The main theme of the work is the issue of gambling. The research is analyzed several aspects  of the gaming market in the context of the historical development, current legislation and the  viewpoint of the interests and behavior of actors. The offer for the gaming market is very  wide. The work deals with gaming machines that pose the greatest risk for pathological  gambling. Of the methods used are significant analysis of pathological gambling, analysis of legislation,  analysis of actors. The thesis analyzes based on the survey. The work presented concrete  measures that can provide a solution to pathological gambling.

The main topic of the thesis are gaming machines that pose the greatest risk for pathological gambling in the municipality Liberec. The theoretical part describes sociopathological phenomena, gambling history, the impact of gambling on society and what opinions have people and municipality to gamble. In the practical part of the research analyzed several perspectives on gambling, among the public and among representatives of the municipality Liberec and other actors. The thesis analyzes the issue on the basis of questionnaires and individual interviews. Results at the end evaluates how the issue is perceived by the general public and other actors.

Introdução: a superexpressão de HER-2 tem correlação com maior agressividade em carcinomas de mama e estômago, e a sua detecção já foi incorporada como rotina na análise destas neoplasias. Critérios ideais para avaliação do HER-2 em câncer de pâncreas permanecem incertos. Objetivos: avaliar o status do HER-2 e o seu valor preditivo em adenocarcinoma pancreático. Materiais e métodos: análise clinicopatológica e imuno-histoquímica de 112 pacientes com diagnóstico de câncer de pâncreas com base nos critérios propostos para câncer de mama (HercepTest™) e de estômago (ToGA Trial). Resultados: pelo HercepTest™ 5 (4.5%) casos apresentaram escore 3+, 3 (2.7%) escore 2+ e 104 (92.9%) escores 0/1+. Na análise pelo ToGA Trial, 9 (8.0%) obtiveram escore 3+, 32 (28.6%) escore 2+ e 71 (63.4%) escores 0/1+. Todos os casos positivos pelo HercepTest™ também o foram para o ToGA Trial. Pacientes com hiperexpressão (3+) apresentaram sobrevida média maior que aqueles sem (0 a 2+) tanto pelo HercepTest™ quanto pelo ToGa Trial (43.88 vs. 10.3 meses, p = 0.029 e 40.7 vs. 10.1 meses, p = 0.013, respectivamente). Os demais parâmetros não mostraram correlação com a expressão de HER-2. Conclusão: diferenças na incidência e no significado prognóstico da superexpressão podem ser decorrentes do pequeno tamanho amostral e do uso de dois critérios diferentes de positividade para HER-2. Estes resultados servem com impulso para novas investigações de superexpressão e amplificação do HER-2 utilizando, além da imuno-histoquímica, métodos como FISH e SISH, a fim de se obter mais opções terapêuticas para oferecer aos pacientes, como agentes anti-HER-2. / Introduction: HER-2 overexpression is correlated with aggressiveness in breast and gastric cancers, and its detection has been incorporated as routine in the analysis of these neoplasms. Ideal criteria for evaluation of HER-2 in pancreatic cancer remain unclear. Objectives: to assess the HER-2 status and its predictive value in pancreatic adenocarcinoma. Material and methods: clinicopathologic and immunohistochemical analysis were undertaken in 112 patients with pancreatic cancer using the criteria proposed for breast (HercepTest™) and stomach cancer (ToGA Trial). Results: using HercepTest™ 5 (4.5%) cases had a score of 3+, 3 (2.7%) had a score of 2+ and 104 (92.9%) had scores of 0/1 +. By ToGA Trial, 9 (8.0%) obtained score of 3+, 32 (28.6%) had a score of 2+ score and 71 (63.4%) had scores of 0/1 +. All positive cases by HercepTest™ also went to the ToGA Trial. Patients with overexpression (3 +) showed greater survival than those without (0 to 2 +) by both HercepTest™ and ToGa Trial (43.88 vs. 10.3 months, p = 0.029 and 40.7 vs. 10.1 months, p = 0.013, respectively). Other parameters did not show correlation with the expression of HER-2. Conclusion: differences in incidence and prognostic significance of overexpression may be explained from small sample size and the use of two different criteria of positivity for HER-2. These results serve as an impulse for new investigations of overexpression/amplification of the HER-2 using, besides immunohistochemistry, FISH and SISH methods, in order to get more treatment options to provide patients, as agents anti-HER-2.

