Submitted by Andreza Leão (andrezaflh@gmail.com) on 2018-06-21T17:35:07Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_TDAHBrasilEspanha.pdf: 3304276 bytes, checksum: ce9bf46771071c64d075c0d52a730602 (MD5) / Approved for entry into archive by Celia Santana (celiasantana@ufpa.br) on 2018-12-12T17:49:28Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_TDAHBrasilEspanha.pdf: 3304276 bytes, checksum: ce9bf46771071c64d075c0d52a730602 (MD5) / Made available in DSpace on 2018-12-12T17:49:28Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_TDAHBrasilEspanha.pdf: 3304276 bytes, checksum: ce9bf46771071c64d075c0d52a730602 (MD5) Previous issue date: 2016-11-30 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A presente tese de doutorado objetivou comparar o TDAH no Brasil e na Espanha sob a perspectiva de mães e professores. Essa obra está dividida em 3 estudos: a) O estudo 1, consistiu em uma revisão de literatura dos estudos de prevalência de TDAH nos cinco continentes, enfocando-se as estimativas de prevalência; o processo de amostragem; o tipo de estudo; os critérios diagnósticos; e, as principais variáveis exploradas pelos estudos; b) O estudo 2 comparou a percepção de mães em relação aos problemas de comportamentos listados no CBCL (Child Behavior Checklist) em duas amostras clínicas independentes compostas por pais de crianças brasileiras e espanholas com o diagnóstico de TDAH. O estudo foi do tipo exploratório-descritivo, documental, retrospectivo, transversal, de caráter quantitativo dos prontuários atendidos entre 2010 a abril de 2015 no Hospital Universitário Virgen de la Arrixaca- Murcia/Espanha, e no Hospital Universitário Bettina Ferro de Souza – Belém/Brasil; c) O estudo 3, comparou a perspectiva dos professores no que tange aos problemas de comportamento nos alunos com o diagnóstico de TDAH. Trata-se de uma investigação documental do tipo exploratória-descritiva, retrospectiva e transversal, em que se recorreu a análise de prontuários de crianças e adolescentes, em especial ao TRF (Teacher Report Form) entre os anos de 2013 e 2014 diagnosticados com TDAH em duas unidades clínicas de psicologia situadas no Brasil e Espanha. A principal contribuição desta obra foi encontrar sintomas semelhantes nas duas amostras. A comparação das duas culturas distintas a partir da perspectiva de dois informantes que representam ambientes diferentes, no caso, as mães que avaliaram o comportamento no ambiente familiar, e os professores que interpretaram os sintomas no ambiente escolar, enriqueceram tais achados. / This PhD thesis aimed to investigate ADHD in Brazil and Spain from the perspective of parents and teachers. This work is divided into three studies: a) Study 1 consisted of a literature review of studies on the prevalence of ADHD in five continents, focusing on the estimates of prevalence; the sampling process; the type of study; diagnostic criteria; and the main variables explored by studies; b) Study 2 compared the perception of mothers in relation to behavior problems listed in the CBCL (Child Behavior Checklist) in two independent clinical samples composed of Brazilian and Spanish children with ADHD diagnosis. The study was exploratory-descriptive, documental, retrospective, cross-sectional, quantitative nature of the medical records treated between 2010 to April 2015 at the University Hospital Virgen de la Arrixaca- Murcia / Spain, and the University Hospital Bettina Ferro de Souza - Belém / Brazil; c) Study 3, compared the teacher’s perspective in relation to behaviour problems in students diagnosed with ADHD. This is a documentary investigation of exploratory-descriptive, retrospective and cross-sectional, in which resorted to analysis of children and adolescents records, especially the TRF (Teacher Report Form) between the years 2013 and 2014 diagnosed with ADHD two clinical psychology units located in Brazil and Spain. The main contribution of this work was to find similar symptoms in two independent samples composed of children and adolescents ADHD diagnosis. The comparison of the two different cultures from the perspective of two informants representing different environments, in this case, mothers who evaluated the behavior in the family environment, and teachers who interpreted the symptoms in the school environment, enriched these findings.

