Made available in DSpace on 2017-05-12T14:36:24Z (GMT). No. of bitstreams: 1 EFEITO DA QUERCETINA OVARIECTOMIZADAS.pdf: 2103814 bytes, checksum: ae46af8ec18f6634ae18e23c19f6e393 (MD5) Previous issue date: 2015-12-07 / Tamoxifen was discovered in 1970 and classified as selective estrogen receptor modulator (SERM) being used as therapy in the treatment of breast cancer. Although benefits has been proven, side effects are intense, and are related to different mechanisms of toxic action, such as oxidative stress and changes in the glycolytic pathway that induce a hyperglycemia and liver damage. The administration of quercetin, a flavonoid with antioxidant potential, that has inhibitory effect on enzyme butyrylcholinesterase, an enzyme possibly associated with hepatotoxicity and hyperglycemia, has benefits on the adverse effects caused by tamoxifen. Thus, first to determine the effect of quercetin on the hyperglycemia caused by tamoxifen, ovariectomized rats were treated orally, with tamoxifen and quercetin; concluding that effects of quercetin are dependent on ratio quercetin/tamoxifen coadministered and the 4.5 ratio is more effective. After, trying to elucidate the mechanisms involved in changes in the glycolytic pathway, oxidative stress and liver damage perfusion was performed in rat liver, studying especially glycogenolysis and gluconeogenesis, using as an indicator of liver damage of butyrylcholinesterase activity and monitoring the oxidative stress. The results showed that quercetin has inhibitory effect on glucose production and enhances the effects generated by tamoxifen in gluconeogenesis, concluding that although quercetin is known for antioxidant activity, in certain concentrations (400 μM) intensifies the damage initially caused by tamoxifen, this effect doesn't occur with lower concentrations of quercetin (200 μM). Therefore, although quercetin has shown to be effective in reducing hyperglycemia caused by tamoxifen, the interaction of quercetin with tamoxifen should be viewed with caution since the effect of this interaction in carbohydrate metabolism is intense, can alter the intracellular redox environment, compromising its integrity and causing serious damage to liver tissue. / O tamoxifeno, descoberto em 1970 foi classificado como modulador seletivo de receptor de estrógeno (SERM) sendo utilizado no tramento e prevenção do câncer de mama e embora seja terapia de escolha no período pós-menopausa seus efeitos colaterais são intensos, e estão relacionados a diferentes mecanismos de ação tóxica, como o estresse oxidativo e alterações na via glicolítica que induzem a hiperglicemia e causam danos hepáticos. A coadministração de quercetina, um flavonoide com potencial antioxidante e que possui efeito inibitório na enzima butirilcolinesterase, enzima essa possivelmente associada a hepatotoxicidade e a hiperglicemia, traria benefícios diante dos efeitos adversos gerados pelo tamoxifeno. Sendo assim, primeiramente, para determinar o efeito da quercetina diante da hiperglicemia causada pelo tamoxifeno, ratas ovariectomizadas foram tratadas via oral com quercetina e tamoxifeno; concluindo que os efeitos da quercetina são dependentes da razão Quercetina/Tamoxifeno coadministrado, e na razão 4,5 a quercetina mostra-se altamentente eficaz. Após, buscando elucidar os mecanismos envolvidos nas alterações na via glicolítica, os danos hepáticos e o estresse oxidativo, foram realizados perfusão em fígado isolado de ratas, estudando em especial a glicogenólise e a gliconeogênese, utilizando como indicador dos danos hepáticos a atividade da butirilcolinesterase e monitorando o estresse oxidativo. Os resultados mostraram que a quercetina possui efeito inibitório (200 μM) sobre a produção de glicose e intensifica os efeitos gerados pelo tamoxifeno na gliconeogênese, concluindo que embora a quercetina seja reconhecida pela sua atividade antioxidante, em determinadas concentrações (400 μM) ela acentua os danos inicialmente causados pelo tamoxifeno, não ocorrendo esse efeito com concentrações mais baixas de quercetina (200 μM). Sendo assim, embora a quercetina tenha se mostrado eficaz, reduzindo a hiperglicemia causada pelo tamoxifeno via oral, a interação da quercetina com tamoxifeno deve ser vista com cautela, pois os resultados mostram que o efeito dessa interação no metabolismo de carboidratos é intenso, podendo alterar o ambiente redox intracelular, comprometer a integridade celular e causar danos graves no tecido hepático.

