This dissertation aimed to explore the usefulness of using force derivatives for onset detection in the isometric mid-thigh pull test. First, we examined applications of three differential calculus principles, first and second derivative, and curvature using visual detection as a reference under different baseline conditions. Second, we compared the best derivative method to a threshold-based method using visual detection as a reference. Results of our first investigation showed trivial differences between many differential calculus methods and visual detection. However, statistical differences exceeding a trivial effect was observed when instantaneous force and rate of force develop were examined. Through the first investigation, first and second derivative emerged as possible viable methods for baseline with a countermovement and for all other baseline conditions, respectively. Results of the second investigation showed similarities to the first investigation with respect to onset time. However, examination of instantaneous force and rate of force development indicated that a threshold-based method tended to overestimate compared to visual detection and a first and second derivative combined method. In fact, the difference between visual detection and the first and second derivative combined method ranged from trivial to moderate under all baseline conditions while the threshold-based method often reached a large difference. Overestimation by the threshold-method was more pronounced for rate of force development. In conclusion, while not perfect, the first and second derivative 3 combined method appears to hold possible practical potential and may be used as an assistant method for entry-level sport scientist plus using visual detection for obvious erroneous values.

Immersive technologies, including augmented reality (AR) and virtual reality (VR), are envisioned to become ubiquitous in future work environments. The implementation of both technologies is associated with versatile benefits, such as decreased costs, reduced physical risks, increased employee self-satisfaction, and lower resource consumption. Despite these potential benefits, the organizational diffusion of immersive technologies faces myriad challenges. For instance, usability problems along with privacy concerns have introduced technology acceptance issues. Addressing these challenges, this cumulative dissertation explores the design, application, and implications of AR and VR systems in the workplace by employing a mixed-methods approach. The contribution of this research is threefold. First, this dissertation provides descriptive insights into user preferences for immersive technologies to inform user-centered design considerations. Second, this dissertation presents design principles to guide the development of four information technology artifacts. Two of these artifacts enable VR-based collaboration in the fields of design thinking and process modeling, while the remaining two artifacts leverage AR to facilitate the crowdsourcing of human intelligence tasks and to support students in distance learning settings. Third, this dissertation develops an e³-value model for the AR and VR business ecosystem to illustrate how technology providers can transform such artifacts into economic value. Taken together, these insights improve understanding the sociotechnical interplay between humans, tasks, and immersive technologies, as well as its economic implications.

In our qualitative master thesis, we explore theories on sustainability in levels, ranging from very weak to very strong. We integrate academic theories with corporate perspectives to provide representatives in the corporate world with an alternative way of conversing and engaging mainly in strong sustainability. The purpose of this paper is to contribute to a richer understanding of what corporate sustainability can be in practice. Our study is a collaboration with business leaders, designers, sustainability professionals and students. Using Design Science Research as an overarching framework for our method, we conducted interviews, focus groups and a survey. The academic theories and the insights from our data were then translated into a visual and verbal co-creation of an artefact (as it is called in Design Science Research). Wording and visualisations are inspired both from the corporate and the academic world. The artefact is intended to be a conversation starter which is hoped to lead to a shift in the strength with which companies work with sustainability, guided by an ecological case for business.

This thesis focuses on the adaptation of formal education to people’s technology- use patterns, theirtechnology-in-practice, where the ubiquitous use of mobile technologies is central. The research question is: How can language learning practices occuring in informal learning environments be effectively integrated with formal education through the use of mobile technology? The study investigates the technical, pedagogical, social and cultural challenges involved in a design science approach. The thesis consists of four studies. The first study systematises MALL (mobile-assisted language learning) research. The second investigates Swedish and Chinese students’ attitudes towards the use of mobile technology in education. The third examines students’ use of technology in an online language course, with a specific focus on their learning practices in informal learning contexts and their understanding of how this use guides their learning. Based on the findings, a specifically designed MALL application was built and used in two courses. Study four analyses the app use in terms of students’ perceived level of self-regulation and structuration. The studies show that technology itself plays a very important role in reshaping peoples’ attitudes and that new learning methods are coconstructed in a sociotechnical system. Technology’s influence on student practices is equally strong across borders. Students’ established technologies-in-practice guide the ways they approach learning. Hence, designing effective online distance education involves three interrelated elements: technology, information, and social arrangements. This thesis contributes to mobile learning research by offering empirically and theoretically grounded insights that shift the focus from technology design to design of information systems.

