Physical inactivity is well known for its effects on increasing health risks contributing to mortality and morbidity. Restrictions imposed due to covid 19 pandemic have immobilized communities worldwide, resulting in remote working and distance learning. Literature evidence directs towards Covid-19 pandemic related physical inactivity and increased sedentary behavior (SB) in the general population, and very little research is carried out on the remote workers in communities that shifted from workplaces to homes. The aim of the study is to examine if working from home before and during Covid 19 - pandemic is associated with changes in physical activity and sedentary behavior among adults. The data was acquired from a cross-sectional Swedish population-based study (n= 1035). Physical Activity (PA) was reported in METs/w (metabolic equivalent minutes per week), and intensity was grouped as Vigorous, Moderate and Light PA. The amount of Work or Studied from home (WSFH) was reported in percentages. Light PA level was higher among the group >50% WSFH than the ≤ 50% group during pandemic and SB was higher among ≤ 50% WSFH group during pandemic. Demographical variations among the WSFH groups showed significant associations in the occupation and education level. In conclusion, the study showed that those who worked or studied more from homes have been physically active in walking (Light PA) and had a lower sedentary time than others. There were no significant difference in physical activity levels  due to the changes in the amount of pandemic-based work or study from home, during the pandemic.

[pt] A pesquisa aplica algumas técnicas de processamento de linguagem natural (PLN) ao domínio da história, tendo como objeto de investigação o Dicionário Histórico-Biográfico Brasileiro (DHBB), obra de estilo enciclopédico concebida pelo Centro de Pesquisa e Documentação de História Contemporânea do Brasil (CPDOC) da Fundação Getulio Vargas (FGV). O objetivo foi criar, a partir do DHBB, um corpus anotado para fins de extração automática de informações, relevante para as Humanidades Digitais, capaz de viabilizar ‘leituras distantes’ da política contemporânea brasileira. O processo completo passa pelas etapas de análise morfossintática do material, identificação de entidades relevantes ao domínio, inclusão de anotação no corpus, definição de relações semânticas de interesse para a pesquisa e mapeamento dos padrões léxico-sintáticos existentes nestas relações. Busca-se com estas etapas preparar os textos para a identificação de estruturas de interesse, isolando as informações relevantes e apresentando-as de forma estruturada. Para testar e avaliar um conjunto de padrões quanto à sua produtividade, foram selecionados como temas de interesse idade de entrada dos biografados na carreira política, formação acadêmica e vínculos familiares. O pressuposto é que utilizando padrões léxico-sintáticos é possível extrair informação de qualidade direcionada ao domínio da História, a partir de um corpus anotado do gênero enciclopédico. Na avaliação dos padrões para a extração do ano de nascimento dos biografados a medida-F foi de 99 por cento, para a extração de relações familiares a medida-F foi de 84% e para informações sobre formação acadêmica o índice de acertos alcançou 99,1 por cento. Essas extrações, por sua vez, permitiram uma leitura distante dos dados do DHBB que nos mostra i) queda da média de idade no que se refere à entrada dos políticos na carreira pública, que passam a se posicionar cada vez mais abaixo dos 40 anos, principalmente os nascidos a partir da década de 1960; ii) declínio acentuado na formação militar, sobretudo para as gerações pós 1920, demonstrando que o treinamento civil estava substituindo o militar enquanto caminho para atingir cargos políticos importantes; e iii) vínculos familiares na política como um fenômeno que se mantêm ao longo do tempo em índices bastante significativos, muitas vezes representando mais de 50 por cento do total de membros de determinadas categorias. As principais contribuições da tese são: criação de um corpus de gênero enciclopédico anotado e disponibilizado para estudos linguísticos e das humanidades; apresentação de metodologia baseada em uma filosofia de enriquecimento cíclico, em que à medida que se vai obtendo mais informações, elas são adicionadas ao próprio corpus melhorando a extração; e compilação de um conjunto de padrões passível de ser adaptado para quaisquer corpora contendo o mesmo tipo de anotações. / [en] The research applies some natural language processing techniques (NLP) to the domain of history, having as object of investigation the Brazilian Historical-Biographical Dictionary (DHBB), an encyclopedic style work conceived by the Centro de Pesquisa e Documentação de História Contemporânea do Brasil (CPDOC) of Fundação Getulio Vargas (FGV). The target is to create, from the DHBB, an annotated corpus for automatic information extraction s purpose, relevant to the Digital Humanities, enabling distant readings of Brazilian contemporary political history. The complete process goes through the morphosyntactic analysis of the material, identification of entities relevant to the domain, inclusion of semantic annotation in the corpus, definition of semantic relations of interest and mapping of lexical-syntactic patterns existing in these relations. These steps seek to prepare the texts for the identification of structures of interest, isolating the relevant information and presenting them in a structured way. To test and evaluate a set of textual patterns regarding their productivity in relation to DHBB, some specific topics were selected: age of the politician when entering public life, academic training and family ties. The assumption is that using lexical-syntactic patterns it is possible to extract high quality information from the domain of History, from an annotated corpus of the encyclopedic genre. In the evaluation of the patterns for extraction of the year of birth of the biographees, the F-measure was 99 per cent, for the extraction of family relationships, the F-measure was 84 per cent and for information on academic training, the correctness index reached 99.1 per cent. These extractions, in turn, allowed us to make a distant reading of the data in the DHBB that shows us i) a drop in the average age with regard to the entry of politicians into the public career, who start to position themselves more and more under 40 years of age, mainly those born from the 1960s; ii) sharp decline in military training, especially for the post-1920 generations, demonstrating that civilian training was replacing military training as a way to reach important political positions; and iii) family ties in politics as a phenomenon that remain over time at very significant rates, often representing more than 50 per cent of the total members of certain categories. The main contributions of the thesis are: creation of an encyclopedic genre corpus annotated and made available for linguistic and humanities studies; presentation of a methodology based on a philosophy of cyclic enrichment, in which, as more information is obtained, they are added to the corpus itself, improving extraction; and compilation of a set of productive patterns that can be adapted for any corpora containing the same type of annotations.

