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The diagnostic accuracy of the HIV 1/2/subtype O Tri-line HIV rapid test in comparison to ELISAManenzhe, Shumani Charlotte January 2018 (has links)
A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Dentistry.
Johannesburg, 2018. / Background: Accurate HIV diagnosis is critical and can be life-saving. A Rapid Test (RT) is considered key to HIV prevention and management. Some studies have found RT to be comparable with ELISA whilst others have reported on lower sensitivity.
Aim and study design: The aim of this retrospective comparative descriptive study was to evaluate the sensitivity and specificity of the Tri-line HIV rapid test device in comparison to ELISA on patient records from Wits Oral Health Centre (WOHC) between 2014 and 2016
Method: The study population comprised records of patients older than18 months who had Tri-Line HIV RT and blood drawn for ELISA on the same day. Descriptive analysis of the data was carried out.
Results: The sensitivity of Tri-line was 80% (CI: 59-93%) and specificity was 100% (CI: 83-100%). The PPV was 100% (CI: 83-100%) and NPV was 80% (CI: 65-90%). ROC area of 0.9 at 95% CI was determined.
Conclusion: Due to a low sample size in this study a definitive conclusion could not be drawn. However on the basis of the results obtained, although the tri-line RT showed lower sensitivity it was shown to be a clinically useful test. / LG2018
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EFFICACY OF DEMINERALIZED BONE MATRIX AS AN OSTEOINDUCTIVE AGENT WHEN USING A BETA-TRICALCIUM PHOSPHATE CARRIERBlice, Rebecca L. January 2006 (has links)
No description available.
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A Comparative Study for the Effect of Tissure Anisotropy on the Behavior of a Single Cardiac Pressure Cycle for a Symmetric Tri-Leaflet ValveThomas, Vineet Sunny 13 December 2010 (has links)
No description available.
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Experimental studies of the homogeneous conversion of sulfur di-oxide to sulfur tri-oxide via natural gas reburningKhan, Ashikur R. January 1999 (has links)
No description available.
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Homogeneous sulfur tri-oxide formation in gas reburning for nitrogen oxides controlJewmaidang, Jirasak January 1999 (has links)
No description available.
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The dynamics of Si small point defects and formation of Si extended structuresDu, Yaojun 07 October 2005 (has links)
No description available.
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Influência da agregação larval na história de vida de Ascia monuste orseis (Godart, 1819) (Lepidoptera, Pieridae) / Influence of larval aggregation on life-history traits of Ascia monuste orseis (Godart, 1819) (Lepidoptera, Pieridae)Santana, Alessandra Figueiredo Kikuda 25 April 2012 (has links)
A agregação em insetos centra-se nas vantagens relativas ao forrageio e no aumento da defesa contra predadores. Além disso, agregações de ovos podem beneficiar-se pelo aumento nas taxas de eclosão larval. Neste trabalho, foram testadas as hipóteses de que agregações de Ascia monuste orseis (Godart, 1819) (Lepidoptera: Pieridae) uma espécie que se alimenta em agregações larvais em plantas da família Brassicaceae - conferem benefícios à performance larval e adulta, na assimilação de alimento pelas larvas, na viabilidade dos ovos e na proteção larval contra inimigos naturais. A possibilidade de um dado comportamento do grupo resultar em maior ataque por inimigos naturais também foi avaliada, bem como um padrão comportamental defensivo em resposta aos inimigos naturais. Para tanto, quatro tratamentos de diferentes tamanhos de agregações larvais foram formados (1, 7, 15 e 30 larvas) para avaliar a performance e a assimilação de alimento em laboratório. Em campo, três tratamentos foram formados (1, 10 e 50 larvas) para testar o efeito do tamanho do tamanho do grupo na predação e parasitismo. A performance do estágio de ovo foi examinada em posturas de tamanhos variados em casa de vegetação. Larvas gregárias desenvolveram-se mais rápido nos ínstares iniciais e tornaram-se fêmeas mais fecundas em comparação às solitárias; entretanto, larvas solitárias apresentaram maior tamanho do que as gregárias. A sobrevivência não diferiu entre os tratamentos em laboratório. Foi observado um menor consumo per capita de alimento por larvas gregárias, sem custos para a