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Développement et évaluation de comprimés enrobés à sec, à base d'amylose substitué, pour la libération contrôlée de médicamentsWang,Hongwei January 2006 (has links)
Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.
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Veríssimo passando Érico a limpo : espelhos e biblioteca em Solo de clarineta /Santos, Davi Siqueira. January 2015 (has links)
Orientador: Antonio Roberto Esteves / Banca: Maria Eunice Moreira / Banca: Miguel Zioli / Banca: Luiz Roberto Velloso Cairo / Banca: Cátia Inês Negrão Berlini de Andrade / Resumo: Érico Veríssimo legou à biblioteca da literatura brasileira uma obra ficcional copiosa. Contudo, o fecho de sua contribuição encontra-se no campo do memorialismo, com o livro, em dois volumes, Solo de clarineta. Poderíamos chamá-lo de um fecho imperfeito, uma vez que a morte, energicamente, interrompeu seu intento de seguir escrevendo, com a sua prolixidade peculiar, acerca dos fatos vividos. Frente a esse quadro, objetivando elaborar uma tese propositiva, subdividimos nossa abordagem em três partes. A primeira reúne o "álbum de família" e o "álbum de viagem", procurando fazer um sobrevoo que conjugue algumas das recordações de Érico sobre sua vida na companhia de pessoas e lugares. A segunda concentra-se em sua biblioteca, orquestrando leituras de formação, de confirmação e contribuições do próprio escritor às estantes da literatura brasileira. A terceira e última parte procura estabelecer uma comparação entre os escritos de memória e os escritos de ficção, para isso, por meio da metáfora do espelho, aproxima ao limite o que se encontra separado em definitivo pela película de vidro refletora, que podemos chamar de discurso da arte. Por meio dessa divisão em três partes, procuraremos promover um movimento de emparedamento do memorialista no romancista. Desse modo, nossa discussão se encaminha para a defesa do argumento de que, ao final de sua carreira, Veríssimo se transforma, via memorialismo, em personagem de si mesmo, procurando com isso lhe proporcionar uma imortalidade, via literatura, que a sua própria constituição biológica só lhe poderia negar / Abstract: Érico Veríssimo gave to the brazilian literature library a large fictional work. However his last contribution is a book of memories in two volumes named Solo de clarineta. We could consider it as an imperfect end because his death, that was not the author's desire, is responsible for interrupting the active of the writer. Faced with this situation, aiming to develop a propositional theory, we subdivided our approach in three parts. The first gathers the "family album" and the "travel album", trying to make an overflight that gets together some recordation of Érico about his life in the company of people and places. The second part focuses on the library of the author, with his readings of formations, his readings of confirmations and his own contributions in the bookcase of Brazilian literature. The third and last part tries to establish a comparison between the memory written and the fictional written. For this, using the mirror's metaphor, this thesis will try to approach things that are apart, that are separated by a reflective glass film, which we can call art speech. Through this division in three parts, the thesis tries to do a movement of tying the memorialist in the novelist. This way, our discussion sustain the argument that, in the end of his career, Veríssimo wanted to be transformed in a character of himself, trying with this to get the immortality, by literature, condition that his biological constitution couldn't provide / Doutor
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Silêncio, sensações e segredos : o narrador e a personagem feminina no romance O lustre (1946), de Clarice Lispector /Santos Júnior, Moisés Gonçalves. January 2015 (has links)
Orientadora: Cleide Antonia Rapucci / Banca: Ana Maria Carlos / Banca: Betina Ribeiro Rodrigues da Cunha / Resumo: Este projeto de pesquisa tem por premissa maior realizar uma análise do segundo romance de Clarice Lispector, O lustre, publicado em 1946 e considerado pela crítica literária e as pesquisas acadêmicas, até o momento, como uma das obras "menores" da escritora. O estudo analisa a construção do narrador e da personagem principal Virgínia, articulados como as categorias narrativas de maior expressividade e ruptura dentro da história. A pesquisa também objetiva evidenciar as marcas de estéticas vanguardistas e modernas, sobretudo do Impressionismo, que reverberam na escritura de Lispector nesse livro. Todo esse percurso investigativo visa firmar O lustre como obra de grande qualidade estético-literária, desmistificando a opinião crítica sobre a menor relevância dessa narrativa, consolidando-o, deste modo, como um dos primeiros romances em que Clarice Lispector conseguiu com maestria transgredir e ampliar os horizontes da prosa brasileira do século XX / Abstract: This project has as its main purpose to analyze Clarice Lispector's second novel, O lustre, published in 1946 and currently considered by literary criticism one of her minor works. The study analyze mainly the development of the narrator and the main character Virginia, as the most expressive categories in the novel, as well as categories of disruption. The research has also the purpose of highlighting the avant-garde and modern aesthetics, especially of Impressionism, which reverberate in Lispector's writing this book. The whole investigation has the purpose of establishing O lustre as a work of great aesthetic and literary quality, demystifying the critical position which defends the little relevance of the book. In fact, in this book Lispector was able to transgress radically Brazilian prose in the 20th century / Mestre
