The automated reverse engineering of wireframes is a common task in topology optimization, fast concept design, bionic and point cloud reconstruction. This article deals with the usage of skeleton-based reconstruction of sketches in 2D images. The result leads to a flexible at least C₁ continuous shape description.

The study of regeneration has inspired centuries of scientific research. Among the many model organisms used in present days, the axolotl has become the gold standard for studying limb regeneration in vertebrates. Limb regeneration is an intricated multi-step process that involves timely regulated events such as an immune response, dedifferentiation and migration of progenitor cells, and the re-establishment of the missing structures. Although axolotl limb regeneration has long been considered a case of perfect regeneration, the mechanisms whereby a regenerated limb is able to properly integrate into the mature tissue seamlessly have long been unstudied. In this work, I have investigated how the skeletal tissue is primed to successfully regenerate and restore its functionality. To properly achieve my research, I have first sought to understand the basic appendicular skeleton biology, particularly, how the skeletal elements change with growth and age. In the first part of my thesis, I show the changes associated with growth in the zeugopodial elements, radius and ulna. A cartilaginous skeleton defines the limb during the early life stages, and ossification starts around the time the animals reach sexual maturity, a process that extends throughout their lives. In the second part of my work, I have extensively described a regeneration-induced skeletal resorption. This process is carried out by osteoclasts and it is absolutely necessary for a successful integration of the skeletal tissue. Interestingly, a direct correlation between the resorption rate and the integration efficiency could be observed. Moreover, my work provides strong evidence linking the formation of the wound epithelium with the induction of skeletal resorption and the position of resorption with blastema formation. Altogether, this work provides a comprehensive study of axolotl skeleton biology in homeostasis and regeneration, with an emphasis on how a histolytic process primes the skeletal tissue for efficient regeneration. From a comparative perspective, the understanding of the events involved in axolotl limb regeneration provides an excellent platform for evaluating how regeneration could be enhanced in non-regenerative animals, such as humans.

This bachelor thesis provides a study of two individuals from Buttle Änge, Gotland and the data of their health at the time of death. Possible profession or status of each individual has been discussed in correlation to the form of burial and then summated into a possible explanation. Individual 1, the buttle warrior, was determined a man with an age between 30-35 years and a stature of 180 centimetres. Individual 2, the armless individual, was determined a man with the age of 20-25 years and a stature of 175 centimetres. The analyse of the human skeletal material and excavation reports gave a context to how these two individuals were buried. The offerings or lack of offerings, in the grave gave an insight to the status of the burial for each individual. The Buttle Warrior gave indication on impact or change in the vertebrae which probably came from the way of movement he had in life. The lack of grave offerings in the grave of the armless individual have been discussed and formed a possible explanation that the armless individual lack skeleton of the arms because of a probable remove just before or short after burial. The two human remains origins from the Roman iron age, a period from 0 to 400 AD, both individuals was dated to a period of 0-150 AD.

We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight into the initial steps of limb patterning. 2)We have examined the roles of different tissues regarding their fates and features of proximo- distal patterning. Our strategy was to transplant GFP+ skin, skeleton, muscle and Schwann cells from transgenic donors to limbs of wild type hosts, amputate through the graft and analyze fluorescent progeny combined with the use of molecular markers. Our results revealed that different subpopulations of blastema cells exist regarding two aspects. First, we found that progeny of skin and skeleton have some tissue specific memory since they did not give rise to muscle lineages. However, cells of the skin contributed to other mesenchymal tissues like cartilage or tendons, while the majority of skeleton- derived cells undergoes self- renewal. Second, we performed one cellular and two molecular assays to investigate what tissues generate cells that exhibit features of proximo- distal patterning. Both assays revealed that Schwann cell- derived progeny do not display such features while progeny of skin, skeleton and muscle did. Therefore, we conclude that the blastema is a heterogeneous mix of cells regarding tissue lineages and features of proximo- distal patterning.

This report is written as a summary of the solution to the problem that the staff for the course TDDD23 at the Swedish university Linköpings universitet wanted two computer game skeletons. One for a scrolling shooter game and one for a strategy game. The games the staff wanted were to be like two existing games. The scrolling shooter was to be like the scrolling shooter from the tutorial GM Tutorial Scrolling Shooter[1]. The strategy game was to be like an existing game called Ancient War[2]. There were some additional requirements that the games had to fulfill. The games were created using Game Maker. It is an easy to use program for creating small computer games. The result of the project was two game skeletons. One for a scrolling shooter game and one for a strategy game. The skeletons were according to the requirements stated.