Includes vita. / Title from PDF of title page. / Document formatted into pages; contains 137 pages. / Thesis (Ph.D.)--University of South Florida, 2003. / Includes bibliographical references. / Text (Electronic thesis) in PDF format. / ABSTRACT: The researcher examined the relationships between tuberous sclerosis, a multi-system genetic disorder, and school functioning through the use of a parent questionnaire and behavior rating scale. Information was gathered on the typical school experiences of children with tuberous sclerosis, including educational placement and services, behavioral functioning, parent involvement, and parent satisfaction. The results indicated that the majority of students with tuberous sclerosis are in special education and receiving related services. Three-quarters received one or more related services through the public school, and 30% received private related services paid for by their parents. Parent involvement was positively correlated with parent satisfaction, and negatively correlated with t-scores on the Withdrawn/Depressed subscale of the CBCL. / ABSTRACT: Parents of children receiving Autism services were generally less satisfied with their children's school experiences than other parents. Parent satisfaction was negatively correlated with the Attention Problems scale of the CBCL. Student age was negatively correlated with time in inclusion and with related services. This information forms the basis for a discussion of school psychologists' roles in the educational success of students with tuberous sclerosis and the critical areas towards which interventions should be directed. / System requirements: World Wide Web browser and PDF reader. / Mode of access: World Wide Web.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-07-25T23:14:34Z No. of bitstreams: 1 AngelicaLopesCordeiroMandu_DISSERT.pdf: 8297335 bytes, checksum: a571100e33585465a7dd9329c7047ab6 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-08-04T20:58:54Z (GMT) No. of bitstreams: 1 AngelicaLopesCordeiroMandu_DISSERT.pdf: 8297335 bytes, checksum: a571100e33585465a7dd9329c7047ab6 (MD5) / Made available in DSpace on 2016-08-04T20:58:54Z (GMT). No. of bitstreams: 1 AngelicaLopesCordeiroMandu_DISSERT.pdf: 8297335 bytes, checksum: a571100e33585465a7dd9329c7047ab6 (MD5) Previous issue date: 2016-02-18 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Os nevos melanoc?ticos (NMs) s?o prolifera??es benignas de c?lulas n?vicas, que podem serencontradas na pele e em mucosas de revestimento, incluindo a mucosa oral. Contudo, osNMs cut?neos s?o mais comuns, quando comparados os que acometem a mucosa oral. Osmecanismos moleculares envolvidos no desenvolvimento dos nevos e os fatores que podeminfluenciar no padr?o de migra??o das c?lulas n?vicas s?o pouco explorados. O objetivo destapesquisa foi analisar a express?o imuno-histoqu?mica das prote?nas E-caderina e Bcl-2 emNMs orais/cut?neos e relacion?-las com as caracter?sticas cl?nicas (sexo, idade, localiza??o,exposi??o ? radia??o solar) e tipos histopatol?gicos. Foram analisados 36 casos de NMs orais34 de NMs cut?neos. Foi utilizada a t?cnina de imuno-histoqu?mica das prote?nas E-caderinae bcl-2, na qual foram analisados a intensidade (fraca, intermedi?ria e forte) e distribui??o demarca??o (focal e difusa). A imunoexpress?o tamb?m foi analisada quanto aos tipos de c?lulasn?vicas (A, B e C). A an?lise estat?stica foi realizada atrav?s dos testes de Qui-Quadradode Pearson e Correla??o de Spearman com n?vel de signific?ncia estabelecido em 5%. Dos 70casos de NMs, 82,9% eram do sexo feminino, 48,6% com idade entre 26-50 anos, 60% eramda ra?a branca, 51,4% foram diagnosticados histopatologicamente como nevos intrad?rmicos/intramucosos e 80% eram NMs adquiridos. A express?o imuno-histoqu?mica da bcl2 e Ecaderinaforam vari?veis na amostra e n?o exibiram associa??o com os par?metros cl?nicos. Aexpress?o da bcl-2 e E-caderina foram vari?veis de acordo com os tipos de c?lulas n?vicas (A,B e C) (p=0,001). A express?o da bcl-2 foi mais difusa em NMs cong?nitos (p=0,002). A Ecaderinafoi positiva em 83,3% dos NMs <1cm (p=0,001) e em exibiu uma fraca marca??oem 73,9% dos NMs que se encontravam em ?reas expostas (p=0,010). Com base nestes resultados,sugere-se que a E-caderina tenha um controle na determina??o dos tipos histopatol?gicosdos NMs, e que a bcl-2 seja um poss?vel marcador de NMs com maior susceptibilidade aodesenvolvimento de les?es malignas. / Melanocytic nevi (MNs) are benign melanocytic proliferations of cells, which can be found in the skin and mucous coat, including the oral mucosa. However, skin NMs are more common when compared to those that affect the oral mucosa. The molecular mechanisms involved in the development of nevi and the factors that can influence the migration pattern of the nevus cells are little explored. The aim of this study was to analyze the immunohistochemical expression of E-cadherin protein and Bcl-2 in oral / skin NMs and relate them to the clinical characteristics (gender, age, location, exposure to solar radiation) and histopathological types. 36 cases of oral NMs and 34 Skin NMs were analyzed. The immunohistochemistry was used of the protein E-cadherin and bcl-2, which were analyzed the intensity (weak, moderate and strong) and distribution marking (diffuse and focal). The immunoreactivity also analyzed as to the types of nevus cells (epithelioid cells -A, -B lymphocyte and fibroblast-like -C). Statistical analysis was performed using the chi-square tests of Pearson and Spearman correlation with significance level set at 5%. Of the 70 cases of NMs, 82.9% were female, 48.6% aged 26-50 years, 51.4% were diagnosed histologically as intradermal / intramucosal nevi and 80% were NMs acquired. Immunohistochemical expression of BCL2 and E-cadherin were variables in the sample and showed no association with clinical parameters. The expression of bcl-2 and E-cadherin were variable according to the types of nevus cells (A, B and C) (P = 0.001). The expression of bcl-2 was more diffuse in congenital MNs (p = 0.002). E-cadherin was positive in 83.3% of MNs <1cm (p = 0.001) and exhibited weak staining in 73.9% of MNs that were in exposed areas (p = 0.010). Based on these results, it is suggested that the E-cadherin has a modulating effect on the migratory properties of NMs, and bcl-2 is a marker of MNs with increased proliferative capacity.