Molybdenum disulfide (MoS2) has been demonstrated to be a potential catalyst in the hydrogen evolution reaction (HER). Due to its highly active edge site, abundance, and low cost, it rivals Pt. However, the potential activity of the MoS2 basal plane has largely been ignored. The physical characteristics of MoS2 and its corresponding band structure change significantly with decreasing thickness, especially at the monolayer limit. Thus, an investigation on the thickness dependence may provide important insights into the MoS2 basal plane activity. In this thesis, the layer dependent electrocatalytic performance is investigated with mono-, bi- and multilayer MoS2 based individual nanodevices. Three conclusions were reached. (1) Monolayers showed exchange current densities more than one order of magnitude higher than that of the multilayers, 0.12 mA/cm2 and 8.7 mA/cm2, respectively. Furthermore, the onset potential of the monolayer was several hundred millivolts lower than that of the multilayer, about 0.2 V vs RHE for the monolayer versus 0.5 V vs RHE for the multilayer. The Tafel slope of 100-200 mV/dec revealed that the rate limiting step was the adsorption of hydrogen. (2) Interestingly, the bilayer sample exhibited an increase in its exchange current density from 0.3 mA/cm2 to 8 mA/cm2 when cycled extensively. This is suspected to be caused by intercalation of hydrogen between the atomic layers. (3) Additionally, the back-gate voltage is applied to tune the Fermi level of the material and the catalytic performance. It was found that the back-gate voltage induces an irreversible change in all samples, increasing the exchange current density by an order of magnitude. The superior basal plane performance of the monolayers to that of the multilayers reveals a new way to optimize the performance of MoS2 as a HER catalyst. In addition, the results above illuminate the yellow brick road to potential improvements in other layered materials as well.

Made available in DSpace on 2014-12-17T14:20:23Z (GMT). No. of bitstreams: 1 KesiaCFApdf.pdf: 668018 bytes, checksum: bc72476e09fd865385a6f8caf4ad8357 (MD5) Previous issue date: 2006-04-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / This research intends to narrate the journey of a simple man who was turned into a saint by a group of believers in Mossor?, west of Rio Grande do Norte. We recognized in the story of Jos? Leite Santana, the "cangaceiro" Jararac?, an appropriated land to build an investigative approach of how characters as different as bandit and saint can be interconnected. From the believers speech, a narrative was created about these detachments of concepts based on the hero myth that is shown here as a part of men?s dealing with death / Nesta pesquisa procura-se narrar a trajet?ria de um homem comum at? se tornar um santo para uma rede de fi?is em Mossor? - Oeste do Rio Grande do Norte. Reconhecemos, na hist?ria de Jos? Leite Santana, o cangaceiro Jararaca, um terreno apropriado para a constru??o de caminhos investigativos de como se d? o entrecruzamento de personagens t?o d?spares quanto o bandido e o santo. A partir das falas dos fi?is tenta-se criar uma narrativa sobre esses deslocamentos de conceitos calcada no mito do her?i que aqui aparece como uma faceta da rela??o do homem com a morte

Made available in DSpace on 2014-12-17T15:12:14Z (GMT). No. of bitstreams: 1 MyrnaSB_DISSERT.pdf: 422171 bytes, checksum: 59ab33c30382bb4356e37a931e5392ef (MD5) Previous issue date: 2011-10-06 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / In the early 1870s, the German Philosopher Friedrich Nietzsche, professor of philology in Basel, researches the ancient Greek philosophers. These studies result in texts as The Preplatonic Philosophers, also known as Lessons on Pre-platonic Philosophers, and Philosophy in Greek tragic age. Using both texts as sources, this dissertation aims elucidating the Nietzsche's interpretation about Heraclitus, in other words, comprehend how Nietzsche recognizes in Heraclitus a philosopher with an aesthetic vision of the world, a contemplative and cheerful view of the world, the becoming, defined by the incessant change, as a child's play that builds and destroy sand castles on the shore. This spectacle, as Nietzsche believed, would be unveiled first by Heraclitus and must be contemplated eternally / No in?cio dos anos de 1870, o fil?sofo alem?o Friedrich Nietzsche, professor de filologia em Basileia, realiza pesquisas sobre os antigos fil?sofos gregos. Estes estudos resultaram na produ??o de textos como Os fil?sofos pr?