Abstract Traumatic brain injury can be a catastrophe for an individual and a huge economic burden for a society. Such injuries are common especially among young men and as many as half of the patients are under the influence of alcohol at the time of injury. Traumatic brain injuries can also frequently cause epileptic seizures. On the other hand, epileptic seizures are often caused by alcohol. A significant reduction in the tax on alcohol in Finland in 2004 led to a 10% increase in its consumption at the population level and a considerable increase in mortality rate among patients with alcoholic liver diseases. The risk of subsequent epileptic seizures and traumatic brain injuries among intoxicated head trauma subjects has not been evaluated before. The present cohort consists of all subjects who were admitted to the emergency room at Oulu University Hospital in 1999 on account of head trauma. These subjects were then followed-up for 10 years, which enabled the effect of the tax reduction on the long-term outcome to be observed. The effect of being under the influence of alcohol at the time of the index head trauma on the onset of a new epileptic seizure problem and further traumatic brain injuries was investigated. The mortality rate among head trauma subjects with harmful drinking increased significantly after the reduction in the alcohol tax, and the subjects with recorded alcohol-related seizure problems experienced an increased risk of death after the price reduction. Head trauma under the influence of alcohol predicted both new-onset seizure problems and traumatic brain injury during the follow-up. The results are in accordance with the previous observations of a rapid increase in mortality among heavy drinkers following a sharp reduction in alcohol prices. Inebriated head trauma subjects have an increased risk of subsequent traumatic brain injury and epileptic seizure. / Tiivistelmä Traumaattinen aivovamma voi olla potilaalle katastrofi ja yhteiskunnalle valtava taloudellinen tappio. Aivovammat ovat yleisiä erityisesti nuorilla miehillä, ja jopa puolet niistä tapahtuu alkoholin vaikutuksen alaisena. Aivovammat aiheuttavat usein epileptisiä kohtauksia, jotka toisaalta usein johtuvat alkoholista. Vuonna 2004 Suomessa tapahtunut mittava alkoholiveron alennus lisäsi väestötasolla alkoholin kokonaiskulutusta 10 % vuoden aikana. Kuolleisuus erityisesti alkoholimaksasairauksiin lisääntyi voimakkaasti. Aiemmin ei ole tiedetty humalassa ilmaantuneen pään vamman vaikutuksesta potilaan riskiin saada uusi aivovamma tai uusi epileptinen kohtaus. Tutkimuskohortin muodostivat vuonna 1999 Oulun yliopistollisen sairaalan päivystyksessä hoidetut päähän vammautuneet potilaat. Heitä seurattiin rekisteritietojen avulla vuoden 2009 loppuun, minkä ansiosta voitiin tutkia veronalennuksen vaikutusta potilaiden pitkäaikaisennusteeseen. Tutkimuksessa havainnoitiin humalassa tapahtuneen pään vamman vaikutusta epileptisen kohtauksen ja uuden aivovamman ilmaantumiseen seuranta-aikana. Haitallisesti alkoholia käyttävien päähän vammautuneiden potilaiden kuolleisuus lisääntyi merkitsevästi alkoholiveron alennuksen jälkeen. Myös alkoholiin liittyvän epileptisen kouristuksen sairastaneilla kuolleisuus lisääntyi merkitsevästi. Alkoholin vaikutuksen alaisena tapahtunut pään vamma oli riskitekijä uudelle epileptiselle kohtaukselle sekä uudelle aivovammalle seuranta-aikana. Tulokset vahvistavat aiempia havaintoja siitä, että alkoholin hinnan voimakas lasku lisää nopeasti alkoholin suurkuluttajien kuolleisuutta. Humalassa päätään loukanneella on lisääntynyt riski saada uusi aivovamma sekä uusi epileptinen kohtaus.

