The instability modes and non-linear behavior of a cavitating flow have been studied based on the experimental data obtained from planar Particle Image Velocimetry (PIV). Three data-driven techniques, Proper Orthogonal Decomposition (POD), Dynamic Mode Decomposition (DMD), and Clustered-based Reduced Order Modeling (CROM), are applied to the snapshots of the fluctuating component of velocity to investigate instability modes of the cavitating flow. DMD and POD analysis yield multiple modes are corresponding to slow-varying drift flow, cloud-shedding, and Kelvin-Helmholtz (KH) instability for a fixed inlet flow condition. The high coherence measure obtained from the instabilities suggests a transfer of energy from the largest scales, fluctuating mean flow, to the smaller scales such as cloud cavitation and Kelvin-Helmholtz (KH) instability. It is demonstrated that the POD decorrelation of length scales yields inherently quasi-periodic time dynamics, e.g., incommensurate frequencies. Moreover, the eigenvalue obtained from DMD revealed multiple harmonic with different decay rates associated with the cloud cavitation. The above-mentioned intermittent transition between distinct cloud shedding regimes is investigated via Clustered-based Reduced Order Modeling (CROM). Four aperiodic shedding regimes are identified. 68% of the time, triplets of vortices are formed, while 28% of the time, a pair of vortices are formed in the near wake of the throat. Dominant mechanisms governing the momentum transport and the turbulence kinetic energy production, destruction, and redistribution in distinct regions of the flow field have been identified using Gaussian Mixture Models (GMMs). The preceding data-driven techniques and in-depth analysis of the results facilitated modeling of the cavitation inception and break-up. Accordingly, a phase transition field model is developed using the ultra-fast Time-Resolved Particle Image Velocimetry (TR-PIV) and vapor void fraction spatial and temporal data. The data acquisition is implemented in a Venturi-type test section. The approximate Reynolds number based upon the throat height is 10,000, and the approximate cavitation number is 1.95. The non-equilibrium cavitation model assumes that the phase production and destruction are correlated to the static pressure field, pressure spatial derivatives, void fraction, and divergence of the velocity field. Finally, the dependence of the model on the empirical constants has been investigated. / Doctor of Philosophy / A cavitation bubble occurs where the pressure field is below the saturation pressure of the liquid. Accumulation of the cavitation bubble forms a cavitating flow. This phenomenon is observed in pumps, propulsion systems, internal combustion engines, and rocket engines. Identifying the mechanisms leading to cavitation-induced damages is imperative in the design of the devices. In this regard, investigation of the cavitation bubble inception, deformation, collapse, and intermittent regime change is mandatory in learning the primary mechanisms of the stresses imposed on the device. Experiments and high-fidelity numerical and analytical methods can be employed to shed light on flow physics. The current study adopted joint experimental methods, data analysis techniques, and computational approaches to scrutinize the unsteady cavitating flow underlying physics as it occurs past the throat of a Venturi-type profile. Different mechanisms of instabilities are identified by applying the data-driven techniques to the raw images of the cavitating flow. The path of the transitions between physically different instabilities mechanisms is examined. The local dominant balance between stress terms in the conservation of momentum equation is identified, and the stress terms roles in cavitating flow instabilities and advective acceleration are determined. A new cavitation model is developed and validated against the experimental results. The new model improves the prediction of the void fraction in different regions of the flow field, making it feasible to simulate different regimes of cavitating flow. Finally, the dominant mechanism governing the liquid-vapor transition and the transport of the void fraction is described.

