Submitted by Pedro Henrique Giocondo Guerra (pedrogiocondoguerra@gmail.com) on 2014-03-31T18:28:41Z No. of bitstreams: 1 Dissertação_de_mestrado_Pedro_Guerra.pdf: 1750136 bytes, checksum: 780ca20cad31dcd4db57da366f768bd8 (MD5) / Approved for entry into archive by PAMELA BELTRAN TONSA (pamela.tonsa@fgv.br) on 2014-03-31T18:31:47Z (GMT) No. of bitstreams: 1 Dissertação_de_mestrado_Pedro_Guerra.pdf: 1750136 bytes, checksum: 780ca20cad31dcd4db57da366f768bd8 (MD5) / Made available in DSpace on 2014-03-31T18:36:18Z (GMT). No. of bitstreams: 1 Dissertação_de_mestrado_Pedro_Guerra.pdf: 1750136 bytes, checksum: 780ca20cad31dcd4db57da366f768bd8 (MD5) Previous issue date: 2014-02-27 / The work offers a historical analysis of the recent measures adopted by the Brazilian federal government for the development of the railways sector, with an aim to verify if the Programa de Aceleração do Crescimento, PAC, represented a paradigm shift. We conclude that the PAC itself did not represent a shift from the paradigm inaugurated with the privatization of the sector that occurred between 1996 and 1998. Nonetheless, it represented the strengthening of the state in its planning role, which had started with the PNLT, in its entrepreneurial role, with the strengthening of Valec and, indirectly, in its regulating role, with the edition of resolutions by ANTT, which aimed to integrate the railway networks under the care of private companies and make them more competitive. / O trabalho analisa historicamente as recentes medidas do governo federal para o desenvolvimento do setor de ferrovias, buscando verificar se o PAC representou uma mudança de paradigma. Conclui-se que o PAC, em si, não rompeu com o paradigma inaugurado pela desestatização do setor, ocorrida entre 1996-1998. No entanto, reforçou o papel do Estado como planejador, iniciado com o PNLT, como empresário, com o fortalecimento da Valec e, de maneira indireta, como regulador, com o a edição de novas resoluções pela ANTT, em resposta a seus objetivos de integrar as malhas ferroviárias concedidas e de torná-las mais competitivas.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-03-02T23:01:37Z No. of bitstreams: 1 JoseGedsonFernandesDaSilva_DISSERT.pdf: 27021892 bytes, checksum: 7b5f5e3fe5ef57651e7226b69f4eea85 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-03-04T21:31:17Z (GMT) No. of bitstreams: 1 JoseGedsonFernandesDaSilva_DISSERT.pdf: 27021892 bytes, checksum: 7b5f5e3fe5ef57651e7226b69f4eea85 (MD5) / Made available in DSpace on 2016-03-04T21:31:17Z (GMT). No. of bitstreams: 1 JoseGedsonFernandesDaSilva_DISSERT.pdf: 27021892 bytes, checksum: 7b5f5e3fe5ef57651e7226b69f4eea85 (MD5) Previous issue date: 2014-07-25 / Petr?leo Brasileiro S.A. - PETROBRAS / A an?lise estratigr?fica de subsuperf?cie de estratos devonianos da Bacia do Rio do Peixe, rec?m-datados por palinologia, resultou na classifica??o de duas novas unidades litoestratigr?ficas reunidas no Grupo Santa Helena. A Forma??o Pil?es (unidade inferior), na qual predominam pelitos escuros e arenitos m?dios a muito finos, associados a conglomerados e brechas. A Forma??o Triunfo (unidade superior) composta por arenitos cinza-esbranqui?ados, grossos a conglomer?ticos, caul?nicos, com estratifica??es cruzadas, conglomerados, pelitos e arenitos finos intercalados. Estas unidades foram caracterizadas com o apoio de testemunhos, amostras laterais e de calha, perfis geof?sicos convencionais e de imagem, de tr?s po?os perfurados pela PETROBRAS, e s?smica 3D. Na Forma??o Pil?es predominam f?cies prodeltaicas, com f?cies de t?lus e debritos subaquosos e de lobos turbid?ticos arenosos intercalados, na parte distal de sistemas de leques deltaicos e f?cies de barras do sistema fluviodeltaico entrela?ado (braided) da Forma??o Triunfo. O Grupo Santa Helena