assimilação de alimento. A viabilidade dos ovos aumentou com o tamanho da agregação de ovos, comprovando o benefício da agregação larval na fase de ovo. A menor predação per capita em agregações larvais maiores conferiu uma maior proteção às larvas de A. monuste orseis contra predadores e parasitoides, através do efeito da diluição do ataque entre os indivíduos do grupo. O parasitoidismo foi mais expressivo em larvas de primeiros ínstares, enquanto que larvas mais tardias foram mais atacadas por predadores, independente do tamanho da agregação. Por fim, eventos comportamentais que envolvem movimentação da cabeça como exploração e alimentação foram mais perigosos para as larvas de A. monuste orseis em comparação ao repouso e deslocamento, semelhantemente a espécies de hábito solitário. Eventos comportamentais supostamente defensivos foram observados em todos os ínstares e tratamentos. As vantagens da agregação em A. monuste orseis mostraram-se especialmente importantes no estágio de ovo e primeiros ínstares, pela diminuição da mortalidade de ovos e vulnerabilidade larval aos inimigos naturais. Esses benefícios provavelmente sobrepõem-se aos custos, como a competição por interferência observada entre as larvas no final do desenvolvimento. Nossos resultados mostram que o malogro dos ovos e os efeitos dos inimigos naturais constituem fortes pressões seletivas na manutenção da agregação de ovos e larval em A. monuste orseis, a qual confere uma melhor performance do ponto de vista bi-trófico, bem como maior probabilidade de sobrevivência individual sob o ponto de vista tri-trófico. / In insects, the gregarious habit has been shown to improve foraging and defense against predation to both larval and adult stages. Egg clusters could also be beneficial through increased larval hatching. In this study, we tested the hypothesis that egg clusters and larval aggregations of the neotropical butterfly Ascia monuste orseis (Godart, 1819) (Pieridae) - a subspecies that uses Brassicaceae as hosts - lead to several benefits from both bi- and tri-trophic perspectives. Larval and adult performances, food assimilation by the larvae, egg viability, as well as protection against natural enemies were assessed from individuals reared either isolated or aggregated. The behavior of larval aggregations was also examined with respect to predation risk, as well as the corresponding larval defensive behaviors after enemy attack. Four treatments with different larval aggregation sizes were assigned (1, 7, 15 e 30 larvae) to assess larval performance and food utilization in the laboratory. In the field, three treatments were assigned (1, 10 e 50 larvae) to evaluate the effects of group size on predation and parasitoidism. Egg performance was examined through egg clusters of different sizes in a greenhouse. Gregarious larvae developed faster, especially in early instars, and became more fecund females than solitary larvae; however, the latter attained larger body size than the former. Under laboratory conditions, survival did not differ among treatments. Lower food ingestion per capita was observed in gregarious larvae, with no cost in food assimilation. The viability of eggs increased as egg aggregation size increased. The lower per capita predation in larger larval aggregations than smaller groups conferred higher protection to A. monuste orseis larvae against natural enemies, through the dilution effects among individuals of the group. Parasitoidism was more intense in small-sized larvae while late instars were more susceptible to predators, regardless of aggregation size. Similar to species with solitary habit, behavioral events which involved head movements as searching and feeding were more dangerous to A. monuste orseis larvae compared to resting and walking. Presumed defensive behaviors were observed in all instars and treatments. Thus, the benefits of aggregation in A. monuste orseis can be seen especially in the egg stage and in first instars, as it reduces egg mortality and larval vulnerability to natural enemies. These benefits probably overcome some costs, such as interference competition in the late instars. Taken together, the results show that egg failure and top-down effects constitute selective pressures in maintaining egg and larval aggregation in A. monuste orseis, by providing better performance from a bi-trophic perspective and increased probability of individual survival from a tri-trophic perspective when compared to solitary individuals.
