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Efeitos do canabidiol no comportamento agressivo induzido por isolamento social em camundongos / Cannabidiol effects on agressive-like behaviors induced by social isolation in miceSantos, Alice Hartmann dos 28 January 2016 (has links)
O Canabidiol (CBD), principal composto não-psicotomimético da Cannabis sativa, possui diversas propriedades farmacológicas, incluindo a indução de efeitos tipoantidepressivos e ansiolíticos em roedores após administração sistêmica. O isolamento social aumenta comportamentos agressivos em camundongos, condição denominada agressão induzida pelo isolamento social ou agressão territorial. Drogas ansiolíticas e antidepressivas podem atenuar comportamentos agressivos. Desse modo, o objetivo do presente trabalho foi avaliar se o CBD atenuaria comportamentos agressivos induzidos pelo isolamento social em camundongos. Camundongos Suíços machos (7-8 semanas de idade no dia do isolamento, 30-40 g no dia do teste) foram mantidos isolados (camundongos residentes) para indução dos comportamentos agressivos. Paralelamente, camundongos co-específicos (camundongos intrusos) foram mantidos agrupados (oito por caixa). Neste modelo, um camundongo intruso da mesma linhagem, sexo e idade foi colocado na caixa moradia do residente. As interações entre os camundongos residente e intruso foram gravadas por 20 min e a latência para a primeira mordida contra o intruso, o número de ataques e o tempo total de ataques foram analisados por um observador cego aos grupos experimentais. Após 10 dias de isolamento social, foi testado se a administração aguda (i.p.) de CBD (5, 15, 30 ou 60 mg/kg), 30 min antes do teste, atenuaria comportamentos agressivos dos camundongos residentes contra os intrusos. Para avaliar a participação de receptores 5-HT1A e CB1 nos efeitos do CBD, grupos independentes de animais receberam 1 injeção prévia de WAY 100635 (antagonista dos receptores 5-HT1A, 0,3 mg/kg) ou AM251 (antagonista dos receptores CB1, 1 mg/kg), 30 min antes do CBD (15 mg/kg). Para controlar possíveis efeitos motores da droga, grupos independentes de animais tratados com doses efetivas de CBD ou não efetivas de WAY100635 ou AM251 foram submetidos ao actímetro para avaliação da atividade locomotora total. O CBD (15 mg/kg) aumentou a latência para o residente atacar o intruso e este efeito foi atenuado tanto pela administração prévia de AM251 (VEI+VEI: 186,62±83,16; VEI+CBD: 956,25±150,77; AM+VEI: 271,71±156,18; AM+CBD: 395,86±208,24; p=0,030) quanto WAY100635 (VEI+VEI: 116,33±29,38; VEI+CBD: 860,87±177,36; WAY+VEI: 305,12±159,16; WAY+CBD: 302,57±154,68; p=0,011). Além disso, o CBD reduziu o número de ataques em todas as doses testadas (VEI: 23,00±3,66; CBD 5: 12,25±2,43; CBD 15: 6,62±2,43; CBD 30: 7,71±3,24; CBD 60: 8,16±2,36; p=0,002) e as doses intermediárias (15 e 30 mg/kg) foram capazes de diminuir o tempo total de ataques (VEI: 114,37±22,65; CBD 5: 80,87±23,83; CBD 15: 40,00±14,58; CBD 30: 25,86±12,88; CBD 60: 54,67±9,68; p=0,018), ambos os efeitos sendo atenuados pelo AM251 (Número de ataques - VEI+VEI: 19,25±2,56; VEI+CBD: 3,25±2,36; AM+VEI: 22,86±4,97; AM+CBD: 14,14±4,10; p=0,028; Tempo total de ataques - VEI+VEI: 66,62±9,19; VEI+CBD: 11,75±9,56; AM+VEI: 118,86±31,00; AM+CBD: 58,71±17,45; p=0,049) e WAY100635 (Número de ataques - VEI+VEI: 30,83±6,77; VEI+CBD: 7,87±4,68; WAY+VEI: 22,50±5,06; WAY+CBD: 23,57±6,74; p=0,059; Tempo total de ataques - VEI+VEI: 151,17±32,65; VEI+CBD: 16,75±10,88; WAY+VEI: 113,75±24,66; WAY+CBD: 76,29±21,36; p=0,002). Não foi observado efeito motor do CBD em nenhuma das doses testadas, bem como do WAY100635 e AM251. Esses resultados evidenciam que o CBD atenua comportamentos agressivos em camundongos e nos permitem sugerir um mecanismo misto, visto que há o envolvimento de receptores CB1 e 5-HT1A. Desse modo, este fitocanabinoide poderia ser uma alternativa terapêutica para tratar comportamentos agressivos associados a transtornos psiquiátricos / Cannabidiol (CBD), a major non-psychotomimetic compound