corresponde ? tectonossequ?ncia devoniana inferior, cuja espessura m?xima conhecida ? de 343 metros (is?cora) no po?o 1-PIL-1-PB (Pil?es n?1), depositada durante um ciclo transgressivo-regressivo em um graben, com eixo deposicional controlado por um segmento NO-SE da Zona de Cisalhamento Patos. O limite inferior desta tectonossequ?ncia ? n?o-conforme e o superior ? discordante com a tectonossequ?ncia cret?cea inferior (Grupo Rio do Peixe), com um hiato de aproximadamente 265 milh?es de anos. Ignimbritos e brechas coignimbr?ticas (brecha vulc?nica Po?o da Jurema), relacionadas a um evento vulc?nico pirocl?stico ainda desconhecido, foram reconhecidas na margem norte do Semigraben de Sousa. H? evid?ncia, a partir de dados de subsuperf?cie, de que este evento ? contempor?neo ao preeenchimento do graben devoniano. Os resultados deste estudo indicam que a evolu??o tectonovulcanossedimentar da bacia ? poli-hist?rica. Esta atualiza??o litoestratigr?fica abre novas perspectivas de pesquisas geol?gicas na Bacia do Rio do Peixe e em outras bacias interiores do Nordeste do Brasil. Os resultados da pesquisa tamb?m contribuem para o melhor conhecimento da evolu??o da Prov?ncia Borborema e da paleogeografia do Gonduana ocidental durante o Eodevoniano. / Subsurface stratigraphic analysis of Devonian strata from the Rio do Peixe Basin, newly recognized by palynological studies, has resulted in the identification of two new lithostratigraphic units assembled in the Santa Helena Group. The Pil?es Formation, the lower unit, is composed mainly of dark mudstones and medium-tovery fine-grained sandstones, with minor conglomerates and breccias. The Triunfo Formation, the upper unit, comprises whitish grey, kaolinitic, coarse-grained to conglomeratic, cross stratified sandstones and conglomerates, with interbedded mudstones and fine-grained sandstones. These units were characterized using cores, sidewall and cuttings samples, conventional logs and image log, from three wells drilled by PETROBRAS, and 3D seismic data. The Pil?es Formation is interpreted as prodeltaic facies, with lesser associated subaqueous talus, debrite and sandy turbidite lobe facies, distal part of fandelta and braided fluviodeltaic facies of Triunfo Formation. The Santa Helena Group corresponds to the Lower Devonian tectono-sequence deposited in a NW-SE-trending graben during a transgressiveregressive cycle. With 343 meters of thickness (isochore) in well 1-PIL-1-PB (Pil?es 1), this sequence has a non-conformity at the lower boundary and its upper boundary is an unconformity with the Lower Cretaceous tectono-sequence (Rio do Peixe Group), that represents a hiatus of about 265 million years. Ignimbrites and coignimbrite breccias (Po?o da Jurema volcanic breccia), related to an unknown pyroclastic volcanic event, were recognized at the northern margin of the Sousa halfgraben. Evidence from well data suggests that this event is coeval with the Devonian graben filling. The present study indicates a polyhistorical tectono-volcanosedimentary evolution of the basin. This lithostratigraphic update brings new perspectives for geological research in the Rio do Peixe Basin, as well as in other inland basins of the Northeastern of Brazil. The results of the research also contribute to the kwnoledge of the Borborema Province and western Gondwana paleogeography during the Early Devonian.

The content of the thesis is the modeling and implementation of the CNC control algorithm. This master thesis contains the description of issues of computer-controlled machines, the research of interpolation algorithms for control CNC machines and the modeling of the selected control algorithm with motor S-curve shaped speed profiles and simulation of chosen algorithms with S-shaped speed profiles in Matlab & Simulink.