This thesis is framed within the research area of Information and Communication Technologies for Development (ICT4D), which is concerned with how ICT can make a difference to the lives of the poor. This study focuses primarily on mobile phones and how they can be used as part of an Agriculture Market Information Service (AMIS) in order to provide crucial information to farmers in Bangladesh. AMIS principally collect, manage and disseminate agricultural market prices and related information through various processes and media. These services are mainly used by farmers. The research question of how mobile phone-based AMIS can be designed and deployed in order to improve opportunities for farmers in Bangladesh is investigated through a design science research approach in four steps; understanding the scope and challenges related to AMIS in least developed countries; diagnosing the situational realities of farmers of Bangladesh; understanding the process of adopting mobile phones and investigating market information practices and preferences in a rural context; and finally designing and implementing a mobile phone based AMIS and evaluating the efficiency and effectiveness of it for the farmers of Bangladesh. In this thesis, development is viewed in terms of bringing about an in-crease in farmers’ capability set directed towards the utilization of resources for the purpose of production and trade. Information and knowledge are important drivers of development and poverty reduction: ICT can create new opportunities to expand the availability, exchange, and impact of information and knowledge. This thesis contributes to ICT4D research and practice through empirical findings, the design of an AMIS, test results, and the development of analytical tools. Its major contributions include an increased understanding of farmers’ attitudes and preferences towards the use of technology in general, and mobile phones in particular, and a broader understanding of ICT for human development in the context of poor rural regions. / Informatics or ICT4D

Mobile technologies are emerging as one way to help address health challenges in many countries, including in Least Developed Countries. Mobile technology can reach a large share of the population but in order to provide effective support to healthcare services, technology, information collection and dissemination, and work processes need to be well aligned. The thesis uses a design science methodological approach and mixes qualitative and quantitative data analysis to address the question of, How can mobile technologies be effectively integrated with routine healthcare services? The study concerns the design, implementation, and evaluation of a mobile technology-based system, called SMSaúde, with the aim of improving the care of patients with HIV/AIDS and tuberculosis in Mozambique. The work started with the elicitation of functional and user requirements, based on focus group discussions. An important challenge, as in many mHealth interventions, was the integration with routine healthcare services and the existing IT systems, as well as developing a scalable technical structure. The system has now been in routine use since 2013 in more than 16 healthcare clinics in Mozambique. Evaluation was done by a randomised controlled study. Analysis of patient records showed that retention in care in urban areas was significantly higher in the intervention group than in the control group. In a user study both patients and health professionals were very positive to the system. The thesis contributes to research by demonstrating how information system artefacts can be constructed and successfully implemented in resource-constrained settings. The practical contributions include the designed artefact itself as well as improved healthcare practices and mHealth policy recommendations.

There are long-standing hypotheses that endogenous ion currents act to control cell dynamics in development, wound healing and regeneration. However, the mechanisms employed by cells to detect the electric field (EF) and translate it into a discernable message to drive specific cell behaviors, such as migration, proliferation and differentiation, are not well understood. A better understanding of how cells are able to sense EFs and react to them is vital to understanding physiological mechanisms are involved in regeneration. Ion channel signaling provides a reasonable suspect for mediating these effects based on their documented involvement in proliferation, migration and differentiation. To investigate mechanisms underlying ionic regulation of critical cellular processes in non-excitable cells, a novel, in vivo assay was developed to screen multiple pharmacological inhibitors of ion channels during larval A. mexicanum tail regeneration. This assay was used to identify individual channels that were then targeted for further analysis regarding their involvement in the regenerative process. Chapter 2 presents data from a study that indicates that a wound-like response can be generated in an invertebrate model by application of exogenous, low-amplitude sine-wave electrical stimulation. This was characterized by recruitment of hemocytes at the stimulation site which was dependent on voltage-gated potassium channels. Chapter 3 presents data from a comprehensive and systematic screen of pharmacological compounds against larval salamander tail regeneration that indicates 8 specific target ion channels. This chapter also describes results indicating specific mechanisms by which these channels may be perturbing regeneration. Chapter 4 presents data that indicate that the Anoctamin 1 channel identified in the aforementioned screen is a regulator of cellular proliferation. This is shown to be accomplished via amplification of intracellular calcium surges and a subsequent increase in the activity of the p44/42 MAPK signaling cascade.

