The open problem in knowledge compilation of whether the language PI is at least as succinct as MODS is answered in the negative. For this purpose a class of Boolean functions with a number of prime implicants that is superpolynomial in their number of false points is constructed. A lower bound (proving that PI is not at least as succinct as MODS), an upper bound (proving that the counterexample cannot yield an exponential separation of PI and MODS) and the precise number of the prime implicants of these functions is computed. Powered by TCPDF (www.tcpdf.org)

β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects invivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.

β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects invivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.

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From beatniks to hippies — challenging and revolving subcultural youths in Sweden 1959 to 1969 The purpose of this work has been to explore and analyse the transformation of the youth subcultures beatniks and hippies in a Swedish context between 1959 and 1969, by searching answers to the following questions: What was the background of the subcultures ? How were these subcultures established, transformed and developed in a Swedish context? What became their typical style and taste?, and in what rooms and places were these cultures practiced by Swedish youths?        Mass media, especially TV but also radio, film, books and records brought the world in and were the main reason youths in Sweden could identify themselves through foreign subcultures. They adapted most of the original style but brought in some local elements.       My studies show a close link between the beatnik-subculture and the hippie-subculture, in Sweden transformed through the mod-subculture. The freedom-movement and visions spread by “the beat-generation” were important as inspiration and guide to unite youths and challenge the national hegemony. The mod-culture established the subcultural practises in public rooms. The transnational bounds in the hippie-culture set a global perspective of the world rather than the previous regional or national perspectives.         It is shown in the study that intersectional boundaries were pushed by the subcultures. They helped to bring up equality among sexes and were a main force for women’s liberation throughout the 60’s. All classes were in some way involved in the subcultures, although they practised them in different ways.         Subcultural youth style was commercialized, popularised and became in many ways mainstream during the 60’s. These youth-cultures had a vast impact on cultural changes as well as changes in society in Sweden during the time of my research.

(EN) This thesis is dedicated to the processes of digitization and metadata description, as well as the links that connect them. In recent years, another topic has been becoming relevant for both mentioned processes - the logical long-term preservation of digital objects. Long-term preservation is dependent on metadata and therefore on the processes of digitization, when some important metadata is created. The first introductory chapter of the thesis briefly describes, with an emphasis on metadata, digitization and theoretical and practical problems of long-term preservation of digital objects. The OAIS reference framework is also analysed, since it is the background for digital preservation and present preservation metadata standards. OAIS is also important for the shape and functionality of digital repositories. Metadata is also the topic of the next chapter of the thesis. General metadata use and its development are discussed, with emphasis on administrative, technical and preservation metadata. The following chapter focuses on the use of metadata in the National Library of the Czech Republic. It describes the evolution during two periods leading up to the present. This section includes comments on how long-term preservation has been reflected in used metadata standards. The second-to-last part...

Introduction : La mortalité associée à l’insuffisance rénale aiguë (acute kidney injury ‘’AKI’’) aux soins intensifs pédiatriques (SIP) dépasse les 50%. Des études antérieures sur la thérapie de remplacement rénal (TRR) ont fait ressortir plusieurs facteurs de risque de mortalité dont le syndrome de défaillance multiviscérale (SDMV) et la surcharge liquidienne ≥ 10 à 20% avant l’initiation de la TRR. L’objectif de cette étude était d’identifier les principaux facteurs de risque de mortalité à 28 jours après l’initiation de la TRR chez les patients atteints d’AKI aux SIP. Méthode : Il s’agit d’une étude de cohorte rétrospective aux SIP d’un centre tertiaire. Tous les enfants ayant reçus de la TRR continue ou de l’hémodialyse intermittente pour AKI, entre janvier 1998 et décembre 2014, ont été inclus. Les facteurs de risque de mortalité ont été préalablement identifiés par quatre intensivistes et deux néphrologues pédiatres et analysés à l’aide d’une régression logistique multivariée. Résultats : Quatre-vingt-dix patients ont été inclus. L’âge médian était de 9 [2-14] ans. La principale indication d’initiation de la TRR était la surcharge liquidienne (64,2%). La durée médiane d’hospitalisation aux SIP était de 18,5 [8,0-31,0] jours. Quarante patients (44,4%) sont décédés dans les 28 jours suivant l’initiation de la TRR et quarante-cinq (50,0%) avant la sortie des SIP. Le score de PELOD ≥ 20 (OR 4,66 ; 95%CI 1,68-12,92) et la surcharge liquidienne ≥ 15% (OR 9,31; 95%CI 2,16-40,11) à l’initiation de la TRR étaient associés de façon indépendante à la mortalité. Conclusion : Cette étude a permis de faire ressortir deux facteurs de risque de mortalité à 28 jours à l’initiation de la TRR : la surcharge liquidienne et la sévérité du SDMV mesurée par le score de PELOD. / Introduction: Mortality rate associated with acute kidney injury (AKI) in pediatric intensive care units (PICU) exceeds 50%. Prior studies on renal replacement therapy (RRT) have highlighted different mortality risk factors including the presence of a multiple organ dysfunction syndrome (MODS) and fluid overload ≥ 10 to 20% before starting RRT. The aim of this study was to identify most important risk factors of 28-day mortality in patients with AKI at RRT initiation in PICU. Methods: We conducted a retrospective cohort study in a tertiary care pediatric center. All critically ill children who underwent acute continuous RRT or intermittent hemodialysis for AKI between January 1998 and December 2014 were included. A case report form was developed and specific risk factors were identified by a panel of four pediatric intensivists and two nephrologists. Risk factors analysis was made using logistic regression in SPSS and SAS software. Results: Ninety patients were included. The median age was 9 [2-14] years. The most common indication for RRT initiation was fluid overload (FO) (64.2%). The median PICU length of stay was 18.5 [8.0-31.0] days. Forty of the 90 patients (44.4%) died within 28 days after RRT initiation and forty-five (50.0%) died before PICU discharge. In a multivariate logistic regression analysis, a PELOD score ≥ 20 (OR 4.66; 95%CI 1.68-12.92) and percentage of FO ≥ 15% (OR 9.31; 95%CI 2.16-40.11) at RRT initiation were independently associated with mortality. Conclusion: This study suggests that fluid overload and severity of MODS measured by PELOD score are two risk factors of 28-day mortality in PICU patients on RRT.

