Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(工学) / 甲第17539号 / 工博第3698号 / 新制||工||1563(附属図書館) / 30305 / 京都大学大学院工学研究科都市環境工学専攻 / (主査)教授 田中 宏明, 教授 米田 稔, 教授 伊藤 禎彦 / 学位規則第4条第1項該当

Abstract Substantially growing data traffic over wireless networks poses increased challenges for mobile network operators in deploying sufficient network resources and managing user mobility. This dissertation considers these challenges to providing satisfactory Quality of Service (QoS) for end-users and studies solutions for better utilization of the heterogeneous network environment. First, the dissertation examines what solutions mobile devices and network management entities can use to dynamically collect valid cross-layer information from different network entities. Cross-layer information allows monitoring of the condition of the network in multiple layers on a user and application basis. The second research topic considers the techniques the network management entities can use to improve resource usage in wireless networks based on the collected cross-layer information. The IEEE 802.21 standard, specified to facilitate handovers between heterogeneous networks, is used as the basis for cross-layer information delivery. This dissertation also focuses on utilization of the standard beyond the inter-access technology handovers. In order to improve resource usage in wireless networks dynamically, event delivery enhancements are proposed for the standard so that it better applies to the requirements of different techniques. Such techniques are traffic priority adjustment, traffic adaptation, packet aggregation, and network protocol header compression. The results show that when a handover is not feasible, these techniques effectively allow sharing of the limited radio resources for the user data according to applications’ importance and type. Mobility management is studied in terms of network information service, one of the main services of IEEE 802.21. The thesis proposes enhancing the information service with a base station cell coverage area database. The database provides significant improvements for the selection of a handover target in a dense base station environment. With all the results taken together, the dissertation provides mobile network operators various means to improve the usage of wireless networks on the basis of applications’ varying QoS requirements. / Tiivistelmä Voimakkaasti kasvava langattomien tietoverkkojen dataliikenne aiheuttaa verkko-operaattoreille haasteita tarjota riittävät verkkoresurssit ja hallita käyttäjien liikkuvuutta. Väitöskirja huomioi nämä haasteet tarjota loppukäyttäjille tyydyttävä palvelunlaatu (QoS) ja tutkii ratkaisuja, joilla heterogeenistä verkkoympäristöä voidaan hyödyntää tehokkaammin. Aluksi väitöskirja tutkii, mitä ratkaisuja päätelaitteet ja verkkohallintatoimijat voivat käyttää keräämään protokollakerrosten välistä (cross-layer) tietoa eri verkkotoimijoilta. Protokollakerrosten välinen tieto mahdollistaa verkon tilan seuraamisen usealla eri kerroksella käyttäjä- ja sovelluskohtaisesti. Toinen tutkimusaihe tarkastelee protokollakerrosten välistä tietoa hyödyntäviä tekniikoita, joita verkonhallintatoimijat voivat käyttää tehostamaan resurssien käyttöä langattomissa verkoissa. IEEE 802.21-standardia, joka on määritetty helpottamaan verkonvaihtoja heterogeenisten verkkojen välillä, käytetään pohjana protokollakerrosten välisen tiedon jakelulle. Väitöskirjassa keskitytään standardin hyödyntämiseen myös muussa kuin verkkoteknologioiden välisen verkonvaihdon yhteydessä. Väitöskirja ehdottaa parannuksia standardin tapahtumatietovälitykseen, jotta se täyttäisi paremmin eri tekniikoiden asettamat vaatimukset dynaamisesti toteutettavista toimista langattomien verkkojen resurssikäytön tehostamiseksi. Nämä tekniikat ovat liikenteen prioriteetin muutokset, liikenteen adaptointi, pakettien yhdistäminen ja verkkoprotokollaotsikoiden pakkaus. Tulokset osoittavat, että kun tukiasema- tai verkonvaihto ei ole mahdollinen, nämä tekniikat mahdollistavat rajattujen verkkoresurssien jakamisen tehokkaasti sovellusten tärkeyden ja tyypin mukaan. Liikkuvuudenhallintaa tutkitaan verkkoinformaatiopalvelun, joka on myös yksi IEEE 802.21-standardin pääpalveluista, kautta. Väitöskirja ehdottaa, että informaatiopalvelua tehostetaan liittämällä siihen tietokanta tukiasemasolujen peittoalueista. Tietokanta tehostaa huomattavasti verkonvaihdon kohteen valintaa tiheissä tukiasemaympäristöissä. Kun väitöskirjan tulokset huomioidaan kokonaisuutena, väitöskirja tarjoaa verkko-operaattoreille useita tapoja tehostaa langattomien verkkojen käyttöä sovellusten vaihtelevien palvelunlaatuvaatimusten perusteella.

