This diploma thesis deals with an optimization of hydrostatic slide of the large-portal gantry machine FRU (TOS Kuřim). First part of the thesis concerns with an analysis of the current practice in hydrostatic guides in the field of heavy gantry machines, an usage of alternative materials for a construction of carrying parts of machines, and possibilities of current simulation methods. Aim of the second part of this thesis is a brief clarification of the principle of mathematical optimization, and creation of general methodology of construction optimization by means of system analysis. Optimization calculations were processed by ANSYS Workbench 11.0. There is achieved adjusted and optimized design of the hydrostatic slide as the result of the thesis. Moreover, the comparison of key deformations was added. Created methodology is applicable in both an area of construction of gantry machines, and a wide spectrum of construction fields.

The subject of this thesis is communication process between a mobile device and a server. The work is concerned with development of application in Windows Mobile in the light of technical limitation. The thesis also deals with the development of application for universal mobile database connector which then enables transparent working with information, obtained from database placed on server, on the mobile device.

The task of this project is to build application for managing of multimedia data in enclosed wireless networks and to present this data to the user. In model case it can be for example city guide - on position given by GPS are presented information about surrounding scene. Application must be capable of downloading data into Pocket PC - PDA and present them to the user as user friendly application.

Cette thèse s’intéresse, en France, à la place de l’assurance maladie privée (ou complémentaire) dans l’organisation globale du système d’assurance, sous l’angle des inégalités sociales et de la solidarité entre les individus bien-portants et les malades. Elle étudie en particulier le rôle joué par l’assurance complémentaire sur l’accès aux soins, la mutualisation des dépenses de santé et le bien-être de la population. Les travaux menés dans cette thèse révèlent l’importance de l’assurance complémentaire pour accéder à des soins reportés dans le temps pour raisons financières. Ils montrent en revanche que, généraliser l’assurance complémentaire, dans le modèle actuel de co-financement des soins, ne permet ni de répondre à des objectifs d’équité ni-même d’améliorer le bien-être de la population. Ils révèlent en sus que l’assurance complémentaire induit une moindre mutualisation des dépenses de santé pour les plus malades et invitent à repenser son rôle dans le financement des soins. / This thesis deals with the place of private health insurance in the overall health insurance scheme in France, focusing on social inequalities and on solidarity between healthy individuals and sick patients. It particular, it addresses the role of private health insurance on access to health care, mutualization of health expenditure, and welfare. The results of this thesis reveal the key role of private health insurance to access to care postponed over time for financial reasons. However, our results also show that generalizing complementary health insurance in the current health insurance scheme does not allow pursuing equity goals nor increasing welfare. They finally reveal that the mutualization induced by private health insurance appears relatively weak, compared to the one induced by public health insurance. They therefore encourage a change in the role of private health insurance in funding medical care.

This work presents steps in creation of remote position tracking application. Document introduces history of geographical positioning and navigation, and describes development of navigation from primitive utilities to complex radio navigation systems. Global Positioning System is described in more detail including NMEA protocol used by GPS receivers. This work also presents several current navigation applications. Based on obtained information work presents analysis, object-oriented design and implementation of remote position tracking system.

MSc. thesis deals with mobile digital assistant T-Mobile MDA II running Linux operating system. The first part presents device identification and parameters' specification of the MDA II. The second part focuses on selection of GNU distribution with Linux bootloader and Linux kernel support comparison. The subject of the last part is MDA II component code implementation and its merging into Linux kernel.

The pocket watch, an ingenious invention that over its 500 year-long development, made it possible for time keeping to become portable and reliable. A symbol of culture, station and importance, that changed the way our society interacts with and uses time. Nordiska museet’s collections contain over a thousand pocket watches and pocket watch movements, all available through the aggregator Swedish Open Cultural Heritage API. With a critical eye towards the outdrawn digitisation process of Swedish museums, this paper intends through statistical analysis to find trends, patterns, and problems relating to the representation of this grand collection. The results reveal negligence surrounding technical descriptors by reason of suboptimal knowledge regarding watchmaking, a confusing naming convention, and a great need for deeper research into the collection.

The exponential growth in medical pharmaceuticals and related clinical trials have created a need to better understand the decision-making factors in the processes for developing hospital medication formularies. The purpose of the study was to identify, rank, and compare major factors impacting hospital formulary decision-making among three prescriber groups serving on a hospital's pharmacy and therapeutics (P&T) committee. Prescribers were selected from the University of Texas, MD Anderson Cancer Center which is a large, multi-facility, academic oncology hospital. Specifically, the prescriber groups studied were comprised of physicians, midlevel providers, and pharmacists. A self-administered online survey was disseminated to participants. Seven major hospital formulary decision-making factors were identified in the scientific literature. Study participants were asked to respond to questions about each of the hospital formulary decision-making factors and to rank the various formulary decision-making factors from the factor deemed most important to the factor deemed least important. There are five major conclusions drawn from the study including three similarities and two significant differences among the prescriber groups and factors. Similarities include: (1) the factor "pharmacy staff's evaluation of medical evidence including formulary recommendations" was ranked highest for all three prescriber groups; (2) "evaluation of medications by expert physicians" was ranked second for physicians and midlevel providers while pharmacists ranked it third; and (3) the factor, "financial impact of the treatment to the patient" was fifth in terms of hospital formulary decision-making statement and ranking by all three prescriber groups. Two significant differences include: (1) for the hospital-formulary decision making statement, "I consider the number of patients affected by adding, removing, or modifying a drug on the formulary when making hospital medication formulary decisions," midlevel providers considered this factor of significantly greater importance than did physicians; and (2) for the ranked hospital formulary decision-making factor, "financial impact of treatment to the institution," pharmacists ranked this factor significantly higher than did physicians. This study contributes to a greater understanding of the three prescriber groups serving on a P&T committee. Also, the study contributes to the body of literature regarding decision-making processes in medicine and specifically factors impacting hospital formulary decision-making. Furthermore, this study has the potential to impact the operational guidelines for the P&T committee at the University of Texas, MD Anderson Cancer Center as well as other hospitals.

In recent years, the potential benefits of high-throughput virtual screening to the drug discovery community have been recognized, bringing an increase in the number of tools developed for this purpose. These programs have to process large quantities of data, searching for an optimal solution in a vast combinatorial range. This is particularly the case for protein-ligand docking, since proteins are sophisticated structures with complicated interactions for which either molecule might reshape itself. Even the very limited flexibility model to be considered here, using ligand conformation ensembles, requires six dimensions of exploration - three translations and three rotations - per rigid conformation. The functions for evaluating pose suitability can also be complex to calculate. Consequently, the programs being written for these biochemical simulations are extremely resource-intensive. This work introduces a pure computer science approach to the field, developing techniques to improve the effectiveness of such tools. Their architecture is generalized to an abstract pattern of nested layers for discussion, covering scoring functions, search methods, and screening overall. Based on this, new stratagems for molecular docking software design are described, including lazy or partial evaluation, geometric analysis, and parallel processing implementation. In addition, a range of novel algorithms are presented for applications such as active site detection with linear complexity (PIES) and small molecule shape description (PASTRY) for pre-alignment of ligands. The various stratagems are assessed individually and in combination, using several modified versions of an existing docking program, to demonstrate their benefit to virtual screening in practical contexts. In particular, the importance of appropriate precision in calculations is highlighted.

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