Automated Test Generation (ATG) has been successfully applied in many domains. For the modeling and simulation language Simulink, there has been research on developing tools for ATG with promising results. However, most tools developed as part of academic research and are not publicly available, or severely limited in their ability to be integrated into an industrial workflow. There are commercial ATG tools for Simulink, with Simulink Design Verifier (SLDV) as the de-facto standard tool. For this thesis, we perform an empirical comparison of manual tests to those generated by SLDV. For the comparison, we used 180 components from the propulsion control software developed by our industry partner. All except two components are compatible for test generation to some extent. The majority of components are partially compatible, requiring block replacement or stubbing. Approximation of floating-point numbers is the primary reason for block replacement, which can be performed automatically by SLDV. Two components were incompatible, and 14 required full stubbing of blocks. Using a pre-processing step, the generated tests achieve similar coverage as the manual tests. We performed a Mann–Whitney U test with the hypothesis that the generated tests achieve higher coverage than the manual tests. There are no statistically significant differences for either decision coverage (0.0719), or condition coverage (0.8357). However, for Modified Condition/Decision Coverage, the generated tests achieve higher coverage, and the difference is significant (0.0027). The limitations of ATG were explored by looking at the cases where the generated tests achieved lower coverage than the manual test. We found that the use of floating-point arithmetic and temporal logic increases the time required for test generation, and causes the analysis to hit the time limit. The test generation does not support all custom S-functions and perform stubbing of these blocks. This made the tool unable to reason about persistent storage. Configuration constants have limited support, which was the reason for the coverage difference in three cases. We have concluded that while much effort is required for custom tooling and initial setup, ATG can prove useful for early fault detection in an industrial workflow. ATG would prove especially useful in an automated continuous integration workflow for integration-level conformance testing.

No description available.

The background and problem statement focuses on antiretroviral therapy (ART) and the use of mobile technology to improve compliance within a primary health care (PHC) context in South Africa. South Africa is one of the countries, globally, with the highest HIV incidence and prevalence and ART enrolled patients visiting PHC facilities. Compliance to ART plays an integral part in effective HIV/AIDS management. HIV/AIDS management entails a complex process of patient education and pharmacological control to improve ART compliance in South Africa. Studies were done in South Africa on reminder messages as most studies focused on chronic conditions in general. A literature review explored what is known about ART and mobile technology to improve compliance. Literature confirmed that compliance through reminder messages were done worldwide and in Sub-Saharan countries. Previous research indicated that the compliance rate of the patients increased through reminder messages. Yet there is a gap in the literature regarding reminder messages combined with health education on ART compliance. The aim of the study was to determine the impact of reminder messages combined with health education on ART compliance among patients receiving ART at a PHC facility Methodology: The study followed a quantitative, experimental, intervention, randomised multi-group, pre- and post measurement design (Creswell, 2012:1, Welman et al., 2012:80). The research design is experimental because the researcher applied an intervention (reminder messages) to two experimental groups. Random sampling was applied and participants were grouped into three groups: Group A, (control group), Group B, (reminder messages only) and Group C (reminder messages combined with health education). A preand post-measurement design is followed as each participant’s pill count and return date were measured before and after the reminder messages with/without health education were given. The sample size was 202 eligible patients receiving Regime 1 and 2 ART’s (Lamuvidine, Tenofovir, Efavirenz, Nevirapine, Alluvia® and Zidovudine) at a PHC facility in the North West, South Africa (N=202). The sample size was determined with guidance of statistical services to ensure that results obtained from the study would be reliable and significant. Data collection was done in three phases. Phase one (1) consisted of collecting the biographical data and a pre-measurement of pill count and return dates for participants in Groups A, B and C. Phase two (2) consisted of sending bi-weekly messages (Group B) via WinSMS and with health education (Group C) for three (3) months. Phase three (3) consisted of post-measurement of participants’ pill count and return date for Groups A,B and C. Data collection stretched over six months (October 2013-March 2014), namely three months pre-measurement, then activation of intervention combined with another three months post-measurement. Descriptive and inferential statistical analysis was conducted through SPSS (SPSS Inc., 2013). Descriptive statistics indicated that more female patients visited the PHC facility for ART on a more regular basis. It was concluded that the experimental group proved a slight increase in compliance with regards to return date after the SMS intervention. No difference was noted in compliance to pill counts. It can also be concluded that pill counts is a complex monitoring procedure with room for error from the patients’ aspect. / MCur, North-West University, Potchefstroom Campus, 2015