from Cannabis sativa plant, induces anxiolytic- and antidepressant-like effects in rodents after systemic administration. Long-term individual housing increases aggressive behavior in mice, a condition named isolation-induced aggression or territorial aggression, which can be attenuated by anxiolytic and antidepressant drugs. Thus, the aim of the present study was to verify whether CBD would attenuate the aggressive behavior induced by social isolation. Male Swiss mice (7-8 weeks of age on the isolation day, 30-40 g on the test day) were individually housed (resident mice) to induce aggressive behavior, while conspecific mice (intruder mice) were grouped housed (eight per cage). In this model, an intruder mouse of the same strain, sex and age is placed in the resident home cage. The resident-intruder interactions were videotaped for 20 min and the latency to the first bite against the intruder, the number of attacks and the total duration of aggressive encounters were recorded and later analyzed by an observer blind to the treatment groups. After 10 days of social isolation, we tested if acute intraperitoneal CBD administration (5, 15, 30 and 60 mg/kg) to the resident mice 30 min prior to the test would attenuate aggressive-like behavior towards the intruder animal. To evaluate the involvement of 5-HT1A and CB1 receptors in the CBD effects, independent groups of animals were injected with WAY100635 (0.3 mg/kg) or AM251(1 mg/kg) 30 min prior to CBD (15 mg/kg). To control possible motor effects, independent animals treated with effective doses of CBD or ineffective doses of WAY100635 or AM251 were submitted to the actimeter to evaluate the total locomotor activity. CBD (15 mg/kg) increased latency to attack the intruder and this effect was attenuated by the prior administration of AM251 (VEI+VEI: 186.62±83.16; VEI+CBD: 956.25±150.77; AM+VEI: 271.71±156.18; AM+CBD: 395.86±208.24; p=0.030) or WAY100635 (VEI+VEI: 116.33±29.38; VEI+CBD: 860.87±177.36; WAY+VEI: 305.12±159.16; WAY+CBD: 302.57±154.68; p=0.011). Moreover, CBD reduced the number of attacks in all tested doses (VEI: 23.00±3.66; CBD 5: 12.25±2.43; CBD 15: 6.62±2.43; CBD 30: 7.71±3.24; CBD 60: 8.16±2.36; p=0.002) as well as the duration of aggressive behavior encounters in the intermediary doses (15 and 30 mg/kg; VEI: 114.37±22.65; CBD 5: 80.87±23.83; CBD 15: 40.00±14.58; CBD 30: 25.86±12.88; CBD 60: 54.67±9.68; p=0.018), both effects were attenuated by AM251 (Number of attacks - VEI+VEI: 19.25±2.56; VEI+CBD: 3.25±2.36; AM+VEI: 22.86±4.97; AM+CBD: 14.14±4.10; p=0.028; Total time of attacks - VEI+VEI: 66.62±9.19; VEI+CBD: 11.75±9.56; AM+VEI: 118.86±31.00; AM+CBD: 58.71±17.45; p=0.049) and WAY100635 (Number of attacks - VEI+VEI: 30.83±6.77; VEI+CBD: 7.87±4.68; WAY+VEI: 22.50±5.06; WAY+CBD: 23.57±6.74; p=0.059; Total time of attacks - VEI+VEI: 151.17±32.65; VEI+CBD: 16.75±10.88; WAY+VEI: 113.75±24.66; WAY+CBD: 76.29±21.36; p=0.002). CBD, in all tested doses, as well as WAY100635 and AM251, did not induce locomotor changes. These findings suggest that CBD decreases aggressive behaviors in mice and allow us to suggest that this effect involves CB1 and 5-HT1A receptors. Therefore, this phytocannabinoid may be therapeutically useful to treat aggressive behaviors that are usually associated with psychiatric disorders
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Social Defeat Stress Causes a Switch in the Neural Systems Mediating Benzodiazepine MotivationDoss, Lilian 07 December 2011 (has links)
