The thesis deals with the implementation of Ethernet-based network communication interface into FPGA chip. VHDL programming language is used for description of the hardware. The interface includes the implementation of link-layer Ethernet protocol and network protocols such as IPv4, ARP, ICMP and UDP. The final design allows bi-directional communication on the transport-layer level of TCP/IP model. The designed interface was implemented into Virtex5 FPGA chip on development board ML506 by Xilinx.

"It is the responsibility of every government to protect the fundamental rights and freedoms of its citizenry and to ensure that the rule of law and justice prevails at all times. Hovewer, children accused of committing crimes are more susceptible to human rights abuses and violations of their legal rights while in detention, either in police cells, prisons or authorised detention centres. They mostly suffer from both the agents of the state as well as from inmates. These violations often take place [behind] closed doors, and society being primarily concerned with keeping offenders locked up rather than about their conditions and human rights being respected, the cries of these children to be treated with dignity and worth go unnoticed despite the constitutional and international guarantee of their rights. The problem therefore is first to examine what rights do children in trouble with the law have under international law in general and specifically within the African human rights sytem with special emphasiis on the rights of children deprived of their liberty. Secondly, to examine how these international instruments are given effect domestically and whether there are challenges encountered in realising these rights. These are the main issues that this research intends to grapple with using South Africa and the Gambia as case studies with a view to making recommendations for better protection of the rights of this category of children. ... This research consist of four chapters. The first chapter is the introduction. It will give the basis and structure of the research which will include a general overview of the problem in the two countries under study. In the second chapter, it will explore the relevant international and African normative framework that protects the rights of children in trouble with the law and the obligations of states towards these children. However, the main focus will be the Convention on the Rights of the Child (CRC) and the African Charter on the Rights and Welfare of the Child (ACRWC), because they are the two main human rights instruments providing specific protection for children's rights in all spheres. The third chapter will be a comparative analysis of the rights of children deprived of their liberty as provided in the municipal laws of South African and the Gambia vis a vis the minimum standards set [out] in the CRC and ACRWC. It will discuss the following issues, namely: defintion of a child, age of criminal responsibility, the best interest, detention as a last resort and for the shortest possible time, separation from adult detainees, role of parents, establishment of separate criminal procedures, right to legal respresentation and assistance, and sentencing options. It will also examine the problems and challenges for implementation. The fourth chapter will conclude and make recommendations on how best to implement the laws and who should be the role players in ensuring that the rights of these children are well protected." -- Introduction. / Thesis (LLM (Human Rights and Democratisation in Africa)) -- University of Pretoria, 2005. / Prepared under the supervision of Professor Gilles Cistac at the Faculty of Law, Universidade Eduardo Mondlane, Maputo, Mocambique / http://www.chr.up.ac.za/academic_pro/llm1/dissertations.html / Centre for Human Rights / LLM

Colorectal cancer (CRC) is the third most common cancer worldwide; it is responsible for nearly 10% of all newly diagnosed cancers and is the second most cause of cancer related death in Europe. Biomarkers for therapy guidance, targeted therapy and survival prognosis are still limited. As CRC is a heterogeneous disease, different parts of the tumor might have varying molecular characteristics which may change during therapy or disease progression. Through solid biopsies and screenings, these local or temporal differences are impossible to monitor. To facilitate detection of these possible temporal changes, a regularly and non-invasively accessible biomarker is required for disease monitoring. Circulating tumor cells (CTCs) might represent such a biomarker as they have been shown to be fluid surrogates of the solid tumor. EpCAM positive CTCs have shown to be prognostic in CRC for survival, but their full potential has not yet been evaluated further. By using the High Definition Single Cell Analysis (HD-SCA) workflow, we were able to analyze the entire spectrum of CTCs and categorize them as the regular CTCs (HD-CTC), CTCs with a smaller nuclear area (CTC-Small), CTCs with low expression of epithelial marker cytokeratin (CTC-LowCK) and CTCs undergoing apoptosis and therefore releasing cell free DNA...

