<p>The most robust neurocognitive effect of marijuana use is memory impairment. Memory deficits are also high among persons living with HIV/AIDS, and marijuana use among this population is disproportionately common. Yet research examining neurocognitive outcomes resulting from co-occurring marijuana and HIV is virtually non-existent. The primary aim of this case-controlled study was to identify patterns of neurocognitive impairment among HIV patients who used marijuana compared to HIV patients who did not use drugs by comparing the groups on domain T-scores. Participants included 32 current marijuana users and 37 non-drug users. A comprehensive battery assessed substance use and neurocognitive functioning. Among the full sample, marijuana users performed significantly worse on verbal memory tasks compared to non-drug users and significantly better on attention/working memory tasks. A secondary aim of this study was to test whether the effect of marijuana use on memory was moderated by HIV disease progression, but these models were not significant. This study also examined whether the effect of marijuana use was differentially affected by marijuana use characteristics, finding that earlier age of initiation was associated with worse memory performance. These findings have important clinical implications, particularly given increased legalization of this drug to manage HIV infection.</p> / Dissertation

O uso indiscriminado de substâncias psicoativas por motoristas e suas conseqüências no trânsito têm sido objeto de grande preocupação por parte de especialistas e da sociedade em geral. O Código de Trânsito Brasileiro de 1997 determina como infração gravíssima \"dirigir sob a influência de álcool, em nível superior a seis decigramas por litro de sangue, ou de qualquer substância entorpecente ou que determine dependência física ou psíquica\". Desta forma, o presente trabalho teve como intuito investigar a utilização da saliva como espécime biológico para verificar o uso de álcool e drogas (anfetamina, metanfetamina, cocaína e maconha) por motoristas no trânsito. Para alcançar esse objetivo, um método foi desenvolvido e validado para determinação seriada desses analitos em uma única alíquota de saliva, utilizando a técnica de headspace e a microextração em fase sólida (SPME). Amostras coletadas aleatoriamente de motoristas de caminhão (n=561) que trafegavam em rodovias de São Paulo foram submetidas ao método proposto. Do total de amostras de saliva analisadas, 17 (3,0%) apresentaram resultado positivo, sendo 8 para etanol, 4 para anfetamina, 2 para cocaína, 2 para tetraidrocanabinol (THC) e 1 para cocaína e THC. A pesquisa retrata de forma pioneira no Brasil a utilização da saliva como possível amostra biológica para monitorar motoristas que estariam dirigindo sob a influência de drogas. / The consequences of car accidents in the traffic when psychoactive drugs are abused by professional drivers are of great concern of specialists in the subject as well as of the general population. For the Brazilian Traffic Code of 1997 to drive under the influence of alcohol, with blood leveI superior to six decigrams per liter, or any other psychoactive drug which causes physical or psychic dependence is considered an infraction in which the transgressor is subject to heavy penalties. The objective of this work was to investigate the possibilities of using saliva as biological samples to screen the use of alcohol and drugs (amphetamine, methamphetamine, cocaine and marijuana) by traffic drivers. In order to achieve this aim, a method was developed and validated for the serial determination of those analites in a single aliquot of a saliva sample. Gas-chromatographic/ headspace for the determination of alcohol and solid phase microextraction (SPME) for the determination of the other drugs were used in the analyses. Samples collected at random from truck drivers (n=561) in public roads in the city of São Paulo were analyzed by the proposed method. The obtained results were: 17 (3.0%) of all analyzed saliva samples were found to be positive, being 8 for ethanol, 4 for amphetamine, 2 for cocaine, 2 for tetrahydrocannabinol (THC) and 1 for cocaine and THC simultaneously. This study pioneered in Brazil the use of saliva as a very convenient biological sample to screen individuaIs driving under the influence of drugs

The aim of this thesis is to sum up the information connected with marijuana and cannabis topic in relation to their effects, use and misuse. At the beginning of my research three hypotheses have been determined . They have been based on the electronic questionnaires which have been answered by respondents in lower secondary schools. The results of my thesis are shown in its applied part. According to the questionnaire the first hypothesis has been confirmed. 17,68 % of survey participants have tried marijuana at least once in their lives. The second hypothesis has not been taken to be true, because although there is a prevention in primary schools, it doesn't provide pupils ' awareness of this problem completely. The third hypothesis has been proved false as well, because more than 50 % of the respondents said that they have already learnt about cannabis in Science. Key words: marijuana, hemp drugs, cannabis, Cannabis sativa

This paper presents an example of price discrimination on the market for marijuana in northern Bohemia in 2006. First, a model for a multifirm market is built, with emphasis on the existence of two types of firms and two qualities good offered. It is shown that in the case of a dealer of two qualities of marijuana there is an incentive to raise the price of the more expensive quality and reduce the price of the cheaper. Using econometric estimates, price discrimination is found in accordance with the predictions of the model in the amount of about 50 crowns per gram.