Benzodiazepines are widely abused by anxious individuals. Consequently, this thesis modeled anxiety in a mouse model in order to investigate benzodiazepine motivation within this sub-population. Using the Tube test of Social Dominance and the Resident/Intruder Paradigm I investigated whether animals identified as dominant or submissive/defeated would differentially display a preference for 0.25 mg/kg midazolam in a conditioned place preference paradigm. Consistent with my hypotheses, benzodiazepine preference was mediated by negative reinforcement as submissive but not dominant mice displayed a preference for midazolam. Furthermore, different neural systems mediated benzodiazepine preference dependent on the stress status of the animal (acute vs. chronic stress) such that, acutely stressed animals experienced benzodiazepine preference through a dopamine-independent pathway whereas chronically stressed animals experienced benzodiazepine preference through a dopamine-dependent pathway. Within chronically stressed mice, blockade of either D1 or D2 receptors attenuated benzodiazepine preference.
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Social Defeat Stress Causes a Switch in the Neural Systems Mediating Benzodiazepine MotivationDoss, Lilian 07 December 2011 (has links)
Benzodiazepines are widely abused by anxious individuals. Consequently, this thesis modeled anxiety in a mouse model in order to investigate benzodiazepine motivation within this sub-population. Using the Tube test of Social Dominance and the Resident/Intruder Paradigm I investigated whether animals identified as dominant or submissive/defeated would differentially display a preference for 0.25 mg/kg midazolam in a conditioned place preference paradigm. Consistent with my hypotheses, benzodiazepine preference was mediated by negative reinforcement as submissive but not dominant mice displayed a preference for midazolam. Furthermore, different neural systems mediated benzodiazepine preference dependent on the stress status of the animal (acute vs. chronic stress) such that, acutely stressed animals experienced benzodiazepine preference through a dopamine-independent pathway whereas chronically stressed animals experienced benzodiazepine preference through a dopamine-dependent pathway. Within chronically stressed mice, blockade of either D1 or D2 receptors attenuated benzodiazepine preference.
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Les énoncés du Surmoi : le Surmoi complexe ou le complexe du Surmoi / The statements of the superego : the superego complex or the complex of superegoKata-Christophe, Anna 08 July 2016 (has links)
Au travers de la thèse j’interroge l’instance de Surmoi en insistant sur son aspect processuel. Le processus surmoïque est constant et très complexe. Ce travail dynamique et topique du Surmoi est lié avec le travail économique de constellation des énonces catégoriques surmoïques qui encadrent et réorganise le mouvement psychique. La constellation des énoncés surmoïques comme une sorte de langage interne est construit dans le lien intersubjectif entre des sujets. L’énoncé c’est un message transmis par l’autre. L’autre apparait comme ancien l’énonciateur qui a laissé des traces dans la réalité psychique et aussi comme celui qui énonce et qui existe dans la réalité actuelle. Je propose l’hypothèse du Surmoi comme la modalité de passage entre le sujet et la culture sous angle des énonces surmoïques venu de l’autre dans les liens par le biais du processus d’identification multiple, ce que construit de la toile de Surmoi multiple. Le Surmoi multiple permet de dépasser la problématique de la paradoxalité et de l’ambuiguité du Surmoi et permet de voir sa double inscription, pulsionnelle et culturelle à la fois. L’autre qui est inscrit dans son environnement groupal prolonge mon hypothèse à ce qui se passe entre le sujet et le groupe est véhiculé dans l’espace psychique interne du Surmoi ce que je montre au travers de la clinique des sujets en malêtre et en crise et avec une fragilité identitaire. Je tente une réflexion sur la capacité contenante de l’institution, représentée par un groupe social institué (le groupe des soignants, le groupe des éducateurs, des professeurs) qui sont placés dans une référence culturelle donnée. Je propose de voir le groupe comme espace potentiel constituant la groupalité interne du Surmoi comme une toile signifiant. Le Surmoi multiple est à la frontière psychique et il est aussi la forme potentielle entre ce qui est intrapsychique et intersubjective. La fonction de l’autre