Die Beiträge der vorliegenden Dissertationsschrift untersuchen zum einen, inwieweit Wetterindexversicherungen einen Beitrag zur Stabilisierung von wetterbedingten Einkommensschwankungen in der Landwirtschaft leisten können. In der Landwirtschaft ist trotz bedeutender wetterbedingter Einkommensschwankungen bisher nur ein sehr verhaltener Einsatz von Indexversicherungen zu beobachten. Allerdings gibt es bislang kaum Studien, die Möglichkeiten zur Reduzierung des mit dem Einsatz von Wetterindexversicherungen verbundenen Basisrisikos untersuchen. Zum anderen wird untersucht, inwieweit Wetterrisiken das Rückzahlungsverhalten landwirtschaftlicher Mikrokreditnehmer beeinflussen. Das Risiko bei der Kreditvergabe an landwirtschaftliche Klein-Betriebe in Entwicklungs- und Schwellenländern gilt aus Bankensicht aufgrund der vergleichsweise hohen Einkommensschwankungen in der landwirtschaftlichen Produktion als besonders hoch. In der Literatur wird das wetterbedingte Einkommensrisiko als wesentlicher Grund für das vergleichsweise hohe Kreditrisiko von landwirtschaftlichen Mikrokrediten angeführt. Allerdings wurde dies bislang noch nicht empirisch verifiziert. Die Dissertationsschrift widmet sich dem Thema in vier Beiträgen, die unterschiedliche Aspekte der übergeordneten Problematik behandeln.

In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. The α-synuclein oligomers are known to be particularly harmful, although the underlying neurotoxic mechanisms are not fully understood. The aim of this thesis was to investigate the pathogenic roles of α-synuclein oligomers and the possibility to target such species with antibody treatment. Passive immunotherapy with α-synuclein antibodies can lead to reduced pathology and ameliorated symptoms in transgenic mice. However, it remains unknown whether the antibodies are taken up by cells or whether they act extracellularly. In Paper I, we assessed cellular internalization of various α-synuclein monoclonal antibodies. The oligomer selective mAb47 displayed the highest uptake, which was promoted by the extracellular presence of α-synuclein. Alpha-synuclein aggregates can be found in both neurons and glial cells, but the pathogenic role of glial deposits has only been sparsely investigated. In Paper II, co-cultures of neurons and glia were exposed to α-synuclein oligomers. The astrocytes in the cultures rapidly accumulated oligomers, which were only partially degraded by lysosomes. The sustained intracellular α-synuclein deposits were associated with mitochondrial stress reactions in the astrocytes.  In Paper III, we sought to explore whether the astrocytic pathology induced by α-synuclein oligomers could be ameliorated by antibody treatment. Pre-incubation of oligomers with mAb47 promoted α-synuclein clearance, reduced astrocytic accumulation and rescued cells from mitochondrial stress. We could demonstrate that binding of the antibody to its antigen in the extracellular space was crucial for these effects to occur. The progressive pathology in PD is believed to be driven by cell-to-cell spreading of α-synuclein aggregates, potentially via exosomes and other extracellular vesicles (EVs). In Paper IV, we found that either fusing α-synuclein to a non-physiological protein tag or introducing the PD-causing A53T mutation directed α-synuclein towards EV secretion. Also, EV-associated α-synuclein was particularly prone to induce toxicity in recipient cells. In conclusion, this thesis sheds new light on the cellular dysfunction related to α-synuclein pathology and on how the underlying pathogenic processes may be targeted by antibody treatment.

