Bacteria frequently encounter changes in their environment and must adapt accordingly. When these changes are predictable, there is evidence of anticipatory gene regulation. For example, the model enteric pathogen Salmonella has a well-defined natural history, typically only encountering iron in the lumen of the gut. However, this bacterium responds to the presence of iron not by upregulating genes needed to thrive in the lumen, but rather the iron-deplete epithelium, the subsequent environment it encounters. This may be similar to Pavlovian conditioning, a type of associative learning that involves pairing two unrelated stimuli and anticipatory behavioural changes. Since conditioning has not been well explored in bacteria, we are investigating whether Salmonella can learn new conditioned responses by pairing two unrelated carbon sources, citrate and maltose. We leveraged a prototype of the Microbial Evolution and Growth Arena (MEGA)-plate motility assay to define a new natural history. By pairing stimuli across a physical landscape, we can select for bacteria that learn to use citrate to anticipate maltose and can quickly deplete the second carbon source. Time-series imaging of bacteria as they swim across the plate shows evidence of emerging variants capable of swimming faster through maltose and unique swimming behaviours through repeated passaging. This approach selects for the fastest swimming bacteria, not necessarily bacteria that have acquired anticipatory regulation. As such, further genetic and transcriptional analysis of the variants are necessary. Similar passaging of Salmonella in broth allowed us to compare anticipatory regulation across a physical and non-physical landscape. Learning to anticipate environmental changes will provide a bacterium with a selective advantage, allowing it to outcompete its conspecifics which are slower to respond. From this investigation, we hope to provide insight into the learning capacity of bacteria and further understand how bacteria exploit memory to problem-solve. / Thesis / Master of Science (MSc) / Bacteria that encounter predictable changes in their environment can acquire anticipatory gene regulation. This may be similar to Pavlovian conditioning, a type of associative learning that involves pairing two unrelated stimuli and anticipatory behavioural changes. Since conditioning has not been well explored in bacteria, we investigate whether Salmonella can learn new behaviours by pairing two unrelated carbon sources, citrate and maltose. We leveraged a motility plate assay to define a new natural history. By pairing stimuli across a physical landscape, we can select for bacteria that learn to use citrate to anticipate maltose. Time-series imaging shows evidence of variants capable of swimming faster through maltose and unique swimming behaviours through repeated passaging. Similar passaging of Salmonella in broth allowed us to compare anticipatory regulation across physical and non-physical landscapes. From this investigation, we hope to further understand the learning capacity of bacteria and how bacteria exploit memory to solve problems.

Anticipation refers to preparation for upcoming events in the environment (Clark, 1998; Ondobaka & Bekkering, 2007; Allen & Friston, 2016). The ability to anticipate – as manifested in the preparatory actions and neural activation in expectation of an upcoming target stimulus – may play a key role in the development of cognitive skills. In the current study, cognitive skills are specified as the execution of stimulus-relevant, goal-directed actions (as indexed by reaction time) and individual differences in the ability to use goals to direct action (as indexed by executive function measures). A cross-sectional investigation was conducted in 40 adults and 40 6- to 8-year-old children to examine the association of neural correlates of anticipatory attention to visual, tactile and auditory stimuli with inter- and intra-individual variation in executive function (EF) abilities. Consistent with prior findings (Weiss, Meltzoff, & Marshall, 2018), the sensorimotor mu rhythm in the alpha range of the EEG signal was suppressed in the contralateral hemisphere during anticipation of tactile stimulation, with the extent of this suppression being related to children’s performance on EF tasks. Within-subject relations were also found between lateralized EEG modulation and single-trial reaction time responses to target stimuli. This relation was evident for visual and tactile stimuli (but not auditory stimuli) and was more prominent in adults than children. Further, these relations were responsible for significant variance in executive function scores using a multi-level model. Results indicated that inter-individual differences in anticipatory sensorimotor mu modulation (not visual alpha or auditory tau rhythms) contributed to the significant association with executive function variability. I discuss anticipatory EEG oscillations as an empirical, quantifiable indicator of stimulus prediction, advancing anticipation as a bridge concept embedded in neuroscientific, behavioral, computational and developmental science. / Psychology