The background and problem statement focuses on antiretroviral therapy (ART) and the use of mobile technology to improve compliance within a primary health care (PHC) context in South Africa. South Africa is one of the countries, globally, with the highest HIV incidence and prevalence and ART enrolled patients visiting PHC facilities. Compliance to ART plays an integral part in effective HIV/AIDS management. HIV/AIDS management entails a complex process of patient education and pharmacological control to improve ART compliance in South Africa. Studies were done in South Africa on reminder messages as most studies focused on chronic conditions in general. A literature review explored what is known about ART and mobile technology to improve compliance. Literature confirmed that compliance through reminder messages were done worldwide and in Sub-Saharan countries. Previous research indicated that the compliance rate of the patients increased through reminder messages. Yet there is a gap in the literature regarding reminder messages combined with health education on ART compliance. The aim of the study was to determine the impact of reminder messages combined with health education on ART compliance among patients receiving ART at a PHC facility Methodology: The study followed a quantitative, experimental, intervention, randomised multi-group, pre- and post measurement design (Creswell, 2012:1, Welman et al., 2012:80). The research design is experimental because the researcher applied an intervention (reminder messages) to two experimental groups. Random sampling was applied and participants were grouped into three groups: Group A, (control group), Group B, (reminder messages only) and Group C (reminder messages combined with health education). A preand post-measurement design is followed as each participant’s pill count and return date were measured before and after the reminder messages with/without health education were given. The sample size was 202 eligible patients receiving Regime 1 and 2 ART’s (Lamuvidine, Tenofovir, Efavirenz, Nevirapine, Alluvia® and Zidovudine) at a PHC facility in the North West, South Africa (N=202). The sample size was determined with guidance of statistical services to ensure that results obtained from the study would be reliable and significant. Data collection was done in three phases. Phase one (1) consisted of collecting the biographical data and a pre-measurement of pill count and return dates for participants in Groups A, B and C. Phase two (2) consisted of sending bi-weekly messages (Group B) via WinSMS and with health education (Group C) for three (3) months. Phase three (3) consisted of post-measurement of participants’ pill count and return date for Groups A,B and C. Data collection stretched over six months (October 2013-March 2014), namely three months pre-measurement, then activation of intervention combined with another three months post-measurement. Descriptive and inferential statistical analysis was conducted through SPSS (SPSS Inc., 2013). Descriptive statistics indicated that more female patients visited the PHC facility for ART on a more regular basis. It was concluded that the experimental group proved a slight increase in compliance with regards to return date after the SMS intervention. No difference was noted in compliance to pill counts. It can also be concluded that pill counts is a complex monitoring procedure with room for error from the patients’ aspect. / MCur, North-West University, Potchefstroom Campus, 2015

Fímbrias do tipo IV estão associadas a diversos fenótipos em bactérias gram-negativas, e o presente estudo consistiu na caracterização da fímbria Pil e investigação de seu papel na adesão bacteriana de isolados de EPEC atípica. Por PCR e RT-PCR foram investigadas a presença e a funcionalidade do operon Pil e os resultados demonstraram que este está sendo transcrito somente nos isolados BA558 e BA956. Os genes pilS e pilV foram clonados em vetor de expressão para obtenção das proteínas Pil recombinantes e produção de anticorpos policlonais. A análise qualitativa dos testes de inibição da adesão utilizando os soros anti-PilS e anti-PilV juntos demonstraram que o isolado BA558 apresentou mudança de fenótipo de adesão. Esses resultados nos permitem concluir que o operon Pil está funcional em BA558 e BA956, e a expressão da fímbria Pil nessas cepas não está relacionada à formação de biofilme e autoagregação, porém a proteína fimbrial PilS juntamente com a adesina PilV parecem exercer uma função acessória importante na interação de BA558 às células HEp-2. / Type IV fimbriae are associated with several phenotypes in gram-negative bacteria. The aim of this study was the characterization of the Pil fimbria and its role in the interaction of atypical EPEC isolates in bacterial adhesion. Using PCR and RT-PCR, we investigated the presence and functionality of the pil operon genes. The results showed that these genes are transcribed only in the BA558 and BA956 isolates. The pilS and pilV genes were cloned into an expression vector for recombinant proteins and polyclonal antibodies production. Qualitative analysis of the adherence inhibition assays using both rabbit sera changed to localized-like the phenotype of BA558 isolate adhesion. Together, these results allow us to conclude that the Pil operon is functional only in the BA558 and BA956 isolates and that the expression of Pil fimbriae in aEPEC is not related to biofilm formation and autoaggregation but, the fimbrial PilS protein together with PilV adhesin seem to play an important accessory function in the interaction between the BA558 and epithelial cells in vitro.