Before 1994 criminal procedure was subject to the sovereignty of Parliament and the untrammelled law enforcement powers of the executive which resulted in the authoritarian and oppressive criminal justice system of the apartheid era. The Constitution, Act 108 of 1996 has since created a democratic state based on the values of the supremacy of the Constitution and the rule of law. The basic principles of criminal procedure are now constitutionalised in the Bill of Rights. The Bill of Rights protects the fundamental rights of individuals when they come into contact with organs of the state which includes the police. The Criminal Procedure Act 51 of 1977 authorises the police to search for and to seize articles, and has long provided the only legal basis for obtaining warrants to search for and to seize articles and for performing such actions without a warrant in certain circumstances. Generally the standard for these measures and actions taken under their purview has been one of reasonableness. Since the birth of the Constitution there has been additional constraints on search and seizure powers. Not only are there now constitutionalised standards by which such legal powers are to be measured, but there is also the possibility of excluding evidence obtained in course of a violation of a constitutional right. The provisions of the Criminal Procedure Act are now qualified by the Constitution. Where feasible a system of prior judicial authorisation in the form of a valid search warrant obtained on sworn information establishing reasonable grounds is a precondition for a valid search or seizure. Search and seizure without a warrant is permitted only in exceptional circumstances such as an immediate threat to person or property. By prohibiting unreasonable searches and seizures the Constitution places important limits on police efforts to detect and investigate crime. The Constitution appreciates the need for legitimate law enforcement activity. / Criminal and Procedural Law / LL.M.

The main purpose of this project is to investigate different tool steels in terms of their ability to withstand material transfer buildup, so-called galling, occurring in SMF (sheet metal forming) operations. The ability to withstand galling is vital to optimize cost-effectiveness and increase the work tool’s effective operational time. This investigation studies four different tool steels, including a TiN-coating, with the intention of evaluating the microstructures, chemical composition and hardness effect on galling resistance in dry conditions using a slider-on-flatsurface (SOFS) tribo-tester which measures the coefficient of friction during sliding. An OP (optical profilometer) was used to measure the size and geometry of lump growth on the tool and damage on the work sheet. A scanning electron microscope (SEM) was used to identify the interacting tribological mechanisms exhibited at different stages during the slide. The SEM figures confirmed three different types of characteristic patterns exhibited in the tracks after tribo- testing which were categorized as mild adhesive, abrasive and severe adhesive damage. A SEM figure that illustrates a ragged contact surface and an obvious change in the sheet materials plastic behavior is in this report regarded as a sign of severe adhesive contact, the characteristics could possibly be explained by local high temperature and high pressure followed by a sudden pressure drop and creation of hardened welds or solders between the two surfaces which increase the frictional input needed for further advancement. Friction coefficients observed in the initial 100% mild adhesive stage were, μ=0,22-0,26 succeeded by abrasive SEM characteristics often in association with mild adhesive contact and friction values between μ=0,25-0,4 which where sometimes followed by severe adhesive SEM characteristics in 100% of the contact zone with friction values between μ=0,34- 0,9 respectively. The tool material that performed best according to the friction detection criteria was Sv21 closely followed by Sleipner (TiN coated) and Va40 (HRC 63.3). Unfortunately was the friction criteria, a significant raise in friction for defining a sliding length to galling, not adequate for dry conditions due to immediate material transfer succeeded by cyclic changes between partial or 100% abrasive+mild adhesive and severe adhesive contact. The mechanism that change abrasive wear in association with mild adhesive contact, (moderate friction