Made available in DSpace on 2017-07-10T13:59:28Z (GMT). No. of bitstreams: 1 EFEITO DA QUERCETINA OVARIECTOMIZADAS.pdf: 2103814 bytes, checksum: ae46af8ec18f6634ae18e23c19f6e393 (MD5) Previous issue date: 2015-12-07 / Tamoxifen was discovered in 1970 and classified as selective estrogen receptor modulator (SERM) being used as therapy in the treatment of breast cancer. Although benefits has been proven, side effects are intense, and are related to different mechanisms of toxic action, such as oxidative stress and changes in the glycolytic pathway that induce a hyperglycemia and liver damage. The administration of quercetin, a flavonoid with antioxidant potential, that has inhibitory effect on enzyme butyrylcholinesterase, an enzyme possibly associated with hepatotoxicity and hyperglycemia, has benefits on the adverse effects caused by tamoxifen. Thus, first to determine the effect of quercetin on the hyperglycemia caused by tamoxifen, ovariectomized rats were treated orally, with tamoxifen and quercetin; concluding that effects of quercetin are dependent on ratio quercetin/tamoxifen coadministered and the 4.5 ratio is more effective. After, trying to elucidate the mechanisms involved in changes in the glycolytic pathway, oxidative stress and liver damage perfusion was performed in rat liver, studying especially glycogenolysis and gluconeogenesis, using as an indicator of liver damage of butyrylcholinesterase activity and monitoring the oxidative stress. The results showed that quercetin has inhibitory effect on glucose production and enhances the effects generated by tamoxifen in gluconeogenesis, concluding that although quercetin is known for antioxidant activity, in certain concentrations (400 μM) intensifies the damage initially caused by tamoxifen, this effect doesn't occur with lower concentrations of quercetin (200 μM). Therefore, although quercetin has shown to be effective in reducing hyperglycemia caused by tamoxifen, the interaction of quercetin with tamoxifen should be viewed with caution since the effect of this interaction in carbohydrate metabolism is intense, can alter the intracellular redox environment, compromising its integrity and causing serious damage to liver tissue. / O tamoxifeno, descoberto em 1970 foi classificado como modulador seletivo de receptor de estrógeno (SERM) sendo utilizado no tramento e prevenção do câncer de mama e embora seja terapia de escolha no período pós-menopausa seus efeitos colaterais são intensos, e estão relacionados a diferentes mecanismos de ação tóxica, como o estresse oxidativo e alterações na via glicolítica que induzem a hiperglicemia e causam danos hepáticos. A coadministração de quercetina, um flavonoide com potencial antioxidante e que possui efeito inibitório na enzima butirilcolinesterase, enzima essa possivelmente associada a hepatotoxicidade e a hiperglicemia, traria benefícios diante dos efeitos adversos gerados pelo tamoxifeno. Sendo assim, primeiramente, para determinar o efeito da quercetina diante da hiperglicemia causada pelo tamoxifeno, ratas ovariectomizadas foram tratadas via oral com quercetina e tamoxifeno; concluindo que os efeitos da quercetina são dependentes da razão Quercetina/Tamoxifeno coadministrado, e na razão 4,5 a quercetina mostra-se altamentente eficaz. Após, buscando elucidar os mecanismos envolvidos nas alterações na via glicolítica, os danos hepáticos e o estresse oxidativo, foram realizados perfusão em fígado isolado de ratas, estudando em especial a glicogenólise e a gliconeogênese, utilizando como indicador dos danos hepáticos a atividade da butirilcolinesterase e monitorando o estresse oxidativo. Os resultados mostraram que a quercetina possui efeito inibitório (200 μM) sobre a produção de glicose e intensifica os efeitos gerados pelo tamoxifeno na gliconeogênese, concluindo que embora a quercetina seja reconhecida pela sua atividade antioxidante, em determinadas concentrações (400 μM) ela acentua os danos inicialmente causados pelo tamoxifeno, não ocorrendo esse efeito com concentrações mais baixas de quercetina (200 μM). Sendo assim, embora a quercetina tenha se mostrado eficaz, reduzindo a hiperglicemia causada pelo tamoxifeno via oral, a interação da quercetina com tamoxifeno deve ser vista com cautela, pois os resultados mostram que o efeito dessa interação no metabolismo de carboidratos é intenso, podendo alterar o ambiente redox intracelular, comprometer a integridade celular e causar danos graves no tecido hepático.

