Made available in DSpace on 2017-05-12T14:47:53Z (GMT). No. of bitstreams: 1 Luciana Espindula de Quadros.pdf: 521227 bytes, checksum: 7de1f8de229e20d0ac01c9f1aa7609c6 (MD5) Previous issue date: 2008-07-24 / This work aiming at contribute for the planning of activities that are influenced by the intensity of hasty water, in that the results condition technical or strategic decisions of order in activities as farming, civil construction and tourism. It was analizy historical series of maximum haste for different durations obtained of raingouge in the town of Cascavel-PR, planning an intense rain probability distribution model through the distribution generalized be adjusted Moments LH for estimate his parameters and the statistical test proposed by Wang (1998) for verification of the quality of the settlements developed in the environment Matlab. Beyond that, them referred series were adjusted through the distribution Gumbel for effect of comparison with the GEV. The results show that the distribution of the kind VEI of the GEV, that corresponds the distribution Gumbel, is not adequate for big periods of return therefore substime the values of the distribution kind VEII. As results are presented the estimates of the parameters of the GEV, the values of the rates for the time being LH, the period of each return duration of rain and the hydrographs of project. / Este trabalho visa contribuir para o planejamento de atividades que são influenciadas pela intensidade da água precipitada, em que os resultados condicionam decisões de ordem técnica ou estratégica em atividades como agropecuária, construção civil e turismo. O objetivo é ajustar um modelo de distribuição de probabilidades de chuva intensa pela distribuição generalizada de valores extremos (GEV), utilizando momentos LH para estimar seus parâmetros e o teste estatístico proposto por Wang (1998) para verificação da qualidade dos ajustes desenvolvidos no ambiente Matlab. Foram analisadas séries históricas de precipitação máximas para diferentes durações, obtidas de pluviográfos no município de Cascavel-PR. Além disso, as referidas séries foram ajustadas por meio da distribuição Gumbel para efeito de comparação com a GEV. Os resultados mostram que a distribuição do tipo VEI da GEV, que corresponde à distribuição Gumbel, não é adequada para grandes períodos de retorno, pois subestima os valores da distribuição tipo VEII. Como resultados são apresentados as estimativas dos parâmetros da GEV, os valores das taxas de momentos LH, o período de retorno para cada duração de chuva e o hietograma de projeto.

Nous proposons une nouvelle structure de données distribuée et scalable appelée LH*RSP2P conçue pour les environnements pair à pair(P2P).Les données de l'application forment un fichier d'enregistrements identifiés par les clés primaires. Les enregistrements sont dans des cases mémoires sur des pairs, adressées par le hachage distribué (LH*). Des éclatements créent dynamiquement de nouvelles cases pour accommoder les insertions. L'accès par clé à un enregistrement comporte un seul renvoi au maximum. Le scan du fichier s'effectue au maximum en deux rounds. Ces résultats sont parmi les meilleurs à l'heure actuelle. Tout fichier LH*RSP2P est également protégé contre le Churn. Le calcul de parité protège toute indisponibilité jusqu'à k cases, où k ≥ 1 est un paramètre scalable. Un nouveau type de requêtes, qualifiées de sûres, protège également contre l'accès à toute case périmée. Nous prouvons les propriétés de notre SDDS formellement par une implémentation prototype et des expérimentations. LH*RSP2P apparaît utile aux applications Big Data, sur des RamClouds tout particulièrement