à travers ses énoncés liés au contexte d’énonciation, est un fil rouge. La thèse tente de montrer que l’énoncé de l’autre organise une scène fournissant une forme potentielle comme une des traces multiples et surmoïques de l’autre chez un autre. La consciance morale – le sens interne qui guide est situé dans le Surmoi autant que la moralité et la culture interiorisé. Les lois sociales et la métacadre permettant de „vivre ensemble” fondent la condition humaine d’un sujet dans l’intitution. La clinique montre que les sujets qui souffrent déposent leur malêtre dans le groupe, qui s’organise comme une scène. Quand la culture portée par ce groupe possède les principes donnant un dispositif opérant, le cadre acquiert aussi une fonction contenante. Le lien entre le sujet et autrui est vu comme un échange d’une scène à une autre scène, ce qui convoque la figure de l’intrus et de l’étranger. Dans la rencontre avec le sujet il s’agit de transformer l’intrus en étranger familier. Par conséquent la quête du lien d’altérité est mise en question. / Through this thesis I question the Superego instance, emphasising its processing aspect. The Superego process is constant and very complex. The dynamic and topical work of the Superego is linked with the categorical, economic work of togetherness of statements that frame and reorganise the psychological movement. The togetherness of Superego statement as a sort of internal language is built in the inter subjective link between persons. The statement is a message transmitted by the ‹ Other ›. The Other appears as the former speaker who has left traces in the psychic reality of the person and also exists and sets the current reality. I propose the hypothesis of the Superego as a transfer mode between the person and his surroundings culture in terms of Superego statements passed from the ‹ other › within the bounds of multiple identifications. A process that builds the canvas of a multiple Superego. Multiple Superego overcomes the problem of paradoxical and ambiguity of simple Superego and demonstrates its double registrar, both drive and cultural. The Other one, registered in his group environment prolongs my hypothesis of what happens between the person and his group carried in the internal psychic space of the Superego. I demonstrate this with clinical cases, the persons with fragile identity in identity crisis. I try to reflect on the restraining capacity of the Institution , represented by an establish social group (eg the caregiver group, the educator group, the teachers) which is placed in a given cultural reference. I propose to see the group as a potential element (space) that will look into the multiple Superego as a workable canvas. Multiple superego is as the psychological border and it is also the potential form between what is intrapsychic and intersubjective.The mental capacity and the function of the other one through his speaking statements related to his surrounding context is a red string of this thesis. The thesis attempts to show that the speaking statement the other one arrange both groupal and psychic space like an scene providing in potential possibility in a multiple traces of superego of the other in another.The moral consciance - the internal sense which guide is located in the Superego as much as internalized morality and culture. Social laws and meta-framework for "living together" based the human condition of each person in intitution. The clinic case shows the suffering person who deposit their pain and ilness on the group, which get organized as a psychic scene. When the culture carried by this group has the principles giving an operating device, the framework also acquires a containing function. The relationship between two persons or person and the others is seen as an exchange from one psychic scene to another, which is associated with problematic of un intruder and un uncanny. In this case the encounter consiste to transform the intruder in familiar uncanny. Away the quest of otherness (alterity) is in question.