Les restructurations occupent plus que jamais le devant de l'actualité. En effet, il ne se passe pas une semaine sans que les médias ne relayent un nouveau plan de restructuration aux conséquences souvent désastreuses sur l'emploi. S'il est vrai que les restructurations sont également présentes en période de croissance économique, elles prennent un relief tout particulier en temps de crise ; c'est à ce moment là qu'elles vont véritablement se révéler. Elles représentent un phénomène complexe qui engendre de nombreuses conséquences économiques, financières et humaines. A partir de ce constat, il paraît évident qu'une stratégie doit être mise en place afin de les anticiper et de sécuriser au mieux l'emploi en France. Le dialogue social est alors privilégié pour atteindre cet objectif. La procédure d'information-consultation des représentants du personnel et la négociation collective peuvent-elles contribuer à la mise en place d'une stratégie d'anticipation collective des restructurations ? Sans se vouloir exhaustive, cette étude tente d'apporter des éléments de réponse à la question soulevée. / Company reorganizations have now become burning issues. Every single week, the media report a new reorganization project whose consequences on employment are disastrous. Of course, reorganizations also take place in times of economic prosperity, however, they take a new dimension in times of crisis when they do reveal themselves. They represent a complex phenomenon which generates a lot of economic, financial and human difficulties. Once this observation made, it seems obvious that a relevant strategy must be put in place to anticipate reorganizations and secure employment in France as best as possible. Social talks are then favoured so as to reach this objective. Can this process of information-consultation of the staff representatives added to collective negotiation talks lead to a better strategy of anticipation of reorganizations? Without being exhaustive, this study tries to bring some possible answers to this question.

Avec le succès des communications sans fil, il devient possible d'accéder au réseau partout et à tout moment sans avoir recours à connecter physiquement les appareils communicants à une infrastructure. Les nœuds (ordinateurs portables, smartphones, etc) peuvent analyser les différents canaux radio afin de pouvoir s'associer à un réseau sans fil disponible (station de base, point d'accès, etc.). Un avantage indéniable de ses technologies sans fil est la possibilité d'être mobile tout en restant connecté. Cependant, la mobilité est une tâche difficile à gérer car elle doit être abordée à différentes couches pour être transparente aux utilisateurs. Dans les MANET (Mobile Ad hoc Network), les protocoles de routage utilisent des métriques pour sélectionner les meilleures routes. Les métriques peuvent refléter la qualité de la liaison sans fil et aider à gérer la mobilité.Mais, un retard important entre l'estimation des métriques et leur inclusion dans le processus de routage rend cette approche inefficace.Les travaux de cette thèse s'intéressent à la proposition de nouvelles méthodes de calcul des métriques de routage pour gérer le problème de la mobilité dans les réseaux ad hoc. Les nouvelles métriques doivent refléter la qualité du lien et être sensibles à la mobilité en même temps. Nous considérons les métriques classiques, en particulier ETX (Expected Transmission Count) et ETT (Expected Transmission Time). Nous introduisons de nouvelles méthodes pour anticiper les valeurs de ces métriques en utilisant des algorithmes de prédiction. Nous utilisons une approche Cross layer, qui permet l'utilisation conjointe de l'information à partir des couches 1, 2 et 3. La validation de nouvelles méthodes de calcul des métriques de routage nécessite une évaluation au travers d'un véritable banc d'essai. Nous avons donc également mis en œuvre les nouvelles métriques de routage dans un testbed afin d'évaluer et de comparer leurs performances avec les métriques classiques. / With the success of wireless communications, it becomes possible to access the network anywhere at any time without the need for physically connect communicating devices in an infrastructure. The nodes (laptops, smartphones, etc.) can analyze different radio channels to be able to associate with an available wireless network (base station, access point, etc.). An undeniable advantage of wireless technologies is the ability to be mobile while staying connected. However, mobility is difficult to manage because it must be addressed at different layers to be transparent to users. In MANET (Mobile Ad hoc Network) routing protocols use metrics to select the best routes. The metric can reflect the quality of the wireless link and help manage mobility.But a significant delay between the estimate metrics and their inclusion in the routing process makes this approach ineffective.The work of this thesis are interested in proposing new methods for calculating routing metrics to manage the problem of mobility in ad hoc networks. The new metrics should reflect the quality of the link and be sensitive to the mobility simultaneously. We consider the classical metrics, particularly ETX (Expected Transmission Count) and ETT (Expected Transmission Time). We introduce new methods to predict the values of these metrics using prediction algorithms.We use a cross layer approach, which allows the joint use of information from layers 1, 2 and 3. The validation of new methods for calculating routing metrics requires evaluation through a real bench test. So we also implemented new routing metrics in a testbed to assess and compare their performance with classical metrics.