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Studies towards the synthesis of bioactive natural products and development of new synthetic methods / Approches synthétiques de produits naturels bioactifs et développement de nouvelles méthodes de synthèseKhanizeman, Rabi'ah Nisha 06 June 2017 (has links)
Plus de la moitié des médicaments mis sur le marché entre 1981 et 2014 sont des produits naturels ou des dérivés. Ainsi, les structures des produits naturels sont une excellente source d'inspiration pour la découverte de nouveaux médicaments. L'introduction de cette thèse met en lumière le rôle important joué par les produits naturels en chimie médicinale. De plus, la préparation de produits naturels peut déboucher sur le développement de nouvelles méthodes de synthèse. Ainsi, au cours de cette thèse une approche synthétique de plusieurs produits naturels a été réalisée. Ces composés présentent des motifs clés tels que des amino-alcools 1,3, des diamines 1,3 ou un tétrahydropyrane. Les études synthétiques réalisées comprennent le développement de nouvelles méthodes pour accéder à ces structures. D'autre part, une réaction de Heck permettant l'accès à des précurseurs de tri-aryl éthylènes a été mise au point. / It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. This, thus, indicates that natural products (NP), together with natural product derived and natural product inspired structures are significant as sources for potential leads towards the discovery of new drugs. The introduction of this thesis thereby highlights the importance of natural products in the field of drug discovery. In addition, the introduction emphasizes on the importance of natural products as a field of research. This is as the synthesis of natural products can result in the development of new synthetic methods which can then be applied to a broader range of applications across the field of chemistry. This new information, thus, bridges a gap in the scientific knowledge and allows for progress in science. Therefore the content of this thesis describes the syntheses and development of new synthetic methods towards bioactive natural products containing 1,3-amino alcohol, 1.3-diamine, THP-ring as well as tri-aryl ethylene unit which represent the key themes of (+)-negamycin (Chapter 1), (-)-cernuine and (+)-cermizine D (Chapter 2), enigmazole A (Chapter 3) and tamoxifen (Chapter 4), respectively.
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Estudo da corrosão localizada da liga de alumínio 7475-T761 por espectroscopia de impedância eletroquímica global e local em meio de sulfato de sódio. / Localized corrosion study of aluminum alloy 7475-T761 in sulfate medium using global and local electrochemical impedance spectroscopy.Ferrari, Jean Vicente 20 July 2011 (has links)
As ligas de Al utilizadas na indústria aeroespacial com finalidade estrutural apresentam microestrutura complexa devido aos tratamentos termo-mecânicos a que são submetidas visando o aumento da resistência mecânica. Estas ligas se caracterizam pela presença de um grande número de intermetálicos (IMs) em sua microestrutura, os quais possuem atividade eletroquímica diferente da matriz provocando problemas de corrosão localizada devido à formação de microcélulas galvânicas. Na última década a espectroscopia de impedância eletroquímica (LEIS) tem se estabelecido como uma poderosa técnica na elucidação de aspectos locais relacionados à corrosão, e também tem servido para estudos de aspectos teóricos referentes à distribuição de potencial e corrente na superfície de eletrodos e suas correlações com a reatividade superficial. Esta técnica se baseia na análise de diferentes impedâncias locais obtidas por meio de um bi-eletrodo posicionado nas proximidades do eletrodo de trabalho. O presente trabalho visa estudar a corrosão localizada da liga de Al 7475-T761, utilizada na estrutura de asas e na fuselagem de aeronaves, em meios contendo íons sulfato por meio de espectroscopia de impedância eletroquímica global (EIS) e por LEIS, associadas à caracterização microestrutural por MEV/EDS. Os resultados dos estudos com as técnicas eletroquímicas globais, juntamente com a caracterização microestrutural, confirmaram que o aumento local do pH devido à reação catódica sobre os IMs é um dos fatores mais importantes na incidência corrosão localizada da liga de Al. Este fenômeno leva à dissolução local da película passiva e a uma importante despolarização da reação de oxidação do Al com grande aumento da corrosão. Já os estudos com o eletrodo de disco rotatório (EDR) mostraram que os íons sulfato melhoram o desempenho da película passiva formada sobre a matriz da liga, e evidenciaram o ataque preferencial dos IMs ricos em