Social science is in crisis. The task of social science is to study “man in situation”: to understand the world as it is for “man”. This thesis charges that this crisis consists in a failure to properly address the philosophical anthropological question “What is man?”. The various social scientific methodologies who have as their object “man” suffer rampant disagreements because they presuppose, rather than consider, what is meant by “man”. It is our intention to show that the root of the crisis is that social science can provide no formal definition of “man”. In order to understand this we propose a phenomenological analysis into the essence of social science. This phenomenological approach will give us reason to abandon the (sexist) word “man” and instead we will speak of wer: the beings which we are. That we have not used the more usual “human being” (or some equivalent) is due to the human prejudice which is one of the major constituents of this crisis we seek to analyse. This thesis is divided into two Parts: normative and evaluative. In the normative Part we will seek a clarification of both “phenomenology” and “social science”. Due to the various ways in which “phenomenology” has been invented we must secure a simipliciter definition of phenomenology as an approach to philosophical anthropology (Chapter 2). Importantly, we will show how the key instigators of the branches of phenomenology, Husserl, Scheler, Heidegger, and Sartre, were all engaged in this task. To clarify our phenomenology we will define the Phenomenological Movement according to various strictures by drawing on the work of Schutz and his notion of provinces of meaning (Chapter 3). This will then be carried forward to show how Schutz’s postulates of social science (with certain clarifications) constitute the eidetic structure of social science (Chapter 4). The eidetic structures of social science identified will prompt several challenges that will be addressed in the evaluative Part. Here we engage in an imperial argument to sort proper science from pseudo-science. The first challenge is the mistaken assumption that universities and democratic states make science possible (Chapter 5). Contra this, we argue that science is predicated on “spare time” and that much institutional “science” is not in fact science. The second challenge is the “humanist challenge”: there is no such thing as nonpractical knowledge (Chapter 6). Dealing with this will require a reconsideration of the epistemic status that science has and lead to the claim of epistemic inferiority. Having cut away pseudo-science we will be able to focus on the “social” of social science through a consideration of intersubjectivity (Chapter 7). Drawing on the above phenomenologists we will focus on how an Other is recognised as Other. Emphasising Sartre’s radical re-conception of “subject” and “object” we will argue that there can be no formal criteria for how this recognition occurs. By consequence we must begin to move away from the assumption of one life-world to various life-worlds, each constituted by different conceptions of wer.

Hypoxia inducible factors (HIFs) are transcription factors and the master regulators of oxygen-dependent gene expression in animals. The focus of this thesis is the distribution of HIF protein in tissues of the fish Fundulus heteroclitus and F. grandis, two widespread species that occur in naturally hypoxic waters. Polyclonal antibodies against HIF-1α, HIF-2α, and HIF-3α were tested on proteins made in vitro and on extracts made from several tissues of normoxic and hypoxic fish. Antibodies against HIF-1α and 3α bound specifically to full length protein made in vitro, and produced bands on western blots of nuclear extracts of near the expected molecular weights for these proteins. Hypoxic exposure did not markedly increase the intensity of these bands, and mass spectrometry failed to identify HIF-1α and 3α peptides in excised gel bands. Thus, further tests of antibody specificity are needed before the tissue distribution of HIF in these fish can be confidently assessed.

Digital analytics kallas den samling teknologier som med olika teknikeranalyserar digitala kanaler (webbsidor, email och även offline data) för attsöka förståelse för kunders beteenden och intentioner. Digital Analytics harblivit en mycket viktig komponent till en stor del webbaserade systemmiljöer,där den stödjer och underlättar affärer och beslutsfattande för organisationer.Men hur väl tillämpas dessa teknologier och hur ser den digitalatransformationen ut som utspelar sig inom organisationer, och hur kan manmäta denna digitala mognadsprocess?Denna studie tillämpar en Design Science Research-approach för att uppfyllamålet om att utveckla en Digital Analytics Maturity Model (DAMM) lämpligför små till medelstora företag, varav en expertpanel bestående av 6 st ledandeforskare inom mognadsforskning och Digital Analytic är tillsatt i formen av enDelphi-undersökning. Resultaten från studien visar bl.a att organisatoriskaaspekter spelar en viktig roll för Digital Analytics samt att utvecklingen av enfunktionsduglig DAMM som är redo att tas i burk är möjligt.