Indiana University-Purdue University Indianapolis (IUPUI) / Raloxifene is an FDA-approved selective estrogen receptor modulator (SERM) that improves tissue quality by binding to collagen and increasing the bound water content in the bone matrix in a cell-independent manner. In this thesis, active tissue formation was induced by non-invasive external tibial loading in female mice and combined with raloxifene treatment to assess their combined effect on bone morphology and mechanical properties. Thermoregulation is an important factor that could have physiological consequences on research outcomes, and was introduced as an additional experimental factor in this study. We hypothesized that by removing the mild cold stress under which normal lab animals are housed, a metabolic boost would allow for further architectural and mechanical improvements as a result of the combination of tibial loading and raloxifene treatment. Ten week old female C57BL/6J mice were treated with raloxifene, underwent tibial loading to a strain level of 2050µε and were housed in thermoneutral conditions (32°C) for 6 weeks. We investigated bone morphology through microcomputed tomography (µCT) and mechanical properties via four-point bending and fracture toughness testing. Results indicated a combined improvement by external loading and raloxifene on geometry, particularly in the cancellous region of the bone, and also in bone mechanics leading to greater improvements than either treatment individually. Temperature did not have a robust impact on either bone architecture or mechanical integrity.

No description available.

Submitted by Rosangela Silva (rosangela.silva3@unioeste.br) on 2017-08-30T17:39:39Z No. of bitstreams: 2 Isabella Calvo Bramatti.pdf: 1175071 bytes, checksum: b4b43f726550d831d384392724e6c260 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-08-30T17:39:39Z (GMT). No. of bitstreams: 2 Isabella Calvo Bramatti.pdf: 1175071 bytes, checksum: b4b43f726550d831d384392724e6c260 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-02-06 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Tamoxifen is classified as a selective estrogen receptor modulator, with much use in the treatment of breast cancer. Quercetin has aroused interest, mainly for its antioxidant action, which may minimize the damage caused by tamoxifen. Due to the lack of studies about the coadministration of quercetin with tamoxifen, the objective of this study was to elucidate the effect upon the cholinergic activity and antioxidante defense. At the study, ovariectomized rats were separated into groups and treated with tamoxifen (5 mg.Kg-1), quercetin (22,5 mg.Kg-1) and the coadministration of tamoxifen (5 mg.Kg-1) plus quercetin (22,5 mg.Kg-1). The hippocampus was isolated and utilized for the determination of acetylcholinesterase and butyrylcholinesterase activity, superoxide dismutase and catalase activity, and the oxidative damage markers (lipid peroxidation and dosage of thiols groups). It was possible observe the oxidant effect of tamoxifen at the hippocampus, where acted like an antagonist at the estrogen receptors, increasing the lipid peroxidation, levels of thiol groups and attenuating catalase activity; in addition to a cholinergic effect, with the decrease of acetylcholinesterase and butyrylcholinesterase activity. When coadministered the quercetin with tamoxifen, it can be seen that at a situation of oxidative stress, the quercetin acts like pro oxidant in the studied. / Tamoxifeno é classificado como um modulador seletivo dos receptores de estrogênio (SERM), sendo muito utilizado no tratamento contra o câncer de mama. A quercetina tem particularmente despertado interesse, principalmente por sua ação antioxidante a qual supostamente poderia vir a minimizar os danos causados pelo tamoxifeno. Devido à falta de estudos sobre a coadministração da quercetina com o tamoxifeno e a ambiguidade sobre a ação de ambos no cérebro, o objetivo deste estudo foi elucidar o efeito sobre a atividade colinérgica e defesa antioxidante. No estudo, ratas ovariectomizadas foram separadas em grupos e tratadas com tamoxifeno (5 mg.Kg-1), quercetina (22,5 mg.Kg-1) e a coadministração de tamoxifeno (5 mg.Kg-1) mais quercetina (22,5 mg.Kg-1). O hipocampo foi isolado e utilizado para a determinação da atividade da acetilcolinesterase, butirilcolinesterase da superóxido dismutase e catalase e dos marcadores de dano oxidativo (lipoperoxidação e dosagem de grupamentos tióis). Foi possível observar a ação oxidante do tamoxifeno no hipocampo, onde agiu como antagonista nos receptores de estrogênio, aumentando a lipoperoxidação, os níveis de tióis e diminuindo a atividade da catalase; além de um efeito colinérgico com a diminuição da atividade da acetilcolinesterase e butirilcolinesterase. Quando coadministrada a quercetina com o tamoxifeno, pode-se observar que em uma situação de estresse oxidativo, a quercetina age como pró-oxidante na dose estudada.