-plat?nicos, tamb?m conhecido como as Li??es, e A filosofia na ?poca tr?gica dos gregos. Usando como fonte principal estes dois textos, esta disserta??o tem como objetivo elucidar a interpreta??o desenvolvida por Nietzsche sobre o fil?sofo Her?clito, ou seja, compreender o que faz Nietzsche reconhecer em Her?cito um fil?sofo que possui uma vis?o est?tica do mundo, uma vis?o contemplativa e alegre do mundo, do devir, marcado pelo eterno construir e destruir, tal como um jogo de crian?a que constr?i e destr?i castelos de areia ? beira mar. Este ? o espet?culo que, segundo Nietzsche, teria sido descortinado primeiramente por Her?clito e que deve ser contemplado eternamente

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-20T23:56:39Z No. of bitstreams: 1 AnaPaulaSantanaFilgueira_DISSERT.pdf: 1452726 bytes, checksum: 1bdae51525d87ba1abec63448cc86e62 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-02T23:59:00Z (GMT) No. of bitstreams: 1 AnaPaulaSantanaFilgueira_DISSERT.pdf: 1452726 bytes, checksum: 1bdae51525d87ba1abec63448cc86e62 (MD5) / Made available in DSpace on 2017-03-02T23:59:00Z (GMT). No. of bitstreams: 1 AnaPaulaSantanaFilgueira_DISSERT.pdf: 1452726 bytes, checksum: 1bdae51525d87ba1abec63448cc86e62 (MD5) Previous issue date: 2016-09-09 / A Eneida, poema ?pico escrito por Publio Vergilius Maro, ? datada de 19 a. C. Esta epopeia narra o trajeto percorrido pelos sobreviventes da Guerra de Troia, liderados pelo her?i Eneias, em busca de uma terra prometida pelos deuses, para fundar uma nova cidade. Nesta pesquisa, tomamos como objeto de estudo o Livro III da Eneida, no qual o personagem Eneias narra como se deu o decorrer dos seus primeiros anos de ex?lio, sempre chegando e partindo de espa?os onde ele passou por experi?ncias que moldaram sua personalidade como l?der pol?tico, militar e religioso, bem como influenciaram seus companheiros de viagem. Realizamos uma reflex?o sobre como essas caracter?sticas agregadas ? figura de Eneias podem nos auxiliar na reflex?o sobre pol?tica, vida c?vica e religi?o da cidade de Roma, durante o per?odo em que a epopeia virgiliana foi produzida, abarcando o governo de Ot?vio Augusto, entre 14 a. C. e 27 d. C. Promovemos uma an?lise sobre mythos, mem?ria e espa?o, identificando como os troianos exilados na Eneida se reconheciam e interagiam com os espa?os nos quais aportaram, nomeadamente, Tr?cia, Delos, Creta, ilhas Estrof?das, Butroto, It?lia e Drep?no, visando demonstrar como uma fonte liter?ria pode sugerir elementos culturais sobre a sociedade que a produziu. / The Aeneid, an epic poem written by Publius Vergilius Maro, is dated 19 a. C. This epic tells the route taken by survivors of the Trojan War, led by Aeneas hero, in search of a promised land of the gods, to found a new city. In this research, we take as an object of study Book III of the Aeneid in which Aeneas character tells how was the course of his first years of exile, always arriving and departing spaces where he went through experiences that shaped his personality as political leader, military and religious, and influenced their travel companions. We carry out a reflection on how these characteristics aggregated to Aeneas figure can help us in thinking about politics, civic life and religion of Rome, during the period in which the epic Virgilian was produced, covering the government of Octavian Augustus, 14 to . C. and 27 d. C. promote an analysis of mythos, memory and space, identifying how the Trojans exiles in Aeneid is recognized and interact with the spaces in which landed in particular Thrace, Delos, Crete, Estrof?das islands, Buthrotum, Italy and Drepano, aiming to demonstrate how a literary source may suggest cultural elements of the society that produced it.