Influências de secreções endógenas e estímulos ambientais durante o período neonatal parecem ser determinantes para programar a atividade neuroendócrina e comportamental na vida adulta. O propósito do presente trabalho foi estudar a interação entre os hormônios gonadais e a manipulação durante o período neonatal sobre a concentração plasmática de corticosterona, gonadotrofinas (hormônios luteinizante e folículo estimulante), e hormônios gonadais (estradiol, progesterona e testosterona) em ratos adultos machos e fêmeas. Para alguns grupos experimentais, filhotes de ratos Wistar foram gonadectomizados, ou submetidos à cirurgia fictícia, antes de 6 horas após o nascimento, ou foram mantidos sem cirurgia. Metade destes animais foram estimulados diariamente, ou foram mantidos sem a manipulação neonatal, durante os primeiros 10 dias de vida. Para outros grupos experimentais, machos foram manipulados diariamente durante o período dos 10 primeiros e gonadectomizados aos 80 dias de vida. Somente a manipulação neonatal não provocou diferenças na concentração plasmática de corticosterona e gonadotrofinas, tanto em machos quanto em fêmeas, mas reduziu a secreção de hormônios gonadais em fêmeas. Enquanto a manipulação em fêmeas gonadectomizadas logo após o nascimento induziu um menor aumento na resposta de corticosterona comparada com às fêmeas não-manipuladas, em machos, a ausência de hormônios gonadais aboliu a redução da resposta ao estresse induzida pela gonadectomia neonatal no grupo não-manipulado. A manipulação aumentou a responsividade do feedback negativo para as gonadotrofinas em machos e fêmeas gonadectomizados no período neonatal. Mas a gonadectomia na idade adulta, em ratos machos manipulados no período neonatal induziu a um menor aumento no LH, comparado aos machos não-manipulados. Deve-se considerar que a castração realizada logo após o nascimento provoca a ausência dos hormônios gonadais durante todo o restante da vida do animal. Em fêmeas, a estimulação ambiental atuou sobre um sistema que não estava sob a influência dos hormônios gonadais. Mas em machos, além dos efeitos pré-natais dos esteróides gonadais, uma interação entre a estimulação neonatal e os efeitos destes hormônios durante o período neonatal provavelmente ocorreu. A estimulação ambiental durante o período neonatal e os hormônios gonadais interagem exercendo um profundo impacto a longo-prazo sobre a atividade do sistema de estresse hipotálamo-hipófise-adrenais e também sobre os mecanismos de controle neuroendócrino do sistema reprodutivo na vida adulta. / Endogenous hormones and environmental stimuli during the neonatal period appear to be determinant to program the behavioral and neuroendocrine profile in adult life. The purpose of the present study was to analyze the interaction between gonadal hormones and handling stimulation during the neonatal period on plasma corticosterone, gonadotrophins (luteinizing and follicle stimulating hormones), and gonadal hormones (estradiol, progesterone and testosterone) in adult male and female rats. For experimental groups, newborn Wistar pups were gonadectomized, or submitted to sham surgery or kept without surgery, at up to 6 hours after delivery. These pups were or stimulated daily by experimental handling, or kept without handling, during the first 10 postnatal days. For another experimental groups, males were stimulated daily on neonatal period (until 10 postnatal days) and gonadectomized at 80 days. Only neonatal handling shows no differences on plasma corticosterone and gonadotrophins, both in male or female rats, but reduced gonadal hormones in female rats. While handling in neonatal gonadectomized females induced a lesser increase in corticosterone response compared with the non-handled ones, in males, the absence of the gonadal hormones abolished the reduction of the stress response induced by neonatal gonadectomy in the non-handled group. Handling increased the negative feedback responsiveness to gonadotrophins of neonatal gonadectomized male and female rats. But, adult gonadectomy of neonatal handled males induced a lesser increase in LH compared with the non-handled ones. It is noteworthy that those castration performed just after birth, provoked the absence of the hormones occurred throughout the life of the animal. In females, early life environmental stimulation occurred upon a nervous system that has not been under the influence of gonadal hormones. In males, besides pre-natal effects of gonadal steroids, an interaction between environmental stimulation and hormonal effects during the neonatal period probably occurred. Environmental stimulation during the neonatal period and gonadal hormones interact and exert a profound long-lasting impact on the activity of the hypothalamic-pituitary-adrenal stress system and also on the reproductive neuroendocrine control mechanisms in adulthood.