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The Effect of Shifting Cases from District Courts to Administrative Proceedings at the Securities and Exchange CommissionGrobecker, Reeve 01 January 2019 (has links)
Using a set of 4708 observations, we analyze the impact of Dodd-Frank on shifting cases from federal courts to administrative courts. Overall, we find that there is a higher probability of a case being an administrative proceeding post Dodd-Frank. In addition, we find a higher average total payment for administrative proceedings post Dodd-Frank, and a lower average total payment for federal court cases post Dodd-Frank. We also find a higher average disgorgement payment for administrative proceedings post Dodd-Frank. While this finding could be the result of the SEC shifting more complex and thus higher paying cases from federal courts to its own, we find that the SEC is not shifting cases strictly away from federal courts that have the highest average payments. Higher average disgorgement payments are simply the result of the SEC litigating more cases with higher average payments in general. Lastly, we find a higher probability of settling for administrative proceedings overall. However, settlement rates for administrative proceedings decrease post Dodd-Frank. This finding reflects an overall decrease in the SEC’s “home court” advantage and undermines the argument that the SEC is shifting weaker cases to its own courts.
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U.S. GAAP Convergence to IFRS and the Risk Implications Involved in ConvergenceSalzman, Benjamin J. 01 January 2011 (has links)
The purpose of this thesis is to examine in depth the process of U.S. GAAP convergence to IFRS. The thesis begins by providing the history of convergence, which include all the measures that have led to the FASB’s and IASB efforts today. Some specific accounting issues that the FASB and IASB are working on in their joint projects to eliminate the differences are explored. The issues that the FASB and IASB need to cover in order to complete their efforts laid out in the Memorandum of Understanding, and even possibly adopting IFRS, are covered next. The risk implications if the United States were to adopt IFRS as it stands today are examined. There are numerous short-term risks if the U.S. adopts IFRS immediately, many of which include increased expenses for companies and more room for managerial manipulation of earnings. After disclosing the short-term risks, the long-term benefits of adopting IFRS, which include decreased costs from consolidation and increased comparability for users of financial statements, are highlighted. The thesis then covers the opinions submitted to the SEC about convergence or endorsement of IFRS. The conclusion includes interviews of three Deloitte professionals on their opinions of convergence, and my views based on my research.
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Estudio de los cambios morfológicos del epitelio corneal en un modelo animal de ojo secoJulio Morán, Gemma 05 July 2006 (has links)
En esta tesis doctoral se ha analizado morfológica y morfométricamente el deterioro que sufre el epitelio corneal de conejo cuando se impide el parpadeo del animal mediante la inserción de un blefarostado.Para ello, se han procesado digitalmente las imágenes de 33 córneas, obtenidas bajo técnicas de microscopía electrónica. Dicho procesado, realizado con el programa de software libre Image J, ha permitido obtener una serie de variables que cuantifican las características celulares, tanto en el epitelio control como en los sometidos al modelo de ojo seco. Posteriormente, se ha realizado un análisis estadístico de los datos.Los resultados obtenidos muestran que el epitelio control aparece como un mosaico celular continuo con diferentes tonos de gris, formas y tamaños. Asociando las variables área y forma celular se pueden discriminar tres tipos celulares. De este modo, las células del epitelio control son en su mayoría células pequeñas, de forma poligonal, tono de gris intermedio-claro y con una elevada densidad de microproyecciones. También aparecen células grandes de forma más circular, tonos más oscuros y densidad de microproyecciones algo menor. La gama de células catalogadas como de tamaño mediano presentan una caracterización más difícil puesto que sus rasgos morfológicos son semejantes tanto a las células grandes como a las pequeñas. A pesar de ello la forma de