Yes / Insulin resistance is associated with impaired endothelial regeneration in response to mechanical injury. We recently demonstrated that insulinlike growth factor–binding protein-1 (IGFBP1) ameliorated insulin resistance and increased nitric oxide generation in the endothelium. In this study, we hypothesized that IGFBP1 would improve endothelial regeneration and restore endothelial reparative functions in the setting of insulin resistance. In male mice heterozygous for deletion of insulin receptors, endothelial regeneration after femoral artery wire injury was enhanced by transgenic expression of human IGFBP1 (hIGFBP1). This was not explained by altered abundance of circulating myeloid angiogenic cells. Incubation of human endothelial cells with hIGFBP1 increased integrin expression and enhanced their ability to adhere to and repopulate denuded human saphenous vein ex vivo. In vitro, induction of insulin resistance by tumor necrosis factor α (TNFα) significantly inhibited endothelial cell migration and proliferation. Coincubation with hIGFBP1 restored endothelial migratory and proliferative capacity. At the molecular level, hIGFBP1 induced phosphorylation of focal adhesion kinase, activated RhoA and modulated TNFα-induced actin fiber anisotropy. Collectively, the effects of hIGFBP1 on endothelial cell responses and acceleration of endothelial regeneration in mice indicate that manipulating IGFBP1 could be exploited as a putative strategy to improve endothelial repair in the setting of insulin resistance. / Funded by a British Heart Foundation Clinical Research Training Fellowship for A.A. R.M.C. holds a British Heart Foundation Intermediate Clinical Research Fellowship. M.T.K. holds a British Heart Foundation Chair in Cardiology. S.B.W. holds a European Research Council Starting Grant.

No / As part of the multidisciplinary safeguarding team, children’s nurses should have a clear understanding of child protection processes and how they have sometimes lacked a systematic approach. Methods of detecting threats to patient safety in high-risk clinical care can also be employed to analyse child protection processes. This article outlines one tool, known as failure mode and effects analysis, which can be used in a framework that takes into account human factors that can influence an individual’s performance. It discusses how this tool can be used to identify and reduce the potential for failure in the serious case review process, in particular by not attributing blame.

The purpose of this study is to gain an understanding of Klawock's Tribal Citizens' relationship to harvesting what is colloquially known as customary and traditional foods and/or native foods. The state and federal governments categorize these culturally specific goods as subsistence foods. An unearthed, 5,360-year-old basket potentially links modern day Klawock Tribal Citizens with their ancestral ties to the region. Throughout this time, families in this region of Southeast Alaska have been participating in a form of indigenous fishery. Despite access to multiple grocery stores and fish canneries, tribal citizens choose to expend their family's efforts to harvest their own sockeye out of the Klawock watershed. Oral history and ethnography and methodologies were employed to record personal relationships with the harvest of these resources while also documenting a context in which these relationships exist. Klawock Cooperative Association's staff worked alongside the student researcher and participants to analyze the data and produce findings. Engaging in customary and traditional activities rewards participants with intrinsic facets of their identity. Alongside reinforcing identities, these activities teach participants about family dynamics and working as a team, as well as the responsibilities that come with. These responsibilities are formed through the assignment of roles and provide people with purpose. The roles of individuals within their family dynamic parallel their understanding of their place within the larger society. Having a purpose and knowing their place shapes participant's accomplishments in the food system and honors them with feelings of pride. Based on these findings, KCA interprets customary and traditional activities as an epistemology in which increased access and participation provides an upwards trajectory of community health.

Many academic institutions are tasked with trying to improve the usability of their online educational support technologies such as ePortfolios, intelligent websites, and other interface technology to make them as efficient as possible to meet the requirements of their end users. This is particularly important for the academic institutions during times and situations when they may not have a live human presence available to respond to various inquiries from their end users about the technology. The challenges of an academic institution in making its ePortfolios viable can cost itself, its end users, as well as its other stakeholders, money, time, and confidence in the technology. This study is about usability testing for improving the user-interface for ePortfolios. This is a qualitative study using the think-aloud protocol (TAP) for data collection and failure modes and effects analysis (FMEA) for data analysis.

Optical microcavities (OMs) are receiving increasing attention owing to their potential applications ranging from cavity quantum electrodynamics, optical detection to photonic devices. Recently, rolled-up structures have been demonstrated as OMs which have gained considerable attention owing to their excellent customizability. To fully exploit this customizability, asymmetric and topological rolled-up OMs are proposed and investigated in addition to conventional rolled-up OMs in this thesis. By doing so, novel phenomena and applications are demonstrated in OMs. The fabrication of conventional rolled-up OMs is presented in details. Then, dynamic mode tuning by a near-field probe is performed on a conventional rolled-up OM. Next, mode splitting in rolled-up OMs is investigated. The effect of single nanoparticles on mode splitting in a rolled-up OM is studied. Because of a non-synchronized oscillating shift for different azimuthal split modes induced by a single nanoparticle at different positions, the position of the nanoparticle can be determined on the rolled-up OM. Moreover, asymmetric rolled-up OMs are fabricated for the purpose of introducing coupling between spin and orbital angular momenta (SOC) of light into OMs. Elliptically polarized modes are observed due to the SOC of light. Modes with an elliptical polarization can also be modeled as coupling between the linearly polarized TE and TM mode in asymmetric rolled-up OMs. Furthermore, by adding a helical geometry to rolled-up structures, Berry phase of light is introduced into OMs. A -π Berry phase is generated for light in topological rolled-up OMs so that modes have a half-integer number of wavelengths. In order to obtain a deeper understanding for existing rolled-up OMs and to develop the new type of rolled-up OMs, complete theoretical models are also presented in this thesis.