cobre por estes íons. No que se refere aos estudos realizados com a LEIS, os mesmos foram desenvolvidos principalmente com pares galvânicos modelos Al 7475/Cu visando simular a atividade eletroquímica que ocorre na interface entre os IMs e a liga. Este enfoque apresentou um aspecto inovador ao empregar pela primeira vez uma liga comercial como um dos componentes de um par galvânico simulado em estudos com a LEIS. Os resultados obtidos com este estudo confirmaram as previsões de modelos teóricos já desenvolvidos para os efeitos da geometria do eletrodo sobre a reatividade na superfície do mesmo, e também mostraram que o bi-eletrodo foi sensível a pequenas mudanças na atividade eletroquímica na interface do par galvânico, o que foi confirmado pelas análises por MEV/EDS. Outro aspecto inovador do presente trabalho com relação ao uso da LEIS foi que, pela primeira vez, foi utilizado um tri-eletrodo para a obtenção dos diagramas de impedância locais. Este sistema permite medir simultaneamente as componentes radial e normal da corrente local, possibilitando um maior refinamento da compreensão dos fenômenos interfaciais locais. Os resultados das medidas com este novo sistema apresentaram boa concordância com o modelo teórico desenvolvido para a resposta de impedância local apresentado neste trabalho, indicando que o mesmo pode se constituir em uma poderosa ferramenta para uma melhor compreensão dos processos interfaciais locais. / Aluminum alloys used in the aerospace industry with structural purpose exhibit a complex microstructure due to thermal and mechanical treatments they are submitted for improving their strength. The microstructure of these alloys is characterized by the presence of a great number of intermetallic (IM) particles, the electrochemical activity of which is different from the matrix leading to the onset of localized corrosion phenomena associated with local galvanic cells. In the last decade local electrochemical impedance spectroscopy (LEIS) has been used as a powerful tool to elucidate local features associated with corrosion and also to study theoretical issues related to current and potential distributions at electrode surfaces and their correlation with surface reactivity. This technique is based on the calculation and analysis of different local impedances acquired by a bi-electrode probe positioned in the vicinity of the electrode surface. The aim of the present work is to study localized corrosion of Al alloy 7475-T761, used with structural purpose in aircraft wings and fuselages, in sulfate containing media using global electrochemical impedance spectroscopy (EIS) and LEIS associated with microstructural characterization by SEM/EDS. The results of the investigations with the global techniques together with the microstructural characterization confirmed that local pH increasing at the matrix/IM interface due to the cathodic reaction on the IMs is the most important cause for the localized corrosion of the alloy. This process leads to local dissolution of the passive layer and to an important depolarization of the Al oxidation reaction leading to a great increase in the corrosion rate of the metal. On the other hand the investigations using the rotating disk electrode (RDE) revealed that sulfate ions increase the anticorrosion performance of the passive layer and are particularly aggressive at Cu-rich IMs. Regarding the studies with the LEIS technique they were mainly performed using an Al 7475/Cu model electrode aiming to simulate the electrochemical activity at the IM/alloy interface. This approach was new as, to the best of our knowledge, it was the first time a commercial alloy was used as one of the component of a model electrode for local electrochemical investigation. The results were in accordance with theoretical models already developed for the effects of geometry induced current and potential distributions on the electrode surface reactivity, and also showed that the bi-electrode was sensitive to minute change of the electrochemical activity at the interface of the galvanic couple, which was confirmed by SEM/EDS analysis. Another originality of the present work regarding the use of LEIS was that, for the first time, a tri-electrode was used to acquire the local impedance diagrams. This system allows the simultaneous measurement of the normal and radial components of the local current making possible a better comprehension of the local interfacial phenomena. The results of the measurements with this new system were in good agreement with the theoretical model for the local electrochemical response presented in this work, indicating that it can be a valuable tool for a better comprehension of the local interfacial processes.