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Autoionizing states and their relevance in electron-ion recombination / Autojonizujuća stanja i njihov značaj u rekombinaciji jona sa elektronimaNikolić, Dragan January 2004 (has links)
<p>Atomic physics plays an important role in determining the evolution stages in a wide range of laboratory and cosmic plasmas. Therefore, the main contribution to our ability to model, infer and control plasma sources is the knowledge of underlying atomic processes. Of particular importance are reliable low temperature dielectronic recombination (DR) rate coefficients.</p><p>This thesis provides systematically calculated DR rate coefficients of lithium-like beryllium and sodium ions via ∆n = 0 doubly excited resonant states. The calculations are based on complex-scaled relativistic many-body perturbation theory in an all-order formulation within the single- and double-excitation coupled-cluster scheme, including radiative corrections.</p><p>Comparison of DR resonance parameters (energy levels, autoionization widths, radiative transition probabilities and strengths) between our theoretical predictions and the heavy-ion storage rings experiments (CRYRING-Stockholm and TSRHeidelberg) shows good agreement.</p><p>The intruder state problem is a principal obstacle for general application of the coupled-cluster formalism on doubly excited states. Thus, we have developed a technique designed to avoid the intruder state problem. It is based on a convenient partitioning of the Hilbert space and reformulation of the conventional set of pairequations. The general aspects of this development are discussed, and the effectiveness of its numerical implementation (within the non-relativistic framework) is selectively illustrated on autoionizing doubly excited states of helium.</p>
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Proteção de sistemas elétricos considerando aspectos de segurança da rede de comunicação / Electric power system protection considering safety aspects of the communication networkCosta, Nilson Santos 28 May 2007 (has links)
O mundo moderno está cada dia mais conectado por todos os meios tecnológicos que existem hoje. Isto permite que mais e mais pessoas possam se comunicar, tornando a estrada da comunicação virtual obrigatória para a sobrevivência das pequenas, médias e grandes empresas públicas e privadas. O grande avanço tecnológico do século 20 foi à utilização em grande escala do PC (personal computer) comumente chamados de microcomputadores. Este avanço também chegou aos sistemas elétricos de potência, tornando as subestações digitalizadas. Estas subestações sendo digitais correm riscos de invasão cibernética interna ou mesmo externa. Embora a possibilidade de invasão cibernética externa seja pequena, ela existe. Diante dessa situação este trabalho propõe a aplicação de um sistema de segurança, aplicado em um sistema elétrico de potência. O trabalho concentra-se especificamente no estudo dos sistemas de detecção de intruso (SDI), nos seus dois modos básicos: o SDI por abuso e SDI por anomalia utilizando redes neurais artificiais. Estes conceitos serão testados em um sistema elétrico de potência simulado, com uma rede de comunicação baseada em microcomputadores e/ou equipamentos microprocessados, com relés digitais reais. Os Softwares, denominados SNORT e Carcará, foram utilizados e extensivamente testados com resultados altamente encorajadores para a função descrita. / Modern world is more connected each day by all technological means available. This allows more people to communicate, turning the virtual communication road obligatory to the survival of small, medium and large companies, whether public or private. The great technological advance of the 20th century was the large use of the PCs (personal computer), usually called microcomputers. This advance also reached the power electric systems with the digitalization of the substations. These digitalized substations, run the risk of cybernetic invasion, internal or even external. Although the possibility of external cybernetic invasion is small, it exists. In that context, the present thesis proposes the application of a security system for an electric power system. The focus will be the study of intruder detection systems (IDS), on its two basic forms: the IDS by abuse and the IDS by anomaly, using artificial neural networks. These concepts will be tested in a simulated electric power system, with a communication network based on microcomputers, with actual digital relays with the digitalization of the substations.