Le présent mémoire s’intéresse au développement du mouvement social Lesbien, Gai, Bisexuel, Trans, Intersex et Queer (LGBTIQ) depuis la chute de la dictature de Ferdinand Marcos en 1986 jusqu’à aujourd’hui. À partir de 1990, le mouvement est caractérisé par un développement rapide. Il était parmi les premiers en Asie du Sud-est à organiser une marche de la fierté et à créer un parti politique LGBTIQ. Toutefois, malgré le dynamisme inhérent à ce mouvement, les communautés LGBTIQ sont toujours discriminées sur le marché du travail, à l’université ou encore dans le système de santé. De plus, elles sont toujours les victimes de violence et de meurtre commis sur la base de leur orientation sexuelle ou de leur genre. Actuellement, le mouvement LGBTIQ n’a toujours pas été en mesure d’obtenir des gains politiques afin de mieux protéger les droits et la sécurité de ces communautés. Même si ce problème pourrait être attribué au conservatisme de l’élite politique ou encore à l’influence du Catholicisme et de l’homophobie dans la société philippine, l’argumentation de ce mémoire propose plutôt que la fragmentation et le manque de cohérence au sein du mouvement ont compliqué la formulation et l’adoption de politiques pouvant régler ces enjeux. Mon analyse du mouvement pendant les 30 dernières années identifie quatre conflits internes majeurs expliquant ce problème 1. la définition de l’identité collective 2. le cadrage utilisé afin de conceptualiser cet enjeu 3. les différentes idéologies structurant l’action des militant.es et 4. les divergences par rapport aux modes d’organisation et aux stratégies employées. Ainsi, ce mémoire tourne l’attention vers ces conflits internes plutôt que vers les facteurs exogènes. Mon argumentation est basée sur 17 entrevues semi-dirigées réalisées à Manille avec des militant.es du mouvement, de mai à octobre 2015. Dans les deux premiers chapitres de ce mémoire, j’analyse la littérature portant sur la théorie des mouvements sociaux en général pour ensuite aborder la littérature traitant précisément sur les Philippines et l’Asie du Sud-est. Cette revue servira de base théorique afin de comprendre les quatre facteurs identifiés ainsi que leur rôle dans la fragmentation du mouvement. Dans le quatrième chapitre, j’analyse la fragmentation du mouvement selon les échelles d’action des militant.es, leurs cibles ainsi que leur trajectoire de mobilisation. Dans le cinquième chapitre, j’explique cette fragmentation à l’aide des quatre facteurs identifiés dans la littérature. / This Master’s thesis investigates the development of the Lesbian, Gay, Bisexual, Trans, Intersex and Queer (LGBTIQ) movement in the Philippines from the fall of Ferdinand Marcos’ dictatorship in 1986 to the present moment. Since then, the LGBTIQ movement has developed rapidly. It was among the first in Southeast Asia to organise a Pride March and to constitute an LGBTIQ political party. However, despite this dynamism, LGBTIQ communities are still discriminated in the workspace, schools, and the healthcare system. Moreover, they are still the victims of homophobic crimes. To the present day, the movement has not been able to secure political protection for the rights and the safety of these communities. Although the current situation can be attributed to a certain extent to conservatism in the ruling class or the strong influence of Catholicism and homophobia, this thesis argues that the fragmentation and the lack of coherence of the movement iii has itself complicated the formulation and implementation of concrete policies. My analysis of the movement’s development throughout the last 30 years will highlight four fundamental conflicts resolving around 1. the definition of one collective identity, 2. the framing used to conceptualize these issues, 3. the different ideologies underlying the social activists’ actions, and 4. the divergence in organisational modes and strategies. As such, this thesis shifts attention from external factors to internal conflicts within the LGBTIQ movement of the Philippines. My arguments are based on 17 interviews with social activists, conducted between May and October 2015 in Manila. In the first two chapters of this thesis, I review current scholarship on social movements in general and about the Philippines and South East Asia in particular. This review will provide the theoretical foundation necessary to identify and understand the four identified social factors and their role on the fragmentation of the movement. In chapter four, I analyse the fragmentation of the movement based on the social activists’ scales of action, their targets of mobilization, and their mobilization trajectories. In chapter five, I analyze this fragmentation through the identified factors in the literature.

