African American women (AAW) are at a high risk for type 2 diabetes, a debilitating and potentially fatal disease for which there is no cure. The purpose of this study was to extend the research of Mosca et al. (2012) by examining the relationship between caregiver status and self-reported health status for AAW 18 years or older diagnosed with type 2 diabetes. The chronic care model (CCM) provided the theoretical framework for this study. The CCM promoted routine care for patients with chronic illnesses to migrate from acute care to proactive, planned, and risk-based protocols. A binomial logistic regression investigated the relationship between caregiver status, categorized as paid or unpaid, and self-reported health status, which was dichotomized as either good to excellent health or poor to fair health. There was a statistically significant relationship between primary caregiver status and self-reported health status among AAW diagnosed with Type 2 diabetes after controlling for age, education, and marital status (p < .004). Based on the fitted binomial logistic regression model, there were 186 cases of AAW with type 2 diabetes; having a paid caregiver was associated with a lower odds of having good to excellent health (OR = 0.294). About 12.3% of the variance in self-report health status was attributable to caregiver status. Overall, 82.6% of predictions were accurate. Nearly all participants required frequent assistance from a caregiver in the preceding 12 months. These findings suggest a critical need for healthcare service providers to educate caregivers as a means to deliver post-acute care to AAW diagnosed with type 2 diabetes, consistent with the CCM.

Hintergrund: Schwindel ist ein häufig vorgetragenes Symptom beim Hausarzt. Seine erhöhte Vergesellschaftung mit Ängstlichkeit und Depressivität ist aber bisher zu wenig untersucht worden, ebenso wenig ist dieser Zusammenhang Gegenstand der hausärztlichen Behandlung von Schwindelpatienten. Zielstellung: Kommen unbekannte psychische Hintergründe in Kombination mit Schwindel im hausärztlichen Patientengut häufiger vor als ohne Schwindel? Ergeben sich daraus als Konsequenz unterschiedliche Versorgungsformen durch den Hausarzt? Wie verhält es sich mit deren subjektiven Gesundheitszustand, dem Erfolg der hausärztlichen Behandlung, dem ihnen entgegengebrachten Verständnis und der Häufigkeit der Arztbesuche der Betroffenen? Studiendesign: Prospektive Multicenterstudie in der Allgemeinpraxis Untersuchungsregion: Zehn Hausarztpraxen in Halle a.d. Saale und Nordsachsen/ Leipzig im städtischen und ländlichen Einzugsbereich, welche von Fachärzten für Allgemeinmedizin geführt wurden. Methodik: Die Studie untersuchte insgesamt 590 zufällig am Untersuchungstag eintreffende Patienten in jeweils einer von insgesamt zehn Hausarztpraxen. Die Ausprägung von Schwindelbeschwerden und eventuell vorhandene Merkmale von Ängstlichkeit und Depressivität beim jeweiligen Patienten wurden mit Elementen des Gießener Beschwerdebogens 24 und der Hospital Anxiety and Depression Scale (deutsche Version) untersucht. Ergebnisse: Die Patienten wurden in eine Gruppe mit relevanten (29,7%, n=175) und in eine Gruppe ohne relevante Schwindelbeschwerden (70,3%, n=408) eingeteilt (Cut off >=8 nach GBB 24). Die Gruppe mit relevantem Schwindel wies häufiger Merkmale für Ängstlichkeit (p<0,001) und Depressivität (p<0,001) in allen Altersgruppen auf, zeigte sich unzufriedener mit ihrem Behandlungserfolg (p=0,004), schätzte ihren aktuellen Gesundheitszustand schlechter ein (p<0,001) und konsultierte ihren Hausarzt in den letzten zwölf Monaten häufiger (p=0,020). Sie stellten sich nach ICPC-2 häufiger wegen neurologischer (p<0,001), psychologischer (p=0,026) und unspezifischer Beschwerden (p<0,001) vor. Sie erhielten mehr Diagnosen aus den ICD-10-Kapitel V (Psychische und Verhaltensstörungen) (p=0,030). Diese Patienten waren nach HADS-D auch häufiger psychisch auffällig (p<0,001). Relevanter Schwindel kam bei Frauen aller Altersgruppen häufiger vor als bei Männern (p<0,001). Dennoch ergaben sich keine Behandlungsunterschiede durch die Hausärzte zwischen beiden Gruppen (p=0,101 bis 0,930 je nach ärztlicher Maßnahme). Schlussfolgerung: Schwindelpatienten weisen häufger Ängstlichkeit und Depressivität auf, welche den Schwindel unterhalten. Dieser Zusammenhang sollte in der Sprechstunde bedacht werden. Die psychischen Hintergründe sollten vom Hausarzt aufgedeckt und behandelt werden. Dadurch könnte der Schwindel und damit der subjektive Gesundheitszustand der betroffenen Patienten verbessert und die Inanspruchnahme des Gesundheitswesens verringert werden.

