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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
31

Untersuchungen zum postnatalen Skelett- und Körpermassewachstum von Hunden der Rasse West Highland White Terrier

Schubert, Daniela 30 November 2010 (has links)
In der Literaturübersicht wird neben der zugrunde gelegten Wachstumsdefinition ein Überblick über bisherige Wachstumsuntersuchungen beim Hund, über die Funktion der Epiphysenfugenscheibe sowie über die Rassegeschichte des West Highland White Terriers gegeben. Desweiteren werden erblich bedingte rassetypische Skeletterkrankungen, die während des Wachstums auftreten, dargestellt. Das Wachstumsverhalten der einzelnen Parameter wird untereinander und mit Angaben aus der Literatur vergleichend dargestellt und diskutiert.
32

Integrating SkePU's algorithmic skeletons with GPI on a cluster / Integrering av SkePUs algoritmiska skelett med GPI på ett cluster

Almqvist, Joel January 2022 (has links)
As processors' clock-speed flattened out in the early 2000s, multi-core processors became more prevalent and so did parallel programming. However this programming paradigm introduces additional complexities, and to combat this, the SkePU framework was created. SkePU does this by offering a single-threaded interface which executes the user's code in parallel in accordance to a chosen computational pattern. Furthermore it allows the user themselves to decide which parallel backend should perform the execution, be it OpenMP, CUDA or OpenCL. This modular approach of SkePU thus allows for different hardware to be used without changing the code, and it currently supports CPUs, GPUs and clusters. This thesis presents a new so-called SkePU-backend made for clusters, using the communication library GPI. It demonstrates that the new backend is able to scale better and handle workload imbalances better than the existing SkePU-cluster-backend. This is achieved despite it performing worse at low node amounts, indicating that it requires less scaling overhead. Its weaknesses are also analyzed, partially from a design point of view, and clear solutions are presented, combined with a discussion as to why they arose in the first place.
33

Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum

Kragl, Martin 25 October 2007 (has links)
We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight into the initial steps of limb patterning. 2)We have examined the roles of different tissues regarding their fates and features of proximo- distal patterning. Our strategy was to transplant GFP+ skin, skeleton, muscle and Schwann cells from transgenic donors to limbs of wild type hosts, amputate through the graft and analyze fluorescent progeny combined with the use of molecular markers. Our results revealed that different subpopulations of blastema cells exist regarding two aspects. First, we found that progeny of skin and skeleton have some tissue specific memory since they did not give rise to muscle lineages. However, cells of the skin contributed to other mesenchymal tissues like cartilage or tendons, while the majority of skeleton- derived cells undergoes self- renewal. Second, we performed one cellular and two molecular assays to investigate what tissues generate cells that exhibit features of proximo- distal patterning. Both assays revealed that Schwann cell- derived progeny do not display such features while progeny of skin, skeleton and muscle did. Therefore, we conclude that the blastema is a heterogeneous mix of cells regarding tissue lineages and features of proximo- distal patterning.
34

Epidemiology and routine care treatment of patients with hip or knee osteoarthritis and chronic lower back pain: real-world evidence from Germany

Hradetzky, E., Ohlmeier, C., Brinkmann, C., Schild, M., Galetzka, W., Schmedt, N., John, T., Kaleth, D., Gothe, H. 06 June 2024 (has links)
Aim Musculoskeletal disorders are a major public health problem in most developed countries. As a main cause of chronic pain, they have resulted in an increasing prescription of opioids worldwide. With regard to the situation in Germany, this study aimed at estimating the prevalence of musculoskeletal diseases such as chronic low back pain (CLBP) and hip/knee osteoarthritis (OA) and at depicting the applied treatment patterns. - Subject and methods German claims data from the InGef Research Database were analyzed over a 6-year period (2011–2016). The dataset contains over 4 million people, enrolled in German statutory health insurances. Inpatient and outpatient diagnoses were considered for case identification of hip/knee OA and CLBP. The World Health Organization (WHO) analgesic ladder was applied to categorize patients according to their pain management interventions. Information on demographics, comorbidities, and adjuvant medication was collected. - Results In 2016, n = 2,693,481 individuals (50.5% female, 49.5% male) were assigned to the study population; 62.5% of them were aged 18–60 years. In 2016, n = 146,443 patients (5.4%) with CLBP and n = 307,256 patients (11.4%) with hip/ knee OA were identified. Of those with pre-specified pain management interventions (CLBP: 66.3%; hip/knee OA: 65.1%), most patients received WHO I class drugs (CLBP: 73.6%; hip/knee OA: 68.7%) as the highest level. - Conclusion This study provides indications that CLBP and hip/knee OA are common chronic pain conditions in Germany, which are often subjected to pharmacological pain management. Compared to non-opioid analgesic prescriptions of the WHO I class, the dispensation of WHO class II and III opioids was markedly lower, though present to a considerable extent.
35