No description available.

No description available.

Primär kutane Lymphome sind typische Krankheitsbilder in der Dermatologie. Obwohl diese Erkrankungen zu den seltenen Krankheiten zählen, sind sie jedoch von therapeutischem und wissenschaftlichen Interesse. Der erste Teil der Arbeit beschäftigt sich mit der Klassifikation und Therapie primär kutaner Lymphome. Die 1997 veröffentlichte EORTC-Klassifikation wird mit ihren wichtigsten Entitäten erläutert. Die EORTC-Klassifikation geht auf spezifische Besonderheiten der primär kutanen Lymphome ein und orientiert sich an der guten Prognose dieser Erkrankungen. Therapeutische Strategien wie der Einsatz von für kutane Lymphome typische Behandlungsmethoden (PUVA, Exzision, Radiatio) als auch gentechnisch hergestellte Medikamente wie therapeutische Antikörper und Vakzinen werden erklärt. Der zweiten Teil der Habilitationsschrift konzentriert sich auf experimentelle Arbeiten zur molekularbiologischen Untersuchung von primär kutanen Lymphomen. Im Mittelpunkt steht die Methode der Mikromanipulation und Einzelzell-PCR. Für die Mykosis fungoides konnte gezeigt werden, daß im initialen Ekzemstadium nur wenige klonale maligne T-Zellen in der Probe nachzuweisen sind. Mit Zunahme des Infiltrates (Plaque) sind die malignen Zellen in der Epidermis oder gruppiert in der Dermis lokalisiert. Im Tumorstadium dominieren die malignen Zellen das dermale Infiltrat (Gellrich S, J Invest Dermatol, 2000). Die Tumorzellen primär kutaner B-Zell-Lymphome weisen einen dem Keimzentrum ähnlichen Mutationsstatus, nämlich somatische Mutationen und intraklonale Diversifikation, auf (Gellrich S, J Invest Dermatol, 1997; Gellrich S, J Invest Dermatol, 2001). Die Daten sprechen für einen noch aktiven Mutationsmechanismus, sogenannte ongoing mutations (Golembowski S, Immunobiology, 2000). Eine Unterform der kutanen Lymphome stellen die primär kutanen CD30+ T-Zell Lymphome dar. In Untersuchungen mittels Mikromanipulation und Einzelzell-PCR wurden CD30+ Zellen aus primär kutanen CD30+ großzelligen Lymphomen hinsichtlich ihrer T-Zell-Klonalität untersucht. Dabei stellte sich heraus, daß nicht alle atypischen Zellen zur Tumorpopulation gehören. Es wird vermutet, daß ein unbekannter Stimulus zur Ausprägung der Zellmorphe und zur Expression des CD30-Moleküls führt (Gellrich S, J Invest Dermatol, 2003). Eine weitere Entität, bei welcher CD30+ Zellen eine Rolle spielen, ist die lymphomatoide Papulose. In den hier dargestellten Untersuchungen wurden CD30+ große atypische Zellen einzeln isoliert und anschließend mittels PCR für die Gene des T-Zell-Rezeptor-Gamma und des Immunglobulinrezeptors amplifiziert bei einem Patienten mit lymphomatoider Papulose und assoziierter Morbus Hodgkin-Erkankung. In zwei von drei Fällen waren diese CD30+ Zellen polyklonal. Die aus der Fragmentanalyse bekannte klonale T-Zell-Population konnte dagegen in CD3+CD30- kleinen Zellen gefunden werden. In einem dritten Fall enthielten die CD30+ Zellen klonale B-Zellen, welche die gleichen Immunglobulingene rearrangiert hatten wie Zellen aus einem zuvor bestehenden Hodgkin-Lymphom desselben Patienten. Diese Ergebnisse lassen vermuten, dass es für das Aufschießen und die Regredienz der Läsionen der lymphomatoiden Papulose einen Stimulus gibt und die klonalen T- und B-Zellen als Begleitinfiltrat ohne pathologische Bedeutung anzusehen sind. Insgesamt bilden die Daten dieser Arbeit eine Grundlage für eine Fortsetzung der Untersuchung zur Ätiopathogenese von primär kutanen Lymphomen und deren Therapie und bieten die Möglichkeiten vielfältiger wissenschaftlicher Kooperationen. / Primary cutaneous lymphomas present with typical clinical features in dermatology. Although these diseases are rare, they particularly are of scientific and therapeutic interest. The first part of this work deals with the classification and treatment of primary cutaneous lymphomas (PCBCL). The 1997 published EORTC classification will be explained according to the good prognosis of PCBCL. Therapeutic strategies as well as typical procedures (PUVA, excision, irradiation) and gene-technically produced drugs (therapeutic antibodies, vaccination) are illustrated in detail. The second part of this publication focuses on the experimental molecular biological work-out, done in primary cutaneous lymphomas by means of micromanipulation and single cell PCR. For the mycosis fungoides could be shown that in the patch stage only a few malignant T cells can be detected. Increasing infiltrates (plaque-stage) are characterized by epidermotrop or dermally grouped atypical cells. In tumor stage dermal atypical T cells are predominating (Gellrich S, J Invest Dermatol, 2003). The tumor cells of primary cutaneous B cell lymphomas are comparable with the stage of mutation of follicle centre cells: somatic mutations and intraclonal diversity (Gellrich S, J Invest Dermatol, 1997; Gellrich S, J Invest Dermatol, 2001). The data indicate, that there may be an active mutation mechanism, the so-called ongoing mutations (Golembowski S, Immunobiology, 2000). One subgroup of PCBCL, are presented by the CD30positve entities. By means of micromanipulation and PCR, single cells were investigated due to T cell clonality. Not all atypical cells belong to the malignant population. It is supposed that an unknown stimulus leads to morphological features and CD30 expression (Gellrich S, J Invest Dermatol, 2003). Another CD30positive entity is reflected by the lymphomatoid papulosis. In these experiments large atypical CD30positve cells were isolated and have been investigated via PCR for T cell receptor g or immunoglobuline heavy and light chain gene rearrangement. The majority of the large CD30postive cells (two cases) belong to a polyclonal T cell population. In the opposite, the small CD3positive cells are the cells persisting within the T cell clone. In another case B cells with the same immunoglobulin gene rearrangement like in a preceding Hodgkin disease of the same patient could be detected. The data seem to underline the fact that reactive polyclonal CD30positive cells are triggered by an unkown stimulus with clonal bystander cells without any pathological significance. In summary, this work could be the basis for further investigations about the etiopathogenesis of PCBCL.