Les causes évolutives de certaines formes de vie en groupe sont bien identifiées mais pas celles des agrégations de diapause des arthropodes (rassemblements monospécifiques d'adultes dans des sites à localisation constante). Dans cette thèse, j'ai testé si, selon l'hypothèse du lek caché, les arthropodes se rassemblent pour trouver leurs partenaires sexuels chez la coccinelle Hippodamia undecimnotata. J'ai montré que les coccinelles se rassemblent dans des endroits avec un repère proéminent et où le risque de pesticides est faible, puis que les conditions abiotiques dans les sites sont défavorables à la survie des coccinelles. Ensuite, j'ai mis en évidence l'occurrence de nombreux accouplements dans les sites d'agrégation. Enfin, j'ai montré que ces accouplements sont peu coûteux en énergie pour les femelles, qui conservent de l'énergie pour les comportements post-agrégation. Cette thèse atteste que les agrégations de diapause font partie du système de reproduction des arthropodes. / The evolutionary significance of some kinds of group living are well-known, some others such as the diapause aggregations remain poorly known although widespread. In this thesis, I tested if the arthropods form diapause aggregations to find their mates according to the hidden lek hypothesis with the ladybird Hippodamia undecimnotata. By using a Species Distribution Model, I showed that ladybirds aggregate in places with a prominent object and where the risk of being sprayed by pesticides is low. Then, I highlighted that abiotic conditions are unfavourable to ladybirds' survival. In a third part, I found that mating is widespread activity in the aggregation sites. Finally, I showed that energetic costs linked to mating are low, and thus allow the ladybirds to disperse and display post aggregations behaviour. This thesis shows that the diapause aggregations are part of the mating system of the arthropods and that sexual selection can be a driver of the evolution of diapause aggregations.

Enterprise Systems like customer-billing systems or financial transaction systems are required to process large volumes of data in a fixed period of time. Those systems are increasingly required to also provide near-time processing of data to support new service offerings. Common systems for data processing are either optimized for high maximum throughput or low latency. This thesis proposes the concept for an adaptive middleware, which is a new approach for designing systems for bulk data processing. The adaptive middleware is able to adapt its processing type fluently between batch processing and single-event processing. By using message aggregation, message routing and a closed feedback-loop to adjust the data granularity at runtime, the system is able to minimize the end-to-end latency for different load scenarios. The relationship of end-to-end latency and throughput of batch and message-based systems is formally analyzed and a performance evaluation of both processing types has been conducted. Additionally, the impact of message aggregation on throughput and latency is investigated. The proposed middleware concept has been implemented with a research prototype and has been evaluated. The results of the evaluation show that the concept is viable and is able to optimize the end-to-end latency of a system. The design, implementation and operation of an adaptive system for bulk data processing differs from common approaches to implement enterprise systems. A conceptual framework has been development to guide the development process of how to build an adaptive software for bulk data processing. It defines the needed roles and their skills, the necessary tasks and their relationship, artifacts that are created and required by different tasks, the tools that are needed to process the tasks and the processes, which describe the order of tasks.

In recent years, patent aggregation and patent trolling activities have received growing attention from all over the world because of the controversial nature of such activities. Somehow it becomes a global obsession to presume that such activities or even the existence of PAEs are problematic by nature and need to be redressed via government intervention, partly due to the unpromising situation in the US. This article seeks to explore the nature of such issue and find out the most appropriate way for China to deal with such issue. The author believes that while such activities might at first sight seem problematic, in fact they are legal commercial practice in general, or more specifically, they are merely strategic uses of patents. This article also argues that there are available remedies under both EU and Chinese legal framework to catch the real problematic conducts derived from such activities. Hence it would seem to the author that even though the quantity of such activities is meant to increase in China, there is neither justification nor need to intervene such activities: the existing legal framework is enough to address certain misconducts; and the market is capable of ensuring its own equilibrium.

