41 |
SAÚDE CARDIOVASCULAR COMO TEMA GERADOR NO CURSO NORMAL / CARDIOVASCULAR HEALTH AS GENERATOR THEME IN THE NORMAL COURSELara, Simone 04 February 2013 (has links)
Cardiovascular diseases represent the first cause of death in Brazil, resulting in high
costs to the public health system in the country. It´s known that the most risk factors
that take to the development of these diseases occurs due to modifiable lifestyle,
such as inadequate nutrition and physical inactivity, and they´re present from
childhood. Therefore, it´s important that the issues involving the practice of healthy
lifestyle are addressed at school so early, in order to prevent these diseases at older
ages. However, for that these health education processes are effective at school in
these early stages of learning, their teachers must be properly prepared for this task.
Thus, the aim of this study was to discuss the health transversal theme, using the
cardiovascular health generator theme with students in the normal course, future
children´s educators and of the early years. To achieve this goal, some
methodological tools were used, such as the physical profile evaluation of the student
and the use of images on the theme. Thus, we start from own body measurements of
student to be closer to the cardiovascular health generator theme, and we use the
images because it´s a fun methodology and widely used by students in the normal
course. We observed, according to the criteria examined, that these students didn´t
constitute as a risk profile for developing cardiovascular diseases (anthropometrics
appropriate), despite the physical activity being below the levels suggested for
healthy individuals. Furthermore, we met a low understanding of young people about
the cardiovascular health perceptions through the images used, this fact may be
associated with a important deficit in addressing these issues in the current training
of these students. Thus, after the discussions in large group about the proper
meaning of the cardiovascular health images, as well as the explanation of the
relation between physical measurements with health profile, it was found that
learning was more meaningful. Thus, at a later time, the students built a didactic
material, consisting of recreational activities about the studied themes for later
application to early years. As a result, we realized the wealth of didactic material
created by students, it was verified by creative and playful nature found in activities.
Through the application of recreational activities built by students in the normal
course to the early years, it was observed the effective participation of children
through questions and curiosities, engaging in recreational and practices activities,
and a important learning about the issues verified through their reports. Finally, the
most appropriated knowledge about the cardiovascular health generator theme, and
issues related to health promotion and cardiovascular disease prevention by students
in the normal course and the early years were some contributions of this study to
improve the teaching and learning process in science and health education. / As doenças cardiovasculares representam a primeira causa de morte no Brasil,
acarretando altos custos ao sistema de saúde pública no país. É conhecido que
grande parte dos fatores de risco que levam ao desenvolvimento destas doenças
ocorre devido a hábitos de vida modificáveis, como a alimentação inadequada e a
inatividade física, e estão presentes desde a infância. Sendo assim, é vital que as
questões que envolvam a prática de hábitos de vida saudáveis sejam abordadas no
ambiente escolar de forma precoce, como forma de prevenção destas doenças em
idades mais tardias. Entretanto, para que estes processos de educação em saúde
sejam efetivos no contexto escolar nestas fases precoces de ensino, seus docentes
devem estar devidamente preparados para esta tarefa. Assim, a proposta deste
estudo foi problematizar o tema transversal saúde, utilizando o tema gerador saúde
cardiovascular com estudantes do curso normal, futuras educadoras infantis e dos
anos iniciais. Inicialmente foram utilizadas algumas ferramentas metodológicas, a
exemplo da avaliação do perfil físico da estudante e do uso de imagens sobre o
tema. Assim, partimos das próprias mensurações corporais da estudante para
aproximá-la do tema gerador saúde cardiovascular, bem como utilizamos as
imagens por se tratar de uma metodologia lúdica e amplamente utilizada pelas
estudantes do curso normal. De acordo com os critérios analisados, observou-se
que estas estudantes avaliadas não se constituíram como um perfil de risco para o
desenvolvimento das doenças cardiovasculares (perfil antropométrico adequado),
apesar da prática de atividade física estar abaixo dos níveis sugeridos para
indivíduos saudáveis. Além disto, verificou-se um baixo nível de entendimento das
jovens acerca das percepções sobre saúde cardiovascular por meio das imagens
utilizadas; fato este que pode estar associado a um déficit importante na abordagem
destes temas na formação atual destas estudantes. Sendo assim, após as
discussões em grande grupo acerca do significado adequado das imagens em
saúde cardiovascular, bem como a explicação sobre a relação das mensurações
físicas com um perfil de saúde, verificou-se que a aprendizagem deste tema se deu
de forma mais significativa. Posteriormente, estas estudantes construíram um
material didático, constando de atividades lúdicas sobre as temáticas estudadas,
para posterior aplicação aos anos iniciais. Como resultados, percebeu-se a riqueza
do material didático criado pelas estudantes, verificado pelo caráter criativo e lúdico
encontrado nas atividades construídas. Através da aplicação das atividades lúdicas
construídas pelos estudantes do curso normal aos anos iniciais, observou-se a
participação efetiva das crianças, através de questionamentos e curiosidades,
envolvimento em atividades lúdicas e práticas, e uma aprendizagem relevante sobre
os temas, verificado através de seus relatos. Por fim, um conhecimento mais
pertinente sobre o tema gerador saúde cardiovascular, e aspectos relacionados à
promoção da saúde e prevenção das doenças cardiovasculares por estudantes do
curso normal e dos anos iniciais, foram algumas das contribuições deste projeto
para melhorar o processo de ensino aprendizagem no ensino de ciências e saúde.