input), to sever adhesive wear, (higher friction input), is dependent on lump shape (lump geometry) and can appear at comparably low speeds 0,04-0,08 [m/s] and low friction energy input (μ=0,34), the magnitude of the change in friction is therefore not always significant and hardly detectable on the friction graph. This was quite unexpected but could be explained by concentration of friction energy rater than the absolute amount. The problem with using friction graphs for galling evaluation was increased even further when a very small lump size and low corresponding rate of material transfer to the tool surface caused a sustainable high raise in friction (μ≈0,3→0,6) on a TiN-coated tool steel called Sleipner. A hardly detectable or similar friction raise for Sv21 and Va40 showed much larger corresponding lump size and rate of material transfer. This means that friction graphs demonstrate a clear problem with quantifying lump size [m3] and rate of  material transfer [m3/s]. Another phenomenon called stick slip behavior, material transfer and lump growth followed by a sudden decrease in lump size and transfer of material back to the work sheet, is also not possible to detect on a friction graph. Because a drop in friction can easily be a change in contact temperature and lump attack angle due to a growing lump and not a decreasing lump.   The conclusion, a friction graph is not suited for galling evaluation and ranking in dry SOFS conditions. A ranking should primarily be based on dimensional OP measurements of the cross section of formed tracks and scratches or preferably by repeated OP measurements of the tool surface during a single test, the last revel the exact lump growth history and true lump growth even in the sliding direction. / civilingenjörsexamen

Le co-transporteur KCC2 spécifique au potassium et chlore a pour rôle principal de réduire la concentration intracellulaire de chlore, entraînant l’hyperpolarisation des courants GABAergic l’autorisant ainsi à devenir inhibiteur dans le cerveau mature. De plus, il est aussi impliqué dans le développement des synapses excitatrices, nommées aussi les épines dendritiques. Le but de notre projet est d’étudier l’effet des modifications concernant l'expression et la fonction de KCC2 dans le cortex du cerveau en développement dans un contexte de convulsions précoces. Les convulsions fébriles affectent environ 5% des enfants, et ce dès la première année de vie. Les enfants atteints de convulsions fébriles prolongées et atypiques sont plus susceptibles à développer l’épilepsie. De plus, la présence d’une malformation cérébrale prédispose au développement de convulsions fébriles atypiques, et d’épilepsie du lobe temporal. Ceci suggère que ces pathologies néonatales peuvent altérer le développement des circuits neuronaux irréversiblement. Cependant, les mécanismes qui sous-tendent ces effets ne sont pas encore compris. Nous avons pour but de comprendre l'impact des altérations de KCC2 sur la survenue des convulsions et dans la formation des épines dendritiques. Nous avons étudié KCC2 dans un modèle animal de convulsions précédemment validé, qui combine une lésion corticale à P1 (premier jour de vie postnatale), suivie d'une convulsion induite par hyperthermie à P10 (nommés rats LHS). À la suite de ces insultes, 86% des rats mâles LHS développent l’épilepsie à l’âge adulte, au même titre que des troubles d’apprentissage. À P20, ces animaux presentent une augmentation de l'expression de KCC2 associée à une hyperpolarisation du potentiel de réversion de GABA. De plus, nous avons observé des réductions dans la taille des épines dendritiques et l'amplitude des courants post-synaptiques excitateurs miniatures, ainsi qu’un déficit de mémoire spatial, et ce avant le développement des convulsions spontanées. Dans le but de rétablir les déficits observés chez les rats LHS, nous avons alors réalisé un knock-down de KCC2 par shARN spécifique par électroporation in utero. Nos résultats ont montré une diminution de la susceptibilité aux convulsions due à la lésion corticale, ainsi qu'une restauration de la taille des épines. Ainsi, l’augmentation de KCC2 à la suite d'une convulsion précoce, augmente la susceptibilité aux convulsions modifiant la morphologie des épines dendritiques, probable facteur contribuant à l’atrophie de l’hippocampe et l’occurrence des déficits cognitifs. Le deuxième objectif a été d'inspecter l’effet de la surexpression précoce de KCC2 dans le développement des épines