCA is a rare disease with that frequently presents with seemingly benign symptoms, if any, few studies have addressed the complexities of concerns in regards to preventive screening of SCCA. Using “Principles and Practice of Screening for Disease” by Wilson and Jungner, this thesis intends to discuss known screening strategies for SCCA and explore knowledge gaps in need of further study before definitive guidelines for SCCA screening can be established. Wilson and Jungner do not specifically address the issue of SCCA; rather, they provide a framework for establishing guidelines for disease screening. This thesis will examine the current understanding of SCCA gained in literature and will apply them to the ten tenets that Wilson and Jungner uphold as necessary criteria that should be considered in order to craft an appropriate screening methodology for a specific disease. These tenets address issues ranging from the severity of the disease in question, available treatments for the disease, and the economic perspective relating the cost of screening to the cost of treatment and management. Analysis of the ten tenets of Wilson and Jungner in relation to SCCA has revealed the need for the cancer research community to gain a better understanding of the role of high-grade intraepithelial lesions, which may act as a precursor to the development of SCCA; however, a significant portion of persons afflicted with HSIL have demonstrated the ability to spontaneously clear them. In addition, this thesis identified a need to gain a better understanding of HPV, especially in chronic variants. Further research to develop SCCA screening guidelines should also evaluate and weigh the effectiveness and practicality of different screening techniques; certain techniques such as anal cytology may be easily implemented on a massive scale, but may be less accurate. Though a rare disease, the progressive yearly increase in incidence (2.2% per year) of SCCA indicates that comprehensive screening guidelines are urgently needed. Using an analysis of a tried and true framework for establishing disease screening guidelines set by Wilson and Jungner, this thesis intends to contribute to the development of a standardized set of screening guidelines for SCCA. In doing so, we hope to allow SCCA to be managed in a manner that minimizes the impact on patients’ quality of life in a cost-effective manner.

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This thesis deals with didactic game in the first two grades of primary school with an emphasis on getting the feedback. The information processed in the theoretical part contains an analysis of childhood game from a psychological point of view, also relevant to the specifics of educational game, its preparation and subsequent teaching process. Furthermore it deals with principles involved in the feedback management and its benefits for pupils and for teacher. The practical part describes the actual situation of the educational game implementation during classwork in three different educational programs. It is supplemented by interviews with teachers and pupils and my own pedagogical action research.

The subject of the thesis is to determine the use of educational games in teaching the Czech language in primary schools, and verify their effectiveness compared with other teaching methods. The work is divided into four parts. The first part is focused on the definition of basic concepts such as play, didactic game, teaching and motivational methods. The second part discusses the occurrence of didactic games in textbooks of Czech language with a focus on the subject matter of the structure of the word. The third part evaluates the results of a questionnaire survey among Czech language teachers in primary schools from the point of view of integration into the phase of the lesson, the reach educational objectives, frequency of using games, etc. The fourth section examines effectiveness of using didactic games in comparison with other teaching methods on the ground of an experiment realized in parallel classes in the fourth grade in teaching the theory of word structure.

The diploma thesis is focused on the creation and use of chemical computer game (adventure) in chemistry teaching, specifically in practice of metals. The aim of this game is to motivate, activate and develop crosscurricular relationships among students of the second grade of elementary schools and lower grades of multi-year grammar school. Adventure brings players to the city of Jihlava, where they learn about the history and monuments of this city.

Recentemente, na indústria naval, a normatização por sociedades classificadoras e pela IMO (International Maritime Organization) tem apresentado uma mudança paulatina, migrando dos procedimentos prescritivos para uma estrutura regulatória baseada em risco. Tal perspectiva oferece algumas vantagens para operadores e armadores (empresas que exploram comercialmente as embarcações): 1) maior capacidade de incorporar projetos inovadores, tecnicamente superiores, a custos aceitáveis; 2) maior confiança quanto à segurança; 3) melhor entendimento de eventos de periculosidade, dos riscos enfrentados em novos projetos e de medidas de mitigação. Especificamente no setor petrolífero, a análise, a avaliação e o gerenciamento de risco são vitais, em face da potencial gravidade dos acidentes no que diz respeito à vida humana, ao meio-ambiente e ao patrimônio. Dado que a maior parte dos acidentes nesta área são motivados por fatores humanos, o propósito deste trabalho é apresentar uma metodologia e técnicas eficientes de análise de confiabilidade humana aplicáveis a esta indústria. Durante as últimas décadas, se desenvolveram várias técnicas para o estudo quantitativo da confiabilidade humana. Na década de oitenta foram desenvolvidas técnicas que modelam o sistema por meio de árvores binárias, não permitindo a representação do contexto em que as ações humanas ocorrem. Desta forma, a representação dos indivíduos, suas inter-relações e a dinâmica do sistema não podem ser bem trabalhadas pela aplicação destas técnicas. Estas questões tornaram latente a necessidade de aprimoramento dos métodos utilizados para a HRA (Human Reliability Analysis). No intuito de extinguir, ou ao menos atenuar, estas limitações alguns autores vêm propondo a modelagem do sistema por meio de Redes Bayesianas. Espera-se que a aplicação desta ferramenta consiga suprimir boa parte das deficiências na modelagem da ação humana com o uso de árvores binárias. Este trabalho apresenta uma breve descrição da aplicação de Redes Bayesianas na HRA. Além disto, apresenta a aplicação desta técnica no estudo da operação de um navio petroleiro, tendo como foco a quantificação da contribuição do fator humano em cenários de colisão. Por fim, são feitas considerações a respeito dos fatores que podem influenciar no desempenho humano e no risco de colisão. / Recently, in the naval industry, the normalization of classification societies and IMO (International Maritime Organization) has presented a gradual change, going from prescriptive procedures to a regulatory structure based on risk. That perspective offers some advantages to operators and constructors: 1) greater capacity to incorporate innovations in design, technically superiors, at acceptable cost; 2) greater confidence as to security; 3) better understanding of hazardous events, the risks faced by new projects and measures of mitigation. Specifically in the oil sector, the analyze, evaluation, and management of risk are vital, in face of the accidents severity potential in respect to human life, environment and property. Given that the greater part of the accidents on this sector is caused by human factors, the purpose of this dissertation is present a methodology and efficient techniques to HRA (Human Reliability Analysis) that can be applied in this industry. During the last decades many techniques were developed to a quantitative study of the human reliability. In the eighties were developed some techniques based in the modeling by means of binaries trees. These techniques do not consider the representation of the context in which the human actions occur. Thus, the representation of individuals, their inter-relationships and dynamics of the system cannot be better worked by the application of these techniques. These issues became the improvement of the used methods for HRA a latent need. With the aim of extinguish, or attenuate at least, these weaknesses some authors proposed the modeling of the human system by means of Bayesians Network. It is expected that with the application of this tool can be suppressed great part of the deficiencies of the human action modeling by means of binaries trees. This work presents a brief description about the application of Bayesians Network in HRA. Additionally, is presented the application of this technique in the study of an oil tanker operation, focusing in the human factor quantification in scenarios of collision. Besides, are presented some considerations about the factors that can influence the human performance and the collision risk.

This diploma thesis is concerned on the creation and use of computer game (adventure). It´s purpose is usability in repeating the teaching of nonmetal chemistry. The game is designed especially for pupils of elementary schools. The adventure takes place in Prachatice. Pupils learn history of the renaissance town during the playing of didactic game. The game contributes to the activation of teaching and the development of interdisciplinary relations.