|
42 |
Relationship between determinants of arterial stiffness assessed by diastolic and suprasystolic pulse oscillometry: comparison of vicorder and vascular explorerTeren, Andrej, Beutner, Frank, Wirkner, Kerstin, Löffler, Markus, Scholz, Markus January 2016 (has links)
Pulse wave velocity (PWV) and augmentation index (AI) are independent predictors of cardiovascular health. However, the comparability of multiple oscillometric modalities currently available
for their assessment was not studied in detail. In the present study, we
aimed to evaluate the relationship between indices of arterial stiffness
assessed by diastolic and suprasystolic oscillometry. In total, 56 volunteers from the general population (23 males; median age 70 years [interquartile range: 65–72 years]) were recruited into observational feasibility study to evaluate the carotid-femoral/aortic PWV (cf/aoPWV), brachial-ankle PWV (baPWV), and AI assessed by 2 devices: Vicorder (VI) applying diastolic, right-sided oscillometry for the determination of all 3 indices, and Vascular explorer (VE) implementing single-point, suprasystolic brachial oscillometry (SSBO) pulse wave analysis for the assessment of cfPWV and AI. Within- and between-device correlations of measured parameters were analyzed. Furthermore, agreement of repeated measurements, intra- and inter-observer concordances were determined and compared for both devices. In VI, both baPWVand cfPWVinter-correlatedwell and showed good level of agreement with bilateral baPWVmeasured byVE (baPWV[VI]– baPWV[VE]R: overall concordance correlation coefficient
[OCCC]¼0.484, mean difference¼1.94 m/s; cfPWV[VI]–baPWV[- VE]R: OCCC¼0.493, mean difference¼1.0m/s). In contrast, SSBO derived aortic PWA (cf/aoPWA[VE]) displayed only weak correlation with cfPWV(VI) (r¼0.196; P¼0.04) and ipsilateral baPWV (cf/ aoPWV[VE]R–baPWV[VE]R: r¼0.166; P¼0.08). cf/aoPWA(VE) correlated strongly with AI(VE) (right-sided: r¼0.725, P<0.001). AI exhibited marginal between-device agreement (right-sided: OCCC¼ 0.298, mean difference: 6.12%). All considered parameters showed good-to-excellent repeatability giving OCCC > 0.9 for 2-point-PWV modes and right-sided AI(VE). Intra- and inter-observer concordances were similarly high except for AI yielding a trend toward better reproducibility in VE (interobserver–OCCC[VI] vs [VE]¼0.774 vs 0.844; intraobserver OCCC[VI] vs [VE]¼0.613 vs 0.769). Both diastolic oscillometry-derived PWV modes, and AI measured either with VI or VE, are comparable and reliable alternatives for the assessment of arterial stiffness. Aortic PWV assessed by SSBO in VE is not related to the corresponding indices determined by traditional diastolic oscillometry.
|
43 |
Effects of Exercise on the Resting Heart Rate: A Systematic Review and Meta-Analysis of Interventional StudiesReimers, Anne Kerstin, Knapp, Guido, Reimers, Carl-Detlev 13 February 2019 (has links)
Resting heart rate (RHR) is positively related with mortality. Regular exercise causes a reduction in RHR. The aim of the systematic review was to assess whether regular exercise or sports have an impact on the RHR in healthy subjects by taking different types of sports into account. A systematic literature research was conducted in six databases for the identification of controlled trials dealing with the effects of exercise or sports on the RHR in healthy subjects was performed. The studies were summarized by meta-analyses. The literature search analyzed 191 studies presenting 215 samples fitting the eligibility criteria. 121 trials examined the effects of endurance training, 43 strength training, 15 combined endurance and strength training, 5 additional school sport programs. 21 yoga, 5 tai chi, 3 qigong, and 2 unspecified types of sports. All types of sports decreased the RHR. However, only endurance training and yoga significantly decreased the RHR in both sexes. The exercise-induced decreases of RHR were positively related with the pre-interventional RHR and negatively with the average age of the participants. From this, we can conclude that exercise—especially endurance training and yoga—decreases RHR. This effect may contribute to a reduction in all-cause mortality due to regular exercise or sports.