Colorectal cancer (CRC) is a major public health problem worldwide. Despite improvements in the diagnostic process and advancement in the treatment methods, the prognosis remains poor. To improve survival rates, it is important to identify people with the predisposition for CRC and to detect the potentially curable early stage of the disease. Furthermore, identifying those who would have an adverse clinical outcome associated with a particular chemotherapy would help to avoid redundant chemotherapy burden in patients and contribute to enhanced therapeutic efficacy, while minimizing treatment-related toxicity. The aim of the Thesis was to search for novel promising diagnostic, prognostic and predictive DNA-based biomarkers of sporadic form of CRC. As each patient is genetically unique, these biomarkers would aid clinicians in better diagnosis and/or in the selection of an optimal type of therapy for an individual CRC patient based on their molecular profile. In order to explore this issue, we investigated several candidate genes in healthy individuals as well as in newly diagnosed cancer patients. The major outcomes of this PhD study, which were fully reported in seven publications included in the present Thesis, are 1) The observation of several candidate single nucleotide polymorphisms in microRNA...

The aim of this thesis is to examine to what extent the Convention on the Rights of the Child may be regarded as an effective instrument for a state’s aim to abolish child trafficking. An underlying aim is to examine what factors make a convention effective in general. The study is conducted through a doctrinal method with a legal sociological perspective, examining the normative aspects of law. In this sense, Ghana’s implementation of Article 35 of the CRC is evaluated, in order to reach the objective of the study. Thus, the Ghanaian legal system constitutes the base upon which the analysis is made. Hereby, the effectiveness of the CRC is measured by the extent to which the commitments made by Ghana, have led to the adoption of concrete measures to improve the rights of children as it pertains to child trafficking, since the ratification of the CRC. An underlying aim is to discover what factors may affect the effectiveness of a convention, such as inadequate legal framework, its application of it or other cultural factors.  In order to measure the effectiveness of the CRC, a normative model is applied, explaining both the notions of compliance versus effectiveness. Herein, it is clarified that: in order to measure the effectiveness of a convention in this matter, one first needs to examine if the national legal framework complies to the convention in question. Thus, in the first part, it is concluded that Ghana has successfully incorporated the CRC in its legal framework. In the second part, it is shown how, despite of the effective incorporation of the CRC, there remains a gap between what is prescribed by law and the manifestation in practice.                                                     Different factors have been concluded to influence the effectiveness of the Convention. In order for a state to implement measures to deal with an issue, there must be a clear standard set out in the convention in the first place. In this regard, it has been noted that the lack of clarity and ambiguity of the wording in Article 35 of the CRC may have affected the effectiveness of the convention. Moreover, it is noted that the nature of the issue: the phenomenon of child trafficking, in itself, is a complex issue with certain elements that makes it more challenging to regulate than “normal” human rights violations. Not least, it is proven how the socio-cultural norms of Ghana have a noticeable effect on the implementation of the Convention. At last, it is demonstrated how the process of norm-internalization in a state may affect the effectiveness of a Convention: it has been shown how Ghana’s policy-making system has not been effective in practice. Nevertheless, the conclusion remains: the effectiveness of a convention depends on the function it serves in the first place. As for the case of the CRC, it remains an effectivetool to abolish child trafficking as long as the States Parties take united responsibility to make it so. / Syftet med denna uppsats är att undersöka i vilken utsträckning barnkonventionen (CRC) kan utgöra ett effektivt instrument för en stats ändamål att avskaffa barnhandel. Ett bakomliggande syfte med studien är att utreda vilka faktorer som gör en konvention effektiv generellt sett. Studien baseras på en rättsdogmatisk metod i ljuset av ett rättsociologiskt perspektiv där de normativa aspekterna av lagen undersöks. I detta avseende utvärderas Ghanas implementering av artikel 35 i CRC för att uppnå syftet med studien. Således vilar den rättsliga analysen på det ghananska rättssystemet som grund. I sammanhanget granskas barnkonventionens effektivitet med avstamp i hur de åtaganden som gjorts av Ghana har lett till vidtagande av konkreta åtgärder för att förbättra barns situation vad gäller barnhandel. En normativ modell tillämpas för att förstå vad begreppen effektivitetoch efterlevnadinnebär i sammanhanget. Här klargörs att, för att mäta effektiviteten av en konvention, måste det först undersökas huruvida det nationella regelverket uppfyller de reglerade skyldigheterna i den ifrågavarande konventionen. I den första delen dras slutsatsen att Ghana har införlivat barnkonventionen på ett tillfredsställande sätt.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                I den andra delen redovisas det hur det kvarstår en diskrepans mellan vad som föreskrivs i lag och hur lagen manifesteras i praktiken, trots det effektiva införlivandet av barnkonventionen. Det påvisas hur olika faktorer påverkar en konventions effektivitet. I detta avseende noteras det att (bristen på) tydlighet och klarhet i ordalydelsen av artikel 35, kan påverka konventionens effektivitet. För att en stat ens ska kunna genomföra åtgärder för att hantera en viss fråga måste det finnas en tydlig standard i konventionen i första hand. Vidare noteras det att problemets natur: fenomenet barnhandel i sig, är en komplex fråga med vissa element som gör det mer utmanande att reglera fenomenet än ”normala” kränkningar av mänskliga rättigheter. Inte minst anmärks det hur de sociokulturella normerna i Ghana har en märkbar effekt på tillämpningen av barnkonventionen.                                                                                                       Slutligen redogörs det för hur olika norminternaliserande faktorer i en stat kan påverka effektiviteten av en konvention: det redovisas hur Ghana brister i författandet av effektiva ”policies” för att åtgärda problematiken. Slutsatsen påvisar hur effektiviteten av en konvention beror på den funktion som konventionen har i första hand. Vad gäller barnkonventionen, utgör den ett effektivt verktyg i kampen mot barnhandel, så länge som medlemsstaterna faktiskt tar enat ansvar i att säkerställa dess effektivitet. / Minor Fields Studies, SIDA