In this thesis we develop methods for dealing with missing data in a univariate response variable when estimating regression parameters. Missing outcome data is a problem in a number of applications, one of which is follow-up studies. In follow-up studies data is collected at two (or more) occasions, and it is common that only some of the initial participants return at the second occasion. This is the case in Paper II, where we investigate predictors of decline in self reported health in older populations in Sweden, the Netherlands and Italy. In that study, around 50% of the study participants drop out. It is common that researchers rely on the assumption that the missingness is independent of the outcome given some observed covariates. This assumption is called data missing at random (MAR) or ignorable missingness mechanism. However, MAR cannot be tested from the data, and if it does not hold, the estimators based on this assumption are biased. In the study of Paper II, we suspect that some of the individuals drop out due to bad health. If this is the case the data is not MAR. One alternative to MAR, which we pursue, is to incorporate the uncertainty due to missing data into interval estimates instead of point estimates and uncertainty intervals instead of confidence intervals. An uncertainty interval is the analog of a confidence interval but wider due to a relaxation of assumptions on the missing data. These intervals can be used to visualize the consequences deviations from MAR have on the conclusions of the study. That is, they can be used to perform a sensitivity analysis of MAR. The thesis covers different types of linear regression. In Paper I and III we have a continuous outcome, in Paper II a binary outcome, and in Paper IV we allow for mixed effects with a continuous outcome. In Paper III we estimate the effect of a treatment, which can be seen as an example of missing outcome data.

Contexte : Les troubles liés à l’usage des substances psychoactives constituent une priorité de santé publique dans le champ des pathologies chroniques. Les indicateurs de type Patient-Reported Outcomes (PRO) offrent des perspectives complémentaires aux indicateurs classiques pour la mesure de l’état de santé des patients et l’appréciation de la qualité des soins. Objectifs : Étudier les propriétés psychométriques de questionnaires de qualité de vie (QV) et les déterminants de la satisfaction précoce vis-à-vis des soins ambulatoires de patients dépendants aux substances de type alcool ou opiacés. Méthode : Les caractéristiques des patients et des médecins ont été recueillies à l’inclusion dans la cohorte SUBUSQOL. La satisfaction précoce a été mesurée quinze jours après la première consultation et ses déterminants ont été testés dans des modèles de régression linéaires multivariés. Les propriétés psychométriques du questionnaire spécifique Q-LES-Q-SF ont été étudiées au préalable sur un échantillon de patients. Résultats : La version française du Q-LES-Q-SF constitue un outil unidimensionnel robuste et fiable, les items du SF-12 et Q-LES-Q-SF présentent peu ou pas de fonctionnement différentiel selon l’âge, le sexe, le niveau d’éducation et le type d’addiction. Peu de variables recueillies sont associées à la satisfaction. Les patients dépendants à l’alcool se révèlent être plus satisfaits des modalités de contact et du délai de rendez-vous et ceux sans aucun antécédent de prise en charge pour leur dépendance plus satisfaits de leur consultation avec le médecin. Conclusion : Les questionnaires SF-12 et Q-LES-Q-SF peuvent être utilisés dans des populations de patients suivis en ambulatoire pour une dépendance aux substances psychoactives / Context: Of chronic diseases, substance use disorders are a public health priority. Patient-reported outcome indicators (PRO) offer additional insights into the classical indicators used to measure the patient’s health status and appreciation of their quality of care. Objectives: to study the psychometric properties of quality of life instruments and to study the determinants of early outpatient satisfaction with ambulatory care in alcohol- or opiate-dependent patients. Method: Patient and physician characteristics were collected in the SUBUSQOL