estas células medianas muestra una marcada tendencia a la pseudopoligonalidad.Cabe señalar también que las células del epitelio sano muestran una clara uniformidad en las uniones intercelulares que aparecen, en su inmensa mayoría, intactas y en la densidad de las microproyecciones que es alta o muy alta en todas las células. Estas dos características son indispensables para una correcta funcionalidad del tejido.Por su parte, los resultados del análisis de las córneas sometidas a diferentes periodos de falta de parpadeo muestran como el deterioro epitelial se inicia entre una y dos horas después de insertar los blefarostatos. Este deterioro se caracteriza, principalmente, por dos alteraciones. Una de ellas es la pérdida progresiva de las uniones intercelulares y la otra es la disminución de la densidad de las microproyecciones. En concreto, las células grandes son las que pierden más precozmente las microproyecciones pero, por el contrario, son las que mantienen mejor la adherencia con sus vecinas. Además, las células presentan, en general, un ligero aumento de tamaño, tendencia hacia la circularidad y uniformidad de los tonos celulares.Gracias a los modelos estadísticos predictivos se han podido establecer, también, las características típicas de cada periodo de privación de parpadeo y el nivel de deterioro en el que se encuentra una córnea determinada.En consecuencia, con esta tesis doctoral se ha desarrollado un criterio cuantitativo que, de forma global, analiza el estado del epitelio corneal. Esta es una herramienta básica para el análisis comparativo de la acción de las lágrimas artificiales de la que, hasta ahora, no se disponía. / To evaluate the changes on the corneal epithelium asociated with a evaporative dry eye model.METHODS. Thirty-tree eyes of 17 New Zealand white rabbits were held open with an eye specula for differents periods of time (12 minutes - 3 hours and 15 minutes). Corneal damage was evaluated by scanning electron microscopy and the digital images were processed for morphometric information with free software program Image J. Finally the data were analyzed statistically with SPSS for Windows.RESULTS. There was significantly changes on epithelium from more than 1 hour without blinking compared with the undessicated eyes. The main features of damage were loss of microvilli density (mean ± sd on the control corneal surface was 48.35 ± 7.25 opposite 34.12 ± 16.74 after more than 1 hour) (p<0.01) and break of intercellular junctions (mean ± sd on the control corneal surface was 0.94 ± 0.11 opposite 0.78 ± 0.3 after more than 1 hour) (p<0.01). Moreover the cells underwent a small but significant (p<0.01) increase in their area and circularity and the cells electron reflex showed a slight but significant (p<0.01) tendency to get darker.By means of logistic regression we were able to predict the degrees of the corneal damage process and we found that the loss of microvilli was earlier than break of intercellular junctions.CONCLUSIONS. The morphometric and statistical analysis of the gradual damage that this dry eye model cause in the corneal epithelium has allowed us to establish an objective and useful method for comparing commercially available artifical tear preparations.
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DI-SEC: Distributed Security Framework for Heterogeneous Wireless Sensor NetworksValero, Marco 16 April 2012 (has links)
Wireless Sensor Networks (WSNs) are deployed for monitoring in a range of critical domains (e.g., health care, military, critical infrastructure). Accordingly, these WSNs should be resilient to attacks. The current approach to defending against malicious threats is to develop and deploy a specific defense mechanism for a specific attack. However, the problem with this traditional approach to defending sensor networks is that the solution for one attack (i.e., Jamming attack) does not defend against other attacks (e.g., Sybil and Selective Forwarding). This work addresses the challenges with the traditional approach to securing sensor networks and presents a comprehensive framework, Di-Sec, that can defend against all known and forthcoming attacks. At the heart of Di-Sec lies the monitoring core (M-Core), which is an extensible and lightweight layer that gathers information and statistics relevant for creating defense modules. Along with Di-Sec, a new user-friendly domain-specific language was developed, the M-Core Control Language (MCL). Using the MCL, a user can implement new defense mechanisms without the overhead of learning the details of the underlying software architecture (i.e., TinyOS, Di-Sec). Hence, the MCL expedites the development of sensor defense mechanisms by significantly simplifying the coding process for developers. The Di-Sec framework has been implemented and tested on real sensors to evaluate its feasibility and performance. Our evaluation shows that Di-Sec is feasible on today’s resource-limited sensors and has a nominal overhead. Furthermore, we illustrate the functionality of Di-Sec by implementing four detection and defense mechanisms for attacks at various layers of the communication stack.