Influências de secreções endógenas e estímulos ambientais durante o período neonatal parecem ser determinantes para programar a atividade neuroendócrina e comportamental na vida adulta. O propósito do presente trabalho foi estudar a interação entre os hormônios gonadais e a manipulação durante o período neonatal sobre a concentração plasmática de corticosterona, gonadotrofinas (hormônios luteinizante e folículo estimulante), e hormônios gonadais (estradiol, progesterona e testosterona) em ratos adultos machos e fêmeas. Para alguns grupos experimentais, filhotes de ratos Wistar foram gonadectomizados, ou submetidos à cirurgia fictícia, antes de 6 horas após o nascimento, ou foram mantidos sem cirurgia. Metade destes animais foram estimulados diariamente, ou foram mantidos sem a manipulação neonatal, durante os primeiros 10 dias de vida. Para outros grupos experimentais, machos foram manipulados diariamente durante o período dos 10 primeiros e gonadectomizados aos 80 dias de vida. Somente a manipulação neonatal não provocou diferenças na concentração plasmática de corticosterona e gonadotrofinas, tanto em machos quanto em fêmeas, mas reduziu a secreção de hormônios gonadais em fêmeas. Enquanto a manipulação em fêmeas gonadectomizadas logo após o nascimento induziu um menor aumento na resposta de corticosterona comparada com às fêmeas não-manipuladas, em machos, a ausência de hormônios gonadais aboliu a redução da resposta ao estresse induzida pela gonadectomia neonatal no grupo não-manipulado. A manipulação aumentou a responsividade do feedback negativo para as gonadotrofinas em machos e fêmeas gonadectomizados no período neonatal. Mas a gonadectomia na idade adulta, em ratos machos manipulados no período neonatal induziu a um menor aumento no LH, comparado aos machos não-manipulados. Deve-se considerar que a castração realizada logo após o nascimento provoca a ausência dos hormônios gonadais durante todo o restante da vida do animal. Em fêmeas, a estimulação ambiental atuou sobre um sistema que não estava sob a influência dos hormônios gonadais. Mas em machos, além dos efeitos pré-natais dos esteróides gonadais, uma interação entre a estimulação neonatal e os efeitos destes hormônios durante o período neonatal provavelmente ocorreu. A estimulação ambiental durante o período neonatal e os hormônios gonadais interagem exercendo um profundo impacto a longo-prazo sobre a atividade do sistema de estresse hipotálamo-hipófise-adrenais e também sobre os mecanismos de controle neuroendócrino do sistema reprodutivo na vida adulta. / Endogenous hormones and environmental stimuli during the neonatal period appear to be determinant to program the behavioral and neuroendocrine profile in adult life. The purpose of the present study was to analyze the interaction between gonadal hormones and handling stimulation during the neonatal period on plasma corticosterone, gonadotrophins (luteinizing and follicle stimulating hormones), and gonadal hormones (estradiol, progesterone and testosterone) in adult male and female rats. For experimental groups, newborn Wistar pups were gonadectomized, or submitted to sham surgery or kept without surgery, at up to 6 hours after delivery. These pups were or stimulated daily by experimental handling, or kept without handling, during the first 10 postnatal days. For another experimental groups, males were stimulated daily on neonatal period (until 10 postnatal days) and gonadectomized at 80 days. Only neonatal handling shows no differences on plasma corticosterone and gonadotrophins, both in male or female rats, but reduced gonadal hormones in female rats. While handling in neonatal gonadectomized females induced a lesser increase in corticosterone response compared with the non-handled ones, in males, the absence of the gonadal hormones abolished the reduction of the stress response induced by neonatal gonadectomy in the non-handled group. Handling increased the negative feedback responsiveness to gonadotrophins of neonatal gonadectomized male and female rats. But, adult gonadectomy of neonatal handled males induced a lesser increase in LH compared with the non-handled ones. It is noteworthy that those castration performed just after birth, provoked the absence of the hormones occurred throughout the life of the animal. In females, early life environmental stimulation occurred upon a nervous system that has not been under the influence of gonadal hormones. In males, besides pre-natal effects of gonadal steroids, an interaction between environmental stimulation and hormonal effects during the neonatal period probably occurred. Environmental stimulation during the neonatal period and gonadal hormones interact and exert a profound long-lasting impact on the activity of the hypothalamic-pituitary-adrenal stress system and also on the reproductive neuroendocrine control mechanisms in adulthood.