cohort. Early satisfaction with care was measured fifteen days after the first consultation. The determinants of satisfaction were tested using multivariate linear models of regression. Prior data on the self-reported health status of a sample of alcohol- or opiate-dependent outpatients were used to investigate the psychometric properties of a specific questionnaire, the Q-LES-Q-SF. Results: Our results establish that the French version of the Q-LES-Q-SF is a unidimensional, valid and reliable instrument of self-reported health status assessment for use in care or medical research and that few items of the SF-12 and the Q-LES-Q-SF displayed differential functioning according to age, sex, educational level and type of substance use disorder. Our results show that few variables are associated with the level of patient satisfaction. Alcohol dependence was strongly associated with higher satisfaction with appointment making, and patients with no history of previous care for substance use disorders had a higher level of satisfaction with the doctor consultation. Conclusion: The use of the SF-12 and the Q-LES-Q-SF is recommended for outpatients suffering from substance use disorders

Orientador: Karina Pavão Patrício / Resumo: Introdução: Estudos recentes demonstram que a conexão com a natureza favorece o bem estar e a saúde humana e pode facilitar a adoção de hábitos de vida mais sustentáveis e saudáveis, entre eles a alimentação. O consumo habitual de alimentos ultraprocessados, além de associar-se à maior prevalência de doenças crônicas, favorece contaminação ambiental por meio das embalagens, em sua maioria plásticos não retornáveis e não recicláveis. Acredita-se que profissionais da saúde com boa conexão com a natureza podem ser promotores da disseminação destes hábitos. Objetivo: Investigar a associação entre conexão com a natureza e motivos para escolhas alimentares, bem-estar subjetivo e saúde autorreferida. Método: Estudo transversal com 146 profissionais da atenção primária à saúde (APS) do município de Botucatu – SP, que responderam aos seguintes instrumentos autoaplicados: 1) Questionário sociodemográfico, que incluiu questão sobre saúde autorreferida; 2) Escala de Conexão com a Natureza (ECN) - escala com 14 itens, que mede o quanto a pessoa se sente integrada ao meio ambiente em uma perspectiva subjetiva e individual e cuja pontuação varia de 14 a 70 pontos; 3) Questionário sobre “Motivos para as escolhas alimentares” (FCQ): com¬posto por 36 itens distribuídos em nove fatores que avaliam aspectos rela¬cionados às escolhas alimentares. Foram avaliadas as pontuações nos diferentes fatores e a associação da pontuação obtida dos fatores “Saúde”, “Conteúdo Natural” e “Preocupação Ética” à ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Current studies show that connectedness to nature improves human well-being and health and can facilitate the adoption of more sustainable and healthy living habits, including eating. The habitual consumption of ultra processed foods, in addition to being associated with a higher prevalence of chronic diseases, lead to environmental contamination through the packaging, mostly non-returnable and non-recyclable plastics. It is believed that health professionals with a high connectedness can be promoters of the dissemination of this knowledge. Objective: To investigate the association between connectedness to nature and food choice motives, subjective well-being and self-reported health. Method: Cross-sectional study with 146 primary health care professionals (PHC) from Botucatu city, SP, who answered the following self-applied tools: 1) A socio-demographic questionnaire, which included a question on self-reported health; 2) Connectedness to Nature Scale (ECN) - scale with 14 items, which measures how much the person feels integrated to the environment in a subjective and individual perspective and whose score varies from 14 to 70 points; 3) Food Choice Questionnaire (FCQ): compiled by 36 items distributed in nine factors that evaluate aspects related to food choices. The scores on the different factors and the association of the score obtained from the "Health", "Natural Content" and "Ethical Concern" factors to the score obtained in the ECN were evaluated; 4) Sub... (Complete abstract click electronic access below) / Mestre