Segundo a Organização Mundial de Saúde a esquizofrenia é um transtorno incapacitante de curso crônico caracterizado pela presença de alucinações e delírios. Alguns trabalhos apontam que o uso de maconha em pessoas com diagnóstico de esquizofrenia pode agravar os sintomas positivos da doença enquanto age positivamente sobre os sintomas negativos. Estudos qualitativos têm surgido na área com o objetivo de compreender os significados que pessoas com diagnóstico de esquizofrenia atribuem ao uso da substância. Esses estudos trazem que essas pessoas possuem uma visão positiva a respeito do uso, que este proporcionaria a elas um estado de relaxamento e alívio de suas tensões, além de relatarem aumento de criatividade e o uso da maconha como forma de atingir um estado espiritual mais elevado, assumindo um caráter de automedicação. Nesse sentido o presente trabalho teve como objetivo conhecer os significados que pessoas com esquizofrenia atribuem ao uso de maconha. Para isso, foi realizado estudo qualitativo, com referencial metodológico clínico-qualitativo. Os participantes foram selecionados em um serviço público de saúde mental especializado em álcool e drogas do interior de São Paulo. Como instrumento de coleta de dados, utilizou-se um roteiro de entrevista semiestruturada. Os critérios de inclusão no estudo foram: estar em atendimento, ou ser oriundo do serviço selecionado; ter diagnóstico de esquizofrenia segundo a CID-10; fazer uso de maconha ou ter feito uso no ano anterior a entrevista; ter mais que 18 anos e não fazer uso de outra droga ilícita, como cocaína ou crack. Foram realizadas um total de 10 entrevistas. Os participantes da pesquisa eram todos do sexo masculino e tinham em média 28 anos de idade. Foram levantadas quatro categorias a partir da análise das entrevistas: a) Percepções a respeito do adoecimento, onde os participantes relatam o preconceito e estigma que envolve o diagnóstico e como alguns sintomas da esquizofrenia os incapacitam para atividades cotidianas; b) Uso de maconha, este iniciado, em sua maioria, na adolescência e sempre na companhia de amigos; c) Esquizofrenia e maconha, onde discursos relacionados sobre aumento de criatividade, capacidade de organizar o pensamento, vivências de espiritualidade e melhora na qualidade do sono se fizeram presentes e d) Tratamento, onde a busca pelo tratamento partia sempre de algum familiar. É importante conhecermos a visão dessas pessoas a respeito do uso de maconha para compreendermos o que sustenta a manutenção deste, além de fornecer novos elementos na construção de um olhar crítico sobre este fenômeno. / According to the World Health Organization schizophrenia is a disabling disorder of chronic course characterized by the presence of hallucinations and delusions. Some studies suggest that the use of marijuana in people diagnosed with schizophrenia may exacerbate the positive symptoms of the disease while it acts positively on the negative symptoms. Qualitative studies have emerged in the area with the goal of understanding the meanings that people diagnosed with schizophrenia attribute to the use of the substance. These studies bring those people have a positive vision regarding the usage, that this would provide them a state of relaxation and relief of the tension, as well as reporting an increase of creativity and the use of marijuana as a way to achieve a spiritual state higher, assuming a character of \"medication\". In this sense, the objective of this study was to understand the meanings that people with schizophrenia attributed to marijuana use. For this reason, a qualitative study was carried out, with a methodological clinical-qualitative. The participants were selected in a public service of mental health who specializes in alcohol and drug use in the interior of São Paulo. As an instrument of data collection, we used a script of semi-structured interview. Inclusion criteria were: being in service, or be from the selected service; have a diagnosis of schizophrenia according to ICD-10; make use of marijuana or having used the year before the interview; have more than 18 years and not make use of other illicit drugs such as cocaine or crack. a total of 10 interviews were conducted. The participants were all male and had an average age of 28. Four categories were raised from the analysis of the interviews: a) Perceptions about the illness, where participants reported prejudice and stigma surrounding the diagnosis and some symptoms of schizophrenia to incapacitate the daily activities; b) Marijuana use, this started, mostly in their teens and always in the company of friends; c) Schizophrenia and cannabis, where speeches related to increased creativity, ability to organize thought, spirituality experiences and improves the quality of sleep were present and d) Treatment, where the search for treatment always started from a family member. It is important to know the vision of these people about marijuana use to understand what supports the maintenance of this, in addition to providing new elements in building a critical look at this phenomenon.