Background: Standardized staging procedures and presentation of oral squamous cell carcinoma (OSCC) patients in multidisciplinary tumor boards (MDTB) before treatment and utilization of elective neck dissection (ND) are expected to improve the outcome, especially in local advanced LAOSCC (UICC stages III–IVB). As standardized diagnostics but also increased heterogeneity in treatment applied so far have not been demonstrated to improve outcome in LAOSCC, a retrospective study was initiated. Methods: As MDTB was introduced into clinical routine in 2007, 316 LAOSCC patients treated during 1991-2017 in our hospital were stratified into cohort 1 treated before (n=104) and cohort 2 since 2007 (n=212). Clinical characteristics, diagnostic procedures and treatment modality of patients were compared using Chi-square tests and outcome analyzed applying Kaplan-Meier plots and log-rank tests as well as Cox proportional hazard regression. Propensity scores (PS) were used to elucidate predictors for impaired distant metastasis-free survival (DMFS) in PS-matched patients. Results: Most patient characteristics and treatment modalities applied showed insignificant alteration. Surgical treatment included significantly more often resection of the primary tumor plus neck dissection, tracheostomy and percutaneous endoscopic gastrostomy tube use. Cisplatin-based chemo-radiotherapy was the most frequent. Only insignificant improved disease- (DFS), progression- (PFS) and event-free (EFS) as well as tumor-specific (TSS) and overall survival (OS) were found after 2006 as local (LC) and locoregional control (LRC) were significantly improved but DMFS significantly impaired. Cox regression applied to PS-matched patients elucidated N3, belonging to cohort 2 and cisplatin-based chemo-radiotherapy as independent predictors for shortened DMFS. The along chemo-radiotherapy increased dexamethasone use in cohort 2 correlates with increased DM. Conclusions: Despite standardized diagnostic procedures, decision-making considering clear indications and improved therapy algorithms leading to improved LC and LRC, shortened DMFS hypothetically linked to increased dexamethasone use had a detrimental effect on TSS and OS.