|
44 |
Comment promouvoir la santé cardiovasculaire chez les jeunes adultes nés très prématurément : perception de la santé et intervention en activité physiqueGirard-Bock, Camille 08 1900 (has links)
Dans le monde, une naissance sur 10 est prématurée, se produisant avant 37 semaines de gestation, et environ 1% sont très prématurées (<30 semaines de gestation). La prématurité est associée à des altérations de la structure et fonction cardiovasculaire qui persistent à l’âge adulte et sont liées aux maladies cardiovasculaires. Il n’y a cependant pas de recommandations cliniques pour le suivi de la santé cardiovasculaire chez les jeunes adultes nés très prématurément. Cette thèse porte sur la prévention des maladies cardiovasculaires dans cette nouvelle population à risque. Ses objectifs principaux sont de décrire les effets à long terme de la prématurité sur la santé adulte et de présenter les avenues de prévention et d’intervention permettant de mitiger ces effets. Son premier chapitre présente une revue de la littérature pertinente alors que son second détaille les méthodes employées pour obtenir les résultats présentés dans les chapitres suivants.
Brièvement, la cohorte HAPI (Health of Adults born Preterm Investigation) est constituée de jeunes adultes nés entre 1986 et 1996 au Québec soit prématurément (<30 semaines de gestation) ou à terme (>37 semaines de gestation). C’est la population étudiée dans les chapitres 3 à 5. Le chapitre 3 présente une diminution de la capacité aérobie à l’effort chez les sujets nés prématurément et explore les facteurs y contribuant, incluant des paramètres hémodynamiques cardiaques. Le chapitre 4 examine la perception de la santé et l’utilisation des services de santé dans cette cohorte et comment ceux-ci sont influencés ou non par les paramètres de santé objectifs identifiés précédemment dans le cadre de l’étude HAPI. Le chapitre 5 présente un plaidoyer en faveur d’un suivi médical à long terme des individus nés très prématurément dont les arguments proviennent de témoignages des participants de l’étude HAPI. Enfin, le chapitre 6 présente les résultats de l’étude HAPI Fit qui avait pour but d’évaluer les effets chez de jeunes adultes nés très prématurément d’une intervention de 14 semaines en activité physique principalement sur la capacité aérobie maximale et secondairement sur les paramètres de santé cardiovasculaire.
L’ensemble de ces résultats permet de brosser un portrait des conséquences cardiovasculaires à long terme de la prématurité et des moyens disponibles pour les mitiger. La dissémination de ces résultats à la population ciblée et à ses soignants constitue la base sur laquelle pourront se bâtir de futurs programmes de prévention dans cette population à risque. / Worldwide, one in ten births is preterm, occurring before the 37th week of gestation, and approximately 1% are very preterm (<30 weeks of gestation). Preterm birth is associated with alterations of cardiovascular structure and function that persist into adulthood and are linked to cardiovascular disease. There are, however, no clinical guidelines regarding long term cardiovascular monitoring for adults who are born very preterm. This thesis’s focus is the prevention of cardiovascular disease in this new at-risk population. Its main objectives are to describe the long-term effects of prematurity on adult health and to present prevention and intervention avenues for mitigating those effects. Its first chapter presents a review of the pertinent literature while its second describes the methods that were employed to obtain results that are presented in subsequent chapters. Briefly, the HAPI (Health of Adults born Preterm Investigation) cohort recruited young adults born between 1986 and 1996 in the province of Quebec either prematurely (<30 weeks of gestation) or at term (>37 weeks of gestation). This is the population studied in chapters 3 to 5. Chapter 3 presents a diminished maximal aerobic capacity in subjects born preterm and explores contributing factors, including cardiac hemodynamic parameters. Chapter 4 examines health perception and healthcare use in the cohort and how these are influenced or not by objective health measurements previously performed in the HAPI study. Chapter 5 advocates for long-term medical follow-up in young adults born preterm, using testimonials from participants in the HAPI cohort. Finally, chapter 6 presents results from the HAPI Fit study which aimed to evaluate the effects in young adults born very preterm of a 14-week exercise intervention on their maximal aerobic capacity and cardiovascular health parameters.