Community coalitions have had successful reductions in adolescent substance abuse, and the legalization of marijuana presents an opportunity for these coalitions to re-evaluate their current methods and messages for preventing adolescent marijuana usage. Using the theory of planned behavior, the purpose of this qualitative study was to determine how legalization of marijuana for recreational purposes affects the methods and messages of coalitions and how the coalition members perceive their efforts to reduce adolescent marijuana usage post-legalization in Colorado. Participants were obtained by recommendations from the executive director in each of four coalitions. A purposive sample of 12 coalition members was interviewed via telephone and recorded. Data from the transcripts were analyzed, coded, and repeated as necessary until themes arose. The major themes suggested that programs alone were inadequate to change adolescents' perception of marijuana, despite the current success of the methods and messages expressed by coalition members. Recommendations included continuing current programs despite legalization, partnering with marijuana retail shops, engaging youth through multiple tactics, developing relationships with youth, and improving parent education to help prevent adolescent marijuana usage. These themes could shape the development of programs that guide adolescents into making better choices, which could ultimately lead to positive social change.

In 2014, Colorado and Washington legalized the cultivation, sale, and consumption of recreational marijuana for anyone over the age of 21. In doing so, the two states presented the first opportunities for marijuana-specific tourism in the United States. Direct benefits of legalization to these first movers, namely tax revenues generated through the sale of marijuana, have been quantified, but the indirect benefits in the tourism sector are as of yet unquantified. Although there is a large body of informal literature and popular media on marijuana tourism, academic study of the subject is scant. Working with a panel composed of 47 of the contiguous United States over the years 2005-2016, this study utilizes a synthetic control methodology to construct hypothetical time series for various tourism indicators for the cases of non-legalization in Colorado and Washington. Comparison of these hypothetical time series to the actual time series reveals the effects of legalization. A similar methodology is applied to all states to find the “placebo effects” and to establish significance. In traveler expenditures, traveler-generated taxes, tourism industry employment, and tourism industry payroll, Washington shows effects of legalization of greater magnitude and significance than those in Colorado. Only 8% of other states show an effect on tourism revenues as large as that of Washington. Additionally this study finds that each state can be approximated with a weighted average of a small group of peers and that weather, price, and an interacted migration and political orientation variable have low predictive power on tourism indicators. Lastly, this study suggests possible causes and policy implications of the discrepancy between the states.

Of the plethora of social problems with which government has had to contend in recent history, few have generated more controversy than the non-therapeutic use of drugs. Many of those which are currently in common use did not exist fifty years ago; but the most dramatic growth in non-therapeutic use has been experienced with a drug that man has known for centuries: marijuana.1 Known generically as Cannabis sativa, internationally as Indian hemp, popularly as marijuana, and in American slang as "pot" or "grass," the drug was introduced to the United States as an intoxicant by itinerate Mexican farm workers in the early decades of this century. The acknowledged use of marijuana in the ghettos and communities of ethnic minorities for several decades stimulated no public outcry with the exception of the sensational press campaigns which led to the passage of the Marihuana Tax Act of 1937.

The type of cancer pain management used may have an effect on the quality of life (QOL) of cancer patients. Researchers have determined that cancer patients are inadequately treated for pain and pain management is an essential determinant of patient survivability and QOL. Numerous clinical studies have been accomplished concerning opioid administration and noncancer and cancer pain management exist. Previous studies have examined the relationship between cannabinoid products, noncancer pain, cancer pain, and related QOL for patients but have not focused on the QOL of cancer patients while also moderating for gender. These relationships were investigated using the health belief model. The cancer pain management treatments (opioids and/or marijuana [cannabis]) and QOL, measured with World Health Organization Quality of Life Survey (WHOQOL-BREF), of 236 cancer patients were analyzed using analysis of variance (ANOVA), planned contrasts, post hoc tests, and moderated ANOVA (PROCESS tool) in the causal-comparative research. Research findings indicated significant benefit in cancer patient physical and psychological QOL in participants using marijuana when compared to participants using opioids and physical QOL for participants using marijuana over participants using both opioids and marijuana combined. Enhanced pain management options for cancer patients in order to reduce opioid side effects, increase pain treatment effectiveness, and improve patient QOL could yield positive social change. Growing rates of opiate addiction, abuse, and mortality are public health concerns and cannabis may be an effective pain treatment to reduce these social costs. This research may be of use to legislators considering rescheduling marijuana to less than Schedule I.

Behavior analysts have had much success in affecting behavior change with individuals diagnosed with intellectual disabilities as well as those who would be considered typically developing with a variety of intervention strategies; most of which involve affecting direct acting contingencies. However, the realm of language-based psychopathology has just begun to be addressed within the field through language based, or indirect acting strategies. Acceptance and Commitment Therapy (ACT) is based on the concept of derived stimulus relations and allows for a behavior analytic treatment of language-based psychopathology. The current study was intended to test the efficacy of a brief protocol-delivered ACT intervention with individuals who smoke marijuana. Oral swab drug screens were the primary dependent variable, along with the Acceptance and Action Questionnaire II (AAQ-II). All six ACT components were taught to each subject using a set list of metaphors and exercises and was assessed using a concurrent/non-concurrent multiple baseline across participants design. Results indicate that the brief protocol impacted levels of marijuana consumption with all three participants and that their self-reported levels of struggle (via the AAQ-II) lessened over the course of the training.