dendritiques de l’hippocampe. Nous avons ainsi surexprimé KCC2 aussi bien in vitro dans des cultures organotypiques d’hippocampe, qu' in vivo par électroporation in utero. À l'inverse des résultats publiés dans le cortex, nous avons observé une diminution de la densité d’épines dendritiques et une augmentation de la taille des épines. Afin de confirmer la spécificité du rôle de KCC2 face à la région néocorticale étudiée, nous avons surexprimé KCC2 dans le cortex par électroporation in utero. Cette manipulation a eu pour conséquences d’augmenter la densité et la longueur des épines synaptiques de l’arbre dendritique des cellules glutamatergiques. En conséquent, ces résultats ont démontré pour la première fois, que les modifications de l’expression de KCC2 sont spécifiques à la région affectée. Ceci souligne les obstacles auxquels nous faisons face dans le développement de thérapie adéquat pour l’épilepsie ayant pour but de moduler l’expression de KCC2 de façon spécifique. / The potassium-chloride cotransporter KCC2 decreases intracellular Cl- levels and renders GABA responses inhibitory. In addition, it has also been shown to modulate excitatory synapse development. In this project, we investigated how alterations of KCC2 expression levels affect these two key processes in cortical structures of a normal and/or epileptic developing brain. First, we demonstrate that KCC2 expression is altered by early-life febrile status epilepticus. Febrile seizures affect about 5% of children during the first year of life. Atypical febrile seizures, particularly febrile status epilepticus, correlate with a higher risk of developing cognitive deficits and temporal lobe epilepsy as adults, suggesting that they may permanently change the developmental trajectory of neuronal circuits. In fact, the presence of a cerebral malformation predisposes to the development of atypical febrile seizures and temporal lobe epilepsy. The mechanisms underlying these effects are not clear. Here, we investigated the functional impact of this alteration on subsequent synapse formation and seizure susceptibility. We analyzed KCC2 expression and spine density in the hippocampus of a well-established rodent model of atypical febrile seizures, combining a cortical freeze lesion at post-natal day 1 (P1) and hyperthermia-induced seizure at P10 (LHS rats). 86% of these LHS males develop epilepsy and learning and memory deficits in adulthood. At P20, we found a precocious increase in KCC2 protein levels, accompanied by a negative shift of the reversal potential of GABA (EGABA) by gramicidin-perforated patch. In parallel, we observed a reduction in dendritic spine size by DiI labelling and a reduction of miniature excitatory postsynaptic current (mEPSC) amplitude in CA1 pyramidal neurons, as well as impaired spatial memory. To investigate whether the premature expression of KCC2 played a role in these alterations in the LHS model, and on seizure susceptibility, we reduced KCC2 expression in CA1 pyramidal neurons by in utero electroporation of shRNA using a triple-probe electrode. This approach lead to reduced febrile seizure susceptibility, and rescued spine size shrinkage in LHS rats. Our results show that an increase of KCC2 levels induced by early-life insults affect seizure susceptibility and spine development and may be a contributing factor to the occurrence of hippocampal atrophy and associated cognitive deficits in LHS rats. Second, we investigated whether KCC2 premature overexpression plays a role in spine alterations in the hippocampus. We overexpressed KCC2 in hippocampal organotypic cultures by biolistic transfection and in vivo by in utero electroporation. In contrast to what was previously published, we observed that both manipulations lead to a decrease in spine density in the hippocampus, as well as an increase in spine head size in vivo. In fact, it has been previously shown that overexpressing KCC2 leads to an increase of spine density in the cortex in vivo. To prove that this discrepancy is due to brain regional differences, we overexpressed KCC2 in the cortex by in utero electroporation, and similarly found an increase in spine density and length. Altogether, our results demonstrate for the first time, that alterations of KCC2 expression are brain circuit-specific. These findings highlights the obstacles we will face to find adequate pharmacological treatment to specifically modulate KCC2 in a region-specific and time-sensitive manner in epilepsy.