At present there is a reliance on behavioral interventions that have been limited in their effectiveness to reduce the public health burden of chronic disease, partly because the effects of social context on the initiation and maintenance of health behaviors is not incorporated into public health policy and practice. Yet current research indicates that there are macro-level structural and contextual influences on population health that cannot be reduced to individual or compositional effects. This study investigated the associations between social structural factors, community social context, individual characteristics, and self-reported correlates of disease. Distal influences included social structural inequalities such as income inequality and absolute deprivation or poverty. Pertinent mechanisms through which these influences might have operated on disease included social contextual factors, such as social capital. Both political economy and the ecosocial perspective were selected to inform this study and to provide the theoretical framework from which hypotheses were derived.The design was a multilevel, retrospective, nonexperimental study using secondary data. The study linked three data sources (2001 Behavioral Risk Factor Surveillance System, Social Capital Community Benchmark Study, and U.S. Census) by Federal Information Processing Standards codes in order for individuals to be placed in their community or state contexts. Results provided mixed evidence of the direct role of structural and contextual inequalities on self-rated health. Any direct effects of social structural inequalities on the health outcomes disappeared once individual factors were included in the models. Findings demonstrated that one dimension of social capital, organizational activism, retained its significant direct effect on general health status, once individual characteristics were considered. Conclusions suggested indirect associations whereby the negative influence of social structural inequalities on health was mediated by the erosion of social trust, which in turn was associated with engaging in risk behavior, thus increasing the odds of reporting hypertension, fair/poor general health, and mental distress. Although results were inconsistent, this study contributed to advancing Healthy People 2010 goals of increasing quality of life and reducing health disparities by advancing understanding of the multilevel nature of perceived health and the chronic diseases they predict.

The overall aim of this thesis was to explore and describe schoolchildren's selfreported-health based on the Health Dialogue concept as well as to identify healthindicators and their possible associations in the perspective of 6 to 16 year-olds,and to provide an analysis of school nurses´ experiences of using the HealthDialogue concept, in the County of Västernorrland. The thesis was based on fourstudies (I-IV). Study I was qualitative using a descriptive design, based onindividual interviews with school nurses who had working experience of using theHealth Dialogue concept. Studies II-IV were quantitative with cross sectional andlongitudinal design based on statistical data from the Health Dialogue concept, apopulation survey among schoolchildren. The data were analyzed usingqualitative content analysis (I) and regression analyses (II-IV).Study I showed that the school nurses had developed their own commonapproach, a health promotion model derived from experiences of working with theHealth Dialogue concept. Study II showed that the most important health variablesinfluencing pre-schoolchildren´s positive self-reported-health were experience ofcomfort in preschool, good sleep, absence of headaches, being physicalactive/playing daily, and not being a victim for bullying. Both boys and girlsneeded to experience comfort, being physical active, and not being bullied. Forgirls, positive self-reported-health seemed to be more dependent on comfort, beingphysical active/playing, and not being bullied, whereas boy’s health was moredependent on eating school lunch daily and not experiencing headaches.Study III revealed that in 10-year-old children´s