Puisque le cancer du sein reste l'une des premières causes de mortalité chez la femme, le diagnostic et le traitement de cette maladie ont plus que jamais besoin d'être améliorés. L'intérêt des composés organométalliques robustes, ciblant le récepteur des œstrogènes, est qu'on peut moduler leurs applications en fonction du métal introduit. Pour la première fois, une entité organométallique stable et lipophilique, le groupement ferrocénique, a été substituée à la chaîne-clé aminée du squelette triphényléthylénique de l'antiœstrogène hydroxytamoxifène, tenue pour être responsable de l'activité du médicament. La chaîne amine des ferrocifènes a également été remplacée par une fonction acide carboxylique. Différentes variations structurelles ont été explorées, afin d'optimiser les propriétés biologiques de ces composés ferrocéniques, qui peuvent être cytotoxiques. Cependant certains de ces composés ont non seulement une activité antiproliférative, mais peuvent aussi servir de précurseurs stables pour la synthèse de radiopharmaceutiques. Il est en effet possible de remplacer le Fer par le Rhénium ou le Technétium suivant la réaction d'échange de ligands, qui est chimiosélective. Les composés organométalliques résultants peuvent être de bons agents ciblés pour la radiothérapie (188Re) ou pour l'imagerie médicale (99mTc). Finalement, afin d'améliorer leur biodisponibilité, deux composés ferrocéniques ont été incorporés dans deux types de nanovecteurs : les nanosphères et les nanocapsules. Leur petite taille et la libération tardive des principes actifs, associés à une activité apoptotique exacerbée sont en accord avec une persistance accrue dans la circulation sanguine, et une activité anticancéreuse prometteuse.

"Are the Letters of Horace Satires?" (Hendrickson 1897: 313). In response to this question, this thesis investigates whether Horace's Sermones and Epistulae 1 all belong to the genre of satura. Ancient and modern evidence from the use of the terms Sermones, Epistulae, and satura, is surveyed, and is found to be inconclusive, but not to preclude Epist. 1 as satura. The nature of specifically Horatian satura is ascertained from the text of Serm. 1, especially Serm. 1.1 and the explicitly literary Serm. 1.4 and 1.10. The redefinition of Lucilian satura, and its political implications are also considered. To confirm Epist. 1 as satura a sequential reading of the three libelli is undertaken, tracing the evolution of the theme of locus: place, both as geographical location, and as status, place in the social hierarchy, in the context of the socio-political environment of the time of composition. Serm. 1.1 as a programmatic poem is shown to establish Epicurean moderation as a prerequisite for a vita beata. In Serm. 1 Horace's status as client-poet of Maecenas and Octavian initially permits this ideal lifestyle in the Urbs. The misperceptions of outsiders lead to a preference for a life of Epicurean quietude in the rus in Serm. 2, although Horace's aequanimitas is disturbed by urban officia, and abuse of libertas dicendi associated particularly with Stoicism. The ideal of rural withdrawal is reinforced in Epist. 1 through an exploration of appropriate behaviour in relationships with potentes amici. Horace's addressees cover the entire range of the social hierarchy, and in his letters he utilizes the arguments of moral philosophy, thus reconciling poetry and philosophy. He achieves a pragmatic compromise whereby he can enjoy libertas in his role as a poet, while acknowledging that personal libertas and true aequanimitas are still to be attained.

Skeletal fragility is characterized by low bone mass, negative changes in bone microarchitecture, and compromised tissue matrix properties, including accumulation of microdamage. Microdamage accumulates in vivo from daily physiological loading and is targeted for repair through a normal remodeling process, thus preventing microcrack growth and potential fracture. However, impaired remodeling is associated with aging and osteoporosis, resulting in an increased accumulation of microdamage which contributes to reduced bone mechanical properties. The current clinical method for assessing increased risk of fracture involves measuring bone mineral density (BMD) of the hip and spine, locations of trabecular bone where high rates of remodeling occur. The bisphosphonate alendronate (ALN) reduces clinical risk for fracture by significantly increasing BMD, but studies have shown a concomitant reduction in intrinsic properties that may be the underlying cause for recent reports of spontaneous fractures with long-term alendronate use. Another anti-resorptive agent called raloxifene (RAL) is a selective estrogen receptor modulator (SERM) and has been shown to modestly improve BMD while decreasing fracture risk to a similar degree as alendronate. The combination of RAL and ALN as a treatment for osteoporosis may provide the benefits of each drug without the negative effects of ALN. Therefore, the overall goal of this thesis was to address the effects of aging and anti-resorptive agents on the properties of bone through the formation of microdamage. Assessment of age-related effects on bone was conducted through quantification of microdamage progression. It was found that old bone results in greater incidences of microdamage progression, reflecting a compromised tissue matrix with reduced resistance to crack growth. Effects of combination treatment with RAL and ALN were evaluated through biomechanical testing, micro-CT imaging, and microdamage quantification. Results showed improved trabecular bone volume and ultimate load with positive effects on trabecular architecture. Combination treatment reduced the proportion of microdamage that may lead to catastrophic fracture, indicating an improvement in the local tissue matrix properties.