Ce travail de thèse a pour objectif de développer et de valider expérimentalement un modèle de diffusion adapté au sang agrégeant, prenant en compte une forte fraction volumique de globules rouges (hématocrite de 40%) et des structures d’agrégats polydisperses. Un modèle développé récemment pour l’estimation de la microstructure du sang est la théorie de milieu effectif combinée à un modèle de facteur de structure monodisperse. Pour augmenter le domaine de validité de ce modèle en hautes fréquences, nous proposons une théorie de milieu effectif prenant en compte la composante incohérente de la diffusion par des agrégats de globules rouges. A l’aide de simulation numériques tridimensionnelles, nous montrons que la nouvelle modélisation permet de prédire les coefficients de rétrodiffusion de façon satisfaisante pour un produit $kR<2$ ($k$ étant le nombre d’ondes et $R$ le rayon d’un agrégat). Par ailleurs, nous proposons une théorie de milieu effectif combinée à un facteur de structure polydisperse afin d’estimer, à partir de la mesure expérimentale du coefficient de rétrodiffusion, des paramètres de structure des agrégats : le rayon moyen de la distribution de tailles, son étalement, et la compacité des agrégats. Des expériences réalisées sur du sang de porc cisaillé dans un dispositif de Couette couplé à une sonde ultrasonore montrent que le modèle polydisperse permet d’obtenir de meilleures courbes d’ajustement des coefficients de rétrodiffusion en comparaison des modèles monodisperses classiques. Les tailles d’agrégats estimées par ultrasons sont corrélées de façon satisfaisante (r$^2$ $\approx$ 0.92) avec les tailles estimées par ailleurs dans un dispositif optique. / This thesis aims to develop and evaluate a scattering model for aggregating blood, taking into account the high volume fraction of red blood cells in blood (40%) and the polydispersity in terms of aggregate size. The effective medium theory combined with the monodisperse structure factor model was recently developed to estimate blood microstructure. In order to improve the modeling at high frequency range, we proposed an effective medium theory that takes into account the incoherent component of the scattering by aggregates of RBCs. Three dimensional simulations were performed and showed that the consideration of the incoherent component allows to approximate the simulation satisfactorily for a product of the wavenumber times the aggregates radius $kR$ up to 2. Besides, we proposed an effective medium theory combined with a polydisperse structure factor. From the measured BSC, this model allows to estimate three structural parameters: the mean radius of the aggregate size distribution, the width of the distribution, and the compactness of the aggregates. Experiments were performed on pig blood shared in a Couette device coupled with an ultrasonic probe, and showed that the polydisperse modeling provides better fitting to the experimental BSC data, when compared to the classical monodisperse models. Satisfactory correlation is obtained (r$^2$ $\approx$ 0.92) between the aggregate sizes estimated with ultrasound and the aggregate sizes estimated on the same sample in an optical device.

Smart Grid (SG) is an electrical grid enhanced with information and communication technology capabilities, so it can support two-way electricity and communication flows among various entities in the grid. The aim of SG is to make the electricity industry operate more efficiently and to provide electricity in a more secure, reliable and sustainable manner. Automated Meter Reading (AMR) and Smart Electric Vehicle (SEV) charging are two SG applications tipped to play a major role in achieving this aim. The AMR application allows different SG entities to collect users’ fine-grained metering data measured by users’ Smart Meters (SMs). The SEV charging application allows EVs’ charging parameters to be changed depending on the grid’s state in return for incentives for the EV owners. However, both applications impose risks on users’ privacy. Entities having access to users’ fine-grained metering data may use such data to infer individual users’ personal habits. In addition, users’ private information such as users’/EVs’ identities and charging locations could be exposed when EVs are charged. Entities may use such information to learn users’ whereabouts, thus breach their privacy. This thesis proposes secure and user privacy-preserving protocols to support AMR and SEV charging in an efficient, scalable and cost-effective manner. First, it investigates both applications. For AMR, (1) it specifies an extensive set of functional requirements taking into account the way liberalised electricity markets work and the interests of all SG entities, (2) it performs a comprehensive threat analysis, based on which, (3) it specifies security and privacy requirements, and (4) it proposes to divide users’ data into two types: operational data (used for grid management) and accountable data (used for billing). For SEV charging, (1) it specifies two modes of charging: price-driven mode and price-control-driven mode, and (2) it analyses two use-cases: price-driven roaming SEV charging at home location and price-control-driven roaming SEV charging at home location, by performing threat analysis and specifying sets of functional, security and privacy requirements for each of the two cases. Second, it proposes a novel Decentralized, Efficient, Privacy-preserving and Selective Aggregation (DEP2SA) protocol to allow SG entities to collect users’ fine-grained operational metering data while preserving users’ privacy. DEP2SA uses the homomorphic Paillier cryptosystem to ensure the confidentiality of the metering data during their transit and data aggregation process. To preserve users’ privacy with minimum performance penalty, users’ metering data are classified and aggregated accordingly by their respective local gateways based on the users’ locations and their contracted suppliers. In this way, authorised SG entities can only receive the aggregated data of users they have contracts with. DEP2SA has been analysed in terms of security, computational and communication overheads, and the results show that it is more secure, efficient and scalable as compared with related work. Third, it proposes a novel suite of five protocols to allow (1) suppliers to collect users accountable metering data, and (2) users (i) to access, manage and control their own metering data and (ii) to switch between electricity tariffs and suppliers, in an efficient and scalable manner. The main ideas are: (i) each SM to have a register, named accounting register, dedicated only for storing the user’s accountable data, (ii) this register is updated by design at a low frequency, (iii) the user’s supplier has unlimited access to this register, and (iv) the user cancustomise how often this register is updated with new data. The suite has been analysed in terms of security, computational and communication overheads. Fourth, it proposes a novel protocol, known as Roaming Electric Vehicle Charging and Billing, an Anonymous Multi-User (REVCBAMU) protocol, to support the priced-driven roaming SEV charging at home location. During a charging session, a roaming EV user uses a pseudonym of the EV (known only to the user’s contracted supplier) which is anonymously signed by the user’s private key. This protocol protects the user’s identity privacy from other suppliers as well as the user’s privacy of location from its own supplier. Further, it allows the user’s contracted supplier to authenticate the EV and the user. Using two-factor authentication approach a multi-user EV charging is supported and different legitimate EV users (e.g., family members) can be held accountable for their charging sessions. With each charging session, the EV uses a different pseudonym which prevents adversaries from linking the different charging sessions of the same EV. On an application level, REVCBAMU supports fair user billing, i.e., each user pays only for his/her own energy consumption, and an open EV marketplace in which EV users can safely choose among different remote host suppliers. The protocol has been analysed in terms of security and computational overheads.