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Análise de sistemas hipotalâmicos envolvidos na organização da defesa intraespecífica. / Analyses of hypothalamic systems involved in the organization of intra-specific defense.Motta, Simone Cristina 30 July 2010 (has links)
Etologicamente, os animais expressam repostas de medo frente a um predador ou a um co-especifico e a organização neural de respostas defensivas intraespecíficas são pouco conhecidas. Assim, o objetivo deste trabalho foi estudar o papel hipotalâmico na organização da defesa intraespecífica. Observamos que o núcleo pré-mamilar dorsal do hipotálamo também está ativo durante nesse tipo de defesa, porém porções distintas do mesmo. A lesão desse núcleo em ratos expostos a derrota social levou a importantes alterações comportamentais, praticamente abolindo comportamentos de defesa passiva. Notamos que regiões do hipotálamo lateral são as principais projeções aferentes do núcleo pré-mamilar dorsal e o principal alvo eferente é a coluna dorsomedial da matéria cinzenta periaquedutal. Concluímos que o hipotálamo é fundamental para a organização da defesa intraespecífica e que comportamentos defensivos inter e intra-específicos se utilizam de caminhos neurais distintos. / In nature, animals express fear responses toward a predator or a co-specific and not much is known about the neural organization of intra-specific defense. Therefore, the aim of this work was to analyze the role that the hypothalamus plays during the intra-specific defense expression. We observed that the dorsal premammilary nucleus is also mobilized during the agonistic encounter, but a different portion. Dorsal premammilary nucleus lesioned intruders led to important defense alterations, almost abolishing passive forms of defensive behavior. Notably, regions in lateral hypothalamus are particularly important for activating the dorsal premammilary nucleus and its efferent projection to the dorsomedial column of periaqueductal gray matter is the most important outcome for the defensive behavior expression. Concluding, the hypothalamus is fundamental for the neural organization of intra-specific defense and inter and intra-specific defensive behaviors are organized by distinct neural pathways.
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Avaliação da exposição prévia a estímulos estressores aversivos inatos e aprendidos sobre o comportamento agressivo de camundongos (Mus musculus albinus): influência de mecanismos GABAérgicos e dopaminérgicos / A behavioral and pharmacological evaluation of aggressive behavior in mice previously exposed to fear or anxiety-like stimuliCunha Neto, João Soares da 02 March 2018 (has links)
Os animais são expostos a diferentes situações que podem colocar em risco sua sobrevivência. Na natureza estas situações, em geral, eliciam medo e ou ansiedade. A agressão é um conjunto de comportamentos direcionados a um indivíduo co específico, ou não, que tem como objetivo a aquisição de recursos ou proteção em situações de risco à sobrevivência. Considerando a interação entre medo/ansiedade e agressividade, este trabalho teve como objetivo estudar se essas situações podem modificar o comportamento agressivo agressividade em camundongos. O propósito deste estudo foi investigar se a pre-exposição de camundongos a estímulos estressores incondicionados (campo aberto, labirinto em cruz elevado, exposição ao rato, exposição a odor de rato) e condicionados (choque nas patas) podem modular o futuro comportamento agressivo em camundongos. Para atingir esse objetivo, os animais foram previamente expostos a diferentes situações capazes de provocar um estado de ansiedade e/ou medo e posteriormente submetidos ao encontro agonístico (teste residente intruso). As alterações na reatividade emocional induzidas pelas variáveis independentes foram medidas usando a resposta de sobressalto potencializado pelo medo e a análise de vocalizações ultrassônicas. Devido à influência relevante da neurotransmissão de GABA na agressão, as mudanças comportamentais induzidas pelas variáveis utilizadas foram associadas com o benzodiazepínico diazepam. Os dados obtidos no presente estudo após análise mostrou que a pré-exposição de camundongos a situações aversivas que provocam medo e / ou ansiedade alteram o seu comportamento. / Aggression is defined as a behavioral repertoire mainly directed to a conspecific for acquisition of resources and protection. In this context, anxiety and fear-like behaviors is commonly triggered by these survivors situations. Since aggression and fear are highly correlated in the present study we investigated whether previous exposure to environmental unconditioned (rat presence and rat odor, open field and elevated plus-maze tests, foot-shocks) and conditioned aversive stimuli (fear-potentiated startle) can modulate future aggressive behavior in mice. To achieve this goal, the animals were previously exposed to different situations able to elicit a state of anxiety and/or fear and later submitted to the agonistic encounter. Changes on the emotional reactivity induced by the independent variables used were measured using the fear-potentiated startle response and ultrasonic vocalizations analysis. Due to the relevant influence of GABA neurotransmission on aggression, behavioral changes induced by the variables used were challenged with the prototypic benzodiazepine diazepam. In addition, regarding human aggression, the most effective and enduring pharmacological intervention rely on compounds that act as dopaminergic antagonists. Therefore, in our study, in order to verify the influence of dopamine neurotransmission on the modulation of aggression pharmacological manipulation was conducted with the systemic administration of the dopamine D2 agonist apomorphine. Both drugs were administered previously to the resident-intruder test. The data obtained in the present study after analysis show that the pre-exposure to aversive situations that trigger fear and/or anxiety changes mice behavior.