Submitted by SBI Biblioteca Digital (sbi.bibliotecadigital@puc-campinas.edu.br) on 2017-06-28T14:15:34Z No. of bitstreams: 1 MAIARA RUBIA MIGUEL.pdf: 1427408 bytes, checksum: 61a34cc9b9b1c406fb22ca38bbfb9af8 (MD5) / Made available in DSpace on 2017-06-28T14:15:34Z (GMT). No. of bitstreams: 1 MAIARA RUBIA MIGUEL.pdf: 1427408 bytes, checksum: 61a34cc9b9b1c406fb22ca38bbfb9af8 (MD5) Previous issue date: 2016-09-12 / Pontif?cia Universidade Cat?lica de Campinas ? PUC Campinas / This study aims to analyze the influences that a religious model has on a religious community, stablishing a correlation between Max Scheler?s conception of religious model, ethical progress and religious experience with the bible text Sermon on Mount, specially, the Antitheses (Mt 5, 17-48) and the Lord?s Prayer ritual orientation. With this purpose, in this study is made a research to identify the religious model from Matthew?s community to understand the powerful influence to the construction of the meanings in the social world of this community. This study was possible approaching Max Scheler?s phenomenological works to contextualize the religious model, religious experience and ethical progress concepts. As well as, it was necessary to go deep in historical, social and exegetical aspects from Matthew?s bible text. It was necessary to enable the correlation method associated to the Matthew?s bible text phenomenological analyses to apply Scheler?s horizon to the bible reality, to answer what is the relation between a religious model and religious experience in the community from the Matthew?s bible text. / O presente trabalho tem o prop?sito de analisar as for?as de influ?ncia que o modelo religioso exerce em uma comunidade religiosa. Isso se fundamenta a partir da correla??o estabelecida entre a conceitua??o de modelo religioso, progresso ?tico e experi?ncia religiosa ao mundo social apreendido do texto b?blico o Serm?o da Montanha. A an?lise ter? como objeto a releitura do texto o Serm?o da Montanha, localizado no Evangelho de Mateus, em espec?fico, as Ant?teses (Mt 5.17-48) e a orienta??o ritual?stica do Pai-Nosso (Mt 6.5-15), ? luz do pensamento de Max Scheler. Partindo desse prop?sito, busca-se identificar o modelo religioso da comunidade mateana e compreender a for?a de influ?ncia desse modelo nos significados do mundo social dessa comunidade. O arcabou?o conceitual foi constru?do tendo como base obras do per?odo fenomenol?gico de Max Scheler para contextualiza??o dos conceitos de modelo religioso, progresso ?tico e experi?ncia religiosa. Foi necess?ria a constru??o de uma abordagem cr?tica dos aspectos hist?ricos, sociais e exeg?ticos da per?cope mateana. Por isso, foi poss?vel, a partir do m?todo da correla??o associado ? an?lise fenomenol?gica do Evangelho de Mateus, aplicar o horizonte conceitual scheleriano ? realidade dos vers?culos b?blicos, a fim de responder qual a rela??o entre modelo religioso e experi?ncia religiosa da comunidade mateana.