The silky shark Carcharhinus falciformis forms the primary elasmobranch bycatch in tuna purse seine fisheries using fish aggregating devices (FADs) in all of the world’s tropical oceans. Its life-history traits of slow growth, late maturation and low fecundity make it vulnerable to over exploitation, as is apparent from historical bycatch trends. Very little is known about the associative behaviour of this species with floating objects, information which is essential in formulating effective mitigation and management measures. This study aims to address this knowledge gap through the use of various electronic tagging techniques in conjunction with dietary analysis. Dietary data were collected from 323 silky sharks incidentally caught at FADs. Approximately 40 percent of the diet consisted of prey associated with FADs while the remaining 60 percent were non-associated species of crustaceans, cephalopods and fishes. These results suggest that the associative behaviour is not primarily driven by trophic enhancement, but is likely a combination of predator avoidance, social interactions and feeding. Fine-scale behavioural data from silky sharks associated with drifting FADs were collected through the use of acoustic telemetry techniques. Acoustic tags were implanted into 38 silky sharks (69- 116 cm TL) at eight FADs. FADs were equipped with satellite linked acoustic receivers and abandoned to drift freely. Presence/absence and swimming depth data were telemetered via the Iridium satellite system. A total of 300 d of behavioural data were collected from 20 tagged individuals. Individuals remain associated with the same FAD for extended periods (min = 2.84 d, max = 30.60 d, mean = 15.69 d). Strong diel patterns were observed in both association and swimming depth. Typically individuals moved away from FADs after sunset and return later during the night, then remain closely associated until the following evening. Vertical behaviour also changed around sunset with sharks using fairly constant depths, within the upper 25 m, during the day and switching to rapid vertical movements during the night, with dives in excess of 250 m recoded. Broader scale movement behaviour was investigated using pop-up archival satellite tags (PSATs). Tags were deployed on 46 silky sharks (86-224.5 cm TL) for a total of 1495 d. Light data were used to calculate geolocation estimates and reconstruct the sharks’ trajectories. Movement patterns differed between animals and according to deployment duration. Several extensive horizontal movements were observed, with an average track length of 3240 km during an average tag deployment of 44.02 d. Horizontal movement patterns were found to correlate very closely with drift patterns of FADs. Consequently, it appears that the movement behaviour of juvenile silky sharks is strongly influenced by the movement of drifting FADs in this region. Ghost fishing of silky sharks through entanglement in FADs was also investigated using data derived from PSATs as well as underwater visual censuses. Thirteen per cent of the tagged sharks became entangled in FADs and entangled sharks were observed in 35 percent of the 51 FADs surveyed. Using this information in conjunction with estimated time that sharks remained entangled in the FAD (from depth data from PSATs), and scaling up according to estimates of FAD numbers, it was found that between 480 000 and 960 000 silky sharks are killed annually in this manner in the Indian Ocean. Subsequent management measures in this region prevent the deployment of FADs with netting that could lead to entanglement. Overall, floating objects appear to play a significant role in the juvenile life stages of silky sharks in this region. While their association with floating objects is clearly advantageous in an evolutionary sense, under current tuna fishery trends, this behaviour is certainly detrimental for the population.