“Poetry makes nothing happen,” W.H. Auden famously articulates in “In Memory of W.B. Yeats, “it survives / A way of happening, a mouth.” The Dumb Weight is a collection of poems that explores this tension, always trying to locate the body, how it speaks, its language. The poems take as their subject the act of making as a performance of knowingness, an assumed familiarity as that of an intimate listener, and attempts to navigate the space between utterance and its subject, it’s author and speaker, speaker and what is spoken, between poem and you—for if what John Ashbery writes in “Paradoxes and Oxymorons,” is true, “the poem is you.”

O objetivo da presente dissertação é mostrar a necessidade dos signos e da linguagem nas teorias de conhecimento na França no século XVIII. Embora muitos outros filósofos tenham investigado a questão da importância e da necessidade da linguagem, tais como Rousseau e Du Marsais, analisamos os textos de Condillac e Diderot, nos quais os signos e a linguagem são considerados essenciais para a aquisição de conhecimento. Tal escolha foi feita, pois tanto Condillac quanto Diderot tomaram o surdo e mudo de nascença como exemplo para corroborarem suas teses sobre a origem da linguagem. A primeira obra apresentada é o Essai sur lorigine des connaissances humaines (Ensaio sobre a origem dos conhecimentos humanos) de Condillac, que baseou seu trabalho no empirismo de John Locke no An Essay Concerning Human Understanding (Ensaio Acerca do Entenimento Humano). Na Primeira Parte do Ensaio, Condillac discute a origem e o desenvolvimento das faculdades da mente e do conhecimento humano. Para ele, a única fonte de todos os nossos conhecimentos encontra-se na sensação e todas as outras operações da mente são derivadas daí. Porém, para que essas operações se desenvolvam o uso dos signos e a linugagem se fazem absolutamente necessários. A Segunda Parte da obra descreve a origem e o progresso da linguagem cujos signos naturais são gradualmente substituídos por signos instituídos e sons articulados, formando-se a linugagem fonética articulada. A segunda obra analisada é o Tratado das Sensações, na qual Condillac demostra como as ideias se originam da sensação. Ele acredita que é necessário estudar os sentidos separadamente para poder distinguir quais ideias devem ser atribuídas a cada sentido. Dessa forma, pode-se observar como os sentidos são treinados e como um sentido pode auxiliar o outro. Em seguida, estudamos a Carta sobre os surdos e mudos de Diderot, texto no qual o autor francês investiga diversos tópicos estéticos, linguísticos e epistemológicos. Ele inicia a Carta com uma discussão sobre as inversões linguísticas e observa que o assunto somente pode ser tratado se primeiramente considerarmos como as linguagens foram formadas, o que conduz o enciclopedista a analisar a ordem natural das ideias e expressões. Para ele, a ordem natural só pode ser verificada por meio de um estduo da linguagem de gestos, visto que, os gestos exprimem melhor que as palavras. Para comprovar sua tese sobre a linguagem de gestos, ele utiliza exemplos da lingugaem gestual de surdos e mudos. Ele então desenvolve uma teoria sobre os hieróglifos, na qual a imagem hieroglífica reúne em uma única expressão todo um conjunto de sensações e ideias, passando pela linguagem de gestos, pantomima, prosódia, música e pintura. Baseado na teoria dos hieróglifos, ele mostra o conflito existente entre a ordem simultânea das ideias formadas em nosso pensamento e a ordem sucessiva do discurso. No final do texto, ele retoma os principais argumentos do debate precedente sobre a ordem das palavras. / The objective of this thesis is to show the necessity of signs and language in the theories of knowledge in France in the 18th century. Although several philosophers investigated the question of the importance and necessity of language, such as Rousseau and Du Marsais, we analysed texts of Condillac and Diderot, in which signs and language are considered to be essential for knowledge acquisition. Such choice was made since Condillac and Diderot considered the deaf-mute from birth as an example to corroborate their theses about the origin of language. The first book presented is the Essai sur lorigine des connaissances humanines by Condillac that based his work in the empiricism in the An Essay Concerning Human Understanding by John Locke. In Part I of the Essay, Condillac discuss the origin and development of the faculties of the mind and human knowledge. According to him, the only source for all knowledge is the sensation and the other operations are derived from this. However, for these operations to be developed the usage of signs and language are absolutely necessary. Part II of the Essay describes the origin and progress of the language which natural signs are gradually replaced by instituted signs and articulate sounds, what turn them into articulate phonetic language. The second text analysed is the Treatise on Sensations in which Condillac demonstrates how ideas come from sensation. He believes that it is necessary to study the senses separately to be able to distinguish which ideas should be assigned to each sense. In this way, it is possible to observe how the senses are trained and how a sense can aid another one. After that, we studied the Letter on the deaf and dumb by Diderot in which the French author investigates several aesthetics, linguistics and epistemological topics. He stars the Letter with a discussion about linguistic inversions and observes that the subject can only be dealt with if first we take into account how languages were formed. This leads the encyclopaedist to analyse the natural order of ideas and expressions. To corroborate his theses about gestural language, he uses examples of the deaf and dumb gestural language. Then, he develops a theory about hieroglyphs, in which the hieroglyphic image joins in one simple expression a whole set of sensations and ideas, going through pantomime, prosody, music and painting. Based on the theory of hieroglyphs, he shows the conflict that exists between the simultaneous order of formed ideas in our thought and the successive order of speech. At the endo of the text, he returns to the main arguments of the previous debate about the order of the words.