Eine wichtige Folge des Status epilepticus ist die Entwicklung einer chronischen Epilepsie. Die genauen Mechanismen und die Kinetik der Epileptogenese sind weitestgehend unklar. Ziel der vorliegenden Arbeit war ein besseres Verständnis des Prozesses durch die In-vitro-Analyse von Lokalisation und Kinetik funktioneller Folgen des Status epilepticus in vivo. In kombinierten Hippokampus-entorhinaler Kortex Hirnschnittpräparaten von Wistar-Ratten nach elektrisch induziertem selbsterhaltendem Status epilepticus (self-sustaining status epilepticus, SSSE) wurden im Niedrig-Magnesium-Modell anfallsartige Ereignisse (AE) ausgelöst und untersucht. Die In-vitro-Analyse der AE wurde eine, vier und acht Wochen nach SSSE durchgeführt. Um das räumliche Verhalten der epileptischen Aktivität beurteilen zu können, wurde die Messung des extrazellulären Feldpotenzials mit der Analyse intrinsischer optischer Signale kombiniert. Im Verlauf nach SSSE kam es zu einer Latenzverkürzung bis zum Auftreten epileptischer Aktivität und zu einer Zunahme der AE-Frequenz. Vier und acht Wochen nach SSSE stieg der Anteil der AE mit großflächigem Ursprung signifikant an. Im Verlauf nach SSSE wurden außerdem zunehmend diskontinuierliche Ausbreitungsmuster der Anfallsaktivität beobachtet. Acht Wochen nach SSSE zeigten 50% der Präparate zudem eine zeitlich und räumlich von den AE unabhängige, hochfrequente Aktivität im Gyrus dentatus. Zusammenfassend wurden eine Latenzverkürzung und eine Zunahme der AE-Frequenz als Hinweise für eine gesteigerte Exzitabilität des Hirngewebes nach SSSE gesehen. Neben dem großflächigen Ursprung deutet auch die Zunahme diskontinuierlicher Ausbreitungsmuster auf eine gesteigerte Synchronizität des neuronalen Netzwerkes nach SSSE hin. Die autonome Aktivität im Gyrus dentatus spricht dafür, dass die in vorangegangenen Studien beschriebenen strukturellen Änderungen in dieser Region mit einer veränderten Funktionalität einhergehen. / The development of chronic epilepsy is a serious consequence of Status epilepticus. Little is known about the mechanisms and kinetic of the epileptogenic process. The aim of this md-thesis was the analysis of localisation and kinetic of functional deficits in vitro after Status epilepticus in vivo. Using the Low-Magnesium-Model, seizure-like events (SLE) were induced in combined hippocampal-entorhinal cortex slices of wistar rats after electrically induced self-sustaining Status epilepticus (SSSE). One, four and eight weeks after SSSE the in-vitro-analysis of SLE was performed. In order to determine onset and spread-pattern of epileptic activity, the measurement of the extracellular field-potential was combined with the imaging of intrinsic optical signals (IOS). In the time course after SSSE there was a reduction of the latency to onset of seizure activity and an increase of the SLE-frequency. Four and eight weeks after SSSE a significant increase of SLE with regional onset was found. In Addition, there was an increase of non-contiguous propagation of seizure activity. Eight weeks after SSSE 50% of the brain-slices showed autonomous high-frequent activity in the dentate gyrus. In conclusion a reduction of the latency to onset of seizure activity and an increase of the SLE-frequency were found. These changes are indicators of increased excitability after SSSE. Other than the regional onset, the non-contiguous spread-pattern also indicates increased synchronicity of the neuronal network after SSSE. The autonomous activity in the dentate Gyrus shows, that the previously described structural changes in this region lead to functional deficits.