Der vorliegende Beitrag befasst sich mit dem Einsatz von Motion-Skeletten bei der kinematischen Analyse von zwei- und dreidimensionalen Getriebestrukturen. Im ersten Teil werden verschiedene Möglichkeiten aufgezeigt, welche Pro/ENGINEER für die Mechanismus-Analyse bietet und bezüglich ihrer Eignung für kinematische Strukturen verglichen. Am Beispiel einer exzentrischen Schubkurbel wird anschließend der Aufbau und die Funktionsweise eines Motion-Skelettes erklärt. Neben der reinen kinematischen Analyse einer solchen Struktur wird auch der Einsatz von BMX zur Optimierung von Koppelgetrieben gezeigt.

This study focuses on the attitudes of museumgoers toward the exhibition of human remains in modern Swedish museums. More specifically, it deals with how their attitudes toward remains are shaped and informed by museums’ materiality and institutionalized authority, whether they think of remains as humans or objects, as well as how these dead bodies ultimately become culturally meaningful to us who are still alive. Through the use of ethnographic field methods including go-along interviews and participant observation, the behaviors and opinions of museumgoers are recorded. With the help of Emmanuel Levinas’ ethical phenomenology and Annemarie Mol’s theory of multiple ontology, the cultural background against which these attitudes have taken shape is examined. The study shows that museumgoers are generally positive toward the exhibition of human remains in museums—an attitude which is influenced by the history, scientific authority, and carefully designed materiality of the museum. Among the perceived benefits of exhibiting human remains, visitors cite the ability of the remains to arouse their curiosity and serve as links to the past, as well as provide material proof that validates the museum’s claims to knowledge. However, this positive attitude is dependent on whether the remains are treated and displayed with respect. This call to treat the dead respectfully can be seen as a universal reaction to the ”face-to-face encounter” as described by Emmanuel Levinas, but at the same time, museumgoers’ interpretation of respect is culturally contingent and heavily influenced by contemporary values such as individuality, scientific objectivity, and equality. Furthermore, the perceived need to treat remains respectfully is directly tied to the perceived humanity of the remains. This is in turn dependent on how close the remains are to us in terms of appearance and temporal distance. By focusing on museumgoers instead of professionals, and through using ethnographic fieldwork to note opinions and their cultural backgrounds, this study attempts to add a fresh perspective and new knowledge to what is currently one of the hottest debates in museology: whether remains even belong in museums. Further, by recognizing that no opinion is formed in a vacuum, the narrow question of displaying death can tell us something bigger about the norms and values of Sweden today.

In der Literaturübersicht wird neben der zugrunde gelegten Wachstumsdefinition ein Überblick über bisherige Wachstumsuntersuchungen beim Hund, über die Funktion der Epiphysenfugenscheibe sowie über die Rassegeschichte des West Highland White Terriers gegeben. Desweiteren werden erblich bedingte rassetypische Skeletterkrankungen, die während des Wachstums auftreten, dargestellt. Das Wachstumsverhalten der einzelnen Parameter wird untereinander und mit Angaben aus der Literatur vergleichend dargestellt und diskutiert.

As processors' clock-speed flattened out in the early 2000s, multi-core processors became more prevalent and so did parallel programming. However this programming paradigm introduces additional complexities, and to combat this, the SkePU framework was created. SkePU does this by offering a single-threaded interface which executes the user's code in parallel in accordance to a chosen computational pattern. Furthermore it allows the user themselves to decide which parallel backend should perform the execution, be it OpenMP, CUDA or OpenCL. This modular approach of SkePU thus allows for different hardware to be used without changing the code, and it currently supports CPUs, GPUs and clusters. This thesis presents a new so-called SkePU-backend made for clusters, using the communication library GPI. It demonstrates that the new backend is able to scale better and handle workload imbalances better than the existing SkePU-cluster-backend. This is achieved despite it performing worse at low node amounts, indicating that it requires less scaling overhead. Its weaknesses are also analyzed, partially from a design point of view, and clear solutions are presented, combined with a discussion as to why they arose in the first place.

We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight into the initial steps of limb patterning. 2)We have examined the roles of different tissues regarding their fates and features of proximo- distal patterning. Our strategy was to transplant GFP+ skin, skeleton, muscle and Schwann cells from transgenic donors to limbs of wild type hosts, amputate through the graft and analyze fluorescent progeny combined with the use of molecular markers. Our results revealed that different subpopulations of blastema cells exist regarding two aspects. First, we found that progeny of skin and skeleton have some tissue specific memory since they did not give rise to muscle lineages. However, cells of the skin contributed to other mesenchymal tissues like cartilage or tendons, while the majority of skeleton- derived cells undergoes self- renewal. Second, we performed one cellular and two molecular assays to investigate what tissues generate cells that exhibit features of proximo- distal patterning. Both assays revealed that Schwann cell- derived progeny do not display such features while progeny of skin, skeleton and muscle did. Therefore, we conclude that the blastema is a heterogeneous mix of cells regarding tissue lineages and features of proximo- distal patterning.