O objetivo da presente dissertação é mostrar a necessidade dos signos e da linguagem nas teorias de conhecimento na França no século XVIII. Embora muitos outros filósofos tenham investigado a questão da importância e da necessidade da linguagem, tais como Rousseau e Du Marsais, analisamos os textos de Condillac e Diderot, nos quais os signos e a linguagem são considerados essenciais para a aquisição de conhecimento. Tal escolha foi feita, pois tanto Condillac quanto Diderot tomaram o surdo e mudo de nascença como exemplo para corroborarem suas teses sobre a origem da linguagem. A primeira obra apresentada é o Essai sur lorigine des connaissances humaines (Ensaio sobre a origem dos conhecimentos humanos) de Condillac, que baseou seu trabalho no empirismo de John Locke no An Essay Concerning Human Understanding (Ensaio Acerca do Entenimento Humano). Na Primeira Parte do Ensaio, Condillac discute a origem e o desenvolvimento das faculdades da mente e do conhecimento humano. Para ele, a única fonte de todos os nossos conhecimentos encontra-se na sensação e todas as outras operações da mente são derivadas daí. Porém, para que essas operações se desenvolvam o uso dos signos e a linugagem se fazem absolutamente necessários. A Segunda Parte da obra descreve a origem e o progresso da linguagem cujos signos naturais são gradualmente substituídos por signos instituídos e sons articulados, formando-se a linugagem fonética articulada. A segunda obra analisada é o Tratado das Sensações, na qual Condillac demostra como as ideias se originam da sensação. Ele acredita que é necessário estudar os sentidos separadamente para poder distinguir quais ideias devem ser atribuídas a cada sentido. Dessa forma, pode-se observar como os sentidos são treinados e como um sentido pode auxiliar o outro. Em seguida, estudamos a Carta sobre os surdos e mudos de Diderot, texto no qual o autor francês investiga diversos tópicos estéticos, linguísticos e epistemológicos. Ele inicia a Carta com uma discussão sobre as inversões linguísticas e observa que o assunto somente pode ser tratado se primeiramente considerarmos como as linguagens foram formadas, o que conduz o enciclopedista a analisar a ordem natural das ideias e expressões. Para ele, a ordem natural só pode ser verificada por meio de um estduo da linguagem de gestos, visto que, os gestos exprimem melhor que as palavras. Para comprovar sua tese sobre a linguagem de gestos, ele utiliza exemplos da lingugaem gestual de surdos e mudos. Ele então desenvolve uma teoria sobre os hieróglifos, na qual a imagem hieroglífica reúne em uma única expressão todo um conjunto de sensações e ideias, passando pela linguagem de gestos, pantomima, prosódia, música e pintura. Baseado na teoria dos hieróglifos, ele mostra o conflito existente entre a ordem simultânea das ideias formadas em nosso pensamento e a ordem sucessiva do discurso. No final do texto, ele retoma os principais argumentos do debate precedente sobre a ordem das palavras. / The objective of this thesis is to show the necessity of signs and language in the theories of knowledge in France in the 18th century. Although several philosophers investigated the question of the importance and necessity of language, such as Rousseau and Du Marsais, we analysed texts of Condillac and Diderot, in which signs and language are considered to be essential for knowledge acquisition. Such choice was made since Condillac and Diderot considered the deaf-mute from birth as an example to corroborate their theses about the origin of language. The first book presented is the Essai sur lorigine des connaissances humanines by Condillac that based his work in the empiricism in the An Essay Concerning Human Understanding by John Locke. In Part I of the Essay, Condillac discuss the origin and development of the faculties of the mind and human knowledge. According to him, the only source for all knowledge is the sensation and the other operations are derived from this. However, for these operations to be developed the usage of signs and language are absolutely necessary. Part II of the Essay describes the origin and progress of the language