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Optimization of the GTRR epithermal neutron filter for BNCT applicationsNewby, Peter George 08 1900 (has links)
No description available.
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Cell cycle affects accumulation of β-D-5-o-Carboranyl-2'-Deoxyuridine(D-CDU) in human glioma cell lineMoore, Casey Benjamin 12 1900 (has links)
No description available.
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Dendronized Polymers and Surfaces: Strategies Toward Novel Therapeutics and BiomaterialsBenhabbour, Soumya Rahima 07 1900 (has links)
Combining linear polymers and dendrimers provides numerous advantages such as increased solubility, biodegradability and a large number of functionalizable peripheral moieties. In this work, novel carborane-containing dendronized polymers were designed as potential candidates for Boron Neutron Capture Therapy (BNCT). These polymers were successfully synthesized using two different approaches. The resulting carborane-functionalized polymers were dendronized using a divergent approach to introduce aliphatic polyester dendrons of generation 1-4 grafted from the polymer backbone. Both approaches produced water-soluble dendronized polymers with high molecular weights. The synthetic approach developed in the first part of this work was also applied in the functionalization of poly(ethylene glycol) (PEG)-grafted gold surfaces with hydrophilic dendrons. In this project, the effect of surface dendronization on protein adsorption was investigated. Contrary to our expectation, protein resistance was found to decrease when the surfaces were covalently functionalized with the hydrophilic dendrons despite their improved hydrophilicity. It was postulated that several factors could be responsible for the increased protein adsorption to the dendronized surfaces, including increased surface area, the introduction of hydrogen-bond donor groups, and a decrease in the mobility of the surface-grafted polymers as a result of inter- and intra-molecular hydrogen bonding between the dendrons. To circumvent these confounding phenomena, while maintaining surface hydrophilicity, we have chosen to covalently attach PEG mono-methyl ether (PEG-OMe) chains of various molecular weight to the peripheral hydroxyl groups of first to fourth generation dendronized surfaces. Results showed that protein adsorption was reduced when dendronized surfaces were grafted with PEG-OMe chains. The hydroxyl-terminated G l-G4 dendronized surfaces and PEG-grafted dendronized surfaces were also investigated for cell adhesion and proliferation. These studies showed that little or no cell adhesion occurred on PEG-grafted gold surfaces. However, greater cell affinity for the dendronized surfaces was observed. When dendronized surfaces were coupled with PEG-OMe chains, cell adhesion was significantly diminished. / Thesis / Doctor of Philosophy (PhD)
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Pharmacokinetics and biodistribution of boron compounds foundations for boron neutron capture theory /Ceberg, Crister. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
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Pharmacokinetics and biodistribution of boron compounds foundations for boron neutron capture theory /Ceberg, Crister. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
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IASB:s hänsynstagande till intressentgruppers åsikter : En studie om normbildningsprocessen för IFRS 16Grundén, Josefin, Ritzler, Cornelia January 2022 (has links)
Redovisningsstandarden IFRS 16 trädde i kraft för redovisningsperioder från den 1:a januari 2019 efter det att intressenter getts möjlighet att uttrycka sina åsikter på ett reviderat utkast. Att låta intressenter uttrycka sina åsikter inför implementering av standarder är en central del av IASB:s normbildningsprocess som gör att de bibehåller sin legitimitet och neutralitet. IASB:s oberoende har dock länge kritiserats för att inte tillgodose det allmänna intresset efter ett flertal incidenter som påvisat att IASB har låtit sig influeras av särskilda intressentgrupper. Uppsatsen behandlar därför IASB:s neutralitet genom normbildningsprocessen med hänsyn till intressentgruppers åsikter uttryckt genom comment letters på det reviderade utkastet ED/2013/6 - Leases. Genom en kvalitativ forskningsmetod med kvantitativa inslag undersöks 340 stycken comment letters. Studiens grundar sig vidare på teorier som capture theory och legitimitetsteorin vilka är teorier som förklarar relationen mellan allmänheten, organisationer och reglerande organ. Resultatet antyder att ingen intressentgrupp tagits i större beaktande än andra och därmed kan IASB:s legitimitet och oberoende inte ifrågasättas på någon starkare grund vad gäller normbildningsprocessen för IFRS 16. Studien bidrar därmed till de skiljaktiga meningar som finns i existerande forskning om huruvida IASB tagit någon intressentgrupp i större beaktande än andra vid framtagandet av en ny redovisningsstandard. / The accounting standard IFRS 16 came to be effective for accounting periods starting 1st of January 2019, after a due process where stakeholders were given the opportunity to express their opinions on an exposure draft. Giving stakeholders the opportunity to express their opinions before implementing a new accounting standard is a key part of IASB:s due process which enables them to maintain their legitimacy and neutrality. IASB:s independency has been widely criticized for not maintaining the interest of the public after numerous incidents which shows that IASB had been influenced by certain stakeholder groups. Therefore, this study examines IASB:s neutrality during the due process in regards to the opinions of stakeholder groups expressed in the comment letters submitted as a response to the exposure draft ED/2013/6 - Leases. Using a qualitative study method with quantitative elements, 340 comment letters were examined. This study is based on theories such as capture theory and legitimacy theory which are theories that explain the relationship between the public, organizations and the regulators. The results indicate that no stakeholder group has had a higher influence and therefore the legitimacy and neutrality of IASB can not be questioned in regards to the due process of IFRS 16. Therefore, this study contributes to the differing opinions in existing research whether IASB has taken any certain stakeholder group into higher consideration in the due process of a new accounting standard.