positive self-reported-health,comfort in school, normal iso- body mass index and absence of headaches wereshown to be significantly important health indicators. Normal iso- body massindex (girls) and absence of headaches (boys) were shown to have a potentiallycausal effect on 10-year-old children's positive self-reported-health. Study IVrevealed several significantly important health indicators in schoolchildren´shealth during three school transitions in the Swedish Education system (betweenthe ages of 6-10, 10-13 and 13-16); not experiencing being sad/depressed,afraid/worried, experiencing the school environment positively (schoolyard andivrestrooms), not being bullied, having good sleep, daily physical activity/play andability to concentrate. Gender and age differences were also identified. The HealthDialogue concept, contributes increased knowledge and a new cross sectional andlongitudinal perspective to individual, school, community and organization’sperception of schoolchildren´s self-reported-health. Furthermore, these resultsdemonstrate the importance and validity of children´s experiences in the context ofhealth and should contribute to future health promotion activities and schoolbasedinterventions.Key words: Health promotion, health dialogue, longitudinal design, school nurses,schoolchildren, self-reported-health. / Det övergripande syftet med avhandlingen var att undersöka och beskrivaskolbarns självrapporterade hälsa baserat på Hälsosamtals konceptet, attidentifiera hälsoindikatorer och deras möjliga samband för skolbarn självskattadehälsa i ett 6 till 16- års perspektiv, och att analysera skolsköterskornas erfarenheterav att använda Hälsosamtals konceptet i Västernorrlands län. Avhandlingenbygger på fyra studier (I-IV). Studie I var kvalitativ med en deskriptiv design,baserad på individuella intervjuer med skolsköterskor med arbetserfarenhet frånHälsosamtals konceptet. Studie II-IV var kvantitativ med tvärsnitt ochlongitudinell design baserat på statistisk data på länsnivå från Hälsosamtalskonceptet bland skolbarn i ålder 6-16 år. Data analyserades med kvalitativinnehållsanalys (I) och regressions analys (II-IV). Studie 1 visade attskolsköterskorna i länet hade utvecklat en egen gemensam strategi och modell förhälsofrämjande arbete. Studie II visade att de viktigaste hälso- indikatorer för barni förskoleklass avseende positivt självrapporterade hälsa var trivsel, god sömn,frånvaro av svår huvudvärk, vara fysiskt aktiv/leka varje dag, samt att inte varautsatt för mobbning. Både pojkar och flickor behövde trivas, vara fysisktaktiva/leka, och inte vara utsatta för mobbning. Flickorna visade sig vara merberoende av trivsel, vara fysiskt aktiva/leka, och inte vara utsatta för mobbning föratt rapportera sin hälsa positivt medan pojkarnas positivt självrapporterande hälsavisade sig bero på daglig skollunch och att inte ha huvudvärk. Studie III visade attför 10-åriga barns positivt självrapporterade hälsa var, trivsel i skolan, normalt iso-BMI och frånvaro av huvudvärk viktiga hälsoindikatorer. Normal iso-BMI visadeett potentiellt kausalt samband för 10-åriga flickors, och frånvaro av huvudvärkvisade ett potentiellt kausalt samband för 10-åriga pojkars positivtsjälvrapporterad hälsa. Studie IV visade flera signifikant viktiga hälsoindikatorer iskolbarns (6-16 år) positivt självrapporterade hälsa, under tre skolövergångar i detsvenska utbildningssystemet (6-10, 10-13, 13-16 år). Att inte känna sigledsen/deprimerad, rädd/orolig, uppleva skolmiljön positivt (skolgården ochtoaletter), inte vara mobbad, sova gott, vara dagligt fysiskt aktiv/leka och att kunnakoncentrera sig visade sig vara viktiga hälsoindikatorer. Dessa hälsoindikatorerviskilde sig avseende på ålder och kön. Denna avhandling bidrar med ökad kunskapom skolbarns självrapporterade hälsa grundat på Hälsosamtals konceptet.Hälsosamtals konceptet tillför nya perspektiv avseende barns hälsa på individ,skola, samhälls/organisations nivå i ett tvärsnitts och longitudinellt perspektiv.Hälsofrämjande arbete i skolan och samhället bör ta barns upplevelser,erfarenheter och synpunkter i beaktande och som giltiga. Resultatet i dennaavhandling hoppas kunna bidra till framtida hälsofrämjande arbete och insatser iskolan.