The purpose of the study is the investigation of the topics of transposition and the transposed major and minor modes as discussed principally by selected French authors of the final twenty years of the seventeenth century and the first three decades of the eighteenth. The sources are relatively varied and include manuals for singers and instrumentalists, dictionaries, independent essays, and tracts which were published in scholarly journals; special emphasis is placed on the observation and attempted explanation of both irregular signatures and the signatures of the minor modes. The paper concerns the following areas: definitions and related concepts, methods for singers and Instrumentalists, and signatures for the tones which were identified by the authors. The topics are interdependent, for the signatures both effected transposition and indicated written-out transpositions. The late Baroque was characterized by much diversity with regard to definitions of the natural and transposed modes. At the close of the seventeenth century, two concurrent and yet diverse notions were in evidence: the most widespread associated "natural" with inclusion within the gamme; that is, the criterion for naturalness was total diatonic pitch content, as specified by the signature. When the scale was reduced from two columns to a single one, its total pitch content was diminished, and consequently the number of the natural modes found within the gamme was reduced. An apparently less popular view narrowed the focus of "natural tone" to a single diatonic pitch, the final of the tone or mode. A number of factors contributed to the disappearance of the long-held distinction between natural and transposed tones: the linking of the notion of "transposed" with the temperament, the establishment of two types of signatures for the minor tones (for tones with sharps and flats, respectively), the transition from a two-column scale to a single-column one, and the recognition of a unified system of major and minor keys.

Ce mémoire s’intéresse à la cohabitation intergénérationnelle en immeubles de type plex, en tant que stratégie de solidarité familiale observée à Montréal. Plus précisément, il s’agit de retracer l’histoire de ce mode d’habiter à travers les récits recueillis auprès d’une dizaine de familles québécoises. Les personnes rencontrées ont évoqué les motivations d’un tel projet, ont parlé de son élaboration, de la vie quotidienne dans le plex, de l’avenir de la cohabitation ou, le cas échéant, des motifs d’y mettre fin. La spécificité de la cohabitation intergénérationnelle en plex est de mettre à profit le cadre bâti résidentiel montréalais, composé d’un grand nombre de plex, dans le but plus ou moins explicite de resserrer les liens de la solidarité familiale. La démarche a donc consisté à reconstituer l’histoire d’une dizaine de familles ayant opté pour un tel mode d’habiter à Montréal, ceci à travers le récit d’un membre de la « génération-pivot », dans chacun de ces familles, susceptible de se situer au carrefour des solidarités : entre ses enfants dans la jeune vingtaine et ses parents et ses parents vieillissants. Deux objectifs principaux ont été poursuivis. Il s’agissait dans un premier temps de retracer le processus menant à une telle stratégie de proximité résidentielle et de détailler ensuite le fonctionnement quotidien de la cohabitation intergénérationnelle. Pour atteindre ces objectifs, trois questions ont guidé l’analyse du discours des répondants. Premièrement, quelles sont les motivations de ces familles? Deuxièmement, à quel point les réalités quotidiennes des membres cohabitants se voient-elles dès lors imbriquées? Troisièmement, quels enjeux sont soulevés par ce mode d’habiter? Les résultats mettent de l’avant de nombreux avantages à la cohabitation intergénérationnelle en plex, par exemple l’accès plus aisé à la propriété pour les jeunes générations, des possibilités accrues d’échanges de services concrets ou encore un sentiment de plus grande sécurité. Les enjeux soulevés par ce mode d’habiter sont également explorés et analysés du point de vue de la notion centrale sur laquelle repose ce projet familial et résidentiel, la notion d’indépendance. / This thesis focuses on intergenerational cohabitation in multi-lodging dwellings (duplexes, triplexes and such) in Montreal. Considering the extreme residential proximity involved, this form of habitation is defined as a strategy of family solidarity. More specifically, the motivations, the day-to-day operation and the challenges of this form of living are at the core of the thesis. The specificity of this form of residential strategy concerns its deep interconnection with Montreal’s built form, which contains a high number of “plexes” throughout its territory, which facilitates intergenerational cohabitation. The method consisted of interviewing ten families on their use of this residential strategy. The canvas of the interviews was chronological in order to emphasize the idea of a “project” that is sometimes inherent to intergenerational cohabitation. This way, the different steps leading to this form of habitation have been identified. The two principal objectives were to outline the process leading to intergenerational cohabitation and to highlight the possibilities of solidarity permitted by the day-to-day side of intergenerational cohabitation. Three questions guided the analysis of the participants’ speech. First, what are their motivations? Second, how is their daily routine affected by the extreme residential proximity? Third, what are the challenges of this form of living? The results show many advantages of this way of living, such as a faster access to ownership and a greater sense of security for elders. Although, some disadvantages have also been observed, especially around the independence of the tenants. Independence is the main way individuals express those disadvantages. On one hand, they wish to keep a maximum of their independence, and on the other hand, they are aware of the necessity to limit it to ensure the cohabitation.