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Captureteorin : Regleringar och konsten att fånga politiska beslut i den demokratiska processen tillämpad på den svenska läkemedelsmarknaden / The Capture Theory. Regulation and the Art of Capturing Political Decision Making in the Democratic Process Applied to the Swedish Market for Pharmaceuticals.Eckard, Nathalie January 2003 (has links)
<p>The Capturetheory wants to give an alternative explanation for the need of regulation. From this point if view the government does not have enough information to make an optimal regulation. There is a possibility for different interest groups to take advantage of the political arena by rent- seeking behaviour. An industry may be willing to be regulated to protect itself from competition. The objective of this paper is to account for the pros and cons of the theory of regulatory capture and also if it can be applied to the Swedish market of pharmaceuticals. The theory of regulatory capture is first and foremost a theory of the motives behind regulation. The Swedish market for pharmaceuticals has been analysed by looking into the underlying force of both the pharmaceutical industry and that of the State. There is room for the regulatory agencies to be captured by the industry because of the information provided to them by the industry. The concluding findings show that the Capture theory can applied to the Swedish market for pharmaceuticals.</p>
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Captureteorin : Regleringar och konsten att fånga politiska beslut i den demokratiska processen tillämpad på den svenska läkemedelsmarknaden / The Capture Theory. Regulation and the Art of Capturing Political Decision Making in the Democratic Process Applied to the Swedish Market for Pharmaceuticals.Eckard, Nathalie January 2003 (has links)
The Capturetheory wants to give an alternative explanation for the need of regulation. From this point if view the government does not have enough information to make an optimal regulation. There is a possibility for different interest groups to take advantage of the political arena by rent- seeking behaviour. An industry may be willing to be regulated to protect itself from competition. The objective of this paper is to account for the pros and cons of the theory of regulatory capture and also if it can be applied to the Swedish market of pharmaceuticals. The theory of regulatory capture is first and foremost a theory of the motives behind regulation. The Swedish market for pharmaceuticals has been analysed by looking into the underlying force of both the pharmaceutical industry and that of the State. There is room for the regulatory agencies to be captured by the industry because of the information provided to them by the industry. The concluding findings show that the Capture theory can applied to the Swedish market for pharmaceuticals.
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Expanding the toolkit for industry analysis: an application of the value capture conceptOsen, Marte Risdal January 2017 (has links)
Submitted by Marte Osen (osen.marte@gmail.com) on 2017-10-10T17:16:01Z
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Dear Marte,
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Withdraw all the numbers of the page before the introduction, but they must to be considered.
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Previous issue date: 2017 / The purpose of this study is to apply value-based business concepts to a product in order to gain insight into the competitive environment within its related industry. This case study is based upon qualitative information from the decision makers in a company producing a product. It is shown that the value based business theories, when organised into one framework, does facilitate the organisation of data, and hence some conclusions about the competitive dynamics of the industry can be drawn. The approach to thinking about business suggested by the value based business concepts might hence lead to insights that can serve as a new background for strategic decisions. / O propósito deste estudo é aplicar conceitos associados à geração e captura de valor a um produto específico para melhor compreender o ambiente competitivo de seu respectivo mercado. Este estudo de caso é baseado em dados qualitativos obtidos de tomadores de decisão de uma empresa produtora do produto em questão. Será mostrado que os conceitos de captura e geração de valor de fato facilitam a organização de dados e, portanto, permite traçar conclusões sobre a dinâmica competitiva da respectiva indústria. A abordagem sugerida a partir destes conceitos permite direcionar perspectivas que podem ser usadas como plano de fundo para tomadas de decisão estratégica.
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