A história política paraguaia pauta-se por longos períodos de predomínio dos dois principais grupos políticos agrupados nos partidos Colorado e Liberal, constatando-se na evolução da estrutura histórica a manutenção de seu predomínio, nos períodos de autoritarismo bem como nos de democratização. O presente trabalho propõe-se a demonstrar que a ideologia é um elemento importante no processo de dominação política no Paraguai, visando sua legitimação, constituindo-se em uma hegemonia. Observa-se que o dinamismo interno dos partidos provido pelas lutas internas partidárias, engendrando em uma estrutura partidária e em um discurso ideológico flexíveis, possibilita a sua continuação ao longo do tempo. Procura-se analisar qual o papel do discurso ideológico na dinâmica interna dos partidos, se influencia no processo de adaptação que permite a sua manutenção histórica. Neste âmbito, busca-se apreciar qual o papel dos intelectuais orgânicos – com atuação na estrutura partidária – na conformação e manutenção do bloco histórico, a fim de observar se de fato o elemento ideológico constitui-se em relevante ferramenta para a sua manutenção. Intenta-se compreender como se comportou historicamente o desenvolvimento do processo de hegemonia dos grupos sociais dominantes, e como este fenômeno possibilitou a acomodação dos interesses divergentes e concorrentes de alguns setores do bloco, e desses com os setores operários e camponeses, mantendo o modelo hegemônico de dominação. A partir do estudo de cinco períodos, procura-se identificar quais são os discursos ideológicos dos partidos Colorado e Liberal, a partir de intelectuais orgânicos representantes das principais correntes dos partidos, assim como elementos que os diferenciam e outros que permanecem ao longo do tempo, visando encontrar a ideia central e os elementos essenciais que movem a ação política partidária. Para tanto, utilizar-se-ão duas classes de fontes empíricas para a pesquisa: as convenções partidárias e suas declarações ideológicas, ademais de obras da produção de intelectuais orgânicos representantes dos dois projetos hegemônicos. / The Paraguayan political history is guided by long predominance periods of the two main political groups grouped in Colorado and Liberal parties, finding in the evolution of the historic structure the maintain of its dominance in both periods of authoritarianism as in democratization. This paper aims to demonstrate that ideology is an important element in the political domination process in Paraguay, seeking its legitimacy, thus becoming a hegemony. It is observed that the internal dynamics of the parties provided by party infighting, engendering in a party structure and a flexible ideological discourse, enables its continuation over time. Seeks to analyze the role of ideological discourse in the internal dynamics of the parties, whether or not influence the adaptation process that allows its historical maintenance. In this context, the aim is to assess what is the role of organic intellectuals – operating in the party structure – in the formation and maintenance of the historical bloc, in order to see if in fact the ideological element constitutes a relevant tool for its maintenance. Attempts to understand how historically behaved the development of hegemony process of dominant social groups, and how this phenomenon has enabled the accommodation of divergent and competing interests of some sectors of the bloc, and those with the workers and peasants sectors, maintaining the hegemonic model of domination. From the study of five periods, seeks to identify what are the ideological discourses of the Colorado and Liberal parties in those moments, from organic intellectuals representatives of mainstream political parties, as well as elements that differentiate the parties and others who remain over time, aimed at finding the central idea and the essential elements that move the partisan political action. To this end, shall be used two classes of empirical sources for the research: the party conventions and their ideological statements, in addition to works of the production of organic intellectual representatives of the two hegemonic projects.