La détermination du partage des éléments sidérophiles et volatils entre métal et silicates aux conditions du manteau profond de la Terre primitive peut fournir des contraintes relatives au mécanisme de formation du noyau terrestre. Des expériences ont été réalisées dans des cellules à enclumes de diamant (DAC) chauffées par laser afin d'étudier l'évolution du partage métal-silicate du soufre et du platine à haute température et haute pression. Le partage est déterminé grâce à la mesure sur échantillons trempés des concentrations par NanoSIMS et sonde électronique. L’affinité du soufre avec le métal, mesurée aux conditions de formation du noyau terrestre, est moins grande qu’attendue. En accord avec les observables cosmochimiques (météorites), il semble que la quantité de soufre dans le noyau ne peut excéder 2 poids%. Les modèles d’accrétion de la Terre, combinés à nos mesures du coefficient de partage du soufre en fonction de la pression et la température, indiquent que la concentration globale de soufre du manteau terrestre doit être le résultat d'une accrétion hétérogène. Ces données indiquent également un apport tardif des éléments volatils au cours de l’accrétion et de la formation du noyau. Les valeurs de partage du platine suggèrent que son abondance dans le manteau terrestre peut être expliquée simplement par la formation du noyau. De manière générale, ces résultats supportent les hypothèses selon lesquelles les noyaux des gros impacteurs n’ont pas pu s’équilibrer entièrement avec le manteau terrestre. Certaines fractions métalliques ont donc pu atteindre le noyau terrestre sans affecter le manteau. L’hypothèse d’un évènement tardif de ségrégation de sulfure durant la formation de la terre pourrait aussi expliquer les compositions du manteau terrestre observées. Ces résultats permettent de caractériser les processus de différenciation du manteau et du noyau et de mieux comprendre la formation de la Terre. / Measurements of the metal-silicate partitioning behavior of siderophile and volatile elements at the conditions of the deep primitive Earth can provide constraints on the mechanisms of terrestrial core formation. Experiments were conducted in a laser-heated diamond anvil cell to investigate the metal-silicate partitioning of sulfur and platinum at high pressures and temperatures. The partitioning behaviors were quantified post-experiment by high resolution NanoSIMS imaging. Sulfur was found to be moderately siderophile at core formation conditions and this, together with cosmochemical estimates, argue that it cannot be a major light element in the core. Accretion modeling with this new partitioning data implies that a heterogeneous accretion scenario can best explain the mantle and bulk Earth sulfur contents. The measured partitioning values for platinum are such that the mantle's platinum abundance can be sufficiently explained by core-mantle equilibration. Overall these results support the hypothesis that the cores of large impactors did not equilibrate fully with the magma ocean and metal could have sequestered to the Earth's core without leaving a record in the mantle. A late sulfide segregation event also likely played a role in establishing the observed mantle compositions. These findings help to further elucidate the accretion history of the Earth and core-mantle differentiation processes.