The objective of this thesis was to defend an alternative approach by health policy makers for improving health outcomes through investing on social factors of peoples' lives, rather than by increasing health expenditures. In order to defend this theory, this master thesis addresses two research questions: Which are the social determinants of health with largest impact on health status of individuals? And what is the statistical correlation between those social determinants of health and self-reported health status, and psychological health, for Germany, Denmark, Spain and Ireland? The first question was answered by developing a comprehensive research among the mostrelevant literature in the field of social determinants of health and the second through the construction of a statistical multiple regression model. According this study the social determinants with largest impact on the health status of individuals are: physical activity, education level, the welfare state, emotional support, socio-economic status, living conditions, working conditions, and life balance. Regarding the results of multiple regression models all variables followed the expected trend and it was possible to proof significant statistical correlation in 7 of the 8 determinants chosen, especially in the cases of working conditions and life balance, where those having problems managing these aspects of life experienced 50% or in some cases 30% of the health status of individuals with positive experiences in these life dimensions.

Cette thèse étudie l'influence du travail sur la qualité de l'emploi et la qualité de vie des individus. Cette dernière est approximée par la perception que les individus ont de leur santé. Le premier chapitre étudie les conséquences de la perte d'emploi liée à la fermeture d'un établissement sur l'ensemble des dimensions de la qualité de l'emploi retrouvé. Nous montrons que ce choc induit une dégradation, y compris sur le long terme, des salaires, de l'insécurité de l'emploi perçue, de la qualité de l'environnement de travail et de la satisfaction des travailleurs. Les deux derniers chapitres tentent de comprendre les déterminants des différences de santé perçue selon le genre. Dans le deuxième chapitre, nous analysons le rôle de la santé mentale dans les écarts de santé déclarée selon le genre. Le troisième chapitre étudie l'influence des normes sociales au travail, sur la santé perçue. Nous montrons que les femmes comme les hommes travaillant dans des collectifs de travail féminins déclarent davantage de problèmes de santé spécifiques que celles et ceux travaillant dans des collectifs masculins. Ce travail souligne donc, d'une part, l'effet négatif de la perte d'emploi sur la qualité de l'emploi retrouvé et la satisfaction à long terme et, d'autre part, l'importance du mal-être et des normes sociales au travail pour comprendre les différences de santé perçue entre les genres. / This thesis studies the influence of work on job and life quality, the latter being considered through the perception that individuals have of their own health. The first chapter focuses on the long-term effects of job losses due to plant closure on job quality. We show that job loss negatively affects wages, perceived job insecurity, the quality of the working environment and job satisfaction, including in the long run. The two last chapters investigate gender differences in self-reported health. The second chapter provides descriptive evidence on the relationships between self-assessed health, gender and mental health problems, i.e. depression and/or affective pains. Finally, in the last chapter, we study the influence of social norms as proxied by the gender structure of the workplace environment, on gender differences in self-reported health. We show that both women and men working in female-dominated environments report more specific health problems than those who work in male-dominated environments. The overall findings of this thesis are twofold. First, losing a job has a negative impact on several dimensions of job quality and satisfaction in the long run. Secondly, mental diseases and social norms at work are important to understand gender-related differences in health perceptions.

African American women (AAW) are at a high risk for type 2 diabetes, a debilitating and potentially fatal disease for which there is no cure. The purpose of this study was to extend the research of Mosca et al. (2012) by examining the relationship between caregiver status and self-reported health status for AAW 18 years or older diagnosed with type 2 diabetes. The chronic care model (CCM) provided the theoretical framework for this study. The CCM promoted routine care for patients with chronic illnesses to migrate from acute care to proactive, planned, and risk-based protocols. A binomial logistic regression investigated the relationship between caregiver status, categorized as paid or unpaid, and self-reported health status, which was dichotomized as either good to excellent health or poor to fair health. There was a statistically significant relationship between primary caregiver status and self-reported health status among AAW diagnosed with Type 2 diabetes after controlling for age, education, and marital status (p < .004). Based on the fitted binomial logistic regression model, there were 186 cases of AAW with type 2 diabetes; having a paid caregiver was associated with a lower odds of having good to excellent health (OR = 0.294). About 12.3% of the variance in self-report health status was attributable to caregiver status. Overall, 82.6% of predictions were accurate. Nearly all participants required frequent assistance from a caregiver in the preceding 12 months. These findings suggest a critical need for healthcare service providers to educate caregivers as a means to deliver post-acute care to AAW diagnosed with type 2 diabetes, consistent with the CCM.