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro / Esta dissertação pretende fornecer uma contribuição acadêmica aos estudos sobre harmonização contábil em blocos econômicos. A pesquisa teve como objetivo analisar o processo de harmonização contábil nos seis países integrantes do MERCOSUL, após a refundação do IASB, em 2001. A metodologia do estudo tem caráter descritivo e natureza analítica, visando descrever as características qualitativas em relação aos aspectos contábeis e regulatórios dos países estudados. Foi realizada uma pesquisa documental em que foram analisados os relatórios sobre harmonização contábil no MERCOSUL e o método aplicado foi o de estudo de múltiplos casos. Os documentos analisados foram: (a) Report on the Observance of Standards and Codes Auditing and Accounting (ROSC A&A), do Banco Mundial; (b) relatório enviado pelos países ao IASB; (c) relatório enviado pelos países ao GLENIF, além das informações disponíveis nos sites oficiais dos próprios países. A pesquisa contribui para resgatar a história do processo de harmonização e alertar para os potenciais impactos das diferenças na preparação dos balanços das empresas que compõem o bloco. / This thesis aims to provide an academic contribution to the studies on accounting harmonization in economic blocs. The research aimed to analyze the accounting harmonization process in the six member countries of Mercosur, after rebuilding the IASB in 2001. The study methodology is descriptive and analytical nature, seeking to describe the qualitative characteristics in relation to accounting and regulatory aspects of countries studied. Documentary research was carried out in the reports on accounting harmonization were analyzed in Mercosur, and the method used was the study of multiple case. The documents analyzed were: (a) Report on the Observance of Standards and Codes - Auditing and Accounting (ROSC A & A) of the World Bank; (B) report submitted by countries to the IASB; (C) report submitted by countries to GLENIF; addition to the information available on the official websites of the countries themselves. The research contributes to rescue the history of the harmonization process and warn of the potential impacts of the differences in the preparation of balance sheets that make up the block.

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro / Esta dissertação pretende fornecer uma contribuição acadêmica aos estudos sobre harmonização contábil em blocos econômicos. A pesquisa teve como objetivo analisar o processo de harmonização contábil nos seis países integrantes do MERCOSUL, após a refundação do IASB, em 2001. A metodologia do estudo tem caráter descritivo e natureza analítica, visando descrever as características qualitativas em relação aos aspectos contábeis e regulatórios dos países estudados. Foi realizada uma pesquisa documental em que foram analisados os relatórios sobre harmonização contábil no MERCOSUL e o método aplicado foi o de estudo de múltiplos casos. Os documentos analisados foram: (a) Report on the Observance of Standards and Codes Auditing and Accounting (ROSC A&A), do Banco Mundial; (b) relatório enviado pelos países ao IASB; (c) relatório enviado pelos países ao GLENIF, além das informações disponíveis nos sites oficiais dos próprios países. A pesquisa contribui para resgatar a história do processo de harmonização e alertar para os potenciais impactos das diferenças na preparação dos balanços das empresas que compõem o bloco. / This thesis aims to provide an academic contribution to the studies on accounting harmonization in economic blocs. The research aimed to analyze the accounting harmonization process in the six member countries of Mercosur, after rebuilding the IASB in 2001. The study methodology is descriptive and analytical nature, seeking to describe the qualitative characteristics in relation to accounting and regulatory aspects of countries studied. Documentary research was carried out in the reports on accounting harmonization were analyzed in Mercosur, and the method used was the study of multiple case. The documents analyzed were: (a) Report on the Observance of Standards and Codes - Auditing and Accounting (ROSC A & A) of the World Bank; (B) report submitted by countries to the IASB; (C) report submitted by countries to GLENIF; addition to the information available on the official websites of the countries themselves. The research contributes to rescue the history of the harmonization process and warn of the potential impacts of the differences in the preparation of balance sheets that make up the block.