Overall, these results allow us to paint a global picture of long-term cardiovascular consequences of prematurity and of possible ways to mitigate them. Dissemination of these results to the target population and their healthcare providers constitute the basis of future prevention programs in this new at-risk population.
|
45 |
Personal Listening Device Use, Hearing, Health and FitnessWagner, Sarah Elizabeth 30 April 2013 (has links)
No description available.
|
46 |
Physical activity and cardiovascular health indicators during early childhood / Physical activity and cardiovascular health in preschoolersProudfoot, Nicole A. January 2020 (has links)
Cardiovascular disease begins to develop in childhood. Physical activity positively impacts cardiovascular health and lowers cardiovascular disease risk in school-aged children and adults; however, there is insufficient evidence to determine the effects of physical activity on cardiovascular health during early childhood. The specific dose of physical activity required for favourable cardiovascular health in this age group is also unknown. The purpose of this thesis was to explore the relationships between physical activity and cardiovascular health indicators during early childhood. In the first study, we found that physical activity engagement has beneficial effects on cardiovascular fitness, blood pressure, autonomic function, and arterial stiffness during early childhood. We then determined in the second study that to avoid unfavourable cardiovascular health, preschool-aged children should engage in at least 240 minutes of activity at any intensity, 80 minutes of moderate-to-vigorous physical activity, or 8700 steps per day. Finally, in the third study we evaluated a novel technique for examining arterial wall properties, carotid artery longitudinal wall motion, and determined that it was weakly associated with an established indicator of arterial stiffness (pulse wave velocity) in early childhood. These findings highlight that the benefits of physical activity on cardiovascular health begin in early childhood and the minimal amount of activity to avoid unfavourable cardiovascular health is higher than current recommendations. For the most part, physical activity benefited boys and girls similarly, although it is unclear if the physical activity targets apply equally to boys. We also determined that carotid artery longitudinal wall motion may not be an indicator of arterial stiffness in young children. Future studies should determine if the favourable effects of physical activity on cardiovascular health during early childhood carry over to later years and if achieving the physical activity targets determined in this thesis are associated with additional health benefits. / Thesis / Doctor of Philosophy (PhD) / Heart disease develops slowly over time, starting in childhood. This thesis explored if physical activity can begin to prevent heart disease even in preschoolers, and how much physical activity preschoolers need in order to keep their hearts and blood vessels healthy. We found that preschool-aged children who were more active had better heart health, including better blood vessel health and higher fitness. While all activity was good, more intense, moderate-to-vigorous physical activity (sometimes called energetic play) was more beneficial and slowed down the stiffening of their blood vessels as the children grew. We determined that preschool-aged children should engage in at least 4 hours of physical activity at any intensity or 80 minutes of moderate-to-vigorous physical activity every day to avoid poor heart health. The findings in this thesis highlight the importance of regular physical activity participation to promote heart health even in preschool-aged children.
|
47 |
Designing, Piloting, and Evaluating the Interdisciplinary Internet Module - Healthy Hearts for Intermediate Grade ChildrenElliott, Eloise 05 August 1997 (has links)
Two issues are prevalent today in K-6 education-- the integration of the Internet into schools, and the emphasis on guiding children to make wise and healthy lifestyle choices. These are the two themes reflected in this study. The purpose of this study was to design, pilot, and evaluate the Interdisciplinary Internet Module - Healthy Hearts (IIM-HH), an on-line four-week learning module for intermediate grade children. The module was developed to educate youngsters about cardiovascular health, and to encourage them to adopt healthy lifestyles and practice making wise health decisions. The module, delivered via the Internet, allows for interactive, self-directed student learning. It also provides intermediate grade teachers with a valuable resource for teaching important healthy lifestyle concepts, as well as a valuable resource for successful implementation of the Internet into existing curriculums.