The control of prolactin secretion is a complex interaction of peptides and neurotransmitters acting either in an inhibitory or stimulating way to effect final secretion of this hormone from the lactotrope cell in the anterior hypothalamus. These factors may act either directly on the lactotrope cell or indirectly by changing either dopamine restraint of prolactin secretion or by modulating peptide substances or neurotransmitters higher up in the hypothalamus. Gonadal steroids may also modulate the effect of peptides or dopamine at the level of the lactotrope. Prolactin's major role in the female rat is one of milk production post - partum, nurturing the young. It probably also has other physiological functions and may play a part in the menstrual cycle although this is controversial. Certainly, pulsatile secretion of prolactin during the menstrual cycle is well established and in the luteal phase this is concomitant with the secretion of luteinizing hormone. Theories explaining the synchronous surges seen during this phase of the menstrual cycle have been proposed and GnRH has been implicated in the genesis of the concordance of these secretory spikes. Using a potent GnRH antagonist an experiment was undertaken to establish the role of GnRH by blocking this hypothalamic peptide and observing the effect that this had on luteinizing hormone, prolactin and follicle stimulating hormone. In the first part of the thesis the control of prolactin secretion is reviewed. In the following section, an experiment was performed using a potent GnRH antagonist. A dose response curve was established for the antagonist action on LH. Then a twice maximum dose of this peptide was administered to three subjects in the midluteal phase of the menstrual cycle and the response of LH, prolactin and FSH was measured. The results indicate that although the GnRH antagonist significantly blocked LH secretory peaks, this action was not observed for either prolactin or FSH. This result is perhaps at variance with previous data which suggested that GnRH was responsible for concordant secretory spikes of LH and prolactin in the midluteal phase of the menstrual cycle.

Der Begriff des »Fake« meint eine mimetische Nachahmung eines anderen Kunstwerks, die im Gegensatz zur Fälschung selbst auf ihren gefälschten Charakter hinweist. Eine Künstlerin reproduzierte Fotografien von Walker Evans; diese eigenen Fotografien präsentierte sie auf ähnliche Weise wie das Vorbild; der Titel, »Sherrie Levine After Walker Evans«, weist die Arbeit als Aneignung aus, die die gewandelten kontextuellen und konzeptuellen Bedingungen des identischen Bilds reflektiert. Das Fake zielt demnach mittels einer genauen Bilduntersuchung auf einen kunsthistorischen Erkenntnisprozeß: Die Reproduktion wird nicht mehr moralisch als Fälschung verurteilt, sondern das Fake wird als Kritik der Institution der Kunst und ihrer Ideologie des Originals betrachtet. Das erste Kapitel widmet sich den neuen künstlerischen Strategien zu Anfang der 1970er Jahre und diskursanalytisch der historischen Fälschungsliteratur, dem Verhältnis von Original und Fälschung, um in Abgrenzung davon den Begriff »Fake« einzuführen. Im zweiten Kapitel werden sieben ausgewählte Beispiele von Fakes auf ihre konzeptuelle Formation hin untersucht. Im letzten Kapitel werden die weitreichenden Konsequenzen dargelegt, die das Fake für die Bild- und Kunsttheorie im Verhältnis zu gesellschaftlichen Entwicklungen bedeutet. / The concept of Fake describes a mimetic imitation of another work of art which, in contrast to forgery, hints at its faked nature. A female artist reproduced photographs by Walker Evans and presented these photographs like the original; the title, "Sherrie Levine After Walker Evans" identifies the work as an appropriation which reflects the contextually and conceptually changed conditions of the identical image. Accordingly, the fake aims at an art historical cognitive process by means of an exact examination of the respective artwork: The reproduction is no longer morally condemned as forgery, but the fake is regarded as criticism of the institution of art and its ideology of the orginal. The first chapter deals with the new artistic strategies at the beginning of the 1970s and, in a discursive analysis, the historical literature of Fake as well as with the relation of orginal and forgery in distinction to the concept of "Fake". In the second chapter seven examples of Fake are examined for their conceptual formation. The third and last chapter is a description of the far reaching consequences of Fake for image and art theory in relation to social developments.