No description available.

La population canadienne-française a une histoire démographique unique faisant d’elle une population d’intérêt pour l’épidémiologie et la génétique. Cette thèse vise à mettre en valeur les caractéristiques de la population québécoise qui peuvent être utilisées afin d’améliorer la conception et l’analyse d’études d’épidémiologie génétique. Dans un premier temps, nous profitons de la présence d’information généalogique détaillée concernant les Canadiens français pour estimer leur degré d’apparentement et le comparer au degré d’apparentement génétique. L’apparentement génétique calculé à partir du partage génétique identique par ascendance est corrélé à l’apparentement généalogique, ce qui démontre l'utilité de la détection des segments identiques par ascendance pour capturer l’apparentement complexe, impliquant entre autres de la consanguinité. Les conclusions de cette première étude pourront guider l'interprétation des résultats dans d’autres populations ne disposant pas d’information généalogique. Dans un deuxième temps, afin de tirer profit pleinement du potentiel des généalogies canadienne-françaises profondes, bien conservées et quasi complètes, nous présentons le package R GENLIB, développé pour étudier de grands ensembles de données généalogiques. Nous étudions également le partage identique par ascendance à l’aide de simulations et nous mettons en évidence le fait que la structure des populations régionales peut faciliter l'identification de fondateurs importants, qui auraient pu introduire des mutations pathologiques, ce qui ouvre la porte à la prévention et au dépistage de maladies héréditaires liées à certains fondateurs. Finalement, puisque nous savons que les Canadiens français ont accumulé des segments homozygotes, à cause de la présence de consanguinité lointaine, nous estimons la consanguinité chez les individus canadiens-français et nous étudions son impact sur plusieurs traits de santé. Nous montrons comment la dépression endogamique influence des traits complexes tels que la grandeur et des traits hématologiques. Nos résultats ne sont que quelques exemples de ce que nous pouvons apprendre de la population canadienne-française. Ils nous aideront à mieux comprendre les caractéristiques des autres populations de même qu’ils pourront aider la recherche en épidémiologie génétique au sein de la population canadienne-française. / The French Canadian founder population has a demographic history that makes it an important population for epidemiology and genetics. This work aims to explain what features can be used to improve the design and analysis of genetic epidemiological studies in the Quebec population. First we take advantage of the presence of extended genealogical records among French Canadians to estimate relatedness from those records and compare it to the genetic kinship. The kinship based on identical-by-descent sharing correlates well with the genealogical kinship, further demonstrating the usefulness of genomic identical-by-descent detection to capture complex relatedness involving inbreeding and our findings can guide the interpretation of results in other population without genealogical data. Second to optimally exploit the full potential of these well preserved, exhaustive and detailed French Canadian genealogical data we present the GENLIB R package developed to study large genealogies. We also investigate identical-by-descent sharing with simulations and highlight the fact that regional population structure can facilitate the identification of notable founders that could have introduced disease mutations, opening the door to prevention and screening of founder-related diseases. Third, knowing that French Canadians have accumulated segments of homozygous genotypes, as a result of inbreeding due to distant ancestors, we estimate the inbreeding in French Canadian individuals and investigate its impact on multiple health traits. We show how inbreeding depression influences complex traits such as height and blood-related traits. Those results are a few examples of what we can learn from the French Canadian population and will help to gain insight on other populations’ characteristics as well as help the genetic epidemiological research within the French Canadian population.