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Combining data mining techniques with multicriteria decision aid in classification problems with composition probabilistc of preferences in trichotomic procedure (CPP-TRI)Silva, Glauco Barbosa da 27 July 2017 (has links)
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D2016 - Glauco Barbosa da Silva.pdf: 5776264 bytes, checksum: d50812d465487f52e8c02b7f636435ab (MD5) / Problem: From Modeling decision maker preferences, the Multicriteria Decision Aid (MCDA) is a field dedicated to the study of real-world decision-making problems that are, usually, too complex and not so well-structured to be considered through the examination of a single point of view (criteria). This feature of MCDA implies that a comprehensive model of a decision maker situation cannot be “created”, but instead, the model should be developed to meet the requirements of the Decision Maker (DM). In general, the development of such a model can only be achieved through an iterative and interactive process, until the preferences of the decision maker are consistently represented in the model. However, an interactive method is a procedure that consists of an alternation of calculation and discussion stages, which presumes that the decision maker is willing to answer a large number of relatively difficult questions. For instance, one of the main difficulties to be faced when interacting with a Decision Maker in order to build a decision aid procedure is the various parameters’ elicitation of the preference model. Methodology: In this thesis, as an alternative to interactive process, among the main streams of MCDA, a Preference Disaggregation Analysis method was used, which is considered to assess or to infer preference models from the given preferential structures and to address decision-aiding activities to elicit preferential information and to construct decision models from decision examples. Combining Composition Probabilistic of Preference with Data Mining techniques, a proposal of a three-step process is presented: attribute selection; clustering; and classification. The first and the second ones are data mining tasks and the last one is a multicriteria task. Purpose: This thesis aims to present a new approach with a Data Mining Layer (attribute selection and/or clustering) in Composition Probabilistic of Preferences in Trichotomic procedure (CPP-TRI), which combines data mining techniques with a Multicriteria Decision Aid method in classification (sorting) problems. Findings: The decision maker ability to comprehend without powerful tools has been exceeded. Therefore, important decisions are often made based not on the information-rich data stored in data repositories, but rather, on intuition of the decision maker. Involved in similar problems, the connections between disaggregation methods and data mining (identifying patterns, extracting knowledge from data, eliciting preferential information and constructing decision models from decision examples) are explored to combine and improve the CPP-TRI Method from Attribute Selection Techniques. / Problem: From Modeling decision maker preferences, the Multicriteria Decision Aid (MCDA) is a field dedicated to the study of real-world decision-making problems that are, usually, too complex and not so well-structured to be considered through the examination of a single point of view (criteria). This feature of MCDA implies that a comprehensive model of a decision maker situation cannot be “created”, but instead, the model should be developed to meet the requirements of the Decision Maker (DM). In general, the development of such a model can only be achieved through an iterative and interactive process, until the preferences of the decision maker are consistently represented in the model. However, an interactive method is a procedure that consists of an alternation of calculation and discussion stages, which presumes that the decision maker is willing to answer a large number of relatively difficult questions. For instance, one of the main difficulties to be faced when interacting with a Decision Maker in order to build a decision aid procedure is the various parameters’ elicitation of the preference model. Methodology: In this thesis, as an alternative to interactive process, among the main streams of MCDA, a Preference Disaggregation Analysis method was used, which is considered to assess or to infer preference models from the given preferential structures and to address decision-aiding activities to elicit preferential information and to construct decision models from decision examples. Combining Composition Probabilistic of Preference with Data Mining techniques, a proposal of a three-step process is presented: attribute selection; clustering; and classification. The first and the second ones are data mining tasks and the last one is a multicriteria task. Purpose: This thesis aims to present a new approach with a Data Mining Layer (attribute selection and/or clustering) in Composition Probabilistic of Preferences in Trichotomic procedure (CPP-TRI), which combines data mining techniques with a Multicriteria Decision Aid method in classification (sorting) problems. Findings: The decision maker ability to comprehend without powerful tools has been exceeded. Therefore, important decisions are often made based not on the information-rich data stored in data repositories, but rather, on intuition of the decision maker. Involved in similar problems, the connections between disaggregation methods and data mining (identifying patterns, extracting knowledge from data, eliciting preferential information and constructing decision models from decision examples) are explored to combine and improve the CPP-TRI Method from Attribute Selection Techniques.
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