Made available in DSpace on 2016-08-10T10:46:45Z (GMT). No. of bitstreams: 1 LAZARO ALVES MARTINS JUNIOR.pdf: 977344 bytes, checksum: a62a188f9b3cb28c468092d2e9472547 (MD5) Previous issue date: 2011-12-20 / The present study aims to analyze the institution of diplomatic immunity procedural matters and the elements that give them footstool, confronting him with the interpretation that leads to its partial exemption for labor law formed in the primeval bodies in the field of enforcement actions against foreign states with local representatives. Boasting the Foreign States sovereignty and therefore valid legislation in their domestic sphere that extends to the territories requiring compliance with diplomatic immunities to the right of diverse country, perquire is the reason for the immunity from enforcement of foreign States, which maintain with retaining legal and logical to see repealed by idiosyncratic understanding within the Labour Court, one of the segments of national jurisdiction, moving away from the literal interpretation of national legislation in force in relations, forgetting the rules of classical hermeneutics, as well as and especially ignoring the laws of those sovereign countries that has not violating fundamental human rights domestically and internationally. It is considered that the Judiciary, under pressure from the defense will be negative adjudication, advancing into the field reserved for the legislative branch that shows silent for reasons of political nature, printing the current understanding wife who defends post-positivist activism justice to the phenomenon of judicialization of social issues. It appears that the understanding implemented by labor justice of first instance and the core of this study empirically equivalent to a placebo and no treatment generates isonomic court plan among workers in violation of his rights by their employers as uniquely allows the attachment of assets will not affect activities diplomatic, legal entities of the external public, not extending this understanding to processes that involve national federal entities bearing the same status before the absolute inalienability and immunity from seizure of their property of any kind. Analysis and construction of the study is based on the literature and case law, having as a basis for inafastabilidade theory of state sovereignty and the consequent effect of its legal system while consistent with the fundamental precepts of acceptance supra. The conclusion is not appropriate to assert depart without sufficient legal basis, implementing the immunity of foreign States constitutionally elect their property as inalienable in our country when the federal entities enjoy the same privilege, the Legislature should implement regramento law that allows the recruited worker in our country by foreign States see themselves adequately compensated for, but without violating the sovereignty emanating from the independent state through its political structures, because this attack compromises the essential harmonization of diplomatic relations in today's globalized times and the usurpation of powers promotes hate among the leading powers to undue interference by the judiciary and growing in the field of legislation, contributing to the weakening of the parliament and conflicts that are causing the fading ideal legal and democratic foundation magnum stamped on national and political activism to foster ideology that favors the current panorama. / O presente estudo tem como objetivo analisar o instituto da imunidade diplomática no âmbito processual e os elementos que lhes dá supedâneo, confrontando-o com a interpretação que leva a sua parcial derrogação pela jurisprudência trabalhista formada nas instâncias primevas no campo das ações de execução contra os estados estrangeiros com representações locais. Gozando os Estados Estrangeiros de soberania e, portanto, de legislação válida em seu âmbito interno que se estende aos territórios diplomáticos exigindo a observância às imunidades perante o direito de país diverso, perquire-se o motivo da imunidade de execução dos Estados Estrangeiros, que mantêm-se com arrimo legal e lógico, se ver derrogada por entendimento idiossincrático no âmbito da Justiça Trabalhista, um dos segmentos da jurisdição nacional, se afastando da interpretação literal da legislação vigente nas relações nacionais, olvidando das regras de hermenêutica clássicas, bem como e sobretudo ignorando a legislação soberana daqueles países que não se apresenta violadora dos direitos humanos fundamentais no plano interno ou internacional. Considera-se que o Poder Judiciário, sob a pressão de lhe ser defesa a negativa da prestação jurisdicional, avança sobre campo reservado ao Poder Legislativo que se mostra omisso por razões de cunho político, imprimindo entendimento que esposa corrente pós-positivista que defende o ativismo judicial diante do fenômeno da judicialização das questões sociais. Constata-se que o entendimento implementado pela justiça laboral de primeiras instâncias e cerne deste estudo equivale empiricamente a um placebo e gera tratamento não isonômico no plano judicial entre trabalhadores prejudicados em seus direitos pelos respectivos empregadores quando permite excepcionalmente a penhora de bens não afetos as atividades diplomáticas, pessoas jurídicas de direito público externo, não estendendo este entendimento aos processos que envolvem entes federativos nacionais que ostentam a mesma natureza jurídica diante da inalienabilidade e impenhorabilidade absoluta de seus bens de qualquer espécie. A análise e construção do estudo fundamenta-se na pesquisa bibliográfica e jurisprudencial, tendo como teoria de base a inafastabilidade da soberania dos Estados e consequente vigência de seu ordenamento jurídico quando em consonância com os preceitos fundamentais de aceitação supranacional. Conclui-se não se asseverar pertinente derrogar, sem base legal suficiente, a imunidade de execução dos Estados Estrangeiros que elegem constitucionalmente seus bens como inalienáveis, quando em nosso país os entes federativos gozam do mesmo privilégio, devendo o Poder Legislativo implementar regramento legal que permita ao trabalhador recrutado em nosso país por Estados Estrangeiros ver-se indenizado por forma adequada, mas, sem violar a soberania que emana do Estado independente através de sua estruturação política, pois, esta agressão compromete a imprescindível harmonização das relações diplomáticas nos tempos globalizados hodiernos e fomenta a usurpação de competências provocando cizânia entre os Poderes com a indevida e crescente ingerência do Judiciário no campo legislativo, contribuindo para o enfraquecimento do parlamento e provocando conflitos que fazem esmorecer o ideal jurídico e democrático estampado no alicerce magno nacional e fomentam o ativismo político com ideologia que se favorece com o atual panorama.