Introduktion: Pandemin och dess konsekvenser innebar flera år av utmaningar på alla nivåer i samhället. Det var särskilt utmanande för ledare att styra sin organisation i rätt riktning då framtiden var oviss och förändringen var oundviklig. Ledarskap påverkas av flera faktorer, varav en avgörande faktor är kontexten. Tidigare forskning framhåller betydelsen av kontexten för att bestämma vilken ledarskapsstil som fungerar bäst. Coronapandemin skulle kunna anses utgöra en sådan kontext där ledare snabbt behövde anpassa sig för att möta de nya kraven. Coronapandemin medförde även utmaningar för ledare att hantera medarbetares välmående. Vår studies relevans bekräftas av tidigare forskning, vilka framhåller behovet av mer forskning för att förstå distansens påverkan på ledarskapet. Vidare blir vår studie särskilt relevant eftersom det är få studier gjorda i Sverige, vilket gör det intressant att undersöka landets unika strategi och dess effekter på ledarskapet i denna kontext. Tidigare forskning framhåller att betydelsen av att förstå effektivt ledarskap har ökat under coronapandemin, och att det är viktigt att ompröva och utveckla befintliga ledarskapsteorier med tanke på de kontinuerliga förändringarna i dagens samhälle.   Syfte: Vår studies syfte är att bidra till ökad förståelse för hur svenska ledare, till följd av införandet av restriktionen gällande att arbeta hemifrån, har anpassat sin ledarskapsstil i en extraordinär situation.   Teoretisk referensram: Den teoretiska referensramen bygger på tidigare studier och teorier om psykosocial arbetsmiljö samt ledarskapsstilarna: transaktionellt-, transformativt- och situationsanpassat ledarskap som vi anser är relevanta för vår studie. Vidare ges även en introduktion till området organisation och distansteorierna presenteras.   Metod: Vår studie genomförs med ett abduktivt angreppssätt och en kvalitativ forskningsmetod. Ett målinriktat urval används för att finna respondenter som uppfyller förutbestämda kriterier. Data från sju respondenter samlas in genom semistrukturerade intervjuer som sedan transkriberas. Avslutningsvis analyseras insamlad data med hjälp av en tematisk analys.   Slutsats: Coronapandemin verkar inte medfört att grunden i ledarnas ledarskap har förändrats i någon större utsträckning. Coronapandemin har dock ställt helt andra krav på ledarna under distansarbetet som i större utsträckning behövt ta hänsyn till medarbetarnas välmående och ta mer ansvar för de sociala delarna som medarbetarna har gått miste om till följd av distansarbetet. I motsats till tidigare forskning, fann vi att tilliten inte blev lidande till följd av distansarbetet. Resultatet indikerade även att respondenterna tidigare erfarenhet av att leda på distans och bättre digitala förutsättningar hade en påverkan på hur smidigt omställningen till att arbeta på distans har kunnat ske.

<p>This project presents a case study of postmodern trauma, working at the boundaries of the humanities and computer science to produce an in-depth examination of trauma writing in David Foster Wallace’s novel <i>Infinite Jest</i>. The goal of this project is to examine the intricacies of syntax and language in postmodern trauma writing through an iterative process I refer to as <i>broken reading</i>, which combines traditional humanities methodologies (close reading) and distant, computational methodologies (Natural Language Processing). Broken reading begins with close reading, then ventures into the distant reading processes of sentiment analysis and entity analysis, and then returns again to close reading when the data must be analyzed and the broken computational elements must be corrected. While examining the syntactical structure of traumatic and non-traumatic passages through this broken reading methodology, I found that Wallace represents trauma as gendered. The male characters in the novel, when recollecting past traumata or undergoing traumatic events, maintain their subject status, recognize those around them as subjects, and are able to engage actively with the world around them. On the other hand, the female characters in the novel are depicted as lacking the same capacities for subjectivity and action. Through computational text analysis, it becomes clear that Wallace writes female trauma in a way that reflects their lack of agency and subjectivity while he writes male trauma in a way that maintains their agency and subjectivity. Through close reading, I was able to discover qualitative differences in Wallace’s representations of trauma and form initial observations about syntactical and linguistic patterns; through distant reading, I was able to quantify the differences I uncovered through close reading by conducting part of speech tagging, entity analysis, semantic analysis, and sentiment analysis. Distant reading led me to discover elements of the text that I had not noticed previously, despite the occasional flaw in computation. The analyses I produced through this broken reading process grew richer because of failure—when I failed as an interpreter, and when computational analysis failed, these failures gave me further insight into the trauma writing within the novel. Ultimately, there are marked syntactical and linguistic differences between the way that Wallace represents male and female trauma, which points toward the larger question of whether other white male postmodern authors gender trauma in their writings, too. This study has generated a prototype model for the <i>broken reading </i>methodology, which can be used to further examine postmodern trauma writing.</p>