Barriers to Colorectal Cancer Screening in People Obtaining Care From Community Mental Health Agencies by Kelly Gardiner MSN, Wayne State University, 1997 BSN, Wayne State University, 1988 Dissertation Submitted in Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University August 2016 Despite being highly treatable with early intervention and preventative screenings, the overall mortality rate of colorectal cancer is substantially higher in participants with a preexisting mental disorder. Variables affecting the likelihood of completing screening for those with mental illnesses were unknown in people who obtain services from a Community Mental Health agency. Using the Health Belief Model, the proposed study investigated the effects of access to transportation, referral to screening, physical ability to complete the colonoscopy prep, type of procedure, awareness of the purpose of screening, anxiety, embarrassment, gender, race, and age to determine which affect completion of colorectal cancer screening. Significant relationships existed between embarrassment, fear of pain, fear of cancer, anxiety, physical ability to do testing, awareness of screening at age 50, FOBT vs Scope procedures, age of first screening, being told to get screening, knowing someone who had screening, and completion of colorectal cancer screening. In the binary logistic model Anxiety was negatively correlated and being told to get screening was positively correlated to completion of colorectal cancer screening and those choosing Scope were more likely to complete than those choosing FOBT. The results of this study may effect positive social change by providing healthcare providers with an increased understanding of variables that influence colorectal cancer screening completion among persons with a diagnosed mental illness, resulting in a changing agenda for effective mental and physical health care in this population.