This dissertation explores the influence of melody on harmonic function in pop and rock songs from around 1950 to the present. While authors define the term "function" in several ways, none consider melody in their explanations, and I contend that any discussion of harmonic function in rock must include melody. I offer a novel perspective on function by defining it through what I call tension-as-anticipation, and I define a "melodic function" that accounts for the sense of tension and relaxation a melody creates within a particular moment in a track. My dissertation defines two types of melodic function—dominant and tonic—based on the melody's goal-directed scale-degree content, position within a phrase, and relation with the harmony. Dominant-melodic function results in two musical phenomena that I call the "imposed dominant" and the "dominant remainder." An imposed dominant occurs when a dominant-melodic function is initially dissonant with the harmony and resolves over a tonic. A dominant remainder occurs when a dominant-melodic function occurs over a harmonic resolution to the tonic, creating a slower dissipation of tension. Tonic-melodic function produces a phenomenon I call the "tonic anticipation," where a melody outlines a tonic mode over a pretonic harmony, creating a maximum sense of tension-as-anticipation. By including melody in considering harmonic function, we can more adequately describe the cycles of tension and resolution found in pop styles.

Previous investigations comparing direct versus indirectly cued movements have consistently shown that indirectly cued movements take longer to prepare (Neely and Heath, 2010) and involve the recruitment of additional brain areas (Connolly et al., 2000). This increase in processing time has been associated with the additional cognitive transformations required of the task (Neely and Heath, 2010). In the present study we investigated whether differences between direct versus indirectly cued movements are also reflected in the time course of motor preparation. Participants performed a targeting task, moving directly to the location of a visual cue (i.e., directly cued movement) or to a location that differed by 60˚, 90˚, or 120˚ with respect to the visual cue provided (i.e., indirectly cued movements). Participants were instructed to initiate their movements concurrently with an anticipated go-signal. To examine the time course of motor preparation, a startling acoustic stimulus (SAS, 124dB) was randomly presented 150 ms, 500 ms, or 1000 ms prior to the go-signal. Results from the startle trials revealed that the time course of motor preparation was similar regardless of the angle of rotation required and hence whether it was a direct or indirectly cued trial. Specifically, motor preparation was delayed until less than 500 ms prior to movement initiation for both direct and indirectly cued movements. These findings indicate that similar motor preparation strategies are engaged for both types of cued movements, suggesting that the time to prepare a motor response may be similar regardless of whether a cognitive transformation is required.

There is a long history of research on the effects of reward motivation on memory, but there are still questions concerning how such motivational variables affect memory. In a study that examined the influence of reward anticipation on episodic memory, Adcock, Thangavel, Whitfield-Gabireli, Knutson, and Gabrieli (2006) found that memory was better for scenes preceded by high value reward cues than low value cues (see also Cushman, 2012; Spaniol, Schain, & Bowen, 2013). More recently, Castel, Murayama, Friedman, McGillivray, & Link (2013) observed that anticipation of reward influences selective attention to “to be remembered” (TBR) words and the memories that are formed in both younger (YA) and older adults (OA). Finally, in an examination of reward-motivated memory for both word items and pairs, Mutter, Luttrell, & Steen (2013) found that high reward enhanced associative memory for word pairs for both YA and OA. The theoretical explanation for this finding attributed word pair stimuli as promoting and high reward motivation as selectively enhancing relational encoding strategies for both OA and YA, producing reward effects for associative recognition performance only. The present study conceptually replicated the methodology from Mutter, Luttrell, and Steen (2013) in an examination of how reward motivation at study affects non-verbal single item recognition and dual item recognition for picture pair stimuli. It was expected that high reward will induce both YA and OA to engage in more extensive encoding of TBR information, but that, due to age-related associative deficits (e.g., Naveh – Benjamin, Hussain, Guez, & Bar-On, 2003), the type of encoded representations would differ for the two groups. YA would perform better than OA on the types of recognition that require memory for relational information (i.e., associative and context recognition), but YA and OA would perform equally well on the types of recognition that require memory for item-specific information (i.e., pair and no context recognition). As compared to the word pair stimuli used by Mutter and colleagues (2013), it was expected that picture pair stimuli would alternatively promote item-specific encoding strategies for both OA and YA and high reward would selectively enhance single item recognition performance.