The aim of this work was to model a four-port waveguide as a simple circuit,by first starting with a two-port then a three-port waveguide. Duethat the work was based on Nathan Marcuvitz book Waveguide handbook,an analytical solution for the circuit parameters was desired. In order toobtain an analytical solution three methods were studied; the Variationalmethod, the Integral equation method and the Static method. Out of thesethree methods the latter was chosen, because its strength of simplifying theboundary conditions. The goal to model a four-port and a three-portedwaveguide was too complicated. This led to that the goal was changed totrying to get a higher accuracy on the existing circuit model for a two-portwaveguide, by solving an extension to the circuit parameter. This was donebecause Marcuvitz only treated the first two modes correctly and it was notclear if the circuit model was stable for the higher orders of Taylor series. Inthe end a circuit model for a waveguide with an iris that treats the first 16modes correctly was solved. By looking at the dispersive properties of thecircuit a comparison with simulation software CST Microwave Studio couldbe done, which resulted in that the circuit model gave good results up to2b/ < 1. It was also showed that the accuracy was about the same as thecircuit model found in Waveguide handbook, but it can be mentioned thatthe accuracy is minimally better for the circuit model that was developed inthis work. Something that was discovered in this work is that the restrictionmentioned in Waveguide handbook for the case when the window is centeredis unreliable, it should be 2b/ < 1. It also appeared that the circuit modelremained stable for higher orders of the Taylor series, in this case up to the16:th order. / M°alet med detta arbete var att modellera en fyr-portars v°agledare somen simpel elektrisk krets, genom att f¨orst b¨orja med en tv°a-portars sedantre-portars -v°agledare. Detta arbete var baserat p°a Nathan Marcuvitz bokWaveguide handbook, d¨arav s¨oktes det en analytisk l¨osning f¨or kretsparametrarna.F¨or att kunna f°a en analytisk l¨osning, studerades tre metoder;Variationsmetoden, Integralsekvationsmetoden samt den Statiskametoden.Av dessa tre metoder valdes den sistn¨amnda, p°a grund av dess styrka medatt f¨orenkla randvillkoren. M°alet att modellera en fyr-portars samt en treportarsv°agledare var alldeles f¨or komplicerat. Detta ledde till att m°alet¨andrades till att f¨ors¨oka f°a en h¨ogre precision p°a den befintliga kretsmodellenf¨or en tv°a portars v°agledare, genom att l¨osa ut flera termer till kretsparametern.Detta gjordes d°a Marcuvitz endast hanterade de tv°a f¨orstamoderna korrekt, samt att det inte framgick ifall kretsmodellen ¨ar stabil f¨orh¨ogre ordningar av Taylor serier. I slut¨andan l¨ostes en kretsmodel f¨or env°agledare med en iris som hanterar de f¨orsta 16 moderna korrekt. Genomatt kolla p°a de dispersiva egenskaperna f¨or kretsen, kunde en j¨amf¨orelse medsimuleringsprogrammet CST Microwave Studio ske, d¨ar slutsatsen blev attkretsmodellen gav goda resultat upp till 2b/ < 1. Det visade ¨aven sig attprecisionen var ungef¨ar densamma som den kretsmodell som°aterfinns i Waveguidehandbook, men det kan n¨amnas att precisionen ¨ar minimalt b¨attref¨or den kretsmodell som togs fram i detta arbete. En sak som uppt¨acktes underdetta arbete var att restriktionen som n¨amns i Waveguide handbook f¨orfallet n¨ar gapet f¨or irisen ¨ar centrerad st¨ammer inte, den b¨or vara 2b/ < 1.Dessutom visade det sig att kretsmodellen fortfarande var stabil f¨or h¨ogreordningar av Taylorserier, i detta fall upp till den 16:e ordningen.