Tidigkristen diet : En XRF-analys av strontium på skelettmaterial från Varnhems gårdskyrka / Early Christian diet : An XRF-analysis of strontium on skeletal material from Varnhems estate church

Bengtsson, Fanny January 2018 (has links)
The aim of this thesis is to study 31 individuals from an early christian cemetery in Varnhem, Sweden and through the use of XRF, study the strontium concentrations and the strontium to calcium ratios in bone and use that as an indicator for diet. The material consists of femurs and teeth and through analyzing this I will compare previous dietary studies using stable carbon, nitrogene and sulphur isotope analyses to see wether quantitative strontium analysis can be used as a way to study diet in prehistoric societies. The conclusion is that XRF is not as thorough as an isotope study but it provides a general knowledge of what the population has been eating where we can determine which individuals has had diet consisting of more meat or terrestrial plants.
36

Effect of long-term ultra-endurance training on telomere length and telomere regulatory protein expressions in vastus lateralis of healthy humans.

Östlund-Lagerström, Lina January 2010 (has links)
No description available.
37

Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

Riquelme-Guzmán, Camilo, Tsai, Stephanie L, Karen Carreon, Nguyen, Congtin, Oriola, David, Schuez, Maritta, Brugués, Jan, Currie, Joshua D, Sandoval-Guzmán, Tatiana 21 May 2024 (has links)
Early events during axolotl limb regeneration include an immune response and the formation of a wound epithelium. These events are linked to a clearance of damaged tissue prior to blastema formation and regeneration of the missing structures. Here, we report the resorption of calcified skeletal tissue as an active, cell-driven, and highly regulated event. This process, carried out by osteoclasts, is essential for a successful integration of the newly formed skeleton. Indeed, the extent of resorption is directly correlated with the integration efficiency, and treatment with zoledronic acid resulted in osteoclast function inhibition and failed tissue integration. Moreover, we identified the wound epithelium as a regulator of skeletal resorption, likely releasing signals involved in recruitment/differentiation of osteoclasts. Finally, we reported a correlation between resorption and blastema formation, particularly, a coordination of resorption with cartilage condensation. In sum, our results identify resorption as a major event upon amputation, playing a critical role in the overall process of skeletal regeneration.
38

Mänskliga kvarlevor från Eldslandet : Arkeologisk biografi om tre selknam-individer / Human remains from Tierra del Fuego : Archaeological biography of three Selknam-individuals

Vera Oliva, Marcela January 2020 (has links)
This work is an archaeological biography of three skeletons brought to Sweden from Tierra del Fuego in the late 1800s by scientist Otto Nordenskjöld and his Swedish expedition to the Magellan countries. These belonged to Selknam men killed by European farmers. In Sweden they were used in studies of comparative anatomy and as teaching and research material. They reflect the European colonial worldview of the 19th- and early 20th centuries, as well as a part of the colonial history of Patagonia and Tierra del Fuego. / Este trabajo es una biografía arqueológica sobre tres esqueletos traídos a Suecia desde Tierra del Fuego a fines de 1800, por el científico Otto Nordenskjöld y su expedición sueca a los países magallánicos. Estos pertenecían a hombres selknam, asesinados por estancieros europeos. En Suecia fueron utilizados en estudios de anatomía comparada y como material de enseñanza e investigación. Son un reflejo de la cosmovisión colonial europea de los siglos XIX y principios del XX, así como una parte de la historia colonial de Patagonia y Tierra del Fuego.

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