A história política paraguaia pauta-se por longos períodos de predomínio dos dois principais grupos políticos agrupados nos partidos Colorado e Liberal, constatando-se na evolução da estrutura histórica a manutenção de seu predomínio, nos períodos de autoritarismo bem como nos de democratização. O presente trabalho propõe-se a demonstrar que a ideologia é um elemento importante no processo de dominação política no Paraguai, visando sua legitimação, constituindo-se em uma hegemonia. Observa-se que o dinamismo interno dos partidos provido pelas lutas internas partidárias, engendrando em uma estrutura partidária e em um discurso ideológico flexíveis, possibilita a sua continuação ao longo do tempo. Procura-se analisar qual o papel do discurso ideológico na dinâmica interna dos partidos, se influencia no processo de adaptação que permite a sua manutenção histórica. Neste âmbito, busca-se apreciar qual o papel dos intelectuais orgânicos – com atuação na estrutura partidária – na conformação e manutenção do bloco histórico, a fim de observar se de fato o elemento ideológico constitui-se em relevante ferramenta para a sua manutenção. Intenta-se compreender como se comportou historicamente o desenvolvimento do processo de hegemonia dos grupos sociais dominantes, e como este fenômeno possibilitou a acomodação dos interesses divergentes e concorrentes de alguns setores do bloco, e desses com os setores operários e camponeses, mantendo o modelo hegemônico de dominação. A partir do estudo de cinco períodos, procura-se identificar quais são os discursos ideológicos dos partidos Colorado e Liberal, a partir de intelectuais orgânicos representantes das principais correntes dos partidos, assim como elementos que os diferenciam e outros que permanecem ao longo do tempo, visando encontrar a ideia central e os elementos essenciais que movem a ação política partidária. Para tanto, utilizar-se-ão duas classes de fontes empíricas para a pesquisa: as convenções partidárias e suas declarações ideológicas, ademais de obras da produção de intelectuais orgânicos representantes dos dois projetos hegemônicos. / The Paraguayan political history is guided by long predominance periods of the two main political groups grouped in Colorado and Liberal parties, finding in the evolution of the historic structure the maintain of its dominance in both periods of authoritarianism as in democratization. This paper aims to demonstrate that ideology is an important element in the political domination process in Paraguay, seeking its legitimacy, thus becoming a hegemony. It is observed that the internal dynamics of the parties provided by party infighting, engendering in a party structure and a flexible ideological discourse, enables its continuation over time. Seeks to analyze the role of ideological discourse in the internal dynamics of the parties, whether or not influence the adaptation process that allows its historical maintenance. In this context, the aim is to assess what is the role of organic intellectuals – operating in the party structure – in the formation and maintenance of the historical bloc, in order to see if in fact the ideological element constitutes a relevant tool for its maintenance. Attempts to understand how historically behaved the development of hegemony process of dominant social groups, and how this phenomenon has enabled the accommodation of divergent and competing interests of some sectors of the bloc, and those with the workers and peasants sectors, maintaining the hegemonic model of domination. From the study of five periods, seeks to identify what are the ideological discourses of the Colorado and Liberal parties in those moments, from organic intellectuals representatives of mainstream political parties, as well as elements that differentiate the parties and others who remain over time, aimed at finding the central idea and the essential elements that move the partisan political action. To this end, shall be used two classes of empirical sources for the research: the party conventions and their ideological statements, in addition to works of the production of organic intellectual representatives of the two hegemonic projects.