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Credit rating agencies and conflicts of interestCrumley, Diana G. 21 August 2012 (has links)
Credit rating agencies are controversial yet influential financial gatekeepers. Many have attributed the recent failures of credit rating agencies to conflicts of interest, such as the agencies’ issuer-pays business model and the agencies’ provision of ancillary services. This report identifies these conflicts; examines recently-finalized Security and Exchange Commission (SEC) regulations proscribing these conflicts; and suggests other possible regulatory measures. The strategies available to regulators are diverse and differ widely in their political and administrative feasibility. These strategies include outright prohibition of conflicts; removing regulatory references to credit ratings; enhancing agency liability; organizational firewalls; performance disclosures; demonstrating due diligence and its results; increasing competition; staleness reforms; internal governance; administrative registration; and requiring alternative business models. While the report primarily focuses on how the most recent financial crisis—and the related market for asset-backed securities—highlighted conflicts of interest at credit rating agencies, this report also examines how credit ratings—and their limitations—affect sovereign debt markets. / text
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Onetti: a escritura como universo autoreferenteReales de Ruas, Liliana January 1997 (has links)
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão / Made available in DSpace on 2012-10-17T00:44:33Z (GMT). No. of bitstreams: 0Bitstream added on 2016-01-08T22:22:19Z : No. of bitstreams: 1
108867.pdf: 2910797 bytes, checksum: e7fcb80c44bda9e359248b8447b89ef1 (MD5) / A narrativa de Juan Carlos Onetti constitui um importante momento, nas letras contemporâneas, de interiorização no mundo ficcional. Trata-se de um universo solipsista onde a escritura se sustenta da própria escritura, expondo a sua retórica constitutiva. Este trabalho mostra como na sistemática exposição do ritual da escritura e na auto-referencialidade da obra, está implícita uma reflexão teórica sobre a 1iteratura e sobre a condição do homem como um ser que se define pela sua lingüisticidade. Analisa o romance Dejemos hablar al viento, lido na sua instância de reflexão sobre a linguagem e a linguagem da ficçao. Os diferentes aspectos analisados tentam mostrar a dialética da produção em Onetti, que persegue a realização artística da idéia de que a distância que separa a palavra da coisa se tornou um espaço incomensurável de virtualidade discursiva, onde naufraga a experiência humana.
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Ruínas de um tempo/templo, ou sobrevivências de Dario Vellozo na literatura do presenteMoreira, Caio Ricardo Bona January 2011 (has links)
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2011 / Made available in DSpace on 2012-10-26T01:10:14Z (GMT). No. of bitstreams: 0Bitstream added on 2013-07-16T20:43:59Z : No. of bitstreams: 1
295021.pdf: 5709089 bytes, checksum: 8e01e7ca54b20327de23fb807f3ea1f4 (MD5) / Este trabalho teve por objetivo desenvolver uma leitura da sobrevivência da poética simbolista na poesia do presente, tendo como base o poeta Dario Vellozo. Pretendemos ler a sua poesia colocando-a em rede, tirando-a da província, e demonstrando que a performance literária de Dario na belle époque curitibana não está distante de movimentos como o dos patafísicos e acephálicos. Os gestos de Dario, ao fomentar uma poesia simbolista mística, ao construir o Templo das Musas e ao criar festividades pagãs em que se travestia de grego e desfilava com seus seguidores pela cidade, não são meramente provincianos, já que estão atravessados pela leitura de simbolistas e decadentistas franceses e pelo surto do misticismo que invade a Europa no século XIX. A partir do cruzamento de tempos e textos do final do século XIX, do início do século XX, e de poemas contemporâneos, bem como da leitura de teóricos como Walter Benjamin, Aby Warburg e Didi-Huberman, observamos como alguns poetas do presente desenvolvem um diálogo inteligente com o simbolismo, revitalizando-o, e dele extraindo uma força capaz de potencializar a sua própria produção. / This work aims to develop an interpretation of the symbolist poetry survival in the contemporary poetry, having as basis the poet Dario Vellozo. We intend to read his poetry putting it in relation, taking it out from the province, and showing that the literary performance of Dario in the belle époque of Curitiba it is not so distant from the movements such as the pataphysics and acephalics. The gestures of Dario, feeding a mystic symbolist poetry, building the Muse Temple (#Templo das Musas#) and creating pagan festivities in which he dressed up like a Greek and marched with his followers through the city, are not provincial acts, since these acts are marked by the reading of French symbolists and decadents and by the outbreak of mysticism that invaded Europe in the nineteenth century. From the correlation of times and texts of late nineteenth century, earlier twentieth century with contemporary poems, as well as the reading of scholars such as Walter Benjamin, Aby Warburg and Didi-Huberman, I intend to investigate how poets like Paulo Leminski, Ricardo Corona, among others, develop a clever dialog with the symbolism, reviving it, and extracting from it a strength capable of leverage its own creation.
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