With the rapidly growing computational power of modern computers, physically based rendering has found its way into real world applications. Real-time simulations and renderings of fire and smoke had become one major research interest in modern video game industry, and will continue being one important research direction in computer graphics. To visually recreate realistic dynamic fire and smoke is a complicated problem. Furthermore, to solve the problem requires knowledge from various areas, ranged from computer graphics and image processing to computational physics and chemistry. Even though most of the areas are well-studied separately, when combined, new challenges will emerge. This thesis focuses on three aspects of the problem, dynamic, real-time and realism, to propose a solution in form of a GPGPU pipeline, along with its implementation. Three main areas with application in the problem are discussed in detail: fluid simulation, volumetric radiance estimation and volumetric rendering. The weights are laid upon the first two areas. The results are evaluated around the three aspects, with graphical demonstrations and performance measurements. Uniform grids are used with Finite Difference (FD) discretization scheme to simplify the computation. FD schemes are easy to implement in parallel, especially with ComputeShader, which is well supported in Unity engine. The whole implementation can easily be integrated into any real-world applications in Unity or other game engines that support DirectX 11 or higher.

The diploma thesis deals with an urban study on the territory of Červený kopec, specifically in the part of the territory of Stráň. It is a locality stated as a brownfield Kohnova cihelna. The proposal aims to make the most of the potential of this site, which lies in its proximity to the city center, the neighborhood of the national natural monument, a significant area of greenery and the views that this place provides due to its topographic situation. A new city district is proposed on the area of 18 hectares, which would cover one of the "brownfield holes" on the map of the city of Brno and at the same time help against the outflow of population to the outskirts of the city and against the creation of urban satellites. Numerous public opinion polls show that they would like to live close to the city, but at the same time especially young families long for their own house in a quiet countryside location. Therefore, a compact development of terraced houses, terrace villas and blocks of flats with private courtyards is proposed here, complemented by quality public space and civic amenities. This new city district would offer housing for about 3,500 new residents.

<div>As destinations of missions in both human and robotic spaceflight become more exotic, a foundational understanding the dynamical structures in the gravitational environments enable more informed mission trajectory designs. One particular type of structure, quasi-periodic orbits, are examined in this investigation. Specifically, efficient computation of quasi-periodic orbits and leveraging quasi-periodic orbits as trajectory design alternatives in the Earth-Moon and Sun-Earth systems. First, periodic orbits and their associated center manifold are discussed to provide the background for the existence of quasi-periodic motion on n-dimensional invariant tori, where n corresponds to the number of fundamental frequencies that define the motion. Single and multiple shooting differential corrections strategies are summarized to compute families 2-dimensional tori in the Circular Restricted Three-Body Problem (CR3BP) using a stroboscopic mapping technique, originally developed by Howell and Olikara. Three types of quasi-periodic orbit families are presented: constant energy, constant frequency ratio, and constant mapping time families. Stability of quasi-periodic orbits is summarized and characterized with a single stability index quantity. For unstable quasi-periodic orbits, hyperbolic manifolds are computed from the differential of a discretized invariant curve. The use of quasi-periodic orbits is also demonstrated for destination orbits and transfer trajectories. Quasi-DROs are examined in the CR3BP and the Sun-Earth-Moon ephemeris model to achieve constant line of sight with Earth and avoid lunar eclipsing by exploiting orbital resonance. Arcs from quasi-periodic orbits are leveraged to provide an initial guess for transfer trajectory design between a planar Lyapunov orbit and an unstable halo orbit in the Earth-Moon system. Additionally, quasi-periodic trajectory arcs are exploited for transfer trajectory initial guesses between nearly stable periodic orbits in the Earth-Moon system. Lastly, stable hyperbolic manifolds from a Sun-Earth L₁ quasi-vertical orbit are employed to design maneuver-free transfer from the LEO vicinity to a quasi-vertical orbit.</div>