La tradition utopique a longtemps entretenu le rêve d'une société idéale située dans un ailleurs, un u-­- topos, le "lieu qui n'est pas" dans L'Utopie de Thomas More. La représentation de ces utopies est indissociable d'un facteur déterminant pour la construction d'un monde meilleur : le progrès. Ainsi, cette tradition se caractérise par l'accent prométhéen d'une telle entreprise, c'est des mains de l'homme que sera façonnée cette nouvelle société. Cependant, le point de vue sur la possibilité d'une société idéale va progressivement s'infléchir, notamment au cours du XIXe siècle, pour s'inverser d'une manière radicale au début du XXe siècle. Nommée anti-­utopie ou contre-­utopie, cette désillusion souligne l'impuissance de l'homme et le rôle ambigu du progrès pour inventer la société parfaite. Parfois utilisée comme synonyme d'anti-­utopie, la dystopie caractérise plus précisément les textes qui décrivent une société dirigée par un système d?oppression absolu, fondé sur un État omnipotent, et presque toujours organisé scientifiquement. Ainsi, des dysfonctionnements de la cité du futur dans Le Monde tel qu'il sera d'Émile Souvestre, en 1846, à l'État Unique dans Nous autres de Evguéni Zamiatine, écrit en 1920, la dystopie évolue en prenant la forme du récit de science-­fiction, et en particulier celle de l'anticipation. Nous verrons, notamment, comment l'utopie prend place dans les oeuvres de Jules Verne et H.G. Wells. Zamiatine, très inspiré par Wells, est le premier grand écrivain du XXe siècle à se servir de la dystopie pour décrire les attributs de la société totalitaire. Ainsi, si notre démarche consiste, dans un premier temps, à désigner les auteurs et textes qui ont participé à l'émergence de la dystopie, notre analyse portera essentiellement sur Nous autres et trois autres romans fondateurs de la dystopie au XXe siècle : Le Meilleur des mondes d'Aldous Huxley, publié en 1932, 1984 de George Orwell, publié en 1948 et Fahrenheit 451 de Ray Bradbury, publié en 1953. Nous étudierons le phénomène totalitaire selon les interprétations qu'en font nos auteurs. Il sera donc question de la collectivisation de l'individu, de la propagande ou du rôle de la science dans l'organisation de la société totalitaire. Mais il s'agira aussi de montrer comment nos dystopies illustrent le combat de l'art contre l'entropie totalitaire, et l'engagement de leurs auteurs dans un véritable discours politique. Enfin, il apparaît essentiel de décrire ce qui apparaît peut-­être comme la forme la plus efficace de la représentation de la dystopie : le film de science-­fiction. Nous verrons pourquoi le roman dystopique peine de plus en plus à soutenir la comparaison face à l'immédiateté du langage de l'image animée. / The utopian tradition a long time maintained the dream an ideal society located in one elsewhere, a u-­topos, the "place which is not" in the Utopia of Thomas More. The representation of these Utopias is indissociable of a determining factor for the construction of a better world: progress. Thus, this tradition is characterized by the Promethean accent of such a company, they are hands of the man who this new society will be worked. However, the point of view on the possibility of an ideal society gradually will inflect, in particular during the 19th century, to be reversed in a radical way at the beginning of the 20th century. Named anti-­Utopia or against-­Utopia, this disillusion underlines the impotence of the man and the ambiguous role of progress to invent the perfect society. Sometimes used as synonym of anti-­Utopia, the dystopia more precisely characterizes the texts which describe a society directed by an absolute system of oppression, based on an omnipotent State, and almost always scientifically organized. Thus, abnormal operations of the city of the future in The World such as it will be of Emile Souvestre, in 1846, in the State Unique in Us of Evgueni Zamiatine, written in 1920, the dystopia evolves by taking the form of the account of science fiction, and in particular that of anticipation. We will see, in particular, how the Utopia takes seat in works of Jules Verne and H.G. Wells. Zamiatine, very inspired by Wells, is the first great writer of the 20th century to be made use of the dystopia to describe the attributes of the totalitarian society. Thus, if our step consists, initially, to appoint the authors and texts which took part in the emergence of the dystopia, our analysis will primarily carry on Us and three other Romance founders of the dystopia at the 20th century: Brave New World of Aldous Huxley, published into 1932, 1984 of George Orwell, published in 1948 and Fahrenheit 451 of Ray Bradbury, published in 1953. We will study the totalitarian phenomenon according to interpretations that make our authors of them. It will be thus a question of the collectivization of the individual, the propaganda or the role of science in the organization of the totalitarian society. But it will also be a question of showing how our dystopies illustrates the combat of art against the totalitarian entropy, and the engagement of their authors in a true political discourse. Lastly, it appears essential to describe what perhaps appears as the most effective form of the representation of the dystopia: the science fiction film. We will see why the novel dystopic sorrow more and more support the comparison face to the immediacy of the language of the moving image.