La presente ricerca nasce da una domanda di un territorio specifico che si è interrogato relativamente ai problemi emotivo-comportamentali dei bambini in età prescolare Tale richiesta ci ha sollecitato da un punto di vista teorico a porre l’attenzione da un lato, sul significato “clinico” dei problemi emotivo-comportamentali dei bambini, dall’altro sul processo di assessment e in particolar modo sulla prospettiva multi-informant . Tale prospettiva è stata nello specifico oggetto di riflessione e indagine empirica soprattutto nel primo studio dove si sono considerate con particolare attenzione le discrepanze tra gli informant e il loro possibile significato. La domanda di ricerca iniziale si è quindi ampliata fino ad affrontare l’individuazione dei fattori protettivi e di rischio nello sviluppo psicologico dei bambini in età prescolare. A questo proposito il secondo studio propone un modello multifattoriale per la comprensione delle problematiche emotivo-comportamentali dei bambini che tiene conto di aspetti individuali e di aspetti relazionali, familiari in primo luogo. Infine, il terzo studio vede l’utilizzo del modello teorico proposto nei i primi due studi su di un campione di genitori che si sono rivolti a un servizio territoriale arrivando a identificare gli elementi del modello che discriminano famiglie considerate normali da quelle definibili come cliniche. / This research developed from a need to answer specific questions about emotional-behavioral problems in preschool children. From a theoretical point of view, this need forced one to focus on the “clinical” meaning of emotional-behavioral problems in pre-school children and their assessment processes, especially from a multi-informant perspective. Particularly, this perspective was a topic of interest in an empirical investigation in the first study, where discrepancies between informants and their possible perceptions were considered with particular attention. The initial research question was expanded to deal with the identification of risk and protective factors in the psychological development of preschool children. On this regard, the second study proposed a multi-factorial model to understand the emotional and behavioral problems of children which took into account individual and relational aspects, including especially the family. Finally, the third study considered the use of a theoretical model proposed in the first two studies with a sample of parents who turned for help to social services to identify from the model critical elements that discriminated families which could be considered functional from those defined as clinical.

No description available.

No description available.

No description available.