Introdução: a superexpressão de HER-2 tem correlação com maior agressividade em carcinomas de mama e estômago, e a sua detecção já foi incorporada como rotina na análise destas neoplasias. Critérios ideais para avaliação do HER-2 em câncer de pâncreas permanecem incertos. Objetivos: avaliar o status do HER-2 e o seu valor preditivo em adenocarcinoma pancreático. Materiais e métodos: análise clinicopatológica e imuno-histoquímica de 112 pacientes com diagnóstico de câncer de pâncreas com base nos critérios propostos para câncer de mama (HercepTest™) e de estômago (ToGA Trial). Resultados: pelo HercepTest™ 5 (4.5%) casos apresentaram escore 3+, 3 (2.7%) escore 2+ e 104 (92.9%) escores 0/1+. Na análise pelo ToGA Trial, 9 (8.0%) obtiveram escore 3+, 32 (28.6%) escore 2+ e 71 (63.4%) escores 0/1+. Todos os casos positivos pelo HercepTest™ também o foram para o ToGA Trial. Pacientes com hiperexpressão (3+) apresentaram sobrevida média maior que aqueles sem (0 a 2+) tanto pelo HercepTest™ quanto pelo ToGa Trial (43.88 vs. 10.3 meses, p = 0.029 e 40.7 vs. 10.1 meses, p = 0.013, respectivamente). Os demais parâmetros não mostraram correlação com a expressão de HER-2. Conclusão: diferenças na incidência e no significado prognóstico da superexpressão podem ser decorrentes do pequeno tamanho amostral e do uso de dois critérios diferentes de positividade para HER-2. Estes resultados servem com impulso para novas investigações de superexpressão e amplificação do HER-2 utilizando, além da imuno-histoquímica, métodos como FISH e SISH, a fim de se obter mais opções terapêuticas para oferecer aos pacientes, como agentes anti-HER-2. / Introduction: HER-2 overexpression is correlated with aggressiveness in breast and gastric cancers, and its detection has been incorporated as routine in the analysis of these neoplasms. Ideal criteria for evaluation of HER-2 in pancreatic cancer remain unclear. Objectives: to assess the HER-2 status and its predictive value in pancreatic adenocarcinoma. Material and methods: clinicopathologic and immunohistochemical analysis were undertaken in 112 patients with pancreatic cancer using the criteria proposed for breast (HercepTest™) and stomach cancer (ToGA Trial). Results: using HercepTest™ 5 (4.5%) cases had a score of 3+, 3 (2.7%) had a score of 2+ and 104 (92.9%) had scores of 0/1 +. By ToGA Trial, 9 (8.0%) obtained score of 3+, 32 (28.6%) had a score of 2+ score and 71 (63.4%) had scores of 0/1 +. All positive cases by HercepTest™ also went to the ToGA Trial. Patients with overexpression (3 +) showed greater survival than those without (0 to 2 +) by both HercepTest™ and ToGa Trial (43.88 vs. 10.3 months, p = 0.029 and 40.7 vs. 10.1 months, p = 0.013, respectively). Other parameters did not show correlation with the expression of HER-2. Conclusion: differences in incidence and prognostic significance of overexpression may be explained from small sample size and the use of two different criteria of positivity for HER-2. These results serve as an impulse for new investigations of overexpression/amplification of the HER-2 using, besides immunohistochemistry, FISH and SISH methods, in order to get more treatment options to provide patients, as agents anti-HER-2.

Introdução: a superexpressão de HER-2 tem correlação com maior agressividade em carcinomas de mama e estômago, e a sua detecção já foi incorporada como rotina na análise destas neoplasias. Critérios ideais para avaliação do HER-2 em câncer de pâncreas permanecem incertos. Objetivos: avaliar o status do HER-2 e o seu valor preditivo em adenocarcinoma pancreático. Materiais e métodos: análise clinicopatológica e imuno-histoquímica de 112 pacientes com diagnóstico de câncer de pâncreas com base nos critérios propostos para câncer de mama (HercepTest™) e de estômago (ToGA Trial). Resultados: pelo HercepTest™ 5 (4.5%) casos apresentaram escore 3+, 3 (2.7%) escore 2+ e 104 (92.9%) escores 0/1+. Na análise pelo ToGA Trial, 9 (8.0%) obtiveram escore 3+, 32 (28.6%) escore 2+ e 71 (63.4%) escores 0/1+. Todos os casos positivos pelo HercepTest™ também o foram para o ToGA Trial. Pacientes com hiperexpressão (3+) apresentaram sobrevida média maior que aqueles sem (0 a 2+) tanto pelo HercepTest™ quanto pelo ToGa Trial (43.88 vs. 10.3 meses, p = 0.029 e 40.7 vs. 10.1 meses, p = 0.013, respectivamente). Os demais parâmetros não mostraram correlação com a expressão de HER-2. Conclusão: diferenças na incidência e no significado prognóstico da superexpressão podem ser decorrentes do pequeno tamanho amostral e do uso de dois critérios diferentes de positividade para HER-2. Estes resultados servem com impulso para novas investigações de superexpressão e amplificação do HER-2 utilizando, além