Diese Arbeit geht der Frage nach den bildungstheoretischen Absichten der Sammlungspraktiken zweier außerordentlicher Kunstkennerinnen und -sammlerinnen der Renaissance nach, Isabella d''Este und Margarethe von Österreich. Ihre Sammlungen formten einen neuen Wissenstypus, indem sie mittels Strukturierung und Visualisierung deutende Ordnungen der Welt erstellten. In den Studioli von Isabella d''Este und von Margarethe von Österreich, die zu Marksteinen einer Entwicklung wurden, die in Nordeuropa erst in der zweiten Hälfte des 16. Jahrhunderts zu ihrer Entfaltung kam, dienen Kunstverständnis, Kunstförderung und Kunsterwerb der höfischen Selbstdarstellung. Mit ihrer Ausstattung repräsentieren sie darüber hinaus die Frühform eines Sammlungsraumes, in dem zukunftsweisende Bildungsprozesse stattfinden. Die vorliegende Arbeit versteht sich somit als Rekonstruktion und Analyse eines impliziten Bildungsprogramms. / The study compares the history of two Renaissance collections, the "studiolo" of Isabella d’Este (1474-1539) and the "petit cabinet" of Margaret of Austria (1480-1530), two extraordinary art experts and collectors sixteenth century. They modelled a new type of knowledge by their method of acquisition as they created an interpretative classification of the world through the use of structure and visualisation. The work focuses on the concepts of knowledge inscribed into the visual structure of those two collections and the pedagogical approaches they enacted. Isabella d’Este’s and Margaret of Austria’s collection rooms became a landmark in a development, which only came into being in northern Europe in the second half of the sixteenth century. This is, in part, due to the fact that the understanding, promotion and acquisition of art became an important aspect of courtly self representation. Furthermore, their collection represents an early form of collection space which created the foundation for future educational processes. Therefore, this work is aims to be a historiography of an educational process as well as the reconstruction and analysis of an implicit pedagogical program. Following an interdisciplinary approach, the research is designed to systematically and historically reconstruct the order, production and representation of knowledge within its social context. The comparative approach aims to grasp the specific pedagogical perspective of each collection. Furthermore it focuses on parallels of their concern of transformation and the functionality of such extraordinary collection activities. Analytical categories such as space, time and hierarchies are used in the analysis of the primary sources. In this way, the collections and corresponding materials will be analysed in order to explain how the implicit educational program can be understood as a forerunner of an educational theory.

L’objet de cette étude est de définir et de préciser les caractéristiques des déplacements de sites dans l’archipel des Cyclades, entre le XIIe siècle et le VIIIe siècle av. n. è. Les quelques études existantes, parfois contradictoires, émettent l’hypothèse que les déplacements se déroulent en trois étapes : un site est abandonné, la communauté se déplace et choisit un nouveau site non loin du premier pour établir un habitat, des lieux de sépulture et des lieux de culte. La validité de ce schéma doit être vérifiée. L’étude établit tout d’abord un bilan du peuplement pour chacune des trente-deux îles retenues. Les sites abandonnés et les sites nouvellement occupés sont répertoriés afin de révéler des discontinuités d’occupation. Des déplacements de sites sont proposés, à titre d’hypothèse. Il est tenu compte du fait que les interprétations sont fondées sur des données matérielles. Les conclusions se révèlent fragiles mais sont fréquemment semblables d’une île à l’autre : les déplacements de sites sont une forme de mobilité spatiale attestée mais dont la mise en œuvre et les facteurs se révèlent plus complexes qu’il ne l’avait été suggéré. Leurs caractéristiques varient aussi en fonction de la période considérée : il faut sans doute envisager une circulation accrue des communautés entre de multiples sites au cours de l’HR IIIC, et non un abandon généralisé des Cyclades ; à partir de la fin du Xe siècle et au cours du Géométrique, les déplacements de sites sont de plus en plus partiels et rares. Cette étude tente de modéliser une forme de mobilité spatiale, ce qui permet de mieux appréhender l’organisation sociale des communautés, objet d’étude central pour cette période. / This doctoral thesis aims at defining and establishing the main characteristics of site relocations, which took place in the Cyclades from the 12th to the 8th centuries BCE. According to scholars who have addressed this form of human mobility and drawn contrasting conclusions, site relocation is a three-stage process: a settlement along with its burial sites and cult places are abandoned, its community moves away and resettles a short distance away, on the very same island. This pattern is placed under scrutiny. First, data is collected in order to describe the islands’ settlement patterns over the period. Abandoned sites and newly occupied sites are recorded; settlement discontinuities are highlighted. Some hypothetical instances of site relocations are suggested. Conclusions are all the more tenuous as they derive from the analysis of artefacts. However, the thirty-two islands that have been investigated seem to follow about the same patterns: site relocation is indeed a relevant notion. Yet, this type of human spatial mobility appears to be far more complex than originally believed, notably in terms of planning and factors. The time span is divided into the LH IIIC, Protogeometric and Geometric periods and site relocation’s definition varies accordingly. Communities probably moved from site to site in the LH IIIC period: the Cyclades were not altogether abandoned. From the 10th century onwards, including the Geometric period, site relocations grew rare or were not completed. This dissertation tentatively models a category of human mobility while trying to offer some insight into the social organisation of communities, which remains a focus of scholarly attention.