A história política paraguaia pauta-se por longos períodos de predomínio dos dois principais grupos políticos agrupados nos partidos Colorado e Liberal, constatando-se na evolução da estrutura histórica a manutenção de seu predomínio, nos períodos de autoritarismo bem como nos de democratização. O presente trabalho propõe-se a demonstrar que a ideologia é um elemento importante no processo de dominação política no Paraguai, visando sua legitimação, constituindo-se em uma hegemonia. Observa-se que o dinamismo interno dos partidos provido pelas lutas internas partidárias, engendrando em uma estrutura partidária e em um discurso ideológico flexíveis, possibilita a sua continuação ao longo do tempo. Procura-se analisar qual o papel do discurso ideológico na dinâmica interna dos partidos, se influencia no processo de adaptação que permite a sua manutenção histórica. Neste âmbito, busca-se apreciar qual o papel dos intelectuais orgânicos – com atuação na estrutura partidária – na conformação e manutenção do bloco histórico, a fim de observar se de fato o elemento ideológico constitui-se em relevante ferramenta para a sua manutenção. Intenta-se compreender como se comportou historicamente o desenvolvimento do processo de hegemonia dos grupos sociais dominantes, e como este fenômeno possibilitou a acomodação dos interesses divergentes e concorrentes de alguns setores do bloco, e desses com os setores operários e camponeses, mantendo o modelo hegemônico de dominação. A partir do estudo de cinco períodos, procura-se identificar quais são os discursos ideológicos dos partidos Colorado e Liberal, a partir de intelectuais orgânicos representantes das principais correntes dos partidos, assim como elementos que os diferenciam e outros que permanecem ao longo do tempo, visando encontrar a ideia central e os elementos essenciais que movem a ação política partidária. Para tanto, utilizar-se-ão duas classes de fontes empíricas para a pesquisa: as convenções partidárias e suas declarações ideológicas, ademais de obras da produção de intelectuais orgânicos representantes dos dois projetos hegemônicos. / The Paraguayan political history is guided by long predominance periods of the two main political groups grouped in Colorado and Liberal parties, finding in the evolution of the historic structure the maintain of its dominance in both periods of authoritarianism as in democratization. This paper aims to demonstrate that ideology is an important element in the political domination process in Paraguay, seeking its legitimacy, thus becoming a hegemony. It is observed that the internal dynamics of the parties provided by party infighting, engendering in a party structure and a flexible ideological discourse, enables its continuation over time. Seeks to analyze the role of ideological discourse in the internal dynamics of the parties, whether or not influence the adaptation process that allows its historical maintenance. In this context, the aim is to assess what is the role of organic intellectuals – operating in the party structure – in the formation and maintenance of the historical bloc, in order to see if in fact the ideological element constitutes a relevant tool for its maintenance. Attempts to understand how historically behaved the development of hegemony process of dominant social groups, and how this phenomenon has enabled the accommodation of divergent and competing interests of some sectors of the bloc, and those with the workers and peasants sectors, maintaining the hegemonic model of domination. From the study of five periods, seeks to identify what are the ideological discourses of the Colorado and Liberal parties in those moments, from organic intellectuals representatives of mainstream political parties, as well as elements that differentiate the parties and others who remain over time, aimed at finding the central idea and the essential elements that move the partisan political action. To this end, shall be used two classes of empirical sources for the research: the party conventions and their ideological statements, in addition to works of the production of organic intellectual representatives of the two hegemonic projects.

The presented dissertation analyses the role of Communist Czechoslovakia in a period of so called "Congo Crisis" in the years 1960-1963, which began after the independence of the Belgian Congo had been declared. Czechoslovakia was the only Eastern Bloc country which had a representative office in the capital city of Leopoldville over a long period of time and had maintained business and diplomatic relations with the former Belgian Congo since the First Republic; therefore it was an irreplaceable mediator between the newly declared Republic of the Congo and Eastern Bloc countries. The individual chapters rely especially on archival documents and analyse the roles of Patrice Lumumba, UN, separatist government of Antoine Gizenga in the Eastern province, namely in the context of Czechoslovakian foreign policy toward African continent in the observed period. The dissertation is grounded especially on documents of the Ministry of Foreign Affairs and archives of the Communist Party of Czechoslovakia. In order to set the dissertation to the international context, it was mainly French, Belgian and Soviet literature, which was used as it offers a very different perspective on the topic in question.