Utgångspunkten för studien var att Kriminalvården fick kritik från barnrättskommittén när det gäller barn till föräldrar som är frihetsberövade. Kritiken riktades bl. a. mot att barn dels reser långt för att besöka sin förälder samt dels att barn som reser långt inte med automatik får förlänga besökstiden på vissa anstalter. Uppsatsen har samtidigt pekat på utmaningar och viktiga förutsättningar för att beakta barnkonventionen inom kriminalvården. I ett svenskt sammanhang, efter att barnkonventionen blivit lag i Sverige 2020, har organisationsutvecklingen med avseende på uppfyllande av barns rättigheter inom den offentliga sektorn varit relativt outforskad. Uppsatsen fyller förhoppningsvis en del av den kunskapsluckan. Syftet med denna studie är att visa hur Kriminalvården utvecklats med avseende på uppfyllande av barnkonventionen. Frågeställningarna fokuserar på hur kriminalvården förbättrar sin verksamhet genom att ständigt beakta barnkonventionen vid ärende som rör barn. Studien genomfördes som en kvalitativ studie. Datainsamlingen till denna studie skedde genom semi-strukturerade intervjuer, nio respondenter som är barnombud på olika nivåer i hierarkin i region väst deltog. Studien visar att Kriminalvården styr sina processer centralt uppifrån genom att informera om lagstiftning och nationella riktlinjer för att förmedla hur barnkonventionen ska beaktas i regioner och lokala enheter. Sedan tolkar varje enhet riktlinjerna på det sättet som passar verksamheten såsom häkte, anstalt eller frivård. Studien visar att det krävs mer samarbete mellan olika myndigheter för att främja arbetet mot barnets bästa. Enligt studien räcker det dock inte med att beakta barnkonventionen i handböckerna eller genom utbildningar utan det ska finnas ett personligt engagemang hos medarbetarna om de ska anses vara kundorienterade. / The starting point for the study was that the Swedish Prison and Probation Service received criticism from the Committee on the Rights of the Child when it comes to children of parents who are deprived of their liberty, criticism that children travel far to visit their parents, and criticism that children who travel far may not automatically extend their visit to certain institutions. At the same time, research has pointed to challenges and important conditions for considering the Convention on the Rights of the Child in the prison service. In a Swedish context, after the Convention on the Rights of the Child becomes law in Sweden in 2020, the organizational development with regard to fulfilling children's rights in the public sector has been relatively unexplored. The research aims to fill part of that knowledge gap. The purpose of the study is to see how the Swedish Prison and Probation Service develops with regard to compliance with the Convention on the Rights of the Child. The issues focus on how the prison service improves its activities in order to constantly consider the Convention on the Rights of the Child in matters concerning children. The study was conducted through a qualitative study. Data collection for this study was done through semi-structured interviews, nine respondents who are children's representatives at different levels in the hierarchy in the region west. The study shows that the Swedish Prison and Probation Service controls processes centrally from above by informing legislation, national guidelines for communicating how the Convention on the Rights of the Child is taken into account to regions and then to local units. Then each unit interprets the guidelines in the way that suits the unit type, such as detention, institution, or probation. The study shows that more cooperation is needed between different authorities to promote work for the best interests of the child. According to the study, however, it is not enough to consider children's conventions in the handbooks or through training, but there must be a personal commitment on the part of employees considered customer-oriented. / <p>2021-06-11</p>

Colorectal cancer (CRC) is the third most common cancer worldwide; it is responsible for nearly 10% of all newly diagnosed cancers and is the second most cause of cancer related death in Europe. Biomarkers for therapy guidance, targeted therapy and survival prognosis are still limited. As CRC is a heterogeneous disease, different parts of the tumor might have varying molecular characteristics which may change during therapy or disease progression. Through solid biopsies and screenings, these local or temporal differences are impossible to monitor. To facilitate detection of these possible temporal changes, a regularly and non-invasively accessible biomarker is required for disease monitoring. Circulating tumor cells (CTCs) might represent such a biomarker as they have been shown to be fluid surrogates of the solid tumor. EpCAM positive CTCs have shown to be prognostic in CRC for survival, but their full potential has not yet been evaluated further. By using the High Definition Single Cell Analysis (HD-SCA) workflow, we were able to analyze the entire spectrum of CTCs and categorize them as the regular CTCs (HD-CTC), CTCs with a smaller nuclear area (CTC-Small), CTCs with low expression of epithelial marker cytokeratin (CTC-LowCK) and CTCs undergoing apoptosis and therefore releasing cell free DNA...

Sexual violence perpetrated against women during armed conflicts represents a severe violation of their fundamental human rights. This heinous act not only inflicts significant harm on the women themselves but also results in the birth of children conceived due to wartime rape. Previous research has marked that children born of war encounter various forms of discrimination, stigma, neglect, abuse, and sometimes limited access to education and healthcare. As a vulnerable group, children born of war often have single mothers who have experienced sexual violence, resulting in potential lack of support from their family and communities. This paper investigates the circumstances and obstacles faced by children born of war but also what is necessary to properly support these children, according to the five organisations interviewed. It shines light on the need for comprehensive support systems to address their specific needs in the future, such as the urgent need for early interventions and psychological support, along with providing children born of war the opportunity to connect with their biological heritage to foster a sense of identity amongst others.