which natural signs are gradually replaced by instituted signs and articulate sounds, what turn them into articulate phonetic language. The second text analysed is the Treatise on Sensations in which Condillac demonstrates how ideas come from sensation. He believes that it is necessary to study the senses separately to be able to distinguish which ideas should be assigned to each sense. In this way, it is possible to observe how the senses are trained and how a sense can aid another one. After that, we studied the Letter on the deaf and dumb by Diderot in which the French author investigates several aesthetics, linguistics and epistemological topics. He stars the Letter with a discussion about linguistic inversions and observes that the subject can only be dealt with if first we take into account how languages were formed. This leads the encyclopaedist to analyse the natural order of ideas and expressions. To corroborate his theses about gestural language, he uses examples of the deaf and dumb gestural language. Then, he develops a theory about hieroglyphs, in which the hieroglyphic image joins in one simple expression a whole set of sensations and ideas, going through pantomime, prosody, music and painting. Based on the theory of hieroglyphs, he shows the conflict that exists between the simultaneous order of formed ideas in our thought and the successive order of speech. At the endo of the text, he returns to the main arguments of the previous debate about the order of the words.

Multimedia technology in theatre is nothing new, but various companies in modern and post-modern Japan, such as Dumb Type, Hatsune Miku, and the robot theatre of Oriza Hirata and Hiroshi Ishiguro, have been experimenting with mediatized technology. This thesis hones in on these Japanese multimedia theatres. It studies the origins of mediatization in theatre, looking at the impact of the innovations made by Adolphe Appia. Furthermore, the growing impact of media technology can create a perception of ‘Liveness’ of these artificial actors. Liveness is a critically important concept, both on and off stage, affecting how one perceives the non-human and the type of relationships that are conveyed between the human and non-human actor, as well as the non-human actor and its human audience. This thesis covers the productions of “A One Woman Show” and a spoiler-heavy discussion on "Super Danganronpa 2 The Stage ~Sayonara Zetsubō Gakuen~" within the context of the impact of projections on stage. Robots and the uncanny valley are also reviewed, with the play "Sayonara" as the primary case study within this topic. Then the thesis analyzes the experimental human theatre of Dumb Type, focusing on their plays "S/N" and "pH," as well Vocaloid concerts and the impact of these characters, especially Hatsune Miku, upon the fans. In the course of this analysis, reasons are suggested as to why these technological innovations have found particular success in Japan. / Graduate

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Le suppresseur de tumeur p53 permet à la cellule de se défendre contre différentes formes de stress. Il joue un rôle de barrière s'opposant à la tumorigenèse: en effet la perte de p53 chez la souris prédispose grandement ces animaux à développer des tumeurs; de même le locus p53 est inactivé dans près de 50% des tumeurs humaines. p53 constitue un facteur de transcription qui se lie à des séquences particulières de l'ADN et active l'expression des gènes adjacents. L'expression orchestrée de ces gènes conduit, directement ou indirectement et suivant le contexte cellulaire, soit à la mort de la cellule soit à l'inhibition de la division cellulaire. Les mécanismes moléculaires médiant ces deux activités biologiques essentielles de p53, de même que les mécanismes influençant le choix de la réponse cellulaire, sont encore mal compris. L'importance de p53 dans ce choix reste également à démontrer. Afin de contribuer à la compréhension de ces mécanismes, le modèle murin déficient pour Mdm4, un régulateur négatif de l'activité de p53, a été choisi. L'inactivation de Mdm4 chez la souris conduit en effet à