da imuno-histoquímica, métodos como FISH e SISH, a fim de se obter mais opções terapêuticas para oferecer aos pacientes, como agentes anti-HER-2. / Introduction: HER-2 overexpression is correlated with aggressiveness in breast and gastric cancers, and its detection has been incorporated as routine in the analysis of these neoplasms. Ideal criteria for evaluation of HER-2 in pancreatic cancer remain unclear. Objectives: to assess the HER-2 status and its predictive value in pancreatic adenocarcinoma. Material and methods: clinicopathologic and immunohistochemical analysis were undertaken in 112 patients with pancreatic cancer using the criteria proposed for breast (HercepTest™) and stomach cancer (ToGA Trial). Results: using HercepTest™ 5 (4.5%) cases had a score of 3+, 3 (2.7%) had a score of 2+ and 104 (92.9%) had scores of 0/1 +. By ToGA Trial, 9 (8.0%) obtained score of 3+, 32 (28.6%) had a score of 2+ score and 71 (63.4%) had scores of 0/1 +. All positive cases by HercepTest™ also went to the ToGA Trial. Patients with overexpression (3 +) showed greater survival than those without (0 to 2 +) by both HercepTest™ and ToGa Trial (43.88 vs. 10.3 months, p = 0.029 and 40.7 vs. 10.1 months, p = 0.013, respectively). Other parameters did not show correlation with the expression of HER-2. Conclusion: differences in incidence and prognostic significance of overexpression may be explained from small sample size and the use of two different criteria of positivity for HER-2. These results serve as an impulse for new investigations of overexpression/amplification of the HER-2 using, besides immunohistochemistry, FISH and SISH methods, in order to get more treatment options to provide patients, as agents anti-HER-2.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / O presente trabalho mostra o estudo da influÃncia da radiaÃÃo de ultra-som sobre a eletrodeposiÃÃo de ligas de Ni-Fe. Foram avaliados a estabilidade e o desempenho eletrocatalÃtico das ligas para a ReaÃÃo de Desprendimento de HidrogÃnio (RDH) em meio alcalino. As ligas eletrodepositadas de Ni-Fe foram obtidas em soluÃÃo 0,06 mol.dm-3 de Ni2SO4.6H2O, 0,48 mol.dm-3 de Na3C3H5O7.2H2O, 0,71 mol.dm-3 de Na2CO3 e 0,16 mol.dm-3 (banho 1) e 0,04 mol.dm-3 de FeSO4.7H2O (banho 2). Foi adicionado 8,4 mL.L-1 de H2SO4 para manter o pH abaixo de 1. A eletrodeposiÃÃo foi realizada sob controle galvanostÃtico variando-se a densidade de corrente de 10 mA.cm-2 a 50 mA.cm-2, na temperatura ambiente (≡ 28ÂC) e de 55ÂC na presenÃa e na ausÃncia da radiaÃÃo de ultra-som. Todos os revestimentos foram depositados em um disco de aÃo-carbono com Ãrea geomÃtrica exposta de 0,7 cm2. A RDH foi estudada em soluÃÃo de NaOH 0,5 mol.dm-3. Foi utilizada para todos os experimentos o eletrodo auxiliar de Pt e o eletrodo de referÃncia de Hg/HgO, OH- (0,5 mol.dm-3). Os revestimentos foram caracterizados por Microscopia EletrÃnica de Varredura (MEV), Voltametria CÃclica (VC) e as propriedades eletrocatalÃticas das ligas de Ni-Fe foram avaliadas por Curva de PolarizaÃÃo de Tafel e por OperaÃÃo ContÃnua. Os resultados mostraram que o ultra-som aumentou a quantidade de Fe eletrodepositada e as ligas obtidas sob a aÃÃo da radiaÃÃo de ultra-som apresentaram o melhor desempenho para a RDH. / The present work shows the study of the ultrasound irradiation influence in the electrodeposition of Ni-Fe coatings. The electrocatalytic performance of these coatings for the hydrogen evolution reaction (her) in alkaline medium was also evaluated. The Ni-Fe coatings were obtained from plating solutions containing 0.06 mol.dm-3 Ni2SO4.6H2O, 0.48 mol.dm-3 Na3C3H5O7.2H2O, 0.71 mol.dm-3 Na2CO3 and 0.16 mol.dm-3 (bath 1) and 0.04 mol.dm-3 FeSO4.7H2O (bath 2). It was also added 8.4 mL L-1 H2SO4 to maintain the pH below 1. The electrodepositions were carried out under galvanostatic control in the range of 10 mA cm-2 to 50 mA cm-2, at room temperature (≈ 28ÂC) and at 55ÂC in the presence and in the absence of ultrasound irradiation. All coatings were deposited on disk mild steel substrate with an exposed geometric area of 0.7 cm2. The hydrogen evolution reaction was studied in 0.5 mol.dm-3 NaOH. In all electrochemical experiments Pt was the auxiliary electrode and Hg/HgO, OH- (0,5 mol.dm-3) was the reference one. The coatings ware characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and the electrocatalytic properties of the Ni-Fe coating were evaluated by Tafel polarization and long-term performance tests. The results showed that the use of the ultrasound irradiation leads to an increase of the Fe content in the electrodeposits. Additionally, the coatings obtained in presence of ultrasound also present the best performance for her.