Dans le cadre des études relatives à la sûreté sismique des installations industrielles, on est amené à se préoccuper de la stabilité de structures libres (des équipements, des containers, des fûts. . . ) posées à même le sol. De nombreuses méthodes ont permis d’établir des critères de sûreté réputés conservatifs, sans qu’il soit besoin de représenter finement le comportement dynamique de l’objet. Dans le cadre de cette thèse, on a cherché à analyser la capacité de prédiction par des modèles numériques du mouvement de corps rigides libres soumis à des séismes impliquant impacts et glissements. Pour cela, on s’est appuyé sur deux campagnes expérimentales qui ont été menées au laboratoire EMSI du CEA/Saclay sur des blocs parallélépipédiques en acier, élancés et disposant de 4 appuis non ponctuels usinés avec des tolérances standards. Dans un premier temps, des essais de lâcher (bloc immobile en appuis sur deux pieds, puis lâché sans source d’excitation extérieure), souvent analysés dans la littérature comme un mouvement plan, ont fait apparaître un mouvement 3D reproductible dans les premiers instants consécutifs au lâcher. L’analyse fine de ce mouvement a permis, d’une part, de conclure qu’il était dû à des défauts de géométrie des pieds et, d’autre part, d’élaborer un modèle numérique représentatif incluant ces défauts. Dans un second temps, il a été question d’étudier l’aptitude du modèle numérique à représenter le comportement dynamique au cours du temps d’un bloc rigide élancé non idéal soumis à des excitations sismiques. Les blocs ont été soumis à 100 réalisations d’un processus stationnaire (essais de variabilité) puis 100 fois à la même accélération (essais de répétabilité). D’un point de vue statistique, et malgré les incertitudes expérimentales, ce travail a permis d’exhiber une bonne adéquation entre les résultats des modèles numériques et les résultats expérimentaux. En outre, il a permis de quantifier la durée au-delà de laquelle une prédiction du comportement ne peut plus être considérée comme pertinente. Pour finir, on s’est attaché à appliquer des outils classiques de fiabilité au problème de bloc rigide soumis à des séismes, ainsi que la méthode récente des Subset Simulations. / In the field of nuclear safety, the stability of free standing structures like containers, barrels or electronical devices is considered to be an important matter. Until now, the literature written on the subject presents some stability criteria known to be conservative without needing to represent in detail the object behavior. This thesis attempts to analyse the capacity numerical models have to predict the behavior of blocks submitted to seismic acceleration, with impacts and friction. To this effect, two experimental campaigns were carried out in the EMSI laboratory (CEA Saclay, France) on slender massive prismatic steel blocks, with 4 machined (i.e. non-ideal) feet. First of all, release tests (the block is in an unsteady position on 2 feet, kept still with a wire, then the wire is cut and the block is released without any ground motion) are usually analysed as a plane motion. Our experiments have shown a reproducible out-of-plane (3D) motion during the first seconds of the release. A detailed analysis highlighted the fact that this 3D motion is induced by geometrical defects on the block feet, and allowed us to build an accurate numerical model of this behavior. The ability of this numerical model to match the dynamic behavior of a non-ideal rigid slender block has been questioned. In a second campaign, 4 blocks were subjected on the one hand to 100 realisations of a stationnary process, and on the other hand 100 times to the same excitation. This accounts for an analysis of the variability of two 100-samples of results obtained under two different input variability levels. From a statistical point of view, despite experimental uncertainties this article demonstrates a good agreement between numerical and experimental results. Finally, some classical tools of reliabily were applied to the rocking block problem, as well as a newer method called Subset Simulation.