l'activation ectopique de p53 in vivo et l'induction de deux types de réponse: apoptose dans le neuroépithélium et arrêt de la prolifération cellulaire dans les tissus non neuronaux. Le profil d'expression des gènes dans les tissus neuronaux et non neuronaux a donc été comparé entre embryons de souris sauvage et mdm4-/- par la technique d'hybridation de biopuces à ADN. Les résultats obtenus suggèrent que le type de réponse dépend du type cellulaire et non de p53 lui-même. En effet les profils d'expression des gènes dans les tissus neuronaux (conditions d'apoptose) et non neuronaux (conditions d'arrêt de la prolifération cellulaire) chez l'embryon de souris mdm4-/- sont comparables. Nous nous sommes ensuite particulièrement intéressés à deux nouveaux gènes dont l'expression est augmentée dans les embryons mdm4-/-. Dans un premier temps, leur induction transcriptionnelle chez l'embryon de souris mdm4-/- a été confirmée par différentes techniques et il a été vérifié qu'ils constituaient tous deux des cibles directes de p53 induites suite à un stress génotoxique. Le premier gène code Dapk1, une protéine suppresseur de tumeur pro-apoptotique présentant une activité de type sérine/thréonine kinase. Ce travail a permis d'établir que Dapk1 participait à une boucle de rétroaction du contrôle de l'activité de p53. Le deuxième gène identifié code la protéine Ptprv, un récepteur transmembranaire présentant une activité de type tyrosine phosphatase. En vue d'étudier la signification physiologique de l'induction transcriptionnelle de ptprv suite à l'activation de p53, des expériences effectuées à partir de matériel biologique issu de souris déficientes pour Ptprv ont été réalisées. Ces expériences confirment le rôle essentiel de Ptprv comme médiateur de l'arrêt du cycle cellulaire en phase G1 induit par p53 suite à un stress génotoxique, à la fois in vitro et in vivo. Par contre, Ptprv ne semble pas influencer l'apoptose induite suite à l'activation de p53. Ce travail a également permis d'établir le rôle essentiel de Ptprv dans la suppression de tumeurs induites chez la souris par activation constitutive de l'oncogène Ras.

Title: Influence of buoyancy dumb-bells on load intensity during shallow water aerobic Objectives: The aim of this theses was to compare the heart rate to several variants during 14 minutes head-out aquatic exercise (with simultaneous legs and arms actions and with simultaneous legs and arms actions using buoyancy dumb-bells). 8 females, clinically healthy and with a regular level of physical activity in age between 25-60 years (age 42 ± 11,4 years) were studied. The other aim of this theses was to compare the heart rate during rest on land and rest in water during shallow water aerobic in an upright position with water level to shoulder depth. Methods: We monitored heart rate changes during 14 minutes head-out aquatic exercise by Sport Tester S610i. The results of the tests were analyzed and evaluated with Polar Precision Performance software. Chi-squared test was used to examine the average difference to heart rate during tests. Results: We found non-significant increases on load intensity during test with using buoyancy dumb-bells. Average heart rate during rest in water showed decreases by 13 beats per minute. Keywords: buoyancy dumb-bells, load intensity, heart rate, shallow water aerobic

This thesis examines the lives of the deaf in late nineteenth century Ontario through a statistical analysis of a dataset from the 1891 Canadian Census. I examine the characteristics of the deaf as compared to the hearing population of Ontario in terms of age, sex, marital status, occupation and geographical distribution. Though there are many statistical differences between the deaf and hearing populations, I am able to show how the availability of a formal education for the deaf in the form of the Ontario Institution for the Deaf and Dumb in Belleville, Ont, had begun to minimize the effects of these differences. Education also allowed for the creation of a socially active Ontario deaf community, held together by the Ontario Deaf-Mute Association and the Ontario Mission for the Deaf.