L’information des patients est devenue un enjeu de santé publique et une composante essentielle de la relation médecin patient. De nombreux auteurs s’accordent à dire que l’information écrite est un complément indispensable à l’obligation d’information orale car elle améliore la qualité des soins et l’adhérence du patient à sa prise en charge. Malgré l’existence de nombreuses Fiches d’Information Patient (FIP), le médecin a du mal à se les approprier. Elles sont souvent non validées, peu lisibles, difficiles à stocker, sans références, sources ni dates de rédaction. La première étape de notre travail a consisté à proposer une méthode pour élaborer des fiches d’information du patient (FIP) et à partir d’elle, 125 FIP concernant des motifs de consultation les plus fréquents en soins primaires. Une étude observationnelle réalisée dans 26 cabinets de médecine générale auprès de 350 patients, a montré d’une part que les patients sont demandeurs de FIP et qu’elles sont appréciées des patients. Et d’autre part, que la compréhension des maladies aiguës est plus limitée que celles des maladies chroniques ou situations de prescription chez les patients à faible niveau scolaire. Une étude interventionnelle randomisée en clusters réalisée dans 24 cabinets de médecine générale auprès de 400 patients, nous a permis de montrer que les FIP permettaient aux patients d’améliorer leur niveau de connaissances sur les pathologies et de modifier positivement leur comportements de santé, y compris pour les patients à faible niveau scolaire. Néanmoins, il n’était pas possible de comparer ces résultats à ceux de la littérature, les protocoles de recherche étant trop hétérogènes (critères de jugement spécifiques d’une situation clinique donnée).Pour surmonter cette difficulté, nous basant sur une « revue des revues » de la littérature, nous avons proposé un modèle théorique décrivant les modalités d’action des FIP au cours de la consultation, à partir duquel nous avons élaboré trois scores génériques utilisables pour tout type de consultation : un score de Communication Médecin Malade (CMM), un score de satisfaction et un score d’adhérence globale. Une fois les propriétés psychométriques de ces scores validés, nous avons étudié leurs déterminants. En situation aiguë, le seul déterminant de la CMM était la qualité de l’information reçu (quoi et que faire multipliant la probabilité d’une bonne communication par 11.9), les caractéristiques du patient n’influençant pas la CMM. L’adhérence globale est déterminée par le type de pathologie (paramètre inflexible) et par la qualité de la CMM. Enfin, la satisfaction, bien que tout autant liée à l’infrastructure, à l’équipe paramédicale et à l’équipe médicale, est également améliorée par une CMM de bonne qualité. En situation aiguë, la CMM est donc primordiale et impacte sur les indicateurs santé usuels que sont la satisfaction et l’adhérence des patients.Enfin, nous avons évalué avec ces nouveaux outils l’impact de 6 FIP sur la CMM, l’adhérence globale du patient et la satisfaction dans deux services d’urgences auprès de 324 patients. Cette étude interventionnelle avant-après nous a permis de montrer que les FIP améliorent: la CMM, la satisfaction vis-à-vis des professionnels de santé, le comportement des patients (qui respectent mieux les modalités de prises des médicaments et reconsultent moins dans les services d’urgences pour une même pathologie) et le comportement des médecins (qui prescrivent moins médicaments et davantage d’examens complémentaires). En situation aiguë, un outil simple pour améliorer la CMM est l’usage de FIP délivrée en complément de l’information orale.La CMM est un critère de jugement fondamental qu’il conviendra à l’avenir d’utiliser plus souvent, notamment pour évaluer les interventions thérapeutiques non pharmacologiques en plein essor, et pour lesquelles la communication est probablement un déterminant majeur de l’efficacité. / Patient information has become a public health issue and an essential component of Doctor-Patient communication (DPC). Many authors agree that written information is an indispensable complement to the obligatory oral information, since it improves the quality of care and the patient adherence. Despite the existence of numerous Patient Information Leaflets (PILs), physicians have difficulty appropriating them; they are often not validated, hard to read, difficult to store, without references, sources and dates of writing. The first step in our work was to propose a methodology for developing PILs and from there, design 125 PILs for the most common reasons for consultation in primary care. An observational study carried out in 26 general practice offices with 350 patients showed that