<p>The main purpose of this project is to investigate different tool steels in terms of their ability to withstand material transfer buildup, so-called galling, occurring in SMF (sheet metal forming) operations. The ability to withstand galling is vital to optimize cost-effectiveness and increase the work tool’s effective operational time. This investigation studies four different tool steels, including a TiN-coating, with the intention of evaluating the microstructures, chemical composition and hardness effect on galling resistance in dry conditions using a slider-on-flatsurface (SOFS) tribo-tester which measures the coefficient of friction during sliding.</p><p>An OP (optical profilometer) was used to measure the size and geometry of lump growth on the tool and damage on the work sheet. A scanning electron microscope (SEM) was used to identify the interacting tribological mechanisms exhibited at different stages during the slide. The SEM figures confirmed three different types of characteristic patterns exhibited in the tracks after tribo- testing which were categorized as mild adhesive, abrasive and severe adhesive damage.</p><p>A SEM figure that illustrates a ragged contact surface and an obvious change in the sheet materials plastic behavior is in this report regarded as a sign of severe adhesive contact, the characteristics could possibly be explained by local high temperature and high pressure followed by a sudden pressure drop and creation of hardened welds or solders between the two surfaces which increase the frictional input needed for further advancement. Friction coefficients observed in the initial 100% mild adhesive stage were, μ=0,22-0,26 succeeded by abrasive SEM characteristics often in association with mild adhesive contact and friction values between μ=0,25-0,4 which where sometimes followed by severe adhesive SEM characteristics in 100% of the contact zone with friction values between μ=0,34- 0,9 respectively. The tool material that performed best according to the friction detection criteria was Sv21 closely followed by Sleipner (TiN coated) and Va40 (HRC 63.3). Unfortunately was the friction criteria, a significant raise in friction for defining a sliding length to galling, not adequate for dry conditions due to immediate material transfer succeeded by cyclic changes between partial or 100% abrasive+mild adhesive and severe adhesive contact. The mechanism that change abrasive wear in association with mild adhesive contact, (moderate friction input), to sever adhesive wear, (higher friction input), is dependent on lump shape (lump geometry) and can appear at comparably low speeds 0,04-0,08 [m/s] and low friction energy input (μ=0,34), the magnitude of the change in friction is therefore not always significant and hardly detectable on the friction graph. This was quite unexpected but could be explained by concentration of friction energy rater than the absolute amount. The problem with using friction graphs for galling evaluation was increased even further when a very small lump size and low corresponding rate of material transfer to the tool surface caused a sustainable high raise in friction (μ≈0,3→0,6) on a TiN-coated tool steel called Sleipner.</p><p>A hardly detectable or similar friction raise for Sv21 and Va40 showed much larger corresponding lump size and rate of material transfer. This means that friction graphs demonstrate a clear problem with quantifying lump size [m3] and rate of  material transfer [m3/s]. Another phenomenon called stick slip behavior, material transfer and lump growth followed by a sudden decrease in lump size and transfer of material back to the work sheet, is also not possible to detect on a friction graph. Because a drop in friction can easily be a change in contact temperature and lump attack angle due to a growing lump and not a decreasing lump.</p><p> </p><p>The conclusion, a friction graph is not suited for galling evaluation and ranking in dry SOFS conditions. A ranking should primarily be based on dimensional OP measurements of the cross section of formed tracks and scratches or preferably by repeated OP measurements of the tool surface during a single test, the last revel the exact lump growth history and true lump growth even in the sliding direction.</p><p> </p> / civilingenjörsexamen