Submitted by Kelson Anthony de Menezes (kelson@ucb.br) on 2016-12-19T19:37:39Z No. of bitstreams: 1 FabiodeBarrosAmaralDissertacao2014.pdf: 2938215 bytes, checksum: 3d899bf568eeae36d21979ba7aafab3c (MD5) / Made available in DSpace on 2016-12-19T19:37:39Z (GMT). No. of bitstreams: 1 FabiodeBarrosAmaralDissertacao2014.pdf: 2938215 bytes, checksum: 3d899bf568eeae36d21979ba7aafab3c (MD5) Previous issue date: 2014-03-31 / The equine chorionic gonadotropin (eCG) has been used as an important resource in the processes of reproduction in animals of economic interest, especially horses and cattle. The eCG molecule consists of a glycoprotein composed of two subunits called alpha and beta which together perform the function of both LH (luteinizing hormone) and FSH (follicle stimulating hormone) and due to this characteristic has great potential to induce ovulation in household species. Based on the aforementioned characteristics, the present work was was aimed at the study and characterization of the structure of eCG using molecular modeling techniques as well as testing its production in cells of the microorganism Pichia pastoris. Furthermore, chimeric models have been proposed linking the eCG and immunoglobulin G (IgG) molecule based on studies that reveal the great potential of it in raising the half-life of other molecules circulating in the organism. Four chimeric models were prepared so that the eCG alpha and beta chains are connected by a hinge, short and flexible regions, while the terminal region of the alpha chain was connected to the N-terminal portion of the CH2 domain of the IgG by another hinge region, thus resulting in a model in which two different molecules are linked. / A gonadotrofina cori??nica equina (eCG) tem sido um importante recurso usado nos processos de reprodu????o em animais de interesse econ??mico, principalmente equinos e bovinos. A mol??cula de eCG consiste em uma glicoprote??na composta de duas subunidades denominadas alfa e beta que juntas desempenham a fun????o tanto de LH (horm??nio luteinizante) como FSH (horm??nio fol??culo estimulante) e devido a essa caracter??stica possui um grande potencial para induzir a ovula????o em esp??cies dom??sticas. Baseando-se nas caracter??sticas citadas, o presente trabalho teve como objetivo estudar e caracterizar a estrutura do eCG utilizando-se t??cnicas de modelagem molecular assim como testar a sua produ????o em c??lulas do microrganismo Pichia pastoris. Al??m disso, foram propostos modelos quim??ricos ligando eCG ?? mol??cula de imunoglobulina G (IgG) tendo como base estudos que revelam o grande potencial da mesma em elevar a meia vida de outras mol??culas em circula????o no organismo. Quatro modelos quim??ricos foram apresentados de forma que as cadeias beta e alfa do eCG s??o conectadas por regi??es hinge que s??o sequ??ncias curtas e flex??veis da mol??cula enquanto que a regi??o terminal da cadeia alfa foi conectada por meio de outra regi??o hinge, ?? por????o N-terminal do dom??nio CH2 da IgG, portanto, resultando em um modelo em que est??o ligadas duas mol??culas diferentes.