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Análise de sistemas hipotalâmicos envolvidos na organização da defesa intraespecífica. / Analyses of hypothalamic systems involved in the organization of intra-specific defense.Simone Cristina Motta 30 July 2010 (has links)
Etologicamente, os animais expressam repostas de medo frente a um predador ou a um co-especifico e a organização neural de respostas defensivas intraespecíficas são pouco conhecidas. Assim, o objetivo deste trabalho foi estudar o papel hipotalâmico na organização da defesa intraespecífica. Observamos que o núcleo pré-mamilar dorsal do hipotálamo também está ativo durante nesse tipo de defesa, porém porções distintas do mesmo. A lesão desse núcleo em ratos expostos a derrota social levou a importantes alterações comportamentais, praticamente abolindo comportamentos de defesa passiva. Notamos que regiões do hipotálamo lateral são as principais projeções aferentes do núcleo pré-mamilar dorsal e o principal alvo eferente é a coluna dorsomedial da matéria cinzenta periaquedutal. Concluímos que o hipotálamo é fundamental para a organização da defesa intraespecífica e que comportamentos defensivos inter e intra-específicos se utilizam de caminhos neurais distintos. / In nature, animals express fear responses toward a predator or a co-specific and not much is known about the neural organization of intra-specific defense. Therefore, the aim of this work was to analyze the role that the hypothalamus plays during the intra-specific defense expression. We observed that the dorsal premammilary nucleus is also mobilized during the agonistic encounter, but a different portion. Dorsal premammilary nucleus lesioned intruders led to important defense alterations, almost abolishing passive forms of defensive behavior. Notably, regions in lateral hypothalamus are particularly important for activating the dorsal premammilary nucleus and its efferent projection to the dorsomedial column of periaqueductal gray matter is the most important outcome for the defensive behavior expression. Concluding, the hypothalamus is fundamental for the neural organization of intra-specific defense and inter and intra-specific defensive behaviors are organized by distinct neural pathways.
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Système de sécurité biométrique multimodal par imagerie, dédié au contrôle d’accès / Multimodal biometric security system based on vision, dedicated to access controlBonazza, Pierre 21 June 2019 (has links)
Les travaux de recherche de cette thèse consistent à mettre en place des solutions performantes et légères permettant de répondre aux problèmes de sécurisation de produits sensibles. Motivé par une collaboration avec différents acteurs au sein du projet Nuc-Track,le développement d'un système de sécurité biométrique, possiblement multimodal, mènera à une étude sur différentes caractéristiques biométriques telles que le visage, les empreintes digitales et le réseau vasculaire. Cette thèse sera axée sur une adéquation algorithme et architecture, dans le but de minimiser la taille de stockage des modèles d'apprentissages tout en garantissant des performances optimales. Cela permettra leur stockage sur un support personnel, respectant ainsi les normes de vie privée. / Research of this thesis consists in setting up efficient and light solutions to answer the problems of securing sensitive products. Motivated by a collaboration with various stakeholders within the Nuc-Track project, the development of a biometric security system, possibly multimodal, will lead to a study on various biometric features such as the face, fingerprints and the vascular network. This thesis will focus on an algorithm and architecture matching, with the aim of minimizing the storage size of the learning models while guaranteeing optimal performances. This will allow it to be stored on a personal support, thus respecting privacy standards.
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