The Module was piloted with two 5th grade classrooms (N=41) and their teachers (N=2). Qualitative findings from multiple data collection sources provided in-depth insights into the content and technical functionality of the module, and participants' recommendations for change. The formative evaluation revealed the changes that needed to be made before implementation with a large population could be successful. It also revealed that the IIM-HH has the potential to be an effective and motivational instructional unit for both students and teachers. / Ph. D.
|
48 |
Educational Intervention: Effects on Heart Disease Risk Factor Knowledge Among African AmericansSmith, Linda M 01 January 2015 (has links)
Abstract
Fatal coronary heart disease among African Americans is associated with a
disproportionate burden of cardiovascular disease (CVD) risk factors. Research has indicated that CVD risk factor knowledge and the prevalence of ideal CVH both persist at suboptimal levels. However, few researchers have investigated the relationship between culturally-tailored community-based heart health sessions, short-term knowledge acquisition of CVD risk factors, and the awareness of the American Heart Association's (AHA's) CVH construct. The purpose of this cross-sectional, secondary analysis study was to examine the interplay between these variables in an urban African American sample. Guided by social cognitive theory, the study analyzed de-identified data (data
sets of demographic characteristics and Heart Disease Facts Questionnaire) from participant responses collected at multiple community sites to assist in the planning of future health programs. Multiple community sites were randomized into an intervention (n = 50) or comparison group (n = 57). Pearson's correlation and multiple regression were used to analyze data. Knowledge was higher for intervention group participants (β =.44, p = .001) and tended to be higher for those with more education (β = .20, p = .06) and those with less income (β = -.22, p = .07). Notably, most participants (73%) reported
awareness of the AHA construct, CVH. The results support culturally-tailored
interventions as a useful strategy for CVD risk reduction. The implication for social change is that initiatives at the community-level may positively impact CVH in minority/ethnic communities and subsequently impact CVD disparities.
|
49 |
ISSUES REGARDING COMPLEX COMMUNITY-BASED CARDIOVASCULAR HEALTH INTERVENTIONSAngeles, Ricardo N. 04 1900 (has links)
<p>The thesis presents three papers discussing some of the methodological issues regarding studies investigating complex community-based cardiovascular health interventions. All three studies involved the Cardiovascular Health Awareness Program (CHAP), a standardised blood pressure and risk factor assessment and educational sessions held in pharmacies or other locally accessible areas in small to mid-sized communities in Ontario, Canada.</p> <p>The first paper reviews the literature and proposes a guide on how to develop a theoretical framework for complex community-based interventions using CHAP as an example. The paper describes a stepwise process of developing a theoretical framework including challenges encountered and strategies employed to overcome them.</p> <p>The second paper presents how recently published randomized controlled trials evaluating complex community-based cardiovascular health interventions monitored and reported implementation fidelity based on a structured review of the published articles and a survey of their primary authors. The results showed that fidelity reporting of included studies was better than those described in previous reviews. Fidelity was verified through self-reports by implementers and supervision by researchers. Strategies described to standardize intervention delivery were through training of implementers and use of implementation guides. The authors’ survey results were consistent with the review results though there were some gaps which could be improved to strengthen fidelity reporting.</p> <p>A data analysis issue with studies investigating complex community-based interventions is that outcomes can be affected by factors from multiple levels. The third paper explores the association of individual, partnership, and community-related factors with CHAP participants’ use of health-related community resources and cardiovascular risk behaviours. This was a cross-sectional analysis of an on-going cohort study. The results showed that individual factors (age and self-efficacy) had the most consistent association with the outcomes. Community and partnership level variables showed less consistent association with the outcome. Methodological and analytical challenges were presented.</p> / Doctor of Philosophy (PhD)
|
50 |
Investigating the role of ketone body metabolism in diabetic kidney diseaseMechchate, Hamza 12 1900 (has links)
Ces dernières années, la compréhension de la relation entre l'alimentation et la santé
métabolique, en particulier dans le contexte du diabète de type 2 (T2D), est devenue de
plus en plus importante. Les régimes riches en graisses (HFD) sont connus pour
exacerber les conditions diabétiques, menant à des complications telles que l'obésité, un
métabolisme déséquilibré, des problèmes cardiovasculaires et un dysfonctionnement
rénal. À l'inverse, les régimes cétogènes (KD) et la supplémentation en cétones (KP),
connus pour augmenter le taux de corps cétoniques dans le sang, ont attiré l'attention
pour leur potentiel dans la gestion du poids, l'amélioration du contrôle de la glycémie et
l'atténuation des complications associées au diabète de type 2.
L'étude a pour but d'évaluer l'efficacité du KD et de KP dans la gestion de la pathogenèse
du T2D et la réduction de la progression de la maladie rénale diabétique dans un modèle
de souris, en se concentrant sur les changements dans les indicateurs métaboliques et
de santé rénale.