1 juli år 2013 trädde en ny skollag i kraft i Sverige. Den nya lagen ger papperslösa barn i Sverige rätt till utbildning. Detta gäller både om barnet har fått avslag av Migrationsverket på sin uppehållstillståndsansökan och om barnet lever gömt och inte sökt uppehållstillstånd. Idag har papperslösa barn rätt till utbildning men detta innebär inte att dessa barn har en skolplikt, utan det avgör barnet själv eller familjen till det papperslösa barnet om rätten ska nyttjas. Denna valfrihet leder till att flera papperslösa barn inte utnyttjar sin rätt till utbildning. Det finns flera orsaker till detta som exempelvis att många papperslösa familjer inte känner till den nya skollagen och att polisen de facto har rätt att omhänderta en papperslös elev från skolan. Då det inte existerar någon garanti för att den papperslösa elevens trygghet i skolan väljer många papperslösa familjer bort denna rättighet på grund av rädslan att barnet skall bli omhändertaget av polisen. I samband med detta har vi identifierat olika dilemman för lärare, dilemman som uppstår vid en sammanstötning mellan lärares yrkesetik och lärares lagstadgade plikter såsom anmälningsplikt. I Sverige har lärare en skyldighet att anmäla, om de misstänker eller får kännedom om att ett barn far illa skall de meddela socialtjänsten. Denna anmälningsplikt orsakar ett stort dilemma för lärare då konsekvensen av en anmälning kan bli förödande för den enskilde papperslösa eleven och dennes familj. För att få en klarare bild av lärarnas dilemman utförde vi intervjuer med olika lärare på Skånska skolor. Vid intervjutillfällena fick vi förklarat för oss att dilemmat med anmälningsplikten och skyddande av papperslösa elever är någonting som lärare fruktar. Utifrån Barnkonventionen, lärares yrkesetik, tystnadsplikt samt specifik skolsekretess kan lärare skydda den enskilde papperslösa eleven. Dock så finns rädslan kvar bland lärarna om vad som händer om en specifik situation leder till att socialtjänsten måste kontaktas. Resultatet av analysen ger en bild av att lärares yrkesetik inte är så stark som andra yrkesetiker, således kan lärare stå upp mot andra myndigheter och neka deras begäran om tillträdde på skolan. / July 1 2013 a new law entered into force in Sweden. The new Education Act gives undocumented children in Sweden right to education. This is regardless whether the child has been rejected by the Migration Board on their residence permit application and shall be rejected or if the child lives in hiding and has not applied for a residence permit. Today, undocumented children's right to education does not mean that undocumented children have a school attendance, this determines the child himself or the family of the undocumented child´s the right to be utilized. This choice leads too many undocumented children do not exercise their right to education. There are several reasons for this, such that many undocumented families are not aware of the new Education Act, but also that the police actually have the right to seize an undocumented student from school. Then there exists no guarantee that the undocumented student's safety at school, many undocumented families declines this right because of the fear of being found and cared for by the police. In connection with this issue, we have identified various dilemmas for teachers, dilemmas that arise when there is a clash between teachers' professional ethics' and teachers' statutory obligations such as notification requirements to authority. In Sweden, teachers have an obligation to notify if they suspect or become aware that a child is being abused to social services. This notification requirement causes a big dilemma for teachers as the consequence of a notification can be devastating for the individual undocumented student and their family. To get a view of the teacher's dilemmas, we conducted interviews with teachers from Skåne. In the interviews we got told by teachers that the dilemma with the notification requirements and protection of undocumented students is something that teachers fear. Thanks to the Convention of Children´s Rights, teachers' professional ethics, teacher´s obligation to observe silence and confidentiality that exists at the school, teachers can protect the individual undocumented student. However, there are fears remain in the teachers about what happens if it comes to the situation where a claim must be made to social services. The results of the analysis gave us that the teachers' professional ethics is not as strong as other professional ethics so that teachers can stand up to other authorities and deny their request for the entry of the school.