patients appreciate PILs. On the other hand, the understanding of Acute Conditions (AC) is more limited than that of chronic diseases or prescription situations, particularly patients with a low school level. A cluster randomized interventional study performed in 24 general practice offices with 400 patients showed that PILs allowed patients to improve their knowledge about pathologies and modify their health behaviors positively, independently of their level of education. Nevertheless, the heterogeneity of the research protocols made it impossible to compare our results with those of the literature.To overcome this scientific hurdle and continue our work on the assessment of PILs, we performed a review of the literature on the subject, constructed a theoretical model describing the various effects of PILs and created three generic scales usable for evaluating the impact of PILs on any type of condition (scales of Doctor-Patient Communication, satisfaction and overall adherence). An observational study carried out in 2 Emergency Departments (ED) allowed us to validate the 3 scores, assess the psychometric properties and elucidate their determinants. In the context of AC, the only determinant of the DPC was the quality of the information received (both information "what to do" and "when to reconsult" have an adjusted Odds Ratio 11.9. Characteristics of the patient did not influence the DPC score. The overall adhesion is determined by the type of pathology (inflexible parameter) and by the quality of the DPC. Finally, although satisfaction was strongly associated with the hospital infrastructure and the attitude of the paramedical and medical staff, a high DPC score multiplied the probability of having a good satisfaction score. In a context of emergency consultations, the DPC is paramount and has an impact on the usual health indicators: satisfaction and adherence.Finally, a before-after intervention study conducted in two ED showed that PILs improve DPC, satisfaction with healthcare professionals, and adherence to medication regimens. PILs decrease the number of reconsultations for the same pathology, in particular return to the ED. They reduce the number of drug prescriptions given by the doctor in favor of complementary examinations and specialized advice. In a context of AC, a PIL given by the doctor improves DPC, the patient’s satisfaction with healthcare professionals and improves both the doctor’s and the patient’s behaviors.The DPC is a fundamental outcome that will need to be measured more frequently in the future, including in acute situations.

Fímbrias do tipo IV estão associadas a diversos fenótipos em bactérias gram-negativas, e o presente estudo consistiu na caracterização da fímbria Pil e investigação de seu papel na adesão bacteriana de isolados de EPEC atípica. Por PCR e RT-PCR foram investigadas a presença e a funcionalidade do operon Pil e os resultados demonstraram que este está sendo transcrito somente nos isolados BA558 e BA956. Os genes pilS e pilV foram clonados em vetor de expressão para obtenção das proteínas Pil recombinantes e produção de anticorpos policlonais. A análise qualitativa dos testes de inibição da adesão utilizando os soros anti-PilS e anti-PilV juntos demonstraram que o isolado BA558 apresentou mudança de fenótipo de adesão. Esses resultados nos permitem concluir que o operon Pil está funcional em BA558 e BA956, e a expressão da fímbria Pil nessas cepas não está relacionada à formação de biofilme e autoagregação, porém a proteína fimbrial PilS juntamente com a adesina PilV parecem exercer uma função acessória importante na interação de BA558 às células HEp-2. / Type IV fimbriae are associated with several phenotypes in gram-negative bacteria. The aim of this study was the characterization of the Pil fimbria and its role in the interaction of atypical EPEC isolates in bacterial adhesion. Using PCR and RT-PCR, we investigated the presence and functionality of the pil operon genes. The results showed that these genes are transcribed only in the BA558 and BA956 isolates. The pilS and pilV genes were cloned into an expression vector for recombinant proteins and polyclonal antibodies production. Qualitative analysis of the adherence inhibition assays using both rabbit sera changed to localized-like the phenotype of BA558 isolate adhesion. Together, these results allow us to conclude that the Pil operon is functional only in the BA558 and BA956 isolates and that the expression of Pil fimbriae in aEPEC is not related to biofilm formation and autoaggregation but, the fimbrial PilS protein together with PilV adhesin seem to play an important accessory function in the interaction between the BA558 and epithelial cells in vitro.