Hierarchical Bayesian Models and Matrix factorization methods provide an unsupervised way to learn latent components of data from the grouped or sequence data. For example, in document data, latent component corn-responds to topic with each topic as a distribution over a note vocabulary of words. For many applications, there exist sparse relationships between the domain entities and the latent components of the data. Traditional approaches for topic modelling do not take into account these sparsity considerations. Modelling these sparse relationships helps in extracting relevant information leading to improvements in topic accuracy and scalable solution. In our thesis, we explore these sparsity relationships for di errant applications such as text segmentation, topical analysis and entity resolution in dyadic data through the Bayesian and Matrix tri-factorization approaches, propos-in scalable solutions. In our rest work, we address the problem of segmentation of a collection of sequence data such as documents using probabilistic models. Existing state-of-the-art Hierarchical Bayesian Models are connected to the notion of Complete Exchangeability or Markov Exchangeability. Bayesian Nonpareil-metric Models based on the notion of Markov Exchangeability such as HDP-HMM and Sticky HDP-HMM, allow very restricted permutations of latent variables in grouped data (topics in documents), which in turn lead to com-mutational challenges for inference. At the other extreme, models based on Complete Exchangeability such as HDP allow arbitrary permutations within each group or document, and inference is significantly more tractable as a result, but segmentation is not meaningful using such models. To over-come these problems, we explored a new notion of exchangeability called Block Exchangeability that lies between Markov Exchangeability and Com-plate Exchangeability for which segmentation is meaningful, but inference is computationally less expensive than both Markov and Complete Exchange-ability. Parametrically, Block Exchangeability contains sparser number of transition parameters, linear in number of states compared to the quadratic order for Markov Exchangeability that is still less than that for Complete Exchangeability and for which parameters are on the order of the number of documents. For this, we propose a nonparametric Block Exchangeable model (BEM) based on the new notion of Block Exchangeability, which we have shown to be a superclass of Complete Exchangeability and subclass of Markov Exchangeability. We propose a scalable inference algorithm for BEM to infer the topics for words and segment boundaries associated with topics for a document using the collapsed Gibbs Sampling procedure. Empirical results show that BEM outperforms state-of-the-art nonparametric models in terms of scalability and generalization ability and shows nearly the same segmentation quality on News dataset, Product review dataset and on a Synthetic dataset. Interestingly, we can tune the scalability by varying the block size through a parameter in our model for a small trade-o with segmentation quality. In addition to exploring the association between documents and words, we also explore the sparse relationships for dyadic data, where associations between one pair of domain entities such as (documents, words) and as-associations between another pair such as (documents, users) are completely observed. We motivate the analysis of such dyadic data introducing an additional discrete dimension, which we call topics, and explore sparse relation-ships between the domain entities and the topic, such as of user-topic and document-topic respectively. In our second work, for this problem of sparse topical analysis of dyadic data, we propose a formulation using sparse matrix tri-factorization. This formulation requires sparsity constraints, not only on the individual factor matrices, but also on the product of two of the factors. To the best of our knowledge, this problem of sparse matrix tri-factorization has not been stud-ide before. We propose a solution that introduces a surrogate for the product of factors and enforces sparsity on this surrogate as well as on the individual factors through L1-regularization. The resulting optimization problem is e - cogently solvable in an alternating minimization framework over sub-problems involving individual factors using the well-known FISTA algorithm. For the sub-problems that are constrained, we use a projected variant of the FISTA algorithm. We also show that our formulation leads to independent sub-problems towards solving a factor matrix, thereby supporting parallel implementation leading to a scalable solution. We perform experiments over bibliographic and product review data to show that the proposed framework based on sparse tri-factorization formulation results in better generalization ability and factorization accuracy compared to baselines that use sparse bi-factorization. Even though the second work performs sparse topical analysis for dyadic data, ending sparse topical associations for the users, the user references with di errant names could belong to the same entity and those with same names could belong to different entities. The problem of entity resolution is widely studied in the research community, where the goal is to identify real users associated with the user references in the documents. Finally, we focus on the problem of entity resolution in dyadic data, where associations between one pair of domain entities such as documents-words and associations between another pair such as documents-users are ob.-served, an example of which includes bibliographic data. In our nil work, for this problem of entity resolution in bibliographic data, we propose a Bayesian nonparametric `Sparse entity resolution model' (SERM) exploring the sparse relationships between the grouped data involving grouping of the documents, and the topics/author entities in the group. Further, we also exploit the sparseness between an author entity and the associated author aliases. Grouping of the documents is achieved with the stick breaking prior for the Dirichlet processes (DP). To achieve sparseness, we propose a solution that introduces separate Indian Bu et process (IBP) priors over topics and the author entities for the groups and k-NN mechanism for selecting author aliases for the author entities. We propose a scalable inference for SERM by appropriately combining partially collapsed Gibbs sampling scheme in Focussed topic model (FTM), the inference scheme used for parametric IBP prior and the k-NN mechanism. We perform experiments over bibliographic datasets, Cite seer and Rexa, to show that the proposed SERM model imp-proves the accuracy of entity resolution by ending relevant author entities through modelling sparse relationships and is scalable, when compared to the state-of-the-art baseline