Before 1994 criminal procedure was subject to the sovereignty of Parliament and the untrammelled law enforcement powers of the executive which resulted in the authoritarian and oppressive criminal justice system of the apartheid era. The Constitution, Act 108 of 1996 has since created a democratic state based on the values of the supremacy of the Constitution and the rule of law. The basic principles of criminal procedure are now constitutionalised in the Bill of Rights. The Bill of Rights protects the fundamental rights of individuals when they come into contact with organs of the state which includes the police. The Criminal Procedure Act 51 of 1977 authorises the police to search for and to seize articles, and has long provided the only legal basis for obtaining warrants to search for and to seize articles and for performing such actions without a warrant in certain circumstances. Generally the standard for these measures and actions taken under their purview has been one of reasonableness. Since the birth of the Constitution there has been additional constraints on search and seizure powers. Not only are there now constitutionalised standards by which such legal powers are to be measured, but there is also the possibility of excluding evidence obtained in course of a violation of a constitutional right. The provisions of the Criminal Procedure Act are now qualified by the Constitution. Where feasible a system of prior judicial authorisation in the form of a valid search warrant obtained on sworn information establishing reasonable grounds is a precondition for a valid search or seizure. Search and seizure without a warrant is permitted only in exceptional circumstances such as an immediate threat to person or property. By prohibiting unreasonable searches and seizures the Constitution places important limits on police efforts to detect and investigate crime. The Constitution appreciates the need for legitimate law enforcement activity. / Criminal and Procedural Law / LL.M.

Crime has been around since the beginning of time. In an evolving society, and the methodology of crime also changes. The methodology of combating and preventing crime should aim to match the speed at which crime occurs. Criminal procedure deals with the powers of the police to investigate crimes.1 The Criminal Procedure Act 51 of 1977 (CPA) contains the principles of search and seizure in chapter 2. The promulgation of the CPA was during a period where the computer was a new phenomenon. At this time, it was inconceivable that technology would ever advance and become so ubiquitous, to the point that technology would infiltrate every aspect of our lives, and laws. There has since been many developments in our law, especially a new Constitutional dispensation.2 There have been developments and technological advancements that have had a direct and indirect bearing on the CPA. People use technology to communicate, transact, and unfortunately, to commit crime. These developments require there to be amendments in the CPA. There has been no specific amendments relating to search and seizure which are of significance in addressing technological advances. It is recommended that the amendments to the CPA include definitions and guidelines for procedural aspects of collection of electronic evidence. / Criminal and Procedural Law / LL. M. (Criminal and Procedural Law)

Diplomová práce Abstract: Operation "VK" and its process in Želiv Monastery from the perspective of Náboženská matice. Master's thesis presents the fate of Želiv Monastery in 1950s caused by operation code named "VK" (monasteries deportation). Operation's purpose was to terminally prevent formation of economical and above all, cultural influence of Roman Catholic Church in recently founded Socialist country. According to unmapped documents from Náboženská matice's archive which is currently placed in National Archive in Prague, I would like to present means in which the communist regime handled monastery property, belongings and people which were interned as prisoners in the monastery. The goal of this thesis is to present profound consequences of monastery abolition using Church archive with roots of legal personality going back to reign of Joseph II. Keywords: Operation "VK", Želiv Monastery, Náboženská matice, Communism, Roman Catholic Church, Internment, Property seizure, "Church Six" Communist Party Central Committee