Cette étude a examiné les effets de diverses interventions diététiques (HFD, KD, KP) sur
une série de paramètres de santé rénale dans un modèle murin de T2D. Sur une période
de 15 semaines, le T2D a été induit chez les souris, suivi d'une exposition de six semaines
à différents régimes. La recherche s'est concentrée sur l'évaluation des changements
dans le poids corporel, la prise alimentaire, la glycémie et les niveaux de cétone, la
tolérance à l'insuline et au glucose, et les fonctions cardiovasculaires et rénales.
L'évaluation des fonctions rénales comprenait le rapport albumine/créatinine, l'azote
uréique du sang (BUN), les niveaux de cystatine C et l'histopathologie. En outre, l'étude
a examiné l'impact de ces régimes sur l'accumulation de lipides dans les tissus rénaux et
les niveaux de triglycérides plasmatiques, afin de comprendre les implications
métaboliques plus larges des choix alimentaires dans la gestion du T2D.
Les résultats ont indiqué que les souris suivant un régime KD présentaient des
améliorations significatives dans plusieurs paramètres par rapport à celles suivant un
régime HFD. Cela incluait une réduction du poids corporel, une meilleure maîtrise
glycémique, une sensibilité accrue à l'insuline et une meilleure santé cardiovasculaire et
rénale. En revanche, la supplémentation en KP n'a pas montré d'effet aussi prononcé
dans plusieurs aspects, y compris l'amélioration du contrôle glycémique et de la fonction
rénale. Intéressant, bien que le régime KD ait été efficace pour réduire les niveaux de
triglycérides plasmatiques, il a paradoxalement conduit à une augmentation de
l'accumulation de lipides dans les tissus rénaux.
En conclusion, l'étude souligne l'efficacité du régime cétogène dans la gestion du poids,
l'amélioration des marqueurs métaboliques et la réduction des complications liées au
diabète dans un modèle de souris de T2D. Elle met également en évidence la complexité
des réponses métaboliques aux interventions diététiques, en particulier en ce qui
concerne la santé rénale et le métabolisme des lipides. Les résultats suggèrent que, bien
que le régime KD puisse offrir de nombreux avantages pour la santé dans le contexte du
diabète, il pourrait également induire des adaptations métaboliques spécifiques à certains
organes. / In recent years, understanding the relationship between diet and metabolic health,
particularly in the context of type 2 diabetes (T2D), has become increasingly important.
High-fat diets (HFD) are known to exacerbate diabetic conditions, leading to complications
such as obesity, dysregulated metabolism, cardiovascular issues, and renal dysfunction.
Conversely, ketogenic diets (KD) and ketone supplementation (KP) known to elevate
ketone bodies in the blood, have been gaining attention for their potential in managing
weight, improving glycemic control, and mitigating complications associated with T2D.
The study aims to evaluate the effectiveness of KD and KP in managing T2D
pathogenesis and reducing the progression of diabetic kidney disease in a mouse model,
focusing on changes in metabolic and renal health indicators.
This study investigated the effects of various dietary interventions (HFD, KD, KP) on a
range of kidney health parameters in a mouse model of T2D. Over 15 weeks, T2D was
induced in mice, followed by a six-week exposure to different diets. The research focused
on evaluating changes in body weight, food intake, blood glucose and ketone levels,
insulin and glucose tolerance, and cardiovascular and renal function. Renal assessment
included albumin-to-creatinine ratio, Blood urea nitrogen (BUN), Cystatin C levels, and
histopathology. Additionally, the study examined the impact of these diets on lipid
accumulation in renal tissues and plasma triglyceride levels, aiming to understand the
broader metabolic implications of dietary choices in T2D management.
Results indicated that mice on a KD exhibited significant improvements in several
parameters compared to those on an HFD. These included reductions in body weight,
enhanced glycemic control, improved insulin sensitivity, and better cardiovascular and
renal health. In contrast, the KP supplementation group did not show as pronounced an
effect in several aspects, including glycemic control and renal function improvement.
Interestingly, while KD was effective in reducing plasma triglyceride levels, it paradoxically
led to increased lipid accumulation in renal tissues.
In conclusion, the study underscores the effectiveness of a ketogenic diet in managing
weight, improving metabolic markers, and mitigating diabetes-related complications in a
mouse model of T2D. It also highlights the complexity of metabolic responses to dietary
interventions, especially concerning renal health and lipid metabolism. The results
suggest that, while the KD diet may offer many health benefits in the context of diabetes,
it may also induce organ-specific metabolic adaptations.
|
Page generated in 0.0746 seconds