This thesis offers an exploration of the writing of an irreducible feminine difference in four novels by women. Drawing from the work of the Continental feminist philosopher Luce Irigaray, I read her conceptual undertaking of sexual difference as precipitating an alternative narrative for feminist thought. The crux of this project involves an inscription of the indeterminable, and thus far elided, category of the feminine, back into the uncontested frameworks of patriarchal knowledge. In so doing, the feminine illuminates what Irigaray calls the “otherwise, elsewhere” that troubles the universality of all masculine discourse. Sexual difference can then be extrapolated from these terms, to anticipate a compelling horizon of possibilities for feminism that lies beyond the deterministic confines of the singular present. Its advent marks the creation of radical feminist lines of inquiry that have yet to be imagined. My study builds on Irigaray’s approach to sexual difference to suggest that the transformative space of literature provides a promising blueprint for its otherwise inchoate articulation. The texts I analyse invoke an anticipatory impulse to think the impossible, and offer an imaginative frame of reference for envisioning these processes of sexual difference. By considering four novels by Marilynne Robinson, Jeanette Winterson, Elena Ferrante, and Rachel Cusk, I illustrate that their engagement with sexual difference is a strategic and combative negotiation of our dominant modes of understanding. More crucially, I examine the dialogue that is inspired by these texts when the intimations of sexual difference are brought together with the evocative possibilities of literature, which might accordingly be extended to affirm a new and reflective cartography for the futures of the feminist imaginary. A further narrative can be located in the sequence of the chapters in my thesis, insofar as each of its novels was published around successive decades apart from 1980- 2014. By alluding to the respective contextual backdrops of these texts, I consider the more overarching trajectory of feminist theory and criticism, in which sexual difference has materialised in its contingent narratives as an enduring, and indeed unsettling, question. It circulates as a speculative theoretical paradigm in the multiple intersections of feminist theory, philosophy, and literary studies. My thesis will argue not only for the altogether difficult and necessary unknowability of feminist thought as it looks ahead to the future, but also for the critical relevance of literary perspectives in explicating these processes of feminist world-making.

This thesis introduces a new theoretical framework from which to view the factors that contribute to stuttering variability. The speech and monitoring interaction (SAMI) framework proposes that there are two systems that account for stuttering variability: the speech production system and the monitoring system. Each system has unique factors that modulate them. Within SAMI, the interaction of these two categories of factors is formalized in a mathematical equation. What is particularly novel about SAMI is the use of a mathematical equation to formalize the interaction between these systems and the specific proposal of the biological substrates of the monitoring system and its interaction with the speech system. The focus of this thesis is on the anticipation of stuttering, which is one of the factors from SAMI that modulates the monitoring system. The goals of the studies were to 1) characterize the degree to which people who stutter (PWS) anticipate stuttering and how accurately they can predict actual stuttering, 2) investigate the correlation between stuttering expectancy on words and the verbal response time to say those word in word naming tasks, and 3) make a qualitative comparison of the behavioral results and the results from a neural network model. Utilizing the SAMI framework it was hypothesized that stuttering expectancy would be positively correlated with the response time and the results from the simulations would qualitatively match the behavioral results. The key finding was that across the group of PWS, there was positive correlation between stuttering expectancy scores and relative reaction times on those words. The degree to which stuttering expectancy was correlated with reaction time within subjects was positively correlated with stuttering severity. A qualitative comparison showed a good fit in between results of the simulations and the behavioral study. This is the first study to show that the expectation of stuttering has an effect on fluent speech production, providing evidence that the anticipation of stuttering is not only correlated with moments of stuttering but may also be a contributing factor to stuttering. The model provides a means of hypothesizing and testing specific neural substrates associated with anticipation of stuttering and its effects on the speech production process.