ALe bloc de latérite taillée (BLT) est l’un des matériaux en terre les plus utilisés parmi tant d’autres dans les constructions traditionnelles de l’Afrique tropical où la roche latéritique est en abondance. La demande grandissante du public et des acteurs locaux concernant ces matériaux de construction va actuellement vers un habitat traditionnel à rénover ou contemporain à concevoir pour demain. Cependant, les caractéristiques et les performances de ce matériau sont encore peu connues, ce qui limite son utilisation dans la maçonnerie. L’objectif de ce travail de thèse est donc de contribuer à la valorisation dans l’habitat de ce matériau traditionnel, universel, économique, à fort potentiel constructif, recyclable mais considéré aujourd’hui comme un sous-produit, voire déchet de carrière pour la terre. Cette étude réalisée sur les sites de l’exploitation de BLT et aux laboratoires est conduite en trois phases. La phase d’étude in-situ a permis de décrire la géologie des sites, les profils des quatre carrières d’étude, les techniques d’exploitations locales du matériau et les différents types d’habitat construits avec le BLT. La phase d’études au laboratoire a permis de déterminer la composition chimique et minéralogique, les propriétés physiques et hydriques (masses volumiques, porosité, absorption d’eau), les performances mécaniques (résistance à la compression, à la flexion, module de Young) et thermique (variation d’humidité et de température) dans un bâtiment pilote construite avec le BLT et à l’utilisation des paramètres obtenues dans les essaies du laboratoire pour modéliser une maçonneries en BLT et étudier la faisabilité de construction d’habitations à plusieurs niveaux. / ALaterite Dimension Stone (LDS) is one of the most used earth materials for traditional constructions in tropical Africa, where the laterite rock is abundant. There is a growing interest about these materials among local stakeholders, for the maintenance and renovation of existent traditional buildings as well as for the conception and design of future constructions. However, little knowledge exists concerning technical characteristics and performances of this material and this hinder its use in masonry. The objective of this work is to give a contribution for the fostering of the utilisation of such material, which is traditional, universal, cheap, with high utilisation potential, recyclable, but currently considered as a by-product or waste from quarries. This study has been carried out in three phases, both at field level (in selected quarries) and at laboratory level. The first phase (in-situ study) allowed the description of (a) the local geology, (b) the geological profiles of four selected quarries, (c) the local utilisation patterns for this material, and (d) the local construction schemes for buildings where LDS are used. The laboratory phase allowed the assessment of the chemical and mineralogical composition of rocks, their physical and hydraulic properties (densities, porosity, water absorption), their mechanical performances (compressive strength, flexural strenght, Young’s modulus) and their thermal features (thermal conductivity, diffusivity). The third phase consisted in the monitoring of thermal parameters (temperature and humidity) in a pilot LDS building and in the numerical modelling of a masonry building, using the results form phase no. 2 as input parameters, with the aim of investigating the feasibility of construction of a multi-storey house.

Les infections du site opératoire (ISO) sont classées au 3ème rang des infections associées aux soins les plus fréquentes en France. Des approches épidémiologiques " classiques " de prévention ont permis une réduction des taux d'ISO d'environ 50% en 20 ans. Malgré ces progrès, les taux d'incidence et le nombre brut d'ISO restent notables en France. De nouveaux outils permettraient d'améliorer la compréhension et la prévention des ISO. Lors d'une approche clinique de la prévention des ISO, nous avons évalué l'efficacité d'éponges de collagène imprégnées de gentamicine pour la prévention des ISO chez des patients à haut risque bénéficiant d'un pontage aorto-coronarien avec double artères mammaires internes. Des Dans un second temps, une approche, épidémiologique, avait pour objectif d'étudier l'accord des hygiénistes et des chirurgiens impliqués dans la surveillance des ISO de 10 pays Européens dans le diagnostic des ISO. La finalité était d'évaluer l'intérêt de la publication des taux d'ISO dans un objectif de benchmarking. La dernière approche était comportementale. Nous avons tout d'abord réalisé une revue systématique de la littérature afin d'évaluer l'état actuel des connaissances concernant l'impact des comportements des équipes opératoires sur la survenue d'ISO ou sur des marqueurs du risque infectieux. Enfin, nous avons présenté le protocole d'une étude en cours de réalisation sur l'évaluation des déplacements des personnels durant 63 interventions de chirurgie cardiaque et orthopédique, enregistrés de manière objective et continue par l'intermédiaire d'un système automatique de capture de mouvement. Ces données seront corrélées à des marqueurs du risque infectieux. / Surgical site infection (SSI) constitutes the third most frequent healthcare associated infection in France. “Classic” epidemiological approaches have already allowed to decrease SSI rate of approximately 50% in 20 years. Despite these improvements, the incidence rate and the crude number of SSI stay important in France. New tools may improve the understanding and the prevention of SSI. In first, through a clinical approach of the SSI prevention, we have evaluated the efficacy of a gentamicin-impregnated collagen sponge reduce sternal wound infections in high-risk cardiac surgery patients. Secondly, an epidemiological approach had the objective to assess the agreement in diagnosing SSI among specialists involved in SSI surveillance in Europe and evaluate the interest of the public reporting of SSI rate in a view of benchmarking. Finally, a behavioural approach has begun by a systematic descriptive review of the literature to evaluate the current evidence regarding the influence of staff behaviours on the infectious risk in operating room. Then, we have presented the protocol of a study in progress on the assessment of movements in the operating room during 63 procedures of cardiac and orthopaedic surgery, recorded with an objective and continuous manner using a motion capture system. These data will be correlated to surrogates of the infectious risk.