Aktuelle Debatten in der Hörgeschädigtenpädagogik beschäftigen sich vor allem mit den Fragen der Sprachbildung hörgeschädigter Kinder im Rahmen der schulischen Inklusion. Übersehen wird dabei oft, dass dieser Diskurs nicht neu ist, sondern bereits historische Vorläufer hat. Ziel dieser Untersuchung ist deshalb, Veränderungsprozesse von Elementarbildung und Sprachbildung hörgeschädigter Kinder im 18. und 19. Jahrhundert vor dem Hintergrund einer sich etablierenden Volksschulbildung zu analysieren, um den schulstrukturellen Wandel und seine Auswirkungen nachzuzeichnen. Auf der Grundlage einer quellenkritischen Rekonstruktion wurden dafür ideen-, sozial- und institutions-geschichtliche Ereignisse und Diskurse im Sinne des kritisch-konstruktiven Ansatzes von Klafki (1971) analysiert. Im Fokus standen dabei die konkreten Auswirkungen (national-) sprachlicher und bildungspolitischer Konzepte auf den Unterricht am Berliner Königlichen Taubstummeninstitut und auf die ländliche Schulpraxis in der Provinz Brandenburg. Die Analysen zeigen, dass die sprachphilosophischen Diskurse in dieser Zeit Fehlannahmen über die Funktion und Bedeutung von Laut- und Gebärdensprachen enthielten, die die Sprachbildungskonzepte für gehörlose Menschen maßgeblich prägten. Außerdem führte die Verallgemeinerungsbewegung, in deren Rahmen zunehmend gehörlose Menschen auch in Volksschulen unterrichtet wurden, dazu dass die ausschließliche Förderung der Lautsprache propagiert wurde. Zweisprachige Bildungskonzepte, mit der Gebärdensprache als festem Bestandteil, wurden aufgegeben. Die besonderen Bedürfnisse gehörloser Menschen wurden weder an allgemeinen Schulen noch an Taubstummeninstituten berücksichtigt und der Zugang zu Bildung setzte damit in der Folgezeit eine einseitige Anpassungsleistung gehörloser Menschen voraus. / Current debates in deaf education are primarily concerned with questions of language education of hearing impaired children as part of school inclusion. It is often overlooked in this context that this discourse is not new, but already has historical antecedents. The aim of this study is therefore to analyse the changing processes of elementary education and language education of hearing impaired children in the 18th and 19th centuries against the background of the on-going establishment of elementary education, in order to reconstruct the structural change of the culture of schooling and its impact. To this end, historical ideas, social and institutional discourses and events were analysed in terms of the critical and constructive approach of Klafki (1971) on the basis of a source-critical reconstruction. The focus was on the specific impact of (national) linguistic and educational approaches to teaching at the Berlin Royal Institute of Deaf and Dumb and the rural school practice in the province of Brandenburg. The analyses show that the discourses on linguistic philosophy at this time contained misperceptions concerning the function and meaning of spoken and signed languages that significantly shaped approaches to language education for deaf people. Furthermore, the movement towards generalisation, in the framework of which deaf people were increasingly also taught in elementary schools, led to the exclusive propagation of the promotion of oral language. Bilingual education concepts, with sign language as an integral part, were abandoned. The special needs of deaf people were not taken into consideration in either public schools or in deaf and dumb institutions, and access to education in the subsequent period thus presupposed a successful unilateral adaptation of deaf people.

A presente dissertação tem como objeto de estudo sistemas da física da matéria condensada que sejam capazes de simular sistemas gravitacionais, tais como buracos negros e universos em expansão, onde processos quânticos tomam parte. Neste estudo nos debruçamos principalmente sobre o modelo do fluido e condensados de Bose-Einstein. No modelo do fluido exploramos a geometria efetiva que surge e os problemas de back-reaction e dos modos trans-planckianos de campos quânticos. No modelo baseado em condensados exploramos sua faceta cosmológica e a possibilidade de campos maciços. Além destes dois modelos de grande relevância na literatura, ainda expomos os análogos em cordas elásticas e os baseados em ondas na superfícies de fluidos e uma análise geral baseada no formalismo lagrangeano para campos. / This dissertation has as object of study systems of condensate-matter physics which can simulate gravitational systems like black holes and expanding universes where quantum processes take place. In this study we lay attention mainly on the fluid model and on Bose-Einstein-condensate-based models. In the fluid model we explore the features of the emergent geometry and other problems like the back-reaction and the trans-planckian modes of quantum fields. In the condensate-based models we explore their cosmological aspects and the possibility for massive fields. Moreover, we shall present two other models, the elastic string and the surface-wave-based models in fluids, and a very general analysis based on the Lagrangean formalism for fields.