Ce mémoire propose une hypothèse alternative pour expliquer les facteurs à l’origine du boom du soja brésilien. En utilisant une approche combinant la théorie de l’organisation et l’économie politique institutionnelle, ce mémoire propose de comparer les modèles d’organisation de la chaîne de valeur soja des États du Mato Grosso et du Paraná. Dans un premier temps, cette recherche est guidée par un souci de documenter les rouages propres à chaque mode d’organisation et de catégoriser ces derniers comme des systèmes à part entière et cohérents. Ainsi, le mode de coordination du Mato Grosso (intégration de la chaîne de valeur) peut être qualifié de modèle hybride se rapprochant davantage du pôle hiérarchie tandis que le mode d’organisation du Paraná (coopérative agroindustrielle) peut être qualifié de mode hybride gravitant davantage vers le pôle marché. La nature des risques est identifiée comme principal déterminant du degré de centralisation de la gouvernance au sein de ces modèles. L’argument soutient que chaque mode de coordination est performant car il est adapté aux conditions locales de production et permet de mitiger les risques propres à chaque région de façon à encourager les échanges économiques. Dans un deuxième temps, cette recherche serait incomplète sans une analyse des facteurs politiques et historiques ayant influencé la trajectoire de développement de chaque région. Ainsi, chaque étude de cas présente un récit détaillé de l’évolution des politiques agraires et des institutions depuis les années 1960, soit le moment où la culture commerciale du soja a commencé à gagner en importance au Brésil. Analyser le changement institutionnel depuis 1960 est primordial pour comprendre comment se sont consolidées les règles du jeu qui sous-tendent aujourd’hui chaque mode de coordination. / This dissertation proposes an alternative argument for explaining the Brazilian soybean boom. Drawing on the theory of organization and on institutional political economy, this research compares the organization of the value chain in the states of Mato Grosso and Paraná. Firstly, this research attempts to detail the internal workings of each mode of organization in order to conceptualize the latter as integral and coherent systems. As a result, Mato Grosso’s coordination mode (supply-chain integration) may be described as a hybrid organizational mode bearing resemblances with hierarchical organization whereas Paraná’s hybrid mode (agro industrial cooperative) tilts towards market organization. We identify the nature of risks as the primary determinant of the degree of governance centralization within each model. As a result, it is argued that each model is coherent and efficient because it serves the purpose of mitigating risks in a way that is responsive and adapted to local production imperatives. Such consideration is of upmost importance given that risk mitigation may encourage transactions and hence, induce economic growth. Secondly, such a research endeavour would be incomplete without a detailed analysis of the political and historical factors that influenced the development trajectory of each region. In order to take those variables into account, the case studies trace the history of the agrarian policies and institutions that shaped the economic landscape of each region starting from the 1960s, this is, when the production of soybeans started gaining importance in Brazil. Analyzing institutional change, it is argued, is critical for understanding the rules of the game that underpin the actual modes of coordination in each region.