La thèse présentée porte sur l’élaboration de nanoparticules polymères fonctionnalisées par le ligand SCH546738 afin de cibler le récepteur CXCR3 surexprimé sur les cellules cancéreuses. La synthèse des copolymères à blocs Poly(triméthylène carbonate)-b-Poly(éthylène glycol) (PTMCb- PEG) et PTMC-b-PEG-SCH546738, puis leurs auto-assemblages dans l’eau avec des pourcentages différents de l’un par rapport à l’autre et enfin l’activité biologique de ces nanoparticules in vitro ont été réalisés. Une série de PTMC-b-PEG de fraction hydrophile massique f différentes (entre 34 et 6%) ont été obtenus par polymérisation par ouverture de cycle (ROP) du monomère triméthylène carbonate (TMC) amorcée par un PEG (MW= 2000 g/mol). Les études d’auto-assemblage ont montré que la fraction hydrophile était liée à la morphologie des objets obtenus (micelles et vésicules) et que la taille et la morphologie pouvaient être modulées en fonction du protocole utilisé. Des PTMC-b-PEG-SCH546738 ont été obtenus par couplage convergent entre le PEG-SCH546738 et le bloc PTMC. Le co auto-assemblage entre les copolymères fonctionnalisés et non fonctionnalisés a été réalisé par nanoprécipitation contrôlée par un système de microfluidique qui permet d’obtenir des polymersomes monodisperses de tailles contrôlées. Le pourcentage molaire de SCH546738 en surface des polymersomes a été fixé à 5, 10 et 20 % et à l’aide d’une nanoparticule contrôle ces échantillons ont pu être testés in vitro sur cellules HEK 293 et U87 surexprimant le CXCR3-A. L’influence du ligand et son pourcentage sur l’internalisation des nanoparticules à différents temps et sur le blocage des voies de signalisation des cellules cancéreuses ont été observés. / This thesis deals with the elaboration of polymeric nanoparticles functionalized by the ligand SCH546738 to target the CXCR3 receptor overexpressed in human healthy or tumoral cells. Poly(trimethylene carbonate-b-Poly(ethylene glycol) (PTMC-b-PEG) blocks copolymers and PTMC-b-PEG-SCH546738 synthesis, then their self-assembly with different ratios in water, and finally biological activity in vitro of these different nanoparticles were studied. A serie of PTMC-b-PEG with different hydrophilic mass fractions f (between 34 and 6%) were obtained by ring opening polymerization (ROP) of trimethylene carbonate (TMC) initiated by a block PEG (MW: 2000 g/mol). Self-assembly studies showed that the hydrophilic mass fraction was related to the morphology of the nano objects (micelles and vesicles) and that size and morphology of nano objects can be changed by the self-assembly protocol. PTMC-b-PEG-SCH546738 were obtained by the convergent coupling between PEG-SCH546738 and PTMC block. The co self-assembly of functionalized and not functionalized copolymers was done by nanoprecipitation controlled by a microfluidic system that allows monodisperse polymersomes with controlled size to be produced. The molar percentage of SCH546738 at the surface of polymersomes was fixed at 5, 10 and 20 %, and with the control nanoparticle, these samples were tested in vitro on HEK 293 and U87 cells overexpressing the CXCR3-A. The influence of the ligand